| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mesut Işı. The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking. Neurochemical research. vol 44. issue 9. 2020-01-20. PMID:31385137. |
inhibitors of acetylcholinesterase (ache), which have an important role in the prevention of excessive ache activity and β-amyloid (aβ) formation are widely used in the symptomatic treatment of alzheimer's disease (ad). |
2020-01-20 |
2023-08-13 |
Not clear |
| Peterson de Andrade, Susimaire P Mantoani, Paulo Sérgio Gonçalves Nunes, Carlos Roca Magadán, Concepción Pérez, Danilo Jordão Xavier, Elza Tiemi Sakamoto Hojo, Nuria E Campillo, Ana Martínez, Ivone Carvalh. Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease. Bioorganic & medicinal chemistry. vol 27. issue 6. 2020-01-15. PMID:30765302. |
acetylcholinesterase (ache) is the key enzyme targeted in alzheimer's disease (ad) therapy, nevertheless butyrylcholinesterase (buche) has been drawing attention due to its role in the disease progression. |
2020-01-15 |
2023-08-13 |
Not clear |
| b' Kre\\xc5\\xa1imir Baumann, Lorena Kordi\\xc4\\x87, Marko Mo\\xc4\\x8dibob, Goran \\xc5\\xa0inko, Sr\\xc4\\x91anka Tomi\\xc4\\x8. Synthesis and In Vitro Screening of Novel Heterocyclic \\xce\\xb2-d-Gluco- and \\xce\\xb2-d-Galactoconjugates as Butyrylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-14. PMID:31382668.' |
the development of selective butyrylcholinesterase (bche) inhibitors may improve the treatment of alzheimer's disease by increasing lower synaptic levels of the neurotransmitter acetylcholine, which is hydrolysed by acetylcholinesterase, as well as by overexpressed bche. |
2020-01-14 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Serdar Durdagi, Francesco Epifano, Salvatore Genovese, Serena Fiorit. Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives. Bioorganic chemistry. vol 84. 2020-01-13. PMID:30530106. |
in the present study, 26 novel o-alkylcoumarin derivatives were synthesized and have been tested at 100 µm for their in vitro inhibitory potential against acetylcholinesterase (ache) and butyrlcholinesterase (bche) targets which are the key enzymes playing role in the pathogenesis of alzheimer's disease. |
2020-01-13 |
2023-08-13 |
Not clear |
| Ya-Jen Chiu, Yu-Hsuan Hsieh, Te-Hsien Lin, Guan-Chiun Lee, Hsiu Mei Hsieh-Li, Ying-Chieh Sun, Chiung-Mei Chen, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease. Neurochemistry international. vol 125. 2020-01-03. PMID:30707915. |
the pathogenesis of alzheimer's disease (ad) is involved in the aggregation of misfolded amyloid β (aβ), which upregulates the activity of acetylcholinesterase (ache), increases the production of reactive oxygen species (ros), enhances neuroinflammation, and eventually leads to neuronal death. |
2020-01-03 |
2023-08-13 |
Not clear |
| François-Xavier Toublet, Cédric Lecoutey, Julien Lalut, Bérénice Hatat, Audrey Davis, Marc Since, Sophie Corvaisier, Thomas Freret, Jana Sopkova de Oliveira Santos, Sylvie Claeysen, Michel Boulouard, Patrick Dallemagne, Christophe Rochai. Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-03. PMID:31370232. |
inhibiting acetylcholinesterase to activate pleiotropic prodrugs with therapeutic interest in alzheimer's disease. |
2020-01-03 |
2023-08-13 |
Not clear |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Prasenjit Mondal, Varsha Gupta, Gaurav Das, Krishnangsu Pradhan, Juhee Khan, Prabir Kumar Gharai, Surajit Ghos. Peptide-Based Acetylcholinesterase Inhibitor Crosses the Blood-Brain Barrier and Promotes Neuroprotection. ACS chemical neuroscience. vol 9. issue 11. 2019-12-23. PMID:30015476. |
design and development of acetylcholinesterase (ache) inhibitor has tremendous implications in the treatment of alzheimer's disease (ad). |
2019-12-23 |
2023-08-13 |
Not clear |
| Hongjin Tang, Ping Song, Jun Li, Dongsheng Zha. Effect of Salvia miltiorrhiza on acetylcholinesterase: Enzyme kinetics and interaction mechanism merging with molecular docking analysis. International journal of biological macromolecules. vol 135. 2019-12-16. PMID:31128195. |
acetylcholinesterase (ache) serves as an important target for alzheimer's disease. |
2019-12-16 |
2023-08-13 |
Not clear |
| Ameneh Tarakemeh, Majid Azizi, Vahid Rowshan, Hassan Salehi, Rosella Spina, François Dupire, Hossein Arouie, Dominique Laurain-Matta. Screening of Amaryllidaceae alkaloids in bulbs and tissue cultures of Narcissus papyraceus and four varieties of N. tazetta. Journal of pharmaceutical and biomedical analysis. vol 172. 2019-12-11. PMID:31060036. |
are an economically important crop for medicines in relation with the alkaloids production, mainly galanthamine, an acetylcholinesterase inhibitor used for the treatment of alzheimer's disease. |
2019-12-11 |
2023-08-13 |
Not clear |
| Esengul Karahisar, Osman Tugay, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Simon Vlad Luca, Krystyna Skalicka-Wozniak, Mustafa Sahi. Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts. Chemistry & biodiversity. vol 16. issue 9. 2019-12-09. PMID:31365785. |
& heldr., were screened against acetylcholinesterase (ache) and butyrylcholinesterase (bche) associated with alzheimer's disease as well as tyrosinase (tyr) linked to parkinson's disease using elisa microplate assay at 200 μg/ml. |
2019-12-09 |
2023-08-13 |
Not clear |
| Gauthie. Acetylcholinesterase inhibitors in the treatment of Alzheimer's disease. Expert opinion on investigational drugs. vol 8. issue 10. 2019-11-20. PMID:11139807. |
acetylcholinesterase inhibitors in the treatment of alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| Gauthie. Acetylcholinesterase inhibitors in the treatment of Alzheimer's disease. Expert opinion on investigational drugs. vol 8. issue 10. 2019-11-20. PMID:11139807. |
acetylcholinesterase inhibitors have been extensively tested in placebo-controlled studies for use as symptomatic drugs in mild-to-moderate stages of alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| Gottwald, Rozansk. Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status. Expert opinion on investigational drugs. vol 8. issue 10. 2019-11-20. PMID:11139819. |
rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating alzheimer's disease: review and current status. |
2019-11-20 |
2023-08-12 |
Not clear |
| Javier Sáez-Valero, David H. Smal. Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 3. issue 3. 2019-11-20. PMID:12214053. |
acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| Homa Hajimehdipoor, Mahmoud Mosaddegh, Farzaneh Naghibi, Ali Haeri, Maryam Hamzeloo-Moghada. Natural sesquiterpen lactones as acetylcholinesterase inhibitors. Anais da Academia Brasileira de Ciencias. vol 86. issue 2. 2019-11-20. PMID:24838542. |
herbal products, owning a reputation as effective agents in many biological studies are now drawing attention for inhibiting acetylcholinesterase, in other words, alzheimer disease. |
2019-11-20 |
2023-08-13 |
Not clear |
| S A Zhivolupov, N A Rashidov, I N Samartsev, E V Jakovle. [A comparative analysis of the efficacy of neuromidin and galantamine in Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 10 Pt 2. 2019-11-20. PMID:26977912. |
to evaluate the cognitive changes in patients with mild to moderate alzheimer's disease after the treatment with acetylcholinesterase inhibitors - neuromidin and galantamine. |
2019-11-20 |
2023-08-13 |
Not clear |
| Sinem Aslan Erdem, F Sezer Senol, Esin Budakoglu, Ilkay Erdogan Orhan, Bilge Sene. Exploring in vitro neurobiological effects and high-pressure liquid chromatography-assisted quantitation of chlorogenic acid in 18 Turkish coffee brands. Journal of food and drug analysis. vol 24. issue 1. 2019-11-20. PMID:28911393. |
the hydroalcoholic extracts of the turkish traditional coffee samples from 18 commercial brands were tested for their neurobiological effects through enzyme inhibition based on enzyme-linked immunosorbance microtiter assays against acetylcholinesterase, butyrylcholinesterase, and tyrosinase, linked to alzheimer's and parkinson's diseases. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cheng-Han Tsai, Yue-Horng Yen, John Po-Wen Yan. Finding of polysaccharide-peptide complexes in Cordyceps militaris and evaluation of its acetylcholinesterase inhibition activity. Journal of food and drug analysis. vol 23. issue 1. 2019-11-20. PMID:28911447. |
acetylcholinesterase (ache) inhibition enhances learning and cognitive ability for treatment of alzheimer's disease. |
2019-11-20 |
2023-08-13 |
Not clear |
| Amira G Zaki, Einas H El-Shatoury, Ashraf S Ahmed, Ola E A Al-Haga. Production and enhancement of the acetylcholinesterase inhibitor, huperzine A, from an endophytic Alternaria brassicae AGF041. Applied microbiology and biotechnology. vol 103. issue 14. 2019-11-12. PMID:31119352. |
huperzine a (hupa) is a potent acetylcholinesterase (ache) inhibitor of a great consideration as a prospective drug candidate for alzheimer's disease treatment. |
2019-11-12 |
2023-08-13 |
Not clear |