| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Razan El Melik, Amanda Dubil, Melanie W Poun. Duration of therapy with acetylcholinesterase inhibitors in patients with mild-to-moderate Alzheimer's disease as reported in the literature. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists. vol 29. issue 6. 2019-03-27. PMID:25202893. |
to review the literature regarding the treatment duration of acetylcholinesterase inhibitor (achei) therapy for mild-to-moderate alzheimer's disease (ad) patients. |
2019-03-27 |
2023-08-13 |
Not clear |
| Yasuyuki Ohta, Mohamed Darwish, Nozomi Hishikawa, Toru Yamashita, Kota Sato, Mami Takemoto, Koji Ab. Therapeutic effects of drug switching between acetylcholinesterase inhibitors in patients with Alzheimer's disease. Geriatrics & gerontology international. vol 17. issue 11. 2019-03-26. PMID:28060449. |
therapeutic effects of drug switching between acetylcholinesterase inhibitors in patients with alzheimer's disease. |
2019-03-26 |
2023-08-13 |
Not clear |
| Yasuyuki Ohta, Mohamed Darwish, Nozomi Hishikawa, Toru Yamashita, Kota Sato, Mami Takemoto, Koji Ab. Therapeutic effects of drug switching between acetylcholinesterase inhibitors in patients with Alzheimer's disease. Geriatrics & gerontology international. vol 17. issue 11. 2019-03-26. PMID:28060449. |
to evaluate the therapeutic effects of switching from one acetylcholinesterase inhibitor (chei), donepezil, galantamine or rivastigmine, to another in alzheimer's disease patients. |
2019-03-26 |
2023-08-13 |
Not clear |
| Huseyin Cavdar, Murat Senturk, Murat Guney, Serdar Durdagi, Gulru Kayik, Claudiu T Supuran, Deniz Ekinc. Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies. Journal of enzyme inhibition and medicinal chemistry. vol 34. issue 1. 2019-03-14. PMID:30734597. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitors are interesting compounds for different therapeutic applications, among which alzheimer's disease. |
2019-03-14 |
2023-08-13 |
Not clear |
| I Tamimi, B Nicolau, H Eimar, S Arekunnath Madathil, A Kezouh, I Karp, F Tamim. Acetylcholinesterase inhibitors and the risk of osteoporotic fractures: nested case-control study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. vol 29. issue 4. 2019-02-25. PMID:29264626. |
the objective of this study was to analyze the effect of acetylcholinesterase inhibitors (acheis) on the risk of osteoporotic fractures in alzheimer patients. |
2019-02-25 |
2023-08-13 |
Not clear |
| Anuradha Thakur, Yoon Sun Chun, Natasha October, Hyun Ok Yang, Vinesh Mahara. Potential of South African medicinal plants targeting the reduction of Aβ42 protein as a treatment of Alzheimer's disease. Journal of ethnopharmacology. vol 231. 2019-02-25. PMID:30496841. |
twenty south african medicinal plant species were selected by conducting a literature review based on the relevant information of their reported traditional medicinal uses and scientific reports against alzheimer's disease, dementia, anxiety, mental illness, depression, acetylcholinesterase inhibition, headache, epilepsy, convulsion, hysteria, and sedative effects. |
2019-02-25 |
2023-08-13 |
Not clear |
| Gabriel Franco Dos Santos, Gesiane da Silva Lima, Geane Pereira de Oliveira, José Dias de Souza Filho, Luciana da Silva Amaral, Edson Rodrigues-Filho, Jacqueline Aparecida Takahash. New AChE inhibitors from microbial transformation of trachyloban-19-oic acid by Syncephalastrum racemosum. Bioorganic chemistry. vol 79. 2019-02-21. PMID:29723742. |
compounds 1-4 were evaluated for inhibition of acetylcholinesterase, enzyme linked to the symptomatic control of alzheimer's disease. |
2019-02-21 |
2023-08-13 |
Not clear |
| Alexey Ivanov, Regina Davletshina, Indira Sharafieva, Gennady Evtugy. Electrochemical biosensor based on polyelectrolyte complexes for the determination of reversible inhibitors of acetylcholinesterase. Talanta. vol 194. 2019-02-11. PMID:30609597. |
reversible inhibitors of acetylcholinesterase are increasingly applied in the alzheimer's disease therapy. |
2019-02-11 |
2023-08-13 |
Not clear |
| Jonathan R de Almeida, Micheli Figueiro, Wanda Pereira Almeida, Carlos Henrique Tomich de Paula da Silv. Discovery of novel dual acetylcholinesterase inhibitors with antifibrillogenic activity related to Alzheimer's disease. Future medicinal chemistry. vol 10. issue 9. 2019-02-04. PMID:29676170. |
discovery of novel dual acetylcholinesterase inhibitors with antifibrillogenic activity related to alzheimer's disease. |
2019-02-04 |
2023-08-13 |
Not clear |
| Ying-Chih Cheng, Yu-Chen Huang, Hsing-Cheng Li. Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis. Dementia and geriatric cognitive disorders. vol 45. issue 5-6. 2019-02-04. PMID:30041236. |
effect of apolipoprotein e ɛ4 carrier status on cognitive response to acetylcholinesterase inhibitors in patients with alzheimer's disease: a systematic review and meta-analysis. |
2019-02-04 |
2023-08-13 |
Not clear |
| Julien Lalut, Gianluca Santoni, Delphine Karila, Cédric Lecoutey, Audrey Davis, Florian Nachon, Israel Silman, Joel Sussman, Martin Weik, Tangui Maurice, Patrick Dallemagne, Christophe Rochai. Novel multitarget-directed ligands targeting acetylcholinesterase and σ European journal of medicinal chemistry. vol 162. 2019-02-04. PMID:30447434. |
novel multitarget-directed ligands targeting acetylcholinesterase and σ pleiotropic intervention may be a requirement for effective limitation of the progression of multifactorial diseases such as alzheimer's disease. |
2019-02-04 |
2023-08-13 |
Not clear |
| S Bretin, A Krazem, N Henkous, C Froger-Colleaux, E Mocaer, C Louis, N Perdaems, A Marighetto, D Beracoche. Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. Psychopharmacology. vol 235. issue 3. 2019-01-25. PMID:29167913. |
since donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in alzheimer's disease patients, an alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both glutamatergic ampa receptors and cholinergic pathways by combining pharmacological treatments. |
2019-01-25 |
2023-08-13 |
mouse |
| Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao, Linguo Zhao, Gang Ding, Zhen Zhong Wan. Identification of Human Acetylcholinesterase Inhibitors from the Constituents of EGb761 by Modeling Docking and Molecular Dynamics Simulations. Combinatorial chemistry & high throughput screening. vol 21. issue 1. 2019-01-18. PMID:29173156. |
identification of natural acetylcholinesterase (ache) inhibitors from egb761 would provide a novel therapeutic approach against the alzheimer's disease. |
2019-01-18 |
2023-08-13 |
human |
| Maryam Nazari, Sayyed Abbas Tabatabai, Elham Rezae. 2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors. Current computer-aided drug design. vol 14. issue 4. 2019-01-11. PMID:30047333. |
acetylcholinesterase enzyme (ache) is the main target in alzheimer's disease therapy and designing of novel ache inhibitors is a great deal of attention. |
2019-01-11 |
2023-08-13 |
Not clear |
| Shanmei Cheng, Wanling Song, Xiaojing Yuan, Yechun X. Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28607438. |
acetylcholinesterase, with a deep, narrow active-site gorge, attracts enormous interest due to its particularly high catalytic efficiency and its inhibitors used for treatment of alzheimer's disease. |
2019-01-10 |
2023-08-13 |
Not clear |
| Xiaojuan Yan, Tinggui Chen, Liwei Zhang, Huizhi D. Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE). International journal of biological macromolecules. vol 119. 2019-01-02. PMID:30048725. |
acetylcholinesterase (ache) inhibitors have been considered as candidates for the treatment of alzheimer's disease (ad) and have been utilized in clinical trials. |
2019-01-02 |
2023-08-13 |
Not clear |
| Nan Zhang, Marc L Gordo. Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients. Clinical interventions in aging. vol 13. 2018-12-20. PMID:30349215. |
donepezil, an acetylcholinesterase inhibitor (achei), has been widely used to treat alzheimer's disease (ad) in china. |
2018-12-20 |
2023-08-13 |
human |
| Leonardo Pisani, Rosa Maria Iacobazzi, Marco Catto, Mariagrazia Rullo, Roberta Farina, Nunzio Denora, Saverio Cellamare, Cosimo Damiano Altomar. Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. European journal of medicinal chemistry. vol 161. 2018-12-18. PMID:30366255. |
herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (ache) and monoamine oxidase b (mao b), key enzymes in neurodegenerative syndromes such as alzheimer's disease (ad), through biotransformation unmasking an alcoholic function upon nitric oxide (no) release. |
2018-12-18 |
2023-08-13 |
human |
| Esra Ucar, Nuraniye Eruygur, Mehmet Atas, Merve Ergul, Mustafa Ergul, Fazli Sozme. Determination of inhibitory activities of enzymes, related to Alzheimer's disease and diabetes mellitus of plane tree (Platanus orientalis L.) extracts and their antioxidant, antimicrobial and anticancer activities. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 11. 2018-12-11. PMID:30213283. |
the aim of the study was to evaluate the inhibitory effects against alzheimer's disease-related enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), diabetes mellitus related enzymes α-glucosidase and α-amylase. |
2018-12-11 |
2023-08-13 |
Not clear |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |