| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suleyman Akocak, Parham Taslimi, Nebih Lolak, Mesut Işık, Mustafa Durgun, Yakup Budak, Cüneyt Türkeş, İlhami Gülçin, Şükrü Beydemi. Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α-Glycosidase and Cholinesterase Inhibitors. Chemistry & biodiversity. vol 18. issue 4. 2021-07-26. PMID:33620128. |
in vitro and in silico inhibitory effects of the novel ureido-substituted sulfaguanidine derivatives were investigated by spectrophotometric methods for α-glycosidase (α-gly), acetylcholinesterase (ache), and butyrylcholinesterase (bche) enzymes associated with diabetes mellitus (dm) and alzheimer's disease (ad). |
2021-07-26 |
2023-08-13 |
Not clear |
| Toshiro Noshita, Kentaro Fujita, Takeru Koga, Hidekazu Ouchi, Akihiro Ta. Synthesis and biological activity of (±)-7,3',4'-trihydroxyhomoisoflavan and its analogs. Bioorganic & medicinal chemistry letters. vol 31. 2021-07-22. PMID:33161123. |
acetylcholinesterase (ache) inhibitors and neurite outgrowth promoters are thought to alleviate the symptoms of degenerative brain disorders, such as alzheimer's disease. |
2021-07-22 |
2023-08-13 |
Not clear |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
the state of the art on acetylcholinesterase inhibitors in the treatment of alzheimer's disease. |
2021-07-22 |
2023-08-13 |
Not clear |
| Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Ki. Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced Initial Burst Release: Effect of Hybridization of Microstructured Lipid Carriers and Albumin. Pharmaceutics. vol 13. issue 6. 2021-07-14. PMID:34208289. |
the daily oral administration of acetylcholinesterase (ache) inhibitors for alzheimer's disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. |
2021-07-14 |
2023-08-13 |
human |
| Wansiri Innok, Asadhawut Hiranrat, Netnapa Chana, Thanyada Rungrotmongkol, Panita Kongsun. In silico and in vitro anti-AChE activity investigations of constituents from Mytragyna speciosa for Alzheimer's disease treatment. Journal of computer-aided molecular design. vol 35. issue 3. 2021-07-13. PMID:33439402. |
acetylcholinesterase (ache), one of the major therapeutic strategies for the treatment of alzheimer's disease (ad) is to increase the acetylcholine (ach) level in the brain by inhibiting the biological activity of ache. |
2021-07-13 |
2023-08-13 |
Not clear |
| Kiran Bagri, Ashwani Kumar, Manisha, Parvin Kuma. Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry. Mini reviews in medicinal chemistry. vol 20. issue 14. 2021-07-12. PMID:31884928. |
acetylcholinesterase inhibitors are the most promising therapeutics for alzheimer's disease treatment as these prevent the loss of acetylcholine and slows the progression of the disease. |
2021-07-12 |
2023-08-13 |
Not clear |
| Kiran Bagri, Ashwani Kumar, Manisha, Parvin Kuma. Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry. Mini reviews in medicinal chemistry. vol 20. issue 14. 2021-07-12. PMID:31884928. |
the drugs approved for the management of alzheimer's disease by the fda are acetylcholinesterase inhibitors but are associated with side effects. |
2021-07-12 |
2023-08-13 |
Not clear |
| Stephen A Adefegha, Bathlomew M Okeke, Ganiyu Obo. Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer's diseases-In vitro. Journal of food biochemistry. vol 45. issue 3. 2021-07-08. PMID:32458455. |
this research work examined and likened effect of eugenol a natural phenolic compound with butylated hydroxylanisole (bha) and butylated hydroxyl toluene (bht) synthetic phenolic compounds with key biomolecules [acetylcholinesterase (ache), butyrylcholinesterase (bche), and monoamine oxidase (mao)] relevant to alzheimer's diseases (ad) in vitro. |
2021-07-08 |
2023-08-13 |
Not clear |
| Isabel C T Proença, Luciana K Gonçalves, Felipe Schmitz, Alexandre Mello, Claudia S Funchal, Angela Wyse, Caroline Dan. Purple grape juice consumption during the gestation reduces acetylcholinesterase activity and oxidative stress levels provoked by high-fat diet in hippocampus from adult female rats descendants. Anais da Academia Brasileira de Ciencias. vol 93. issue 2. 2021-07-05. PMID:34190844. |
the enzyme acetylcholinesterase participates in the end of cholinergic transmission and it has been shown that its activity is increased in some diseases that affect the brain, including alzheimer disease. |
2021-07-05 |
2023-08-13 |
rat |
| Shengkai Zhou, Zhao Li, Peng Liu, Sheng Wang, Jian Zhao, Guobao Zhan. Donepezil Prevents ox-LDL-Induced Attachment of THP-1 Monocytes to Human Aortic Endothelial Cells (HAECs). Chemical research in toxicology. vol 33. issue 4. 2021-07-02. PMID:32174113. |
donepezil is a well-known acetylcholinesterase inhibitor with its primary application being the treatment of alzheimer's disease. |
2021-07-02 |
2023-08-13 |
human |
| Zhe Jin, Chao Zhang, Miao Liu, Simeng Jiao, Jing Zhao, Xiaoping Liu, Huangquan Lin, David Chi-Cheong Wan, Chun H. Synthesis, biological activity, molecular docking studies of a novel series of 3-Aryl-7 Journal of biomolecular structure & dynamics. vol 39. issue 7. 2021-07-02. PMID:32266865. |
synthesis, biological activity, molecular docking studies of a novel series of 3-aryl-7 the acetylcholinesterase inhibitors play a critical role in the drug therapy for alzheimer's disease. |
2021-07-02 |
2023-08-13 |
Not clear |
| Yanyu Wang, Yanping Zhao, Chaochun Wei, Nana Tian, Hong Ya. 4D-QSAR Molecular Modeling and Analysis of Flavonoid Derivatives as Acetylcholinesterase Inhibitors. Biological & pharmaceutical bulletin. vol 44. issue 7. 2021-07-01. PMID:34193695. |
flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (ache) inhibitory activity for treating alzheimer's disease (ad). |
2021-07-01 |
2023-08-13 |
Not clear |
| Jared A Miles, Jeevak S Kapure, Girdhar Singh Deora, Charlotte Courageux, Alexandre Igert, José Dias, Ross P McGeary, Xavier Brazzolotto, Benjamin P Ros. Rapid discovery of a selective butyrylcholinesterase inhibitor using structure-based virtual screening. Bioorganic & medicinal chemistry letters. vol 30. issue 24. 2021-06-25. PMID:33039562. |
acetylcholinesterase inhibitors are the mainstay of alzheimer's disease treatments, despite having only short-term symptomatic benefits and severe side effects. |
2021-06-25 |
2023-08-13 |
human |
| Hongtao Du, Xinyu Jiang, Meng Ma, Huili Xu, Shuang Liu, Fang M. Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. Bioorganic & medicinal chemistry letters. vol 30. issue 24. 2021-06-25. PMID:33137375. |
a novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (ache) and β-amyloid peptide (aβ) aggregation inhibitors for the treatment of alzheimer's disease. |
2021-06-25 |
2023-08-13 |
Not clear |
| Phujinn Honorio, Supawadee Sainimnuan, Supa Hannongbua, Patchreenart Saparpakor. Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations. Chemico-biological interactions. vol 344. 2021-06-25. PMID:34033838. |
acetylcholinesterase (ache) plays a vital role in alzheimer's disease (ad), which is one of the most common causes of dementia. |
2021-06-25 |
2023-08-13 |
Not clear |
| Faez Saleh Al-Hamed, Ola M Maria, Jeff Phan, Ahmed Al Subaie, Qiman Gao, Alaa Mansour, Lina Abu Nada, Imane Boukhatem, Osama A Elkashty, Simon D Tran, Marie Lordkipanidzé, Zahi Badran, Faleh Tamim. Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model. Biomolecules. vol 10. issue 9. 2021-06-24. PMID:32937955. |
donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate alzheimer's disease. |
2021-06-24 |
2023-08-13 |
rat |
| Benoit David, Pascal Schneider, Philipp Schäfer, Jörg Pietruszka, Holger Gohlk. Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-06-24. PMID:33478277. |
discovery of new acetylcholinesterase inhibitors for alzheimer's disease: virtual screening and for more than two decades, the development of potent acetylcholinesterase (ache) inhibitors has been an ongoing task to treat dementia associated with alzheimer's disease and improve the pharmacokinetic properties of existing drugs. |
2021-06-24 |
2023-08-13 |
Not clear |
| Dae Yeon Won, Seong Jun Byun, Jin Sook Jeong, Ju-Young Shi. Association Between Acetylcholinesterase Inhibitors and Osteoporotic Fractures in Older Persons With Alzheimer's Disease. Journal of the American Medical Directors Association. vol 21. issue 8. 2021-06-23. PMID:31926798. |
association between acetylcholinesterase inhibitors and osteoporotic fractures in older persons with alzheimer's disease. |
2021-06-23 |
2023-08-13 |
Not clear |
| Dae Yeon Won, Seong Jun Byun, Jin Sook Jeong, Ju-Young Shi. Association Between Acetylcholinesterase Inhibitors and Osteoporotic Fractures in Older Persons With Alzheimer's Disease. Journal of the American Medical Directors Association. vol 21. issue 8. 2021-06-23. PMID:31926798. |
to identify the association between the use of acetylcholinesterase inhibitors (acheis) and risk of osteoporotic fractures in older persons with alzheimer's disease (ad). |
2021-06-23 |
2023-08-13 |
Not clear |
| Monica A Silva, Alessandra S Kiametis, Werner Trepto. Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of chemical information and modeling. vol 60. issue 7. 2021-06-17. PMID:32096991. |
donepezil is a second generation acetylcholinesterase (ache) inhibitor for treatment of alzheimer's disease (ad). |
2021-06-17 |
2023-08-13 |
Not clear |