| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahdi Abbas-Mohammadi, Mahdi Moridi Farimani, Peyman Salehi, Samad Nejad Ebrahimi, Ali Sonboli, Celine Kelso, Danielle Skropet. Acetylcholinesterase-inhibitory activity of Iranian plants: Combined HPLC/bioassay-guided fractionation, molecular networking and docking strategies for the dereplication of active compounds. Journal of pharmaceutical and biomedical analysis. vol 158. 2018-11-08. PMID:29960238. |
in order to search for discovery of acetylcholinesterase (ache) inhibitors, as a therapeutic strategy for treatment of the alzheimer's disease, twenty-five iranian plants have been evaluated by an in vitro enzymatic ellman method and molecular docking study. |
2018-11-08 |
2023-08-13 |
Not clear |
| Stephen Adeniyi Adefegh. Functional Foods and Nutraceuticals as Dietary Intervention in Chronic Diseases; Novel Perspectives for Health Promotion and Disease Prevention. Journal of dietary supplements. vol 15. issue 6. 2018-11-07. PMID:29281341. |
this review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-i converting enzyme [ace], acetylcholinesterase [ache], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [alzheimer's disease] and erectile dysfunction). |
2018-11-07 |
2023-08-13 |
Not clear |
| Bruk Getachew, Tamaro Hudson, Thomas Heinbockel, Antonei B Csoka, Yousef Tizab. Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29804239. |
donepezil (don), a centrally acting, reversible and non-competitive acetylcholinesterase (ache) inhibitor, approved for use in alzheimer's disease (ad), may also attenuate etoh-induced cognitive impairment. |
2018-11-06 |
2023-08-13 |
human |
| Sita Sharan Patel, Ramsaneh Raghuwanshi, Misha Masood, Ashish Acharya, Surendra Kumar Jai. Medicinal plants with acetylcholinesterase inhibitory activity. Reviews in the neurosciences. vol 29. issue 5. 2018-10-23. PMID:29303784. |
acetylcholinesterase (ache) is an enzyme that metabolises the ach at synaptic cleft resulting in alzheimer's disease. |
2018-10-23 |
2023-08-13 |
human |
| Olushola Alonge, Fahad Mujtaba Iqbal, Elzbieta Cifonell. Collapse in the elderly: rivastigmine-induced heart block and a literature review of the pharmacology of acetylcholinesterase inhibitors used in Alzheimer's disease. BMJ case reports. vol 2018. 2018-10-12. PMID:29666099. |
collapse in the elderly: rivastigmine-induced heart block and a literature review of the pharmacology of acetylcholinesterase inhibitors used in alzheimer's disease. |
2018-10-12 |
2023-08-13 |
Not clear |
| Gokalp Ozmen Guler, Gokhan Zengin, Firat Karadag, Adriano Mollica, Carene Marie Nancy Picot, Mohamad Fawzi Mahomoodall. HPLC-DAD profiles and pharmacological insights of Onobrychis argyrea subsp isaurica extracts. Computational biology and chemistry. vol 76. 2018-10-12. PMID:30081342. |
this study sets out to investigate into antioxidant and inhibitory activities of o. argyrea extracts (ethyl acetate, methanol, and water) against key enzymes linked to diabetes (α-amylase, α-glucosidase), alzheimer's disease (acetylcholinesterase, butyrylcholinesterase), and skin hyperpigmentation (tyrosinase). |
2018-10-12 |
2023-08-13 |
Not clear |
| Xiaocong Pang, Hui Fu, Shilun Yang, Lin Wang, Ai-Lin Liu, Song Wu, Guan-Hua D. Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer's Disease Agents Using Pharmacophore, 3D-QSAR, and Molecular Docking Approaches. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-10-04. PMID:28933746. |
dl0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for alzheimer's disease treatment. |
2018-10-04 |
2023-08-13 |
Not clear |
| Rui Xu, Ganyuan Xiao, Yan Li, Hongyan Liu, Qing Song, Xiaoyu Zhang, Ziyi Yang, Yunxiaozhu Zheng, Zhenghuai Tan, Yong Den. Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry. vol 26. issue 8. 2018-10-02. PMID:29500132. |
multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2h)-one-n-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against alzheimer's disease. |
2018-10-02 |
2023-08-13 |
Not clear |
| Claudio Méndez-Rojas, Gabriel Quiroz, Mario Faúndez, Carlos Gallardo-Garrido, C David Pessoa-Mahana, Hery Chung, Eduardo Gallardo-Toledo, Claudio Saitz-Barría, Ramiro Araya-Maturana, Marcelo J Kogan, María C Zúñiga-López, Patricio Iturriaga-Vásquez, Carla Valenzuela-Gutiérrez, Hernán Pessoa-Mahan. Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core. Archiv der Pharmazie. vol 351. issue 5. 2018-09-20. PMID:29611620. |
with the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of alzheimer's disease, we synthesized and evaluated a novel series of indole-benzoxazinones (family i) and benzoxazine-arylpiperazine derivatives (family ii) for potential human acetylcholinesterase (hache) inhibitory properties. |
2018-09-20 |
2023-08-13 |
human |
| Shuai Qian, Lisi He, Qianwen Wang, Yin Cheong Wong, Marvin Mak, Chun-Yu Ho, Yifan Han, Zhong Zu. Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease. Life sciences. vol 207. 2018-09-20. PMID:29966606. |
intranasal delivery of a novel acetylcholinesterase inhibitor hls-3 for treatment of alzheimer's disease. |
2018-09-20 |
2023-08-13 |
Not clear |
| María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grand. Nutraceutical Potential of Phenolics from 'Brava' and 'Mansa' Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of 'Picual' and 'Cornicabra'. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-03. PMID:29561824. |
extra-virgin olive oils (evoos) obtained from 'brava' and 'mansa', varieties recently identified from galicia (northwestern spain), were selected for in vitro screening to evaluate their capacity to inhibit key enzymes involved in alzheimer's disease (ad) (acetylcholinesterase (ache), butyrylcholinesterase (buche) and 5-lipoxygenase (5-lox)), major depressive disorder (mdd) and parkinson's disease (pd) (monoamine oxidases: |
2018-09-03 |
2023-08-13 |
Not clear |
| Odunayo Michael Agunloye, Ganiyu Obo. Modulatory effect of caffeic acid on cholinesterases inhibitory properties of donepezil. Journal of complementary & integrative medicine. vol 15. issue 1. 2018-08-27. PMID:28941354. |
background donepezil hydrochloride commonly used in the management of alzheimer's disease (ad), exhibiting its inhibitory effects on acetylcholinesterase and butyrylcholinesterase activity thereby enhance cognitive function. |
2018-08-27 |
2023-08-13 |
human |
| Fei Mao, Huan Wang, Wei Ni, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang, Jian L. Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. vol 9. issue 2. 2018-08-17. PMID:29068218. |
design, synthesis, and biological evaluation of orally available first-generation dual-target selective inhibitors of acetylcholinesterase (ache) and phosphodiesterase 5 (pde5) for the treatment of alzheimer's disease. |
2018-08-17 |
2023-08-13 |
mouse |
| Natalie Cortes, Karina Sierra, Fernando Alzate, Edison H Osorio, Edison Osori. Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study. Phytochemical analysis : PCA. vol 29. issue 2. 2018-08-16. PMID:29044771. |
enzymatic inhibition of acetylcholinesterase (ache) is an essential therapeutic target for the treatment of alzheimer's disease (ad) and ache inhibitors are the first-line drugs for it treatment. |
2018-08-16 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, Dariusz Jedrejek, F Sezer Senol, Ramin Ekhteiari Salmas, Serdar Durdagi, Iwona Kowalska, Lukasz Pecio, Wieslaw Olesze. Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 42. 2018-08-13. PMID:29655693. |
many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (ache) and butyrylcholinesterase (bche), the key enzymes in the pathology of alzheimer's disease (ad). |
2018-08-13 |
2023-08-13 |
Not clear |
| Christoph Mueller, Gayan Perera, Richard D Hayes, Hitesh Shetty, Robert Stewar. Associations of acetylcholinesterase inhibitor treatment with reduced mortality in Alzheimer's disease: a retrospective survival analysis. Age and ageing. vol 47. issue 1. 2018-07-30. PMID:28655175. |
associations of acetylcholinesterase inhibitor treatment with reduced mortality in alzheimer's disease: a retrospective survival analysis. |
2018-07-30 |
2023-08-13 |
Not clear |
| Tae Woog Kang, Su-Ji Jeon, Hye-In Kim, Jung Hyun Park, DaBin Yim, Hye-Rim Lee, Jong-Min Ju, Man-Jin Kim, Jong-Ho Ki. Optical Detection of Enzymatic Activity and Inhibitors on Non-Covalently Functionalized Fluorescent Graphene Oxide. ACS nano. vol 10. issue 5. 2018-07-27. PMID:27136042. |
it has been of great interest to measure the activity of acetylcholinesterase (ache) and its inhibitor, as ache is known to accelerate the aggregation of the amyloid beta peptides that underlie alzheimer's disease. |
2018-07-27 |
2023-08-13 |
Not clear |
| Ümide Demir Özkay, Özgür Devrim Can, Begüm Nurpelin Sağlık, Nazlı Tura. A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats. Pharmacological reports : PR. vol 69. issue 6. 2018-07-27. PMID:29132093. |
acetylcholinesterase (ache) inhibitors are frequently prescribed to mitigate the cognitive decline in alzheimer's disease. |
2018-07-27 |
2023-08-13 |
rat |
| Gauresh S Somani, Mruniya S Nahire, Aakash D Parikh, Mandar B Mulik, Priya J Ghumatkar, Kirti S Laddha, Sadhana Sathay. Neuroprotective effect of Cubebin: A dibenzylbutyrolactone lignan on scopolamine-induced amnesia in mice. The Indian journal of medical research. vol 146. issue 2. 2018-07-27. PMID:29265027. |
acetylcholinesterase (ache) inhibitors represent a major class of drugs which provide symptomatic relief and improvement in cognitive function in alzheimer's disease (ad). |
2018-07-27 |
2023-08-13 |
mouse |
| Kandasamy Saravanan, Chinnasamy Kalaiarasi, Poomani Kumaradha. Understanding the conformational flexibility and electrostatic properties of curcumin in the active site of rhAChE via molecular docking, molecular dynamics, and charge density analysis. Journal of biomolecular structure & dynamics. vol 35. issue 16. 2018-07-20. PMID:27897077. |
acetylcholinesterase (ache) is an important enzyme responsible for alzheimer's disease, as per report, keto-enol form of curcumin inhibits this enzyme. |
2018-07-20 |
2023-08-13 |
human |