| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cho Rong Kim, Soo Jung Choi, Yoon Kyung Kwon, Jae Kyeom Kim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shi. Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice. Biological & pharmaceutical bulletin. vol 39. issue 7. 2017-01-27. PMID:27374288. |
the pathogenesis of alzheimer's disease (ad) has been linked to the deficiency of neurotransmitter acetylcholine (ach) in the brain, and the main treatment strategy for improving ad symptoms is the inhibition of acetylcholinesterase (ache) activity. |
2017-01-27 |
2023-08-13 |
mouse |
| Rabya Munawar, Nousheen Mushtaq, Sadia Arif, Ahsaan Ahmed, Shamim Akhtar, Sumaira Ansari, Sadia Meer, Zafar S Saify, Muhammad Ari. Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents. American journal of Alzheimer's disease and other dementias. vol 31. issue 3. 2017-01-17. PMID:26385945. |
compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in alzheimer's disease. |
2017-01-17 |
2023-08-13 |
Not clear |
| Katsuyoshi Mizukami, Hiroyasu Akatsu, Eric E Abrahamson, Zhiping Mi, Milos D Ikonomovi. Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26293308. |
studies of acetylcholine degrading enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) in alzheimer's disease (ad) have suggested their potential role in the development of fibrillar amyloid-β (aβ) plaques (amyloid plaques). |
2017-01-09 |
2023-08-13 |
Not clear |
| Mina Saeedi, Maedeh Golipoor, Mohammad Mahdavi, Alireza Moradi, Hamid Nadri, Saeed Emami, Alireza Foroumadi, Abbas Shafie. Phthalimide-Derived N-Benzylpyridinium Halides Targeting Cholinesterases: Synthesis and Bioactivity of New Potential Anti-Alzheimer's Disease Agents. Archiv der Pharmazie. vol 349. issue 4. 2017-01-09. PMID:26898241. |
in order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of alzheimer's disease, we designed and synthesized phthalimide-based acetylcholinesterase (ache) inhibitors (7) containing a substituted n-benzylpyridinium residue. |
2017-01-09 |
2023-08-13 |
Not clear |
| Alberto Castagna, Antonino Maria Cotroneo, Giovanni Ruotolo, Pietro Garer. The CITIRIVAD Study: CITIcoline plus RIVAstigmine in Elderly Patients Affected with Dementia Study. Clinical drug investigation. vol 36. issue 12. 2017-01-02. PMID:27587069. |
acetylcholinesterase inhibitors (acheis), such as rivastigmine, coadministered with cholinergic precursors, such as citicoline, could be effective in alzheimer's disease (ad) and in mixed dementia (md), because they are able to increase the intrasynaptic levels of acetylcholine more than the single drugs given alone. |
2017-01-02 |
2023-08-13 |
Not clear |
| Hana Florian, Andreas Meier, Serge Gauthier, Stanley Lipschitz, Yunzhi Lin, Qi Tang, Ahmed A Othman, Weining Z Robieson, Laura M Gaul. Efficacy and Safety of ABT-126 in Subjects with Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Study. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26967214. |
efficacy and safety of abt-126 in subjects with mild-to-moderate alzheimer's disease on stable doses of acetylcholinesterase inhibitors: a randomized, double-blind, placebo-controlled study. |
2016-12-29 |
2023-08-13 |
human |
| Alok Sharma, Marc Bemis, Alicia R Desilet. Role of Medium Chain Triglycerides (Axona®) in the Treatment of Mild to Moderate Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 29. issue 5. 2016-12-13. PMID:24413538. |
treatment of alzheimer's disease (ad) with acetylcholinesterase inhibitors or n-methyl-d-aspartate (nmda) receptor antagonists provides symptomatic relief but do not prevent its progression. |
2016-12-13 |
2023-08-12 |
Not clear |
| Mahboobeh Eslami, Seyed Majid Hashemianzadeh, Kowsar Bagherzadeh, Seyed Abolfazl Seyed Sajad. Molecular perception of interactions between bis(7)tacrine and cystamine-tacrine dimer with cholinesterases as the promising proposed agents for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 34. issue 4. 2016-12-13. PMID:26043757. |
as a matter of fact, design of compounds that can inhibit cholinesterases activities (acetylcholinesterase and butylcholinesterase) has been introduced as an efficient method to treat alzheimer's. |
2016-12-13 |
2023-08-13 |
Not clear |
| Dongmei Wang, Hanyong Jin, Junling Wang, Shanshan Guan, Zuoming Zhang, Weiwei Ha. Exploration of the chlorpyrifos escape pathway from acylpeptide hydrolases using steered molecular dynamics simulations. Journal of biomolecular structure & dynamics. vol 34. issue 4. 2016-12-13. PMID:26155973. |
aph is significantly more sensitive than acetylcholinesterase, a target of alzheimer's disease, to inhibition by organophosphorus (op) compounds. |
2016-12-13 |
2023-08-13 |
Not clear |
| Shahid A Khan, Sher B Khan, Zarbad Shah, Abdullah M Asir. Withanolides: Biologically Active Constituents in the Treatment of Alzheimer's Disease. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 12. issue 3. 2016-12-13. PMID:26527154. |
withanolides are affective plant secondary metabolites which inhibit acetylcholinesterase and butyrylcholinesterase enzyme and thus possibly will be the future drug for alzheimer's disease. |
2016-12-13 |
2023-08-13 |
Not clear |
| Denise D Correa, Maria Kryza-Lacombe, Raymond E Baser, Kathryn Beal, Lisa M DeAngeli. Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study. Journal of neuro-oncology. vol 127. issue 2. 2016-12-13. PMID:26738844. |
the goal of this pilot study was to examine the efficacy of donepezil, an acetylcholinesterase inhibitor used to treat alzheimer's disease, in improving cognitive functions in brain tumor patients previously treated with rt + chemotherapy or chemotherapy alone. |
2016-12-13 |
2023-08-13 |
Not clear |
| Janusch Blautzik, Daniel Keeser, Marco Paolini, Valerie Kirsch, Albert Berman, Ute Coates, Maximilian Reiser, Stefan J Teipel, Thomas Meind. Functional connectivity increase in the default-mode network of patients with Alzheimer's disease after long-term treatment with Galantamine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26796681. |
acetylcholinesterase inhibitors (acheis) are efficacious for the treatment of mild to moderate forms of alzheimer's dementia (ad). |
2016-12-13 |
2023-08-13 |
human |
| Abdul Hameed, Syeda Tazeen Zehra, Saba Abbas, Riffat Un Nisa, Tariq Mahmood, Khurshid Ayub, Mariya Al-Rashida, Jürgen Bajorath, Khalid Mohammed Khan, Jamshed Iqba. One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies. Bioorganic chemistry. vol 65. 2016-12-13. PMID:26851737. |
moreover, the synthesized compounds were screened for cholinesterases (acetylcholinesterase and butyrylcholinesterase) inhibition which are consider to be major malefactors of alzheimer's disease (ad) to find lead compounds for further research in ad therapy. |
2016-12-13 |
2023-08-13 |
Not clear |
| Houssem Boulebd, Lhassane Ismaili, Manuela Bartolini, Abdelmalek Bouraiou, Vincenza Andrisano, Helene Martin, Alexandre Bonet, Ignacio Moraleda, Isabel Iriepa, Mourad Chioua, Ali Belfaitah, José Marco-Contelle. Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). vol 21. issue 4. 2016-12-13. PMID:27023499. |
imidazopyranotacrines as non-hepatotoxic, selective acetylcholinesterase inhibitors, and antioxidant agents for alzheimer's disease therapy. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ya Wang, Zheng Lai, Xi-Xi Li, Ri-Ming Yan, Zhi-Bin Zhang, Hui-Lin Yang, Du Zh. Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China. World journal of microbiology & biotechnology. vol 32. issue 2. 2016-11-03. PMID:26745980. |
our findings highlight that h. serrata grown in jinggang mountain harbors a rich and fascinating endophytic fungus community with potential ache inhibitory activity, which could further broaden the natural acetylcholinesterase inhibitors resources used for alzheimer's disease treatment. |
2016-11-03 |
2023-08-13 |
Not clear |
| Zeng Li, Chaoyu Mu, Bin Wang, Juan Ji. Graveoline Analogs Exhibiting Selective Acetylcholinesterase Inhibitory Activity as Potential Lead Compounds for the Treatment of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 21. issue 2. 2016-10-19. PMID:26805806. |
graveoline analogs exhibiting selective acetylcholinesterase inhibitory activity as potential lead compounds for the treatment of alzheimer's disease. |
2016-10-19 |
2023-08-13 |
Not clear |
| Cristiane Bezerra da Silva, Arnildo Pott, Selene Elifio-Esposito, Luciane Dalarmi, Kátia Fialho do Nascimento, Ligia Moura Burci, Maislian de Oliveira, Josiane de Fátima Gaspari Dias, Sandra Maria Warumby Zanin, Obdulio Gomes Miguel, Marilis Dallarmi Migue. Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina. Molecules (Basel, Switzerland). vol 21. issue 1. 2016-10-11. PMID:26760993. |
trials were performed with four drugs commercialized in brazil: donepezil, tacrine, galantamine and rivastigmine, utilized in the control of alzheimer's disease, to inhibit the activity of acetylcholinesterase. |
2016-10-11 |
2023-08-13 |
Not clear |
| Manuela E García, José L Borioni, Valeria Cavallaro, Marcelo Puiatti, Adriana B Pierini, Ana P Murray, Alicia B Peñéñor. Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies. Steroids. vol 104. 2016-10-05. PMID:26362598. |
in this context, acetylcholinesterase (ache) inhibitors comprise one type of the compounds most actively studied in the search for an effective treatment of symptoms of alzheimer's disease. |
2016-10-05 |
2023-08-13 |
Not clear |
| Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun, Kamil Kuc. 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment. Molecules (Basel, Switzerland). vol 20. issue 12. 2016-10-05. PMID:26690394. |
7-methoxytacrine-p-anisidine hybrids as novel dual binding site acetylcholinesterase inhibitors for alzheimer's disease treatment. |
2016-10-05 |
2023-08-13 |
Not clear |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of ache can have therapeutic applications (e.g., drugs for alzheimer's disease) or neurotoxic consequences (e.g., pesticides). |
2016-09-12 |
2023-08-13 |
human |