| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
old and new acetylcholinesterase inhibitors for alzheimer's disease. |
2017-03-10 |
2023-08-13 |
Not clear |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
to date, pharmacological treatment of alzheimer's disease (ad) includes acetylcholinesterase inhibitors (acheis) for mild-to-moderate ad, and memantine for moderate-to-severe ad. |
2017-03-10 |
2023-08-13 |
Not clear |
| Jamiu A Saliu, Ayodeji A Olabiy. Aqueous extract of Securidaca longipendunculata Oliv. and Olax subscropioidea inhibits key enzymes (acetylcholinesterase and butyrylcholinesterase) linked with Alzheimer's disease in vitro. Pharmaceutical biology. vol 55. issue 1. 2017-03-10. PMID:27927065. |
and olax subscropioidea inhibits key enzymes (acetylcholinesterase and butyrylcholinesterase) linked with alzheimer's disease in vitro. |
2017-03-10 |
2023-08-13 |
Not clear |
| Kyung Hoan Im, Trung Kien Nguyen, Jae Kwang Kim, Jae-Hyuk Choi, Tae Soo Le. Evaluation of Anticholinesterase and Inflammation Inhibitory Activity of Medicinal Mushroom Phellinus pini (Basidiomycetes) Fruiting Bodies. International journal of medicinal mushrooms. vol 18. issue 11. 2017-03-08. PMID:28008813. |
acetylcholinesterase and butyrylcholinesterase inhibitory effects of a methanol extract and a hot water extract were moderate and comparable with those of galanthamine, the standard drug used to treat the early stages of alzheimer's disease. |
2017-03-08 |
2023-08-13 |
rat |
| Syed Mohd Danish Rizvi, Sibhghatulla Shaikh, Deeba Naaz, Shazi Shakil, Adnan Ahmad, Mohd Haneef, Adel M Abuzenada. Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:26886763. |
kinetics and molecular docking study of an anti-diabetic drug glimepiride as acetylcholinesterase inhibitor: implication for alzheimer's disease-diabetes dual therapy. |
2017-03-06 |
2023-08-13 |
Not clear |
| Jeelan Basha Shaik, Bhagath Kumar Palaka, Mohan Penumala, Siddhartha Eadlapalli, Manidhar Darla Mark, Dinakara Rao Ampasala, Ramakrishna Vadde, Damu Amooru Gangaia. Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. Chemical biology & drug design. vol 88. issue 1. 2017-03-01. PMID:26833890. |
in line with this modern paradigm, a series of 8-imino-2-oxo-2h,8h-pyrano[2,3-f]chromene analogs (4a-q) were synthesized and evaluated for their multitarget-directed activity on acetylcholinesterase, butyrylcholinesterase (buche), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (abts) radical, and amyloid-β peptide (aβ) specific targets for alzheimer's disease therapy. |
2017-03-01 |
2023-08-13 |
Not clear |
| Jeelan Basha Shaik, Bhagath Kumar Palaka, Mohan Penumala, Siddhartha Eadlapalli, Manidhar Darla Mark, Dinakara Rao Ampasala, Ramakrishna Vadde, Damu Amooru Gangaia. Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. Chemical biology & drug design. vol 88. issue 1. 2017-03-01. PMID:26833890. |
overall, these results lead to discovery of fused tricyclic coumarins as promising dual binding site inhibitors of acetylcholinesterase and afford multifunctional compounds with potential impact for further pharmacological development in alzheimer's therapy. |
2017-03-01 |
2023-08-13 |
Not clear |
| Begüm Nurpelin Sağlık, Sinem Ilgın, Yusuf Özka. Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes. European journal of medicinal chemistry. vol 124. 2017-02-28. PMID:27783974. |
donepezil (dnp), an acetylcholinesterase (ache) inhibitor, is one of the most preferred choices in alzheimer diseases (ad) therapy. |
2017-02-28 |
2023-08-13 |
Not clear |
| Gisele S da Silva, Micheli Figueiró, Claudio F Tormena, Fernando Coelho, Wanda P Almeid. Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Aβ42 peptide fibrils formation. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-02-27. PMID:26928712. |
acetylcholinesterase inhibitors and compounds that trigger aβ amyloid oligomerization and fibrillization represent an opportunity to discover new drug candidates to treat alzheimer's disease. |
2017-02-27 |
2023-08-13 |
Not clear |
| Arlan da Silva Gonçalves, Tanos Celmar Costa França, Osmair Vital de Oliveir. Computational studies of acetylcholinesterase complexed with fullerene derivatives: a new insight for Alzheimer disease treatment. Journal of biomolecular structure & dynamics. vol 34. issue 6. 2017-02-24. PMID:26219766. |
computational studies of acetylcholinesterase complexed with fullerene derivatives: a new insight for alzheimer disease treatment. |
2017-02-24 |
2023-08-13 |
human |
| Divan G van Greunen, Werner Cordier, Margo Nell, Chris van der Westhuyzen, Vanessa Steenkamp, Jenny-Lee Panayides, Darren L Rile. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil. European journal of medicinal chemistry. vol 127. 2017-02-21. PMID:27823887. |
a series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which is currently used for the management of mild to severe alzheimer's disease. |
2017-02-21 |
2023-08-13 |
Not clear |
| Youssef Dgachi, Olga Sokolov, Vincent Luzet, Justyna Godyń, Dawid Panek, Alexandre Bonet, Hélène Martin, Isabel Iriepa, Ignacio Moraleda, Cristina García-Iriepa, Jana Janockova, Lysiane Richert, Ondrej Soukup, Barbara Malawska, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismail. Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy. European journal of medicinal chemistry. vol 126. 2017-02-21. PMID:27918993. |
tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for alzheimer's disease therapy. |
2017-02-21 |
2023-08-13 |
Not clear |
| Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Den. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 126. 2017-02-21. PMID:27951485. |
aurone mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of alzheimer's disease. |
2017-02-21 |
2023-08-13 |
Not clear |
| Zhi-Min Wang, Pei Cai, Qiao-Hong Liu, Ding-Qiao Xu, Xue-Lian Yang, Jia-Jia Wu, Ling-Yi Kong, Xiao-Bing Wan. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27484514. |
rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of alzheimer's disease. |
2017-02-13 |
2023-08-13 |
mouse |
| Zhi-Min Wang, Pei Cai, Qiao-Hong Liu, Ding-Qiao Xu, Xue-Lian Yang, Jia-Jia Wu, Ling-Yi Kong, Xiao-Bing Wan. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27484514. |
a series of novel donepezil derivatives was designed, synthesized and evaluated as multifunctional acetylcholinesterase (ache) inhibitors for the treatment of alzheimer's disease (ad). |
2017-02-13 |
2023-08-13 |
mouse |
| Donald E Moss, Ruth G Perez, Haruo Kobayash. Cholinesterase Inhibitor Therapy in Alzheimer's Disease: The Limits and Tolerability of Irreversible CNS-Selective Acetylcholinesterase Inhibition in Primates. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2017-02-13. PMID:27858711. |
cholinesterase inhibitor therapy in alzheimer's disease: the limits and tolerability of irreversible cns-selective acetylcholinesterase inhibition in primates. |
2017-02-13 |
2023-08-13 |
human |
| Maria Barbara Pisano, Sofia Cosentino, Silvia Viale, Delia Spanò, Angela Corona, Francesca Esposito, Enzo Tramontano, Paola Montoro, Carlo Ignazio Giovanni Tuberoso, Rosaria Medda, Francesca Pintu. Biological Activities of Aerial Parts Extracts of Euphorbia characias. BioMed research international. vol 2016. 2017-02-10. PMID:27314007. |
ethanolic extracts from leaves and flowers displayed the highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase, showing potential properties against alzheimer's disease. |
2017-02-10 |
2023-08-13 |
Not clear |
| Shuqun Zhang, Bo Hou, Huaiyu Yang, Zhili Zu. Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives. Archives of pharmacal research. vol 39. issue 5. 2017-02-07. PMID:26832327. |
acetylcholinesterase (ache) is an important enzyme in the pathogenesis of alzheimer's disease (ad). |
2017-02-07 |
2023-08-13 |
Not clear |
| Himanshu Kumar Bhakta, Chan Hum Park, Takako Yokozawa, Byung-Sun Min, Hyun Ah Jung, Jae Sue Cho. Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors. Archives of pharmacal research. vol 39. issue 6. 2017-02-07. PMID:27106028. |
we evaluated the major active components isolated from corni fructus: loganin, morroniside, and 7-o-galloyl-d-sedoheptulose as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche), and β-site amyloid precursor protein (app) cleaving enzyme 1 (bace1) for use in alzheimer's disease treatment. |
2017-02-07 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
the amyloid precursor protein (app) and acetylcholinesterase (ache) are multi-faceted proteins with a wide range of vital functions, both crucially linked with the pathogenesis of alzheimer's disease (ad). |
2017-01-30 |
2023-08-13 |
Not clear |