| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obie. Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). Fitoterapia. vol 128. 2018-07-20. PMID:29772299. |
the focus of this study was on inhibition of enzymes involved in the pathogenesis alzheimer's disease (ad) including prime amyloid beta (aβ) producing enzyme (β-secretase: bace-1) and disease progression enzymes including acetylcholinesterase (ache), butyrylcholinesterase (bche), histone deacetylase (hdac), and tyrosinase along with the catecholamine l-dopa, by using olive biophenols. |
2018-07-20 |
2023-08-13 |
Not clear |
| Speranta Avram, Maria Mernea, Eyup Bagci, Lucian Hritcu, Livia-Cristina Borcan, Dan Florin Mihailesc. Advanced Structure-activity Relationships Applied to Mentha spicata L. Subsp. spicata Essential Oil Compounds as AChE and NMDA Ligands, in Comparison with Donepezil, Galantamine and Memantine - New Approach in Brain Disorders Pharmacology. CNS & neurological disorders drug targets. vol 16. issue 7. 2018-07-18. PMID:28088901. |
alzheimer's disease (ad) therapy is based on several natural and synthetic compounds that act as acetylcholinesterase (ache) and n-methyl-d-aspartate receptor (nmda) ligands that have limited efficiency in relieving ad symptoms. |
2018-07-18 |
2023-08-13 |
Not clear |
| Joyshree Biswas, Sonam Gupta, Dinesh Kumar Verma, Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Poonam Goswami, Sharad Sharma, Sarika Sing. Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. Cellular signalling. vol 42. 2018-07-18. PMID:29126976. |
the alzheimer's related pathological marker like acetylcholinesterase (ache) activity, tau phosphorylation and amyloid aggregation were observed after stz administration. |
2018-07-18 |
2023-08-13 |
rat |
| Tomáš Siatka, Markéta Adamcová, Lubomír Opletal, Lucie Cahlíková, Daniel Jun, Martina Hrabinová, Jiří Kuneš, Jakub Chlebe. Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae). Molecules (Basel, Switzerland). vol 22. issue 7. 2018-07-06. PMID:28708094. |
among them, inhibition of acetylcholinesterase, butyrylcholinesterase, and prolyl oligopeptidase can be beneficial targets in the treatment of alzheimer's disease. |
2018-07-06 |
2023-08-13 |
Not clear |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Zhengrong Mei, Peiying Zheng, Xiangping Tan, Ying Wang, Bing Sit. Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury. Metabolic brain disease. vol 32. issue 6. 2018-07-03. PMID:28748496. |
huperzine a (hupa) is a potent acetylcholinesterase inhibitor (achei) that has been used treatment of alzheimer's disease (ad). |
2018-07-03 |
2023-08-13 |
mouse |
| Zdenka Kristofikova, Jan Ricny, Ondrej Soukup, Jan Korabecny, Eugenie Nepovimova, Kamil Kuca, Daniela Ripov. Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1. Dementia and geriatric cognitive disorders. vol 43. issue 1-2. 2018-06-22. PMID:27988521. |
reversible acetylcholinesterase inhibitors are used in alzheimer disease therapy. |
2018-06-22 |
2023-08-13 |
Not clear |
| Jeong Hyun Jeong, Bo Young Choi, A Ra Kho, Song Hee Lee, Dae Ki Hong, Sang Hwon Lee, Sang Yup Lee, Hong Ki Song, Hui Chul Choi, Sang Won Su. Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. International journal of molecular sciences. vol 18. issue 11. 2018-06-19. PMID:29099058. |
donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for alzheimer's disease. |
2018-06-19 |
2023-08-13 |
Not clear |
| Thais B Fernandes, Micael R Cunha, Renata P Sakata, Thalita M Candido, André R Baby, Maurício T Tavares, Euzébio G Barbosa, Wanda P Almeida, Roberto Parise-Filh. Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer's Disease. Archiv der Pharmazie. vol 350. issue 11. 2018-06-15. PMID:28940630. |
synthesis, molecular modeling, and evaluation of novel sulfonylhydrazones as acetylcholinesterase inhibitors for alzheimer's disease. |
2018-06-15 |
2023-08-13 |
Not clear |
| Liao-Bin Dong, Xing-De Wu, Xin Shi, Zhi-Jun Zhang, Jing Yang, Qin-Shi Zha. Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi. Organic letters. vol 18. issue 18. 2018-06-07. PMID:27583693. |
compounds 1 and 4 showed potent acetylcholinesterase (ache) inhibitory activities, and 4 is a good lead natural product for the treatment of alzheimer's disease. |
2018-06-07 |
2023-08-13 |
Not clear |
| Adam Kostelnik, Pavel Kopel, Alexander Cegan, Miroslav Pohank. Construction of an Acetylcholinesterase Sensor Based on Synthesized Paramagnetic Nanoparticles, a Simple Tool for Neurotoxic Compounds Assay. Sensors (Basel, Switzerland). vol 17. issue 4. 2018-05-17. PMID:28338634. |
acetylcholinesterase (ache) is an enzyme playing crucial role in neurotransmission and the enzyme is targeted by various molecules like alzheimer's drugs, pesticides and warfare agents. |
2018-05-17 |
2023-08-13 |
Not clear |
| Shifu Xiao, Tao Wang, Xiuqiang Ma, Yingyi Qin, Xia Li, Zhongxin Zhao, Xueyuan Liu, Xiaoping Wang, Hengge Xie, Qinpu Jiang, Li Sun, Benyan Luo, Lan Shang, Weixian Chen, Yan Bai, Muni Tang, Maolin He, Lan Wu, Qilin Ma, Deren Hou, Jia H. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial. Age and ageing. vol 46. issue 5. 2018-05-14. PMID:28419192. |
efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate alzheimer's disease: a phase ii multicenter randomised controlled trial. |
2018-05-14 |
2023-08-13 |
Not clear |
| Shifu Xiao, Tao Wang, Xiuqiang Ma, Yingyi Qin, Xia Li, Zhongxin Zhao, Xueyuan Liu, Xiaoping Wang, Hengge Xie, Qinpu Jiang, Li Sun, Benyan Luo, Lan Shang, Weixian Chen, Yan Bai, Muni Tang, Maolin He, Lan Wu, Qilin Ma, Deren Hou, Jia H. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial. Age and ageing. vol 46. issue 5. 2018-05-14. PMID:28419192. |
inhibition of acetylcholinesterase (ache) has been a effective treatment for alzheimer's disease (ad). |
2018-05-14 |
2023-08-13 |
Not clear |
| Alessio Cimmino, Marco Masi, Marco Evidente, Stefano Superchi, Antonio Evident. Amaryllidaceae alkaloids: Absolute configuration and biological activity. Chirality. vol 29. issue 9. 2018-05-11. PMID:28649696. |
among them, great importance for practical applications in medicine has galanthamine, which has already spawned an alzheimer's prescription drug as a potent and selective inhibitor of the enzyme acetylcholinesterase. |
2018-05-11 |
2023-08-13 |
Not clear |
| Zübeyde Erbayraktar, Ahmet Evlice, Görsev Yener, N Nuray Ulus. Effects of donepezil on liver and kidney functions for the treatment of Alzheimer's disease. Journal of integrative neuroscience. vol 16. issue 3. 2018-05-07. PMID:28891516. |
aim of the present study is to investigate the effects of medication with donepezil (acetylcholinesterase inhibitor) on the liver and kidney function in alzheimer's disease (ad) and to compare the effects of donepezil medication during short (one month) and long term (six years) follow-ups. |
2018-05-07 |
2023-08-13 |
human |
| M Rejwan Ali, Mostafa Sadoqi, Simon G Møller, Allal Boutajangout, Mihaly Meze. Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies. Journal of molecular graphics & modelling. vol 76. 2018-05-02. PMID:28711758. |
in this report we assessed by docking and molecular dynamics the binding mechanisms of three fda-approved alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (ache): donepezil, galantamine and rivastigmine. |
2018-05-02 |
2023-08-13 |
Not clear |
| Rosanna Caliandro, Alessandro Pesaresi, Luca Cariati, Antonio Procopio, Manuela Oliverio, Doriano Lamb. Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-01. PMID:29651884. |
acetylcholinesterase inhibitors were introduced for the symptomatic treatment of alzheimer's disease (ad). |
2018-05-01 |
2023-08-13 |
Not clear |
| Patrizia Russo, Aliaksei Kisialiou, Rossana Moroni, Giulia Prinzi, Massimo Fin. Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease. Current drug targets. vol 18. issue 10. 2018-04-27. PMID:26424395. |
effect of genetic polymorphisms (snps) in chrna7 gene on response to acetylcholinesterase inhibitors (achei) in patients with alzheimer's disease. |
2018-04-27 |
2023-08-13 |
Not clear |
| Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuc. Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-04-23. PMID:28788095. |
tacrine (tha), the first clinically effective acetylcholinesterase (ache) inhibitor and the first approved drug for the treatment of alzheimer's disease (ad), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. |
2018-04-23 |
2023-08-13 |
human |
| I Tamimi, S A Madathil, A Kezouh, B Nicolau, I Karp, F Tamim. Effect of acetylcholinesterase inhibitors on post-surgical complications and mortality following a hip fracture: a cohort study. Journal of musculoskeletal & neuronal interactions. vol 17. issue 2. 2018-03-21. PMID:28574413. |
this study was designed to determine whether the use of acetylcholinesterase inhibitors is associated with a decrease in post-surgical mortality and complications in hip fracture patients with alzheimer's disease. |
2018-03-21 |
2023-08-13 |
Not clear |