| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Renata P Sakata, Micheli Figueiro, Daniel F Kawano, Wanda P Almeid. Effect on Acetylcholinesterase and Anti-oxidant Activity of Synthetic Chalcones having a Good Predicted Pharmacokinetic Profile. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 13. issue 7. 2017-12-05. PMID:28545385. |
acetylcholinesterase (ache) is an important target in the development of drug to treat alzheimer's disease (ad). |
2017-12-05 |
2023-08-13 |
Not clear |
| Jeannette Gonzalez, Jennifer Ramirez, Jason P Schwan. Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase. Amino acids. vol 48. issue 12. 2017-12-04. PMID:27522651. |
for the two major classes of cholinesterases, such as acetylcholinesterase (ache) and butyrylcholinesterase (bche), previous studies reported bche activity is elevated in patients with alzheimer's disease, while ache levels remain the same or decrease. |
2017-12-04 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
modulators of acetylcholinesterase activity: from alzheimer's disease to anti-cancer drugs. |
2017-11-29 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs for different neurodegenerative diseases (such as alzheimer's and parkinson's) as well as toxins. |
2017-11-29 |
2023-08-13 |
Not clear |
| Nicolaas I Bohnen, Martijn L T M Müller, Daniel I Kaufe. Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-[(11) C]MP4A PET study. International journal of geriatric psychiatry. vol 31. issue 8. 2017-11-20. PMID:27001751. |
dementia with lewy bodies can be well-differentiated from alzheimer's disease by measurement of brain acetylcholinesterase activity-[(11) c]mp4a pet study. |
2017-11-20 |
2023-08-13 |
Not clear |
| Galina F Makhaeva, Sofya V Lushchekina, Natalia P Boltneva, Olga G Serebryakova, Elena V Rudakova, Alexey A Ustyugov, Sergey O Bachurin, Alexander V Shchepochkin, Oleg N Chupakhin, Valery N Charushin, Rudy J Richardso. 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. Bioorganic & medicinal chemistry. vol 25. issue 21. 2017-11-17. PMID:28986116. |
9-substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for alzheimer's disease treatment. |
2017-11-17 |
2023-08-13 |
Not clear |
| Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva-Dimitrova, Iva Valkova, Evdokiya Salamanova, Spiro Konstantinov, Irini Doytchinov. Docking-based design and synthesis of galantamine-camphane hybrids as inhibitors of acetylcholinesterase. Chemical biology & drug design. vol 90. issue 5. 2017-11-13. PMID:28374576. |
galantamine (gal) as an acetylcholinesterase inhibitor (achei) is among the main drugs approved for the treatment of alzheimer's disease. |
2017-11-13 |
2023-08-13 |
Not clear |
| Brianna E Glynn-Servedio, Trisha Seys Ranol. AChE Inhibitors and NMDA Receptor Antagonists in Advanced Alzheimer's Disease. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists. vol 32. issue 9. 2017-11-07. PMID:28855009. |
the objective of this article is to review the available evidence for duration of treatment with, and considerations for discontinuation of, acetylcholinesterase inhibitors and n-methyl-d-aspartate receptor antagonists in alzheimer's disease. |
2017-11-07 |
2023-08-13 |
Not clear |
| Jana Wiemann, Julia Karasch, Anne Loesche, Lucie Heller, Wolfgang Brandt, René Csu. Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase. European journal of medicinal chemistry. vol 139. 2017-10-31. PMID:28802122. |
these compounds may be regarded as promising candidates for the development of efficient inhibitors of acetylcholinesterase being useful for the treatment of alzheimer's disease. |
2017-10-31 |
2023-08-13 |
Not clear |
| Maria I Cruz, Honorina Cidade, Madalena Pint. Dual/multitargeted xanthone derivatives for Alzheimer's disease: where do we stand? Future medicinal chemistry. vol 9. issue 14. 2017-10-25. PMID:28832188. |
to date, the current therapy for alzheimer's disease (ad) based on acetylcholinesterase inhibitors is only symptomatic, being its efficacy limited. |
2017-10-25 |
2023-08-13 |
Not clear |
| Talita P C Chierrito, Susimaire Pedersoli-Mantoani, Carlos Roca, Carlos Requena, Victor Sebastian-Perez, Willian O Castillo, Natalia C S Moreira, Concepción Pérez, Elza T Sakamoto-Hojo, Catarina S Takahashi, Jesús Jiménez-Barbero, F Javier Cañada, Nuria E Campillo, Ana Martinez, Ivone Carvalh. From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease. European journal of medicinal chemistry. vol 139. 2017-10-16. PMID:28863358. |
from dual binding site acetylcholinesterase inhibitors to allosteric modulators: a new avenue for disease-modifying drugs in alzheimer's disease. |
2017-10-16 |
2023-08-13 |
human |
| Jana Wiemann, Anne Loesche, René Csu. Novel dehydroabietylamine derivatives as potent inhibitors of acetylcholinesterase. Bioorganic chemistry. vol 74. 2017-10-10. PMID:28797788. |
nowadays, the inhibition of acetylcholinesterase is one of the main pharmacological strategies for the treatment of alzheimer's disease. |
2017-10-10 |
2023-08-13 |
Not clear |
| Liang Peng, Zhengxing Rong, Hao Wang, Biyun Shao, Lei Kang, Hong Qi, Hongzhuan Che. A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease. Biomedical chromatography : BMC. vol 31. issue 10. 2017-10-09. PMID:28295437. |
a novel assay to determine acetylcholinesterase activity: the application potential for screening of drugs against alzheimer's disease. |
2017-10-09 |
2023-08-13 |
Not clear |
| Leonardo Pisani, Marco Catto, Annalisa De Palma, Roberta Farina, Saverio Cellamare, Cosimo D Altomar. Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties. ChemMedChem. vol 12. issue 16. 2017-10-09. PMID:28570763. |
acetylcholinesterase (ache) inhibitors still comprise the majority of the marketed drugs for alzheimer's disease (ad). |
2017-10-09 |
2023-08-13 |
Not clear |
| Ahmet Turan Isik, Pinar Soysal, Cansu Usare. Effects of Acetylcholinesterase Inhibitors on Balance and Gait Functions and Orthostatic Hypotension in Elderly Patients With Alzheimer Disease. American journal of Alzheimer's disease and other dementias. vol 31. issue 7. 2017-10-04. PMID:27585748. |
effects of acetylcholinesterase inhibitors on balance and gait functions and orthostatic hypotension in elderly patients with alzheimer disease. |
2017-10-04 |
2023-08-13 |
Not clear |
| Ahmet Turan Isik, Pinar Soysal, Cansu Usare. Effects of Acetylcholinesterase Inhibitors on Balance and Gait Functions and Orthostatic Hypotension in Elderly Patients With Alzheimer Disease. American journal of Alzheimer's disease and other dementias. vol 31. issue 7. 2017-10-04. PMID:27585748. |
the present study was designed to evaluate the effect of acetylcholinesterase inhibitor (achei) therapy on balance, gait, and orthostatic hypotension (oh) in elderly patients with alzheimer's disease (ad). |
2017-10-04 |
2023-08-13 |
Not clear |
| Asante R Kamkwalala, Paul A Newhous. Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease. Current Alzheimer research. vol 14. issue 4. 2017-10-04. PMID:27697062. |
beyond acetylcholinesterase inhibitors: novel cholinergic treatments for alzheimer's disease. |
2017-10-04 |
2023-08-13 |
human |
| Kyung Won Park, Eun-Joo Kim, Hyun Jeong Han, Yong S Shim, Jae C Kwon, Bon D Ku, Kee Hyung Park, Hyon-Ah Yi, Kwang K Kim, Dong Won Yang, Ho-Won Lee, Heeyoung Kang, Oh Dae Kwon, SangYun Kim, Jae-Hyeok Lee, Eun Joo Chung, Sang-Won Park, Mee Young Park, Bora Yoon, Byeong C Kim, Sang Won Seo, Seong Hye Cho. Efficacy and tolerability of rivastigmine patch therapy in patients with mild-to-moderate Alzheimer's dementia associated with minimal and moderate ischemic white matter hyperintensities: A multicenter prospective open-label clinical trial. PloS one. vol 12. issue 8. 2017-10-04. PMID:28786987. |
studies investigating the impact of white matter hyperintensities (wmhs) on the response of acetylcholinesterase inhibitors in patients with alzheimer's disease (ad) have presented inconsistent results. |
2017-10-04 |
2023-08-13 |
Not clear |
| Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Xia Yang, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Den. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry. vol 25. issue 6. 2017-10-02. PMID:28237559. |
multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against alzheimer's disease. |
2017-10-02 |
2023-08-13 |
Not clear |
| Ana-Belen Cutillas, Alejandro Carrasco, Ramiro Martinez-Gutierrez, Virginia Tomas, Jose Tudel. Salvia officinalis L. Essential Oils from Spain: Determination of Composition, Antioxidant Capacity, Antienzymatic, and Antimicrobial Bioactivities. Chemistry & biodiversity. vol 14. issue 8. 2017-09-27. PMID:28477412. |
because of their known relation with inflammatory illnesses and alzheimer's disease, respectively, the inhibition of lipoxygenase and acetylcholinesterase was studied using the eos. |
2017-09-27 |
2023-08-13 |
Not clear |