| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaan Kucukoglu, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin, Claudiu T Supura. Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes. Bioorganic chemistry. vol 86. 2020-04-13. PMID:30743172. |
recently, inhibition of carbonic anhydrase (hca) and acetylcholinesterase (ache) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, and alzheimer's disease. |
2020-04-13 |
2023-08-13 |
Not clear |
| Xue Cui, Yu-E Guo, Jia-Hui Fang, Chang-Jie Shi, Na Suo, Ru Zhang, Xin Xi. Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination. Acta pharmacologica Sinica. vol 40. issue 11. 2020-04-13. PMID:30918344. |
here we report that donepezil, an acetylcholinesterase inhibitor (achei) developed for the treatment of alzheimer's disease (ad), significantly promotes opc to ol differentiation. |
2020-04-13 |
2023-08-13 |
Not clear |
| Jiajia Zhao, Tianjing Ren, Mengbi Yang, Yufeng Zhang, Qianwen Wang, Zhong Zu. Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment. Xenobiotica; the fate of foreign compounds in biological systems. vol 50. issue 4. 2020-03-31. PMID:31298070. |
donepezil (dpz) is an acetylcholinesterase (ache) inhibitor used in the mild to moderately severe alzheimer's disease. |
2020-03-31 |
2023-08-13 |
rat |
| Khayrya A Youssif, Eman G Haggag, Ali M Elshamy, Mohamed A Rabeh, Nagwan M Gabr, Amany Seleem, M Alaraby Salem, Ahmed S Hussein, Markus Krischke, Martin J Mueller, Usama Ramadan Abdelmohse. Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts. PloS one. vol 14. issue 11. 2020-03-20. PMID:31693694. |
metabolomic profiling was performed on methanolic extracts of l. coccineus and m. lutea and resulted in the identification of 12 compounds, then docking was performed to investigate the possible interaction between the identified compounds and human acetylcholinesterase, butyrylcholinesterase, and glutathione transferase receptor, which are associated with the progress of alzheimer's disease. |
2020-03-20 |
2023-08-13 |
human |
| Virendra Kumar Meena, Shubhra Chaturvedi, Rakesh Kumar Sharma, Anil Kumar Mishra, Puja Panwar Hazar. Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics. Molecular pharmaceutics. vol 16. issue 6. 2020-03-16. PMID:31059278. |
acetylcholinesterase (ache) has been an important biomarker for diagnosing alzheimer's disease (ad), due to reduction in ache activity in post-mortem brains of ad patients. |
2020-03-16 |
2023-08-13 |
Not clear |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Luis F Aguila. An in vitro study on the interaction of the anti-Alzheimer drug rivastigmine with human erythrocytes. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32092302. |
the inhibition of the enzyme acetylcholinesterase (ache) is a frequently used therapeutic option to treat alzheimer's disease (ad). |
2020-03-16 |
2023-08-13 |
human |
| Yamini Madav, Sarika Wairkar, Bala Prabhaka. Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease. Brain research bulletin. vol 146. 2020-03-10. PMID:30634016. |
the available line of therapy for treating alzheimer's includes acetylcholinesterase inhibitors, nmda(n-methyl-d-aspartate) antagonists and their combination which gives only symptomatic relief rather than treating the root cause of ad. |
2020-03-10 |
2023-08-13 |
Not clear |
| Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T Supura. Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-03-05. PMID:31899985. |
they were also investigated as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase, which are associated with several diseases such as alzheimer, parkinson and pigmentation disorders. |
2020-03-05 |
2023-08-13 |
Not clear |
| Branko N Huisa, Ronald G Thomas, Shelia Jin, Tilman Oltersdorf, Curtis Taylor, Howard H Feldma. Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer's Disease Clinical Trials: Potential for Confounding by Indication. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30636733. |
memantine and acetylcholinesterase inhibitor use in alzheimer's disease clinical trials: potential for confounding by indication. |
2020-03-02 |
2023-08-13 |
Not clear |
| Branko N Huisa, Ronald G Thomas, Shelia Jin, Tilman Oltersdorf, Curtis Taylor, Howard H Feldma. Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer's Disease Clinical Trials: Potential for Confounding by Indication. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30636733. |
acetylcholinesterase inhibitors (acheis) and memantine are commonly prescribed medications for alzheimer's disease (ad). |
2020-03-02 |
2023-08-13 |
Not clear |
| Irina Zueva, José Dias, Sofya Lushchekina, Vyacheslav Semenov, Marat Mukhamedyarov, Tatiana Pashirova, Vasiliy Babaev, Florian Nachon, Natalia Petrova, Leniz Nurullin, Lucia Zakharova, Victor Ilyin, Patrick Masson, Konstantin Petro. New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease. Neuropharmacology. vol 155. 2020-02-28. PMID:31132435. |
new evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of alzheimer's disease. |
2020-02-28 |
2023-08-13 |
mouse |
| Yueyao Jiang, Chenqi Liu, Wanchen Zhai, Ning Zhuang, Tengfei Han, Zhiying Din. The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route. International journal of nanomedicine. vol 14. 2020-02-20. PMID:31819426. |
huperzine a (hupa) is a selective acetylcholinesterase inhibitor used to treat alzheimer's disease. |
2020-02-20 |
2023-08-13 |
Not clear |
| Jinhui Hu, Ya-Dan Huang, Tingting Pan, Tianhua Zhang, Tao Su, Xingshu Li, Hai-Bin Luo, Ling Huan. Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30252439. |
design, synthesis, and biological evaluation of dual-target inhibitors of acetylcholinesterase (ache) and phosphodiesterase 9a (pde9a) for the treatment of alzheimer's disease. |
2020-02-18 |
2023-08-13 |
Not clear |
| R Giacconi, C Giuli, T Casoli, M Balietti, L Costarelli, M Provinciali, A Basso, F Piacenza, D Postacchini, R Galeazzi, P Fattoretti, L Nisi, P Fabbietti, R Papa, M Malavolt. Acetylcholinesterase inhibitors in Alzheimer's disease influence Zinc and Copper homeostasis. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 55. 2020-02-18. PMID:31345366. |
acetylcholinesterase inhibitors in alzheimer's disease influence zinc and copper homeostasis. |
2020-02-18 |
2023-08-13 |
Not clear |
| Mira Syahfriena Amir Rawa, Zurina Hassan, Vikneswaran Murugaiyah, Toshihiko Nogawa, Habibah A Waha. Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation. Journal of ethnopharmacology. vol 245. 2020-02-18. PMID:31419500. |
enhancement of cholinergic functions in the brain via acetylcholinesterase inhibition is one of the main therapeutic strategies to improve symptoms associated with alzheimer's or related cognitive deficits. |
2020-02-18 |
2023-08-13 |
Not clear |
| Oscar Galarce-Bustos, Jessy Pavón, Karem Henríquez-Aedo, Mario Arand. Detection and identification of acetylcholinesterase inhibitors in Annona cherimola Mill. by effect-directed analysis using thin-layer chromatography-bioassay-mass spectrometry. Phytochemical analysis : PCA. vol 30. issue 6. 2020-02-17. PMID:31183917. |
acetylcholinesterase (ache) inhibitors are considered an important strategy in the treatment of neurological disorders such as alzheimer's disease. |
2020-02-17 |
2023-08-13 |
Not clear |
| Yu-Ting Hu, Xin-Lu Chen, Shu-Han Huang, Qiong-Bin Zhu, Si-Yang Yu, Yi Shen, Arja Sluiter, Joost Verhaagen, Juan Zhao, Dick Swaab, Ai-Min Ba. Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 29. issue 4. 2020-02-12. PMID:30511454. |
early growth response-1 regulates acetylcholinesterase and its relation with the course of alzheimer's disease. |
2020-02-12 |
2023-08-13 |
mouse |
| Bhupinder Kumar, Ashish Ranjan Dwivedi, Bibekananda Sarkar, Sukesh Kumar Gupta, Sairam Krishnamurthy, Anil K Mantha, Jyoti Parkash, Vinod Kuma. 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 1. 2020-02-06. PMID:30296051. |
4,6-diphenylpyrimidine derivatives as dual inhibitors of monoamine oxidase and acetylcholinesterase for the treatment of alzheimer's disease. |
2020-02-06 |
2023-08-13 |
Not clear |
| James T Brewster, Simone Dell'Acqua, Danny Q Thach, Jonathan L Sessle. Classics in Chemical Neuroscience: Donepezil. ACS chemical neuroscience. vol 10. issue 1. 2020-02-06. PMID:30372021. |
this review is focused on donepezil and covers the background, synthetic routes, structure-activity relationships, binding interactions with acetylcholinesterase, pharmacokinetics and metabolism, efficacy, adverse effects, and historical importance of this leading therapeutic in the treatment of alzheimer's disease and true classic in chemical neuroscience. |
2020-02-06 |
2023-08-13 |
Not clear |
| Muhammad Adnan Bashir, Arif-Ullah Khan, Haroon Badshah, Edson Rodrigues-Filho, Zia Ud Din, Aslam Kha. Synthesis, characterization, molecular docking evaluation, antidepressant, and anti-Alzheimer effects of dibenzylidene ketone derivatives. Drug development research. vol 80. issue 5. 2020-01-27. PMID:30964563. |
both a1k1 and a2k2 showed high binding affinities against various proteins involved in depression and alzheimer's mechanisms like monoamine oxidase b, acetylcholinesterase, norepinephrine transporter 2, serotonin transporter, dopamine receptor, serotonin receptor modulator, and beta-amyloid targets. |
2020-01-27 |
2023-08-13 |
mouse |