| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prayasee Baruah, Mostofa Ataur Rohman, Semen O Yesylevskyy, Sivaprasad Mitr. Therapeutic potency of substituted chromones as Alzheimer's drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation. BioImpacts : BI. vol 9. issue 2. 2020-10-01. PMID:31334039. |
therapeutic potency of substituted chromones as alzheimer's drug: elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rafael Vincent Manalo, Maries Ann Silvestre, Aza Lea Anne Barbosa, Paul Mark Medin. Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition. Biomedicines. vol 5. issue 2. 2020-09-30. PMID:28536360. |
virgin coconut oil (vco) has been the subject of several studies which have aimed to alleviate alzheimer's disease (ad) pathology, focusing on in vitro antioxidant and acetylcholinesterase (ache) inhibitory activities. |
2020-09-30 |
2023-08-13 |
human |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by dementia, excessive acetylcholinesterase (ache) activity, formation of neurotoxic amyloid plaque, and tau protein aggregation. |
2020-09-30 |
2023-08-13 |
rat |
| Nuno M Xavier, Eduardo C de Sousa, Margarida P Pereira, Anne Loesche, Immo Serbian, René Csuk, M Conceição Oliveir. Synthesis and Biological Evaluation of Structurally Varied 5'-/6'-Isonucleosides and Theobromine-Containing Pharmaceuticals (Basel, Switzerland). vol 12. issue 3. 2020-09-30. PMID:31269639. |
we have previously demonstrated the ability of 5' and 6'-isonucleosides to inhibit the activity of acetylcholinesterase, a major target for alzheimer's disease therapy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Karen E. Anderso. Dementia in Parkinson's Disease. Current treatment options in neurology. vol 6. issue 3. 2020-09-29. PMID:15043803. |
however, medication used to treat alzheimer's disease, such as acetylcholinesterase inhibitors, may slow progression of memory loss in some pd patients. |
2020-09-29 |
2023-08-12 |
Not clear |
| Sedigheh Bakhtiari, Nahid Beladi Moghadam, Marjan Ehsani, Hamed Mortazavi, Siamak Sabour, Mahin Bakhsh. Can Salivary Acetylcholinesterase be a Diagnostic Biomarker for Alzheimer? Journal of clinical and diagnostic research : JCDR. vol 11. issue 1. 2020-09-29. PMID:28274046. |
can salivary acetylcholinesterase be a diagnostic biomarker for alzheimer? |
2020-09-29 |
2023-08-13 |
Not clear |
| Douglas W Wilson, Paul Nash, Harpal Singh Buttar, Keith Griffiths, Ram Singh, Fabien De Meester, Rie Horiuchi, Toru Takahash. The Role of Food Antioxidants, Benefits of Functional Foods, and Influence of Feeding Habits on the Health of the Older Person: An Overview. Antioxidants (Basel, Switzerland). vol 6. issue 4. 2020-09-29. PMID:29143759. |
the role of functional foods was considered as a potential treatment of dementia and alzheimer's disease through inhibition of acetylcholinesterase as well as similar treatments based on herbs, spices and antioxidants therein. |
2020-09-29 |
2023-08-13 |
human |
| Thaiane Coelho Dos Santos, Thaís Mota Gomes, Bruno Araújo Serra Pinto, Adriana Leandro Camara, Antonio Marcus de Andrade Pae. Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy. Frontiers in pharmacology. vol 9. 2020-09-29. PMID:30405413. |
naturally occurring acetylcholinesterase inhibitors and their potential use for alzheimer's disease therapy. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jabril Eldufani, Gilbert Blais. The role of acetylcholinesterase inhibitors such as neostigmine and rivastigmine on chronic pain and cognitive function in aging: A review of recent clinical applications. Alzheimer's & dementia (New York, N. Y.). vol 5. 2020-09-29. PMID:31194017. |
acetylcholinesterase inhibitors (ache-is) have been proven as an efficient therapeutic resource for significant improvement in dementia of alzheimer's disease and chronic pain due to the fact that cholinergic deficit is considered as an early finding in cognitive impairment and persisting pain. |
2020-09-29 |
2023-08-13 |
Not clear |
| Diogo Alexandre Siebert, Flávia de Mello, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Mick. Determination of acetylcholinesterase and α-glucosidase inhibition by electrophoretically-mediated microanalysis and phenolic profile by HPLC-ESI-MS/MS of fruit juices from Brazilian Myrtaceae Natural product research. vol 34. issue 18. 2020-09-28. PMID:30618311. |
determination of acetylcholinesterase and α-glucosidase inhibition by electrophoretically-mediated microanalysis and phenolic profile by hplc-esi-ms/ms of fruit juices from brazilian myrtaceae alzheimer's disease and diabetes mellitus are contemporary diseases of great concern. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xinmeng Song, Tiejie Wang, Linxiu Guo, Yibao Jin, Jue Wang, Guo Yin, Kun Jiang, Lijun Wang, Hongrong Huang, Long Zen. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32148536. |
acetylcholinesterase (ache) inhibition and antioxidants are two common strategies for the treatment in the early stage of alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Chanjuan Zhang, Likun Hu, Dong Liu, Jian Huang, Wenhan Li. Circumdatin D Exerts Neuroprotective Effects by Attenuating LPS-Induced Pro-Inflammatory Responses and Downregulating Acetylcholinesterase Activity Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32523534. |
circumdatin d exerts neuroprotective effects by attenuating lps-induced pro-inflammatory responses and downregulating acetylcholinesterase activity alzheimer's disease (ad) is a prevalent neurodegenerative disorder with multifactorial causes, of which systemic inflammation may play a key role to promote neurodegeneration, and acetylcholinesterase (ache) is a target protein to induce cholinergic transmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Marine Droguerre, Adeline Duchêne, Christèle Picoli, Benjamin Portal, Camille Lejards, Bruno P Guiard, Johann Meunier, Vanessa Villard, Nicole Déglon, Michel Hamon, Franck Mouthon, Mathieu Charvéria. Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32612499. |
donepezil (dpz) is an acetylcholinesterase inhibitor used in alzheimer's disease to restore cognitive functions but is endowed with limited efficacy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joana Ferreira, Sara Santos, Helena Pereir. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32765630. |
acetylcholinesterase (ache) inhibitors are used to treat alzheimer's patients because they enhance cholinergic neurotransmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jee Hyun Yi, Daniel J Whitcomb, Se Jin Park, Celia Martinez-Perez, Saviana A Barbati, Scott J Mitchell, Kwangwook Ch. M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology. Brain communications. vol 2. issue 2. 2020-09-28. PMID:32766549. |
acetylcholinesterase inhibitors are one of the few treatment options for alzheimer's disease, where levels of available acetylcholine are enhanced to counteract the cholinergic loss. |
2020-09-28 |
2023-08-13 |
Not clear |
| Benjamin Vidal, Marine Droguerre, Marco Valdebenito, Luc Zimmer, Michel Hamon, Franck Mouthon, Mathieu Charvéria. Pharmaco-fUS for Characterizing Drugs for Alzheimer's Disease - The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32903470. |
donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
mouse |
| Sajini D Hettiarachchi, Yiqun Zhou, Elif Seven, Madepalli K Lakshmana, Ajeet K Kaushik, Hitendra S Chand, Roger M Leblan. Nanoparticle-mediated approaches for Alzheimer's disease pathogenesis, diagnosis, and therapeutics. Journal of controlled release : official journal of the Controlled Release Society. vol 314. 2020-09-25. PMID:31647979. |
deposition of the amyloid β plaques has been identified as the most common ad pathology; however, the excessive accumulation of phosphorylated or total tau proteins, reactive oxygen species, and higher acetylcholinesterase activity are also strongly associated with alzheimer's dementia. |
2020-09-25 |
2023-08-13 |
Not clear |
| A S Rao, S S Yadav, Priya Singh, Abhishek Nandal, Neetu Singh, S A Ganaie, Neelam Yadav, Rajesh Kumar, M S Bhandoria, Pradeep Bansa. A comprehensive review on ethnomedicine, phytochemistry, pharmacology, and toxicity of Tephrosia purpurea (L.) Pers. Phytotherapy research : PTR. vol 34. issue 8. 2020-09-24. PMID:32147928. |
acetylcholinesterase inhibitory action reported from this plant aids its utilization for the development of drugs for alzheimer's and dementia neurological disorders. |
2020-09-24 |
2023-08-13 |
Not clear |
| Jeelan Basha Shaik, Daniel Pushparaju Yeggoni, Yelamanda Rao Kandrakonda, Mohan Penumala, Raveendra Babu Zinka, Kasi Viswanath Kotapati, Mark Manidhar Darla, Dinakara Rao Ampasala, Rajagopal Subramanyam, Damu Gangaiah Amoor. Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase. Bioorganic chemistry. vol 88. 2020-09-22. PMID:31102808. |
synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti alzheimer agents and investigation of binding mechanism with acetylcholinesterase. |
2020-09-22 |
2023-08-13 |
Not clear |
| Murat Boztas, Parham Taslimi, Mirali Akbar Yavari, Ilhami Gulcin, Ertan Sahin, Abdullah Menze. Synthesis and biological evaluation of bromophenol derivatives with cyclopropyl moiety: Ring opening of cyclopropane with monoester. Bioorganic chemistry. vol 89. 2020-09-22. PMID:31174041. |
acetylcholinesterase inhibitors are the most popular drugs applied in the treatment of diseases such as alzheimer's disease, parkinson's disease, senile dementia, and ataxia, among others. |
2020-09-22 |
2023-08-13 |
Not clear |