| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vyacheslav E Semenov, Irina V Zueva, Marat A Mukhamedyarov, Sofya V Lushchekina, Elena O Petukhova, Lilya M Gubaidullina, Evgeniya S Krylova, Lilya F Saifina, Oksana A Lenina, Konstantin A Petro. Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease. Molecules (Basel, Switzerland). vol 25. issue 18. 2021-04-06. PMID:32932702. |
novel acetylcholinesterase inhibitors based on uracil moiety for possible treatment of alzheimer disease. |
2021-04-06 |
2023-08-13 |
Not clear |
| Óscar M Bautista-Aguilera, Lhassane Ismaili, Mourad Chioua, Rudolf Andrys, Monika Schmidt, Petr Bzonek, María Ángeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Francisco López-Muñoz, Isabel Iriepa, Bernard Refouvelet, Kamil Musilek, José Marco-Contelle. Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy. International journal of molecular sciences. vol 21. issue 11. 2021-03-30. PMID:32486316. |
acetylcholinesterase inhibition of diversely functionalized quinolinones for alzheimer's disease therapy. |
2021-03-30 |
2023-08-13 |
Not clear |
| Soomaayeh Heysieattalab, Leila Sadegh. Effects of Delphinidin on Pathophysiological Signs of Nucleus Basalis of Meynert Lesioned Rats as Animal Model of Alzheimer Disease. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32297026. |
alzheimer's disease (ad) is an advanced neurodegenerative disorder greatly accompanied by cognitive deficits, oxidative stress, inflammation, amyloid plaques deposition, and acetylcholinesterase (ache) hyper-activation. |
2021-03-29 |
2023-08-13 |
rat |
| Mary Nokuthula Sibanyoni, Sushil Kumar Chaudhary, Weiyang Chen, Hamid-Reza Adhami, Sandra Combrinck, Vinesh Maharaj, Daniela Schuster, Alvaro Viljoe. Isolation, in vitro evaluation and molecular docking of acetylcholinesterase inhibitors from South African Amaryllidaceae. Fitoterapia. vol 146. 2021-03-22. PMID:32479767. |
inhibition of acetylcholinesterase (ache) is considered a promising strategy for the treatment of alzheimer's disease (ad) and dementia. |
2021-03-22 |
2023-08-13 |
Not clear |
| Alberto Castagna, Ciro Manzo, Andrea Fabbo, Roberto Lacava, Carmen Ruberto, Giovanni Ruotol. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clinical drug investigation. vol 41. issue 2. 2021-03-22. PMID:33484469. |
combined therapy of memantine or acetylcholinesterase inhibitors, with cholinergic precursors such as citicoline, can be effective in alzheimer's disease. |
2021-03-22 |
2023-08-13 |
Not clear |
| Samir F de A Cavalcante, Alessandro B C Simas, Marcos C Barcellos, Victor G M de Oliveira, Roberto B Sousa, Paulo A de M Cabral, Kamil Kuča, Tanos C C Franç. Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention. Biomolecules. vol 10. issue 3. 2021-03-18. PMID:32155996. |
this article describes acetylcholinesterase (ache), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by alzheimer's disease, or as a warfare method due to the action of nerve agents. |
2021-03-18 |
2023-08-13 |
Not clear |
| Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The inefficacy of donepezil on glycated-AChE inhibition: Binding affinity, complex stability and mechanism. International journal of biological macromolecules. vol 160. 2021-03-17. PMID:32454110. |
donepezil (dpz) is a well-known drug for alzheimer's disease that inhibits acetylcholinesterase activity (ache). |
2021-03-17 |
2023-08-13 |
Not clear |
| Nemanja Vaci, Ivan Koychev, Chi-Hun Kim, Andrey Kormilitzin, Qiang Liu, Christopher Lucas, Azad Dehghan, Goran Nenadic, Alejo Nevado-Holgad. Real-world effectiveness, its predictors and onset of action of cholinesterase inhibitors and memantine in dementia: retrospective health record study. The British journal of psychiatry : the journal of mental science. 2021-03-17. PMID:32713359. |
the efficacy of acetylcholinesterase inhibitors and memantine in the symptomatic treatment of alzheimer's disease is well-established. |
2021-03-17 |
2023-08-13 |
Not clear |
| Jovana Mišković, Maja Karaman, Milena Rašeta, Nenad Krsmanović, Sanja Berežni, Dragica Jakovljević, Federica Piattoni, Alessandra Zambonelli, Maria Letizia Gargano, Giuseppe Venturell. Comparison of Two Journal of fungi (Basel, Switzerland). vol 7. issue 2. 2021-03-16. PMID:33557141. |
comparison of two in recent years, fungi have been recognized as producers of acetylcholinesterase (ache) inhibitors, agents important for the prevention of alzheimer's disease (ad). |
2021-03-16 |
2023-08-13 |
Not clear |
| Ramón Cacabelo. Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 16. issue 8. 2021-03-12. PMID:32520597. |
cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to the introduction of acetylcholinesterase inhibitors (acheis) in 1993 (tacrine) to enhance cholinergic neurotransmission as the first line of treatment against alzheimer's disease (ad). |
2021-03-12 |
2023-08-13 |
Not clear |
| Thai-Son Tran, Minh-Tri Le, Thi-Cam-Vi Nguyen, The-Huan Tran, Thanh-Dao Tran, Khac-Minh Tha. Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some Molecules (Basel, Switzerland). vol 25. issue 17. 2021-03-12. PMID:32867308. |
synthesis, in silico and in vitro evaluation for acetylcholinesterase and bace-1 inhibitory activity of some acetylcholinesterase (ache) and beta-secretase (bace-1) are two attractive targets in the discovery of novel substances that could control multiple aspects of alzheimer's disease (ad). |
2021-03-12 |
2023-08-13 |
Not clear |
| Thai-Son Tran, Thanh-Dao Tran, The-Huan Tran, Thanh-Tan Mai, Ngoc-Le Nguyen, Khac-Minh Thai, Minh-Tri L. Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity. Molecules (Basel, Switzerland). vol 25. issue 18. 2021-03-11. PMID:32899576. |
acetylcholinesterase (ache) and β-secretase (bace-1) have become attractive therapeutic targets for alzheimer's disease (ad). |
2021-03-11 |
2023-08-13 |
Not clear |
| Jason Kho, Adam Ioannou, Amit K J Mandal, Constantinos G Missouri. Donepezil induces ventricular arrhythmias by delayed repolarisation. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 3. 2021-03-11. PMID:33230575. |
acetylcholinesterase inhibitors such as donepezil delay the progression of alzheimer's dementia by increasing acetylcholine concentrations in the central nervous system. |
2021-03-11 |
2023-08-13 |
Not clear |
| Golaleh Ghotbi, Mohammad Mahdavi, Zahra Najafi, Farshad Homayouni Moghadam, Maryam Hamzeh-Mivehroud, Soodabeh Davaran, Siavoush Dastmalch. Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for Alzheimer's disease. Bioorganic chemistry. vol 103. 2021-03-09. PMID:32890993. |
design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for alzheimer's disease. |
2021-03-09 |
2023-08-13 |
Not clear |
| Thai-Son Tran, Minh-Tri Le, Thanh-Dao Tran, The-Huan Tran, Khac-Minh Tha. Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches. Molecules (Basel, Switzerland). vol 25. issue 16. 2021-03-04. PMID:32785161. |
acetylcholinesterase (ache) and beta-secretase (bace-1) are the two crucial enzymes involved in the pathology of alzheimer's disease. |
2021-03-04 |
2023-08-13 |
Not clear |
| Osamu Imamura, Masaaki Arai, Minori Dateki, Kazuhiko Oishi, Kunio Takishim. Donepezil-induced oligodendrocyte differentiation is mediated through estrogen receptors. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:31778582. |
using primary mouse embryonic neural stem cells (nscs), we previously demonstrated that donepezil, an acetylcholinesterase inhibitor developed for the treatment of alzheimer's disease, stimulates the differentiation of nscs into oligodendrocytes and neurons, albeit at the expense of astrogenesis. |
2021-03-02 |
2023-08-13 |
mouse |
| Naglaa F El-Sayed, Marwa El-Hussieny, Ewies F Ewies, Marwa A Fouad, Leila S Boulo. New phosphazine and phosphazide derivatives as multifunctional ligands targeting acetylcholinesterase and β-Amyloid aggregation for treatment of Alzheimer's disease. Bioorganic chemistry. vol 95. 2021-03-01. PMID:31838287. |
new phosphazine and phosphazide derivatives as multifunctional ligands targeting acetylcholinesterase and β-amyloid aggregation for treatment of alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Nor Atiqah Jusril, Ain Nur Najihah Muhamad Juhari, Syahrul Imran Abu Bakar, Wan Mazlina Md Saad, Mohd Ilham Adena. Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-01. PMID:32721993. |
combining in silico and in vitro studies to evaluate the acetylcholinesterase inhibitory profile of different accessions and the biomarker triterpenes of alzheimer's disease (ad) is a neurodegenerative disease and the most cause of dementia in elderly adults. |
2021-03-01 |
2023-08-13 |
Not clear |
| Sarfaraz Shaikh, Pratik Dhavan, Ganesh Pavale, M M V Ramana, B L Jadha. Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic chemistry. vol 96. 2021-02-26. PMID:31978679. |
design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against alzheimer's disease. |
2021-02-26 |
2023-08-13 |
Not clear |
| Prayasee Baruah, Abhinandan Das, Debojit Paul, Suman Chakrabarty, Kripamoy Aguan, Sivaprasad Mitr. Sulfonylurea Class of Antidiabetic Drugs Inhibit Acetylcholinesterase Activity: Unexplored Auxiliary Pharmacological Benefit toward Alzheimer's Disease. ACS pharmacology & translational science. vol 4. issue 1. 2021-02-23. PMID:33615172. |
sulfonylurea class of antidiabetic drugs inhibit acetylcholinesterase activity: unexplored auxiliary pharmacological benefit toward alzheimer's disease. |
2021-02-23 |
2023-08-13 |
Not clear |