| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine N Metz, Valentin A Pavlo. Treating disorders across the lifespan by modulating cholinergic signaling with galantamine. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33219523. |
cholinergic drugs, including the centrally acting acetylcholinesterase inhibitor, galantamine, which are in clinical use for the treatment of alzheimer's disease and other neurodegenerative and neuropsychiatric disorders, have been rediscovered as anti-inflammatory agents. |
2021-11-17 |
2023-08-13 |
Not clear |
| Murilo K A Yonekawa, Bruna de B Penteado, Amanda Dal'Ongaro Rodrigues, Estela M G Lourenço, Euzébio G Barbosa, Silvia C das Neves, Rodrigo J de Oliveira, Maria R Marques, Denise B Silva, Dênis P de Lima, Adilson Beatriz, Jean P Oses, Jeandre A Dos S Jaques, Edson Dos A Dos Santo. l-Hypaphorine and d-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue. Bioorganic & medicinal chemistry letters. vol 47. 2021-11-15. PMID:34146704. |
acetylcholinesterase (acheis) inhibitors are used to treat neurodegenerative diseases like alzheimer's disease (ad). |
2021-11-15 |
2023-08-13 |
human |
| Ana E Gonçalves, Ângela Malheiros, Camila A Casarin, Lara de França, David L Palomino-Salcedo, Leonardo L G Ferreira, Adriano D Andricopulo, María J Dávila-Rodríguez, Leticia C Lacava, Aldo S de Oliveira, Marcia M de Souz. 2',6'-dihydroxy-4'-methoxy Dihydrochalcone Improves the Cognitive Impairment of Alzheimer's Disease: A Structure-activity Relationship Study. Current topics in medicinal chemistry. vol 21. issue 13. 2021-11-15. PMID:34218788. |
chalcones and dihydrochalcones present potent inhibition of acetylcholinesterase, currently considered the most efficient approach for symptomatic treatment of alzheimer's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Duo Cao, Peng Sun, Sumana Bhowmick, Yahui Wei, Bin Guo, Yanhong Wei, Luis A J Mur, Zhenliang Su. Secondary metabolites of endophytic fungi isolated from Huperzia serrata. Fitoterapia. vol 155. 2021-11-15. PMID:34419561. |
the natural product huperzine a isolated from huperzia serrata is a targeted inhibitor of acetylcholinesterase that has been approved for clinical use in the treatment of alzheimer's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Fatima Y Adeowo, Tosin P Oyetunji, Murtala A Ejalonibu, Umar Ndagi, Hezekiel M Kumalo, Monsurat M Lawa. Tailored Modeling of Rivastigmine Derivatives as Dual Acetylcholinesterase and Butyrylcholinesterase Inhibitors for Alzheimer's Disease Treatment. Chemistry & biodiversity. vol 18. issue 11. 2021-11-15. PMID:34547176. |
tailored modeling of rivastigmine derivatives as dual acetylcholinesterase and butyrylcholinesterase inhibitors for alzheimer's disease treatment. |
2021-11-15 |
2023-08-13 |
human |
| Fatima Y Adeowo, Tosin P Oyetunji, Murtala A Ejalonibu, Umar Ndagi, Hezekiel M Kumalo, Monsurat M Lawa. Tailored Modeling of Rivastigmine Derivatives as Dual Acetylcholinesterase and Butyrylcholinesterase Inhibitors for Alzheimer's Disease Treatment. Chemistry & biodiversity. vol 18. issue 11. 2021-11-15. PMID:34547176. |
herein, we integrate computational and theoretical methodologies to unveil rivastigmine derivatives as dual inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (buche) for alzheimer's disease (ad) management. |
2021-11-15 |
2023-08-13 |
human |
| Shoaib Manzoor, Moustafa T Gabr, Bisma Rasool, Kavita Pal, Nasimul Hod. Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34562674. |
dual targeting of acetylcholinesterase and tau aggregation: design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for alzheimer's disease. |
2021-11-15 |
2023-08-13 |
Not clear |
| Patricia A Vignaux, Eni Minerali, Thomas R Lane, Daniel H Foil, Peter B Madrid, Ana C Puhl, Sean Ekin. The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase. Chemical research in toxicology. vol 34. issue 5. 2021-11-12. PMID:33400519. |
acetylcholinesterase (ache) is an important drug target in neurological disorders like alzheimer's disease, lewy body dementia, and parkinson's disease dementia as well as for other conditions like myasthenia gravis and anticholinergic poisoning. |
2021-11-12 |
2023-08-13 |
human |
| Yuki Takada-Takator. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 141. issue 6. 2021-11-11. PMID:34078793. |
donepezil, the most widely used drug for the treatment of alzheimer's disease (ad), is an acetylcholinesterase (ache) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. |
2021-11-11 |
2023-08-13 |
rat |
| Etta Y L Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K L Kwan, Miranda L Xu, Karl W K Tsi. Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Molecular pharmacology. vol 100. issue 5. 2021-11-10. PMID:34531295. |
acetylcholinesterase inhibitors (acheis), the most developed treatment strategies for alzheimer's disease (ad), will be used in clinic for, at least, the next decades. |
2021-11-10 |
2023-08-13 |
Not clear |
| Etta Y L Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K L Kwan, Miranda L Xu, Karl W K Tsi. Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Molecular pharmacology. vol 100. issue 5. 2021-11-10. PMID:34531295. |
significance statement: acetylcholinesterase inhibitors (acheis) are the most developed treatment strategies for alzheimer's disease (ad) and will be used in clinic for at least the next decades. |
2021-11-10 |
2023-08-13 |
Not clear |
| Balázs Knakker, Vilmos Oláh, Attila Trunk, Balázs Lendvai, György Lévay, István Hernád. Delay-dependent cholinergic modulation of visual short-term memory in rhesus macaques. Behavioural brain research. vol 396. 2021-11-09. PMID:32891649. |
then, we studied how cholinergic neuromodulation influences vwm maintenance using the muscarinic receptor antagonist scopolamine administered alone as transient amnestic treatment, and in combination with two doses of the acetylcholinesterase inhibitor donepezil, a widely used alzheimer's medication probing for the reversal of scopolamine-induced impairments. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jieun Kim, Hyun-Ju Lee, Seon Kyeong Park, Jin-Hee Park, Ha-Ram Jeong, Soojung Lee, Heeyong Lee, Eunyoung Seol, Hyang-Sook Ho. Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling. International journal of molecular sciences. vol 22. issue 19. 2021-11-08. PMID:34638977. |
the acetylcholinesterase inhibitors donepezil and rivastigmine have been used as therapeutic drugs for alzheimer's disease (ad), but their effects on lps- and aβ-induced neuroinflammatory responses and the underlying molecular pathways have not been studied in detail in vitro and in vivo. |
2021-11-08 |
2023-08-13 |
mouse |
| Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Koki Chiba, Takeshi Wada, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyam. Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 4. 2021-11-05. PMID:33064166. |
donepezil, an inhibitor for acetylcholinesterase used for patients with alzheimer's disease, has been shown to inhibit i |
2021-11-05 |
2023-08-13 |
Not clear |
| Ivan Sanchis, Roque Spinelli, Nicolas Aschemacher, Alvaro Sebastían Sian. Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants. Amino acids. 2021-11-05. PMID:34738177. |
the use of acetylcholinesterase (ache) inhibitors, antioxidants or multitarget compounds are among the main strategies against alzheimer's disease (ad). |
2021-11-05 |
2023-08-13 |
Not clear |
| Brunella Biscussi, Victoria Richmond, Carlos Javier Baier, Pau Arroyo Mañez, Ana Paula Murra. Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogs with Potent Cholinesterase Inhibition. CNS & neurological disorders drug targets. vol 19. issue 8. 2021-11-02. PMID:32888280. |
currently approved alzheimer's disease medications mainly comprise acetylcholinesterase inhibitors. |
2021-11-02 |
2023-08-13 |
Not clear |
| Selin S Suner, Mehtap Sahiner, Ramesh S Ayyala, Venkat R Bhethanabotla, Nurettin Sahine. Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities. Journal of fluorescence. vol 31. issue 6. 2021-10-26. PMID:34424483. |
finally, cys cds were also shown to inhibit the acetylcholinesterase (ache) enzyme, which is used in the treatment of alzheimer's disease, even at the low concentration of 100 μg/ml. |
2021-10-26 |
2023-08-13 |
Not clear |
| Sara Young, Enoch Chung, Michael A Che. Cardiovascular Complications of Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Narrative Review. Annals of geriatric medicine and research. vol 25. issue 3. 2021-10-22. PMID:34610666. |
cardiovascular complications of acetylcholinesterase inhibitors in patients with alzheimer's disease: a narrative review. |
2021-10-22 |
2023-08-13 |
Not clear |
| Sara Young, Enoch Chung, Michael A Che. Cardiovascular Complications of Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Narrative Review. Annals of geriatric medicine and research. vol 25. issue 3. 2021-10-22. PMID:34610666. |
while acetylcholinesterase inhibitors are used to treat a wide range of patients with alzheimer's disease, acetylcholinesterase inhibitor use has also been associated with a variety of cardiovascular complications, including bradycardia and syncope. |
2021-10-22 |
2023-08-13 |
Not clear |
| Leiming Zhang, Yanqin Song, Chengwen Lu, Jianqiao Zhang, Jiani Yuan, Tian Wang, Fenghua F. The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice. Experimental and therapeutic medicine. vol 5. issue 3. 2021-10-21. PMID:23403922. |
the acetylcholinesterase inhibitor (achei), huperzine a has been used in the treatment of the cognitive deterioration associated with alzheimer's disease (ad). |
2021-10-21 |
2023-08-12 |
mouse |