| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashish Patel, Drashti Shah, Yug Patel, Stuti Patel, Meshwa Mehta, Tushar Bambharoliy. A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current drug targets. 2022-12-14. PMID:36515018. |
a review on recent development of novel heterocycles as acetylcholinesterase inhibitor for the treatment of alzheimer's disease. |
2022-12-14 |
2023-08-14 |
Not clear |
| Ashish Patel, Drashti Shah, Yug Patel, Stuti Patel, Meshwa Mehta, Tushar Bambharoliy. A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current drug targets. 2022-12-14. PMID:36515018. |
acetylcholinesterase (ache) has obtained a renewed interest as a therapeutic target in alzheimer's disease (ad) due to increased neural cells' function by increasing the concentration of acetylcholine. |
2022-12-14 |
2023-08-14 |
Not clear |
| Giuseppe Uras, Xinuo Li, Alessia Manca, Antonella Pantaleo, Marco Bo, Jinyi Xu, Stephanie Allen, Zheying Zh. Development of p-Tau Differentiated Cell Model of Alzheimer's Disease to Screen Novel Acetylcholinesterase Inhibitors. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499118. |
development of p-tau differentiated cell model of alzheimer's disease to screen novel acetylcholinesterase inhibitors. |
2022-12-11 |
2023-08-14 |
Not clear |
| Vyacheslav E Semenov, Irina V Zueva, Sofya V Lushchekina, Eduard G Suleimanov, Liliya M Gubaidullina, Marina M Shulaeva, Oksana A Lenina, Konstantin A Petro. Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 27. issue 22. 2022-11-26. PMID:36431954. |
novel uracil-based inhibitors of acetylcholinesterase with potency for treating memory impairment in an animal model of alzheimer's disease. |
2022-11-26 |
2023-08-14 |
Not clear |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Meriem Lamrani, Talia Serseg, Khedidja Benarous, Ibrahim Sifi, Mohamed Yousf. Hydroxycoumarins and some flavonoids from Pistacia atlantica Desf. as multi-targets inhibitors for Alzheimer's disease: Molecular docking and ADMET studies. Current computer-aided drug design. 2022-11-06. PMID:36336813. |
the present study aimed to identify new selective inhibitors for acetylcholinesterase, butyrylcholinesterase, monoacylglycerol lipase, beta-secretase, and asparagine endopeptidase, the targets enzymes in alzheimer's disease. |
2022-11-06 |
2023-08-14 |
Not clear |
| Nguyen Huy Hung, Pham Minh Quan, Prabodh Satyal, Do Ngoc Dai, Vo Van Hoa, Ngo Gia Huy, Le Duc Giang, Nguyen Thi Ha, Le Thi Huong, Vu Thi Hien, William N Setze. Acetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants. Molecules (Basel, Switzerland). vol 27. issue 20. 2022-10-27. PMID:36296686. |
furthermore, they are also of interest as aromatherapeutic agents in the treatment of alzheimer's disease, and inhibition of the enzyme acetylcholinesterase (ache) has been evaluated as an important mechanism. |
2022-10-27 |
2023-08-14 |
human |
| Ana Matošević, Anamarija Knežević, Antonio Zandona, Nikola Maraković, Zrinka Kovarik, Anita Bosa. Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297332. |
as butyrylcholinesterase (bche) plays a role in the progression of symptoms and pathophysiology of alzheimer's disease (ad), selective inhibition of bche over acetylcholinesterase (ache) can represent a promising pathway in treating ad. |
2022-10-27 |
2023-08-14 |
Not clear |
| Phujinn Honorio, Supa Hannongbua, Patchreenart Saparpakor. Roles of hybrid donepezil scaffolds as potent human acetylcholinesterase inhibitors using in silico interaction analysis, drug-likeness, and pharmacokinetics prediction. Chemico-biological interactions. 2022-10-27. PMID:36302488. |
acetylcholinesterase (ache) is currently one of the potent targets for the treatment of alzheimer's disease (ad). |
2022-10-27 |
2023-08-14 |
human |
| Ilkay Erdogan Orhan, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Sule Irmak, Ozden Ozgun Acar, Gurbet Celik Turgut, Alaattin Sen, Ana-Maria Zbancioc, Simon Vlad Luca, Adrianna Skiba, Krystyna Skalicka Wozniak, Gabriela Tataring. Evaluation of anti-Alzheimer activity of synthetic coumarins by combination of in vitro and in silico approaches. Chemistry & biodiversity. 2022-10-25. PMID:36282001. |
series of synthetic coumarin derivatives (1-16) were tested against acetylcholinesterase (ache) and butyrylcholinesterase (bche), two enzymes linked to the pathology of alzheimer's disease (ad). |
2022-10-25 |
2023-08-14 |
human |
| Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Su. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease. European journal of medicinal chemistry. vol 244. 2022-10-12. PMID:36223681. |
design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and nrf2 activating functions for alzheimer's disease. |
2022-10-12 |
2023-08-14 |
Not clear |
| Qian Guo, Qinfeng Cai, Fang Huang, Zhen Wei, Jian-Zhi Wang, Bin Zhang, Rong Liu, Yang Yang, Xiaochuan Wang, Hong-Lian L. The Therapeutic Effects of Seven Lycophyte Compounds on Cell Models of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2022-10-03. PMID:36189599. |
as an acetylcholinesterase inhibitor (achei), huperzine-a (hup-a) is marketed for treatment of mild to moderate alzheimer's disease (ad) for decades in china. |
2022-10-03 |
2023-08-14 |
Not clear |
| Opeyemi Babatunde Ogunsuyi, Folorunsho Bright Omage, Olawande Chinedu Olagoke, Ganiyu Oboh, João Batista Teixeria Roch. Phytochemicals from African eggplants ( Journal of biomolecular structure & dynamics. 2022-09-27. PMID:36165440. |
phytochemicals from african eggplants ( acetylcholinesterase inhibitors (acheis) like donepezil are commonly used to treat alzheimer's disease. |
2022-09-27 |
2023-08-14 |
Not clear |
| Nebih Lolak, Süleyman Akocak, Mustafa Durgun, Hatice Esra Duran, Adem Necip, Cüneyt Türkeş, Mesut Işık, Şükrü Beydemi. Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors. Molecular diversity. 2022-09-22. PMID:36136229. |
to discover alternative substances to compounds used to treat many diseases, especially treating alzheimer's disease (ad) and parkinson's disease targeting carbonic anhydrase (hca) and acetylcholinesterase (ache) enzymes, is important. |
2022-09-22 |
2023-08-14 |
Not clear |
| Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R Bennett, David Greenberg, David A Bennett, Hermona Sore. Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-09-19. PMID:36117917. |
acetylcholinesterase and butyrylcholinesterase (ache and bche) are involved in modulating cholinergic signaling, but their roles in alzheimer's and parkinson's diseases (ad and pd) remain unclear. |
2022-09-19 |
2023-08-14 |
Not clear |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |
| Şevval Karaca, Derya Osmaniye, Begum Nurpelin Sağlık, Serkan Levent, Sinem Ilgın, Yusuf Özkay, Ahmet Çağrı Karaburun, Zafer Asım Kaplancıklı, Nalan Gundogdu-Karaburu. Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease. RSC advances. vol 12. issue 36. 2022-09-12. PMID:36090440. |
the use of dual acetylcholinesterase (ache)-monoamine oxidase b (mao-b) inhibitors is a new approach in the treatment of alzheimer disease (ad). |
2022-09-12 |
2023-08-14 |
Not clear |
| Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decke. Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC medicinal chemistry. vol 13. issue 8. 2022-09-12. PMID:36092149. |
as levels of acetylcholinesterase (ache) decrease while levels of butyrylcholinesterase (bche) increase in later stages of alzheimer's disease (ad), bche stands out as a promising target for treatment of ad. |
2022-09-12 |
2023-08-14 |
mouse |
| Hormoz Pourtaher, Alireza Hasaninejad, Aida Iraj. Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-08. PMID:36075926. |
design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against alzheimer's disease. |
2022-09-08 |
2023-08-14 |
Not clear |
| Hormoz Pourtaher, Alireza Hasaninejad, Aida Iraj. Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-08. PMID:36075926. |
the objective of this study was to design new polysubstituted pyrrole derivatives as selective acetylcholinesterase (ache) inhibitors to target alzheimer's disease. |
2022-09-08 |
2023-08-14 |
Not clear |