| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Garcia-Ratés, Paul Morrill, Henry Tu, Gwenael Pottiez, Antoine-Scott Badin, Cristina Tormo-Garcia, Catherine Heffner, Clive W Coen, Susan A Greenfiel. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. vol 105. 2017-06-21. PMID:26867503. |
here we show for the first time that (1) a peptide derived from acetylcholinesterase, with independent trophic functions that turn toxic in maturity, is significantly raised in the alzheimer midbrain and cerebrospinal fluid; (2) a synthetic version of this peptide enhances calcium influx and eventual production of amyloid beta and tau phosphorylation via an allosteric site on the α7 nicotinic receptor; (3) a synthetic cyclic version of this peptide is neuroprotective against the toxicity not only of its linear counterpart but also of amyloid beta, thereby opening up the prospect of a novel therapeutic approach. |
2017-06-21 |
2023-08-13 |
Not clear |
| Kjartan F Herrik, Arne Mørk, Nelly Richard, Christoffer Bundgaard, Jesper F Bastlund, Inge E M de Jon. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus. Neuropharmacology. vol 107. 2017-06-19. PMID:27039041. |
the 5-ht6 receptor has emerged as a promising target for cognitive disorders and combining a 5-ht6 receptor antagonist with an acetylcholinesterase inhibitor (achei) represents a novel approach for the symptomatic treatment of alzheimer's disease (ad). |
2017-06-19 |
2023-08-13 |
rat |
| Ping-Ping Lin, Xue-Ning Li, Fei Yuan, Wei-Li Chen, Meng-Jie Yang, Hong-Rong X. Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A. Biochemical and biophysical research communications. vol 480. issue 2. 2017-06-13. PMID:27751854. |
evaluation of the in vitro and in vivo metabolic pathway and cytochrome p450 inhibition/induction profile of huperzine a. huperzine a (hupa), one of the reversible and selective acetylcholinesterase inhibitors derived from chinese herb huperzia serrata, possesses affirmative action of ameliorating cognitive dysfunction of alzheimer's disease. |
2017-06-13 |
2023-08-13 |
human |
| Leonardo Pisani, Roberta Farina, Marco Catto, Rosa Maria Iacobazzi, Orazio Nicolotti, Saverio Cellamare, Giuseppe Felice Mangiatordi, Nunzio Denora, Ramon Soto-Otero, Lydia Siragusa, Cosimo Damiano Altomare, Angelo Carott. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. Journal of medicinal chemistry. vol 59. issue 14. 2017-06-09. PMID:27347731. |
aiming at modulating two key enzymatic targets for alzheimer's disease (ad), i.e., acetylcholinesterase (ache) and monoamine oxidase b (mao b), a series of multitarget ligands was properly designed by linking the 3,4-dimethylcoumarin scaffold to 1,3- and 1,4-substituted piperidine moieties, thus modulating the basicity to improve the hydrophilic/lipophilic balance. |
2017-06-09 |
2023-08-13 |
human |
| Muhammad Shakil Shah, Shafi Ullah Khan, Syeda Abida Ejaz, Saifullah Afridi, Syed Umar Farooq Rizvi, Muhammad Najam-Ul-Haq, Jamshed Iqba. Cholinesterases inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones. Biochemical and biophysical research communications. vol 482. issue 4. 2017-05-29. PMID:27865835. |
super-activation of cholinesterases (acetylcholinesterase and butyrylcholinesterase) are linked to various neurological problems most precisely alzheimer's disease (ad), which leads to senile dementia. |
2017-05-29 |
2023-08-13 |
Not clear |
| Jianqiao Zhang, Leiming Zhang, Xue Sun, Yanting Yang, Liang Kong, Chengwen Lu, Guangyao Lv, Tian Wang, Hongbo Wang, Fenghua F. Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation. The Journal of pharmacology and experimental therapeutics. vol 359. issue 2. 2017-05-26. PMID:27535978. |
acetylcholinesterase inhibitors for alzheimer's disease treatment ameliorate acetaminophen-induced liver injury in mice via central cholinergic system regulation. |
2017-05-26 |
2023-08-13 |
mouse |
| Jianqiao Zhang, Leiming Zhang, Xue Sun, Yanting Yang, Liang Kong, Chengwen Lu, Guangyao Lv, Tian Wang, Hongbo Wang, Fenghua F. Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation. The Journal of pharmacology and experimental therapeutics. vol 359. issue 2. 2017-05-26. PMID:27535978. |
alzheimer's disease patients, while treated with acetylcholinesterase inhibitor (achei), may take apap when they suffer from cold or pain. |
2017-05-26 |
2023-08-13 |
mouse |
| Tanzeel Ur Rehman, Islam Ullah Khan, Muhammad Ashraf, Hamadeh Tarazi, Sadaf Riaz, Muhammad Ya. An Efficient Synthesis of bi-Aryl Pyrimidine Heterocycles: Potential New Drug Candidates to Treat Alzheimer's Disease. Archiv der Pharmazie. vol 350. issue 3-4. 2017-05-15. PMID:28220522. |
the enzyme inhibitory potential of these compounds was investigated against acetylcholinesterase (ache) and butyrylcholinesterase (bche) because these enzymes play a crucial role in the treatment of alzheimer's disease. |
2017-05-15 |
2023-08-13 |
Not clear |
| Malavalli Madaiah, Bidarur K Jayanna, Arakere S Manu, Maralekere K Prashanth, Hosakere D Revanasiddappa, Bantal Veeres. Synthesis, Characterization, and Evaluation of Difluoropyrido[4,3-b]indoles as Potential Agents for Acetylcholinesterase and Antiamnesic Activity. Archiv der Pharmazie. vol 350. issue 3-4. 2017-05-15. PMID:28326602. |
acetylcholinesterase (ache) inhibitors are currently the most widely prescribed drugs for alzheimer's disease. |
2017-05-15 |
2023-08-13 |
rat |
| Shu-Yu Tai, Chun-Hung Chen, Chen-Yu Chien, Yuan-Han Yan. Cilostazol as an add-on therapy for patients with Alzheimer's disease in Taiwan: a case control study. BMC neurology. vol 17. issue 1. 2017-04-26. PMID:28231822. |
combination therapy using acetylcholinesterase inhibitors (acheis) and cilostazol is of unknown efficacy for patients with alzheimer's disease (ad). |
2017-04-26 |
2023-08-13 |
Not clear |
| Dorothea Kaufmann, Anudeep Kaur Dogra, Ahmad Tahrani, Florian Herrmann, Michael Win. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer's Disease Target. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27589716. |
extracts from traditional chinese medicinal plants inhibit acetylcholinesterase, a known alzheimer's disease target. |
2017-04-17 |
2023-08-13 |
Not clear |
| Dorothea Kaufmann, Anudeep Kaur Dogra, Ahmad Tahrani, Florian Herrmann, Michael Win. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer's Disease Target. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27589716. |
inhibition of acetylcholinesterase (ache) is a common treatment for early stages of the most general form of dementia, alzheimer's disease (ad). |
2017-04-17 |
2023-08-13 |
Not clear |
| Kyung Hoan Im, Trung Kien Nguyen, Jaehyuk Choi, Tae Soo Le. In Vitro Antioxidant, Anti-Diabetes, Anti-Dementia, and Inflammation Inhibitory Effect of Trametes pubescens Fruiting Body Extracts. Molecules (Basel, Switzerland). vol 21. issue 5. 2017-04-13. PMID:27196881. |
the acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory effects of me and hwe were moderate and comparable with galanthamine, the standard drug to treat early stages of alzheimer's disease (ad). |
2017-04-13 |
2023-08-13 |
rat |
| Yan-Xiu Chen, Guan-Zeng Li, Bin Zhang, Zhang-Yong Xia, Mei Zhan. Molecular evaluation of herbal compounds as potent inhibitors of acetylcholinesterase for the treatment of Alzheimer's disease. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27176468. |
molecular evaluation of herbal compounds as potent inhibitors of acetylcholinesterase for the treatment of alzheimer's disease. |
2017-04-06 |
2023-08-13 |
Not clear |
| Eun Bi Kuk, A Ra Jo, Seo In Oh, Hee Sook Sohn, Su Hui Seong, Anupom Roy, Jae Sue Choi, Hyun Ah Jun. Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L. Archives of pharmacal research. vol 40. issue 3. 2017-04-04. PMID:28093699. |
anti-alzheimer's disease activity of compounds from the root bark of morus alba l. the inhibition of acetylcholinesterase (ache), butyrylcholinesterase (bche), and β-site amyloid precursor protein cleaving enzyme 1 (bace1) plays important roles in prevention and treatment of alzheimer's disease (ad). |
2017-04-04 |
2023-08-13 |
Not clear |
| Asokkumar Kuppusamy, Madeswaran Arumugam, Sonia Georg. Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer's disease. International journal of biological macromolecules. vol 95. 2017-04-03. PMID:27871793. |
combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of alzheimer's disease. |
2017-04-03 |
2023-08-13 |
Not clear |
| Asokkumar Kuppusamy, Madeswaran Arumugam, Sonia Georg. Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer's disease. International journal of biological macromolecules. vol 95. 2017-04-03. PMID:27871793. |
these molecular docking and in vitro analyses could lead to the further development of potent acetylcholinesterase inhibitors for the treatment of alzheimer's disease. |
2017-04-03 |
2023-08-13 |
Not clear |
| R Haussmann, M Doni. [Memantine as add-on medication to acetylcholinesterase inhibitor therapy for Alzheimer dementia]. Der Nervenarzt. vol 88. issue 1. 2017-03-21. PMID:27822591. |
[memantine as add-on medication to acetylcholinesterase inhibitor therapy for alzheimer dementia]. |
2017-03-21 |
2023-08-13 |
Not clear |
| Qiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Sun, Wei Zheng, Weiwei Zhang, Wei Sheng, Qihong Zhang, Hongzhuan Chen, Hao Wang, Zhuibai Qi. Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis. Journal of enzyme inhibition and medicinal chemistry. vol 32. issue 1. 2017-03-17. PMID:28274151. |
multifunctional carbamate-type acetylcholinesterase (ache) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for alzheimer's disease (ad). |
2017-03-17 |
2023-08-13 |
Not clear |
| Dan Zhou, Wei Zhou, Jun-Ke Song, Zhang-Ying Feng, Ran-Yao Yang, Song Wu, Lin Wang, Ai-Lin Liu, Guan-Hua D. DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway. Acta pharmacologica Sinica. vol 37. issue 11. 2017-03-15. PMID:27498773. |
1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride (dl0410) is a novel synthetic dual acetylcholinesterase (ache)/butyrocholinesterase (buche) inhibitor, which has shown a potential therapeutic effect on alzheimer's disease (ad). |
2017-03-15 |
2023-08-13 |
mouse |