| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Todd J Eckroat, Danielle L Manross, Seth C Cowa. Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015-Present: Synthesis and Biological Activity. International journal of molecular sciences. vol 21. issue 17. 2021-02-16. PMID:32825138. |
acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-mediated neuronal transmission in the central nervous system, contains a unique structure with two binding sites connected by a gorge region, and it has historically been the main pharmacological target for treatment of alzheimer's disease. |
2021-02-16 |
2023-08-13 |
Not clear |
| Donald E Mos. Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Are Irreversible Inhibitors the Future? International journal of molecular sciences. vol 21. issue 10. 2021-02-12. PMID:32414155. |
improving anti-neurodegenerative benefits of acetylcholinesterase inhibitors in alzheimer's disease: are irreversible inhibitors the future? |
2021-02-12 |
2023-08-13 |
Not clear |
| b' Darja Koutov\\xc3\\xa1, Negar Maafi, Radim Havelek, Lubom\\xc3\\xadr Opletal, Gerald Blunden, Martina \\xc5\\x98ez\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa1, Lucie Cahl\\xc3\\xadkov\\xc3\\xa. Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family. Molecules (Basel, Switzerland). vol 25. issue 10. 2021-02-12. PMID:32429491.' |
one of them, galantamine, is already used in the therapy of alzheimer's disease as a long acting, selective, reversible inhibitor of acetylcholinesterase. |
2021-02-12 |
2023-08-13 |
human |
| Amira G Zaki, El-Sayed R El-Sayed, M Abd Elkodous, Gharieb S El-Sayya. Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery. Applied microbiology and biotechnology. vol 104. issue 11. 2021-02-01. PMID:32285176. |
microbial acetylcholinesterase inhibitors for alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery. |
2021-02-01 |
2023-08-13 |
Not clear |
| Hiroshi Aoyama, Tomohiro Dour. Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene. Bioorganic & medicinal chemistry letters. vol 30. issue 4. 2021-01-28. PMID:31901380. |
recently, it has been reported that dantrolene has a weak inhibitory effect on acetylcholinesterase (ache), which is a therapeutic drug target for alzheimer's disease. |
2021-01-28 |
2023-08-13 |
Not clear |
| Sai Vamshi R Jonnalagadda, Andrew James Gerace, Kathleen Thai, Jonathan Johnson, Kostas Tsimenidis, Joseph M Jakubowski, Christina Shen, Kendal J Henderson, Phanourios Tamamis, Manos Gkika. Amyloid Peptide Scaffolds Coordinate with Alzheimer's Disease Drugs. The journal of physical chemistry. B. vol 124. issue 3. 2021-01-25. PMID:31881810. |
herein, we report the first to our knowledge amyloid materials, encompassing a gaiig amyloidogenic core, which bind to alzheimer's disease (ad) drugs, by mimicking the mechanism by which the same ad drugs bind to enzymes according to experimentally resolved structures, including the target enzyme acetylcholinesterase (ache). |
2021-01-25 |
2023-08-13 |
Not clear |
| Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz, Claudiu T Supura. Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2021-01-25. PMID:32401067. |
the calix[4]azacrown substituted sulphonamide schiff bases were also investigated as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase enzymes, associated with several diseases such as alzheimer, parkinson, and pigmentation disorders. |
2021-01-25 |
2023-08-13 |
human |
| Mehmet Ilkin Naharci, Ilker Tasc. Comment on "Association Between Acetylcholinesterase Inhibitors and Osteoporotic Fractures in Alzheimer's Patients". Journal of the American Medical Directors Association. vol 21. issue 5. 2021-01-22. PMID:32334774. |
comment on "association between acetylcholinesterase inhibitors and osteoporotic fractures in alzheimer's patients". |
2021-01-22 |
2023-08-13 |
Not clear |
| Ju Hwan Kim, Seong Jun Byun, Ju-Young Shi. Authors' Response to Association between Acetylcholinesterase Inhibitors and Osteoporotic Fractures in Older Persons With Alzheimer's Disease. Journal of the American Medical Directors Association. vol 21. issue 5. 2021-01-22. PMID:32334775. |
authors' response to association between acetylcholinesterase inhibitors and osteoporotic fractures in older persons with alzheimer's disease. |
2021-01-22 |
2023-08-13 |
Not clear |
| Sarah Naguib, Alexandra Bernardo-Colón, Caroline Cencer, Neha Gandra, Tonia S Re. Galantamine protects against synaptic, axonal, and vision deficits in experimental neurotrauma. Neurobiology of disease. vol 134. 2021-01-13. PMID:31778813. |
galantamine is an fda-approved acetylcholinesterase inhibitor used to treat mild-moderate alzheimer's disease. |
2021-01-13 |
2023-08-13 |
mouse |
| Edwin C K Tan, Kristina Johnell, J Simon Bell, Sara Garcia-Ptacek, Johan Fastbom, Peter Nordström, Maria Eriksdotte. Do Acetylcholinesterase Inhibitors Prevent or Delay Psychotropic Prescribing in People With Dementia? Analyses of the Swedish Dementia Registry. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 28. issue 1. 2021-01-04. PMID:31331724. |
to investigate whether acetylcholinesterase inhibitor (achei) use prevents or delays subsequent initiation of psychotropic medications in people with alzheimer's disease (ad) and lewy body dementia (lbd). |
2021-01-04 |
2023-08-13 |
Not clear |
| Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Daniela Ribeiro Alves, Jane Eire Silva Alencar de Menezes, Francisco Ernani Alves Magalhães, Francisca Crislândia Oliveira Silva, Jacilene Silva, Emmanuel Silva Marinho, Selene Maia de Morai. Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:31853730. |
the level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. |
2020-12-21 |
2023-08-13 |
Not clear |
| Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Daniela Ribeiro Alves, Jane Eire Silva Alencar de Menezes, Francisco Ernani Alves Magalhães, Francisca Crislândia Oliveira Silva, Jacilene Silva, Emmanuel Silva Marinho, Selene Maia de Morai. Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:31853730. |
the main compounds used for alzheimer's treatment are acetylcholinesterase inhibitors. |
2020-12-21 |
2023-08-13 |
Not clear |
| Arnavaz Hajizadeh Barfejani, Mahbod Jafarvand, Seyed Mohammad Seyedsaadat, Roozbeh Tarighati Rasekh. Donepezil in the treatment of ischemic stroke: Review and future perspective. Life sciences. vol 263. 2020-12-15. PMID:33058916. |
donepezil, an acetylcholinesterase inhibitor, improves cognition and global function in patients with alzheimer's and vascular dementia via modulation of acetylcholine receptors and downstream inflammatory response. |
2020-12-15 |
2023-08-13 |
Not clear |
| Malcolm Lane, D'Arice Carter, Joseph D Pescrille, Yasco Aracava, William P Fawcett, G William Basinger, Edna F R Pereira, Edson X Albuquerqu. Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes. The Journal of pharmacology and experimental therapeutics. vol 375. issue 1. 2020-12-14. PMID:32759369. |
earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate alzheimer's disease (ad), and other centrally acting reversible acetylcholinesterase (ache) inhibitors can serve as adjunct pretreatments against poisoning by organophosphorus compounds, including the nerve agent soman. |
2020-12-14 |
2023-08-13 |
monkey |
| Moustafa T Gabr, Simone Brog. MicroRNA-Based Multitarget Approach for Alzheimer's Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis. Journal of medicinal chemistry. vol 63. issue 17. 2020-12-11. PMID:32787143. |
microrna-based multitarget approach for alzheimer's disease: discovery of the first-in-class dual inhibitor of acetylcholinesterase and microrna-15b biogenesis. |
2020-12-11 |
2023-08-13 |
Not clear |
| Michał Wiciński, Eryk Wódkiewicz, Karol Górski, Maciej Walczak, Bartosz Malinowsk. Perspective of SGLT2 Inhibition in Treatment of Conditions Connected to Neuronal Loss: Focus on Alzheimer's Disease and Ischemia-Related Brain Injury. Pharmaceuticals (Basel, Switzerland). vol 13. issue 11. 2020-12-01. PMID:33187206. |
canagliflozin and dapagliflozin may possess acetylcholinesterase inhibiting activity, resembling in this matter alzheimer's disease-registered therapies. |
2020-12-01 |
2023-08-13 |
mouse |
| Yan Guo, Hongyu Yang, Zhongwei Huang, Sen Tian, Qihang Li, Chenxi Du, Tingkai Chen, Yang Liu, Haopeng Sun, Zongliang Li. Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-27. PMID:31979317. |
design, synthesis, and evaluation of acetylcholinesterase and butyrylcholinesterase dual-target inhibitors against alzheimer's diseases. |
2020-11-27 |
2023-08-13 |
Not clear |
| Katie Malone, Jules C Hanco. QT interval prolongation and Therapeutic advances in drug safety. vol 11. 2020-11-20. PMID:32874532. |
qt interval prolongation and acetylcholinesterase inhibitors (acheis) including donepezil, galantamine and rivastigmine are used to treat alzheimer's disease (ad). |
2020-11-20 |
2023-08-13 |
Not clear |
| Hulya Akıncıoğlu, İlhami Gülçi. Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer's Disease. Mini reviews in medicinal chemistry. vol 20. issue 8. 2020-11-09. PMID:31902355. |
potent acetylcholinesterase inhibitors: potential drugs for alzheimer's disease. |
2020-11-09 |
2023-08-13 |
Not clear |