| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| I V Zueva, V E Semenov, M A Mukhamedyarov, S V Lushchekina, A D Kharlamova, E O Petukhova, A S Mikhailov, S N Podyachev, L F Saifina, K A Petrov, O A Minnekhanova, V V Zobov, E E Nikolsky, P Masson, V S Rezni. 6-Methyluracil derivatives as acetylcholinesterase inhibitors for treatment of Alzheimer's disease. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639718. |
6-methyluracil derivatives as acetylcholinesterase inhibitors for treatment of alzheimer's disease. |
2016-03-15 |
2023-08-13 |
mouse |
| K Petro. Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639720. |
acetylcholinesterase (ache) inhibitors are widely used in medicine for pharmacological correction of cholinergic neurotransmission pathologies such as myasthenia gravis (mg) and alzheimer's disease [1, 2]. |
2016-03-15 |
2023-08-13 |
Not clear |
| Jacqueline B Palmer, Jennifer S Albrecht, Yujin Park, Sarah Dutcher, Gail B Rattinger, Linda Simoni-Wastila, Loreen D Walker, Ilene H Zuckerma. Use of drugs with anticholinergic properties among nursing home residents with dementia: a national analysis of Medicare beneficiaries from 2007 to 2008. Drugs & aging. vol 32. issue 1. 2016-03-11. PMID:25491558. |
many individuals with dementia also receive acetylcholinesterase inhibitors (acheis), indicated for mild to moderate alzheimer's disease. |
2016-03-11 |
2023-08-13 |
Not clear |
| Pierre Bohn, Fabienne Gourand, Cyril Papamicaël, Méziane Ibazizène, Martine Dhilly, Vincent Gembus, Florent Alix, Mihaela-Liliana Ţînţaş, Francis Marsais, Louisa Barré, Vincent Levache. Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25695305. |
with the aim of improving the efficiency of marketed acetylcholinesterase (ache) inhibitors in the symptomatic treatment of alzheimer's disease, plagued by adverse effects arising from peripheral cholinergic activation, this work reports a biological evaluation of new central ache inhibitors based on an original "bio-oxidizable" prodrug strategy. |
2016-03-07 |
2023-08-13 |
mouse |
| Amir R Afshari, Hamid R Sadeghnia, Hamid Mollazade. A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease. Advances in pharmacological sciences. vol 2016. 2016-03-04. PMID:26941792. |
the current management of alzheimer's disease (ad) focuses on acetylcholinesterase inhibitors (acheis) and nmda receptor antagonists, although outcomes are not completely favorable. |
2016-03-04 |
2023-08-13 |
Not clear |
| Songwei Duan, Xiaoyin Guan, Runxuan Lin, Xincheng Liu, Ying Yan, Ruibang Lin, Tianqi Zhang, Xueman Chen, Jiaqi Huang, Xicui Sun, Qingqing Li, Shaoliang Fang, Jun Xu, Zhibin Yao, Huaiyu G. Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease. Neurobiology of aging. vol 36. issue 5. 2016-02-29. PMID:25771396. |
silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of alzheimer's disease. |
2016-02-29 |
2023-08-13 |
mouse |
| Jaspreet Kaur Dhanjal, Sudhanshu Sharma, Abhinav Grover, Asmita Da. Use of ligand-based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating Alzheimer's. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 71. 2016-02-10. PMID:25960230. |
use of ligand-based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating alzheimer's. |
2016-02-10 |
2023-08-13 |
Not clear |
| Jaspreet Kaur Dhanjal, Sudhanshu Sharma, Abhinav Grover, Asmita Da. Use of ligand-based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating Alzheimer's. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 71. 2016-02-10. PMID:25960230. |
the fda approved drugs for alzheimer's belong to the category of acetylcholinesterase inhibitors. |
2016-02-10 |
2023-08-13 |
Not clear |
| Lütfiye Ömür Demirezer, Perihan Gürbüz, Emine Pelin Kelicen Uğur, Mine Bodur, Nadire Özenver, Ayse Uz, Zühal Güvenal. Molecular docking and ex vivo and in vitro anticholinesterase activity studies of Salvia sp. and highlighted rosmarinic acid. Turkish journal of medical sciences. vol 45. issue 5. 2016-02-09. PMID:26738360. |
to evaluate acetylcholinesterase (ache) inhibitory activity and antioxidant capacity of the major molecule from salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of alzheimer disease (ad). |
2016-02-09 |
2023-08-13 |
Not clear |
| Anne Leinonen, Marjaana Koponen, Sirpa Hartikaine. Systematic Review: Representativeness of Participants in RCTs of Acetylcholinesterase Inhibitors. PloS one. vol 10. issue 5. 2016-01-26. PMID:25933023. |
to determine whether there are differences in age and sex distribution and presence of comorbidities between participants included in randomized controlled trials of acetylcholinesterase inhibitors and nationwide cohort of persons with alzheimer's disease. |
2016-01-26 |
2023-08-13 |
human |
| Philip M Bath, Joanna M Wardla. Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions. International journal of stroke : official journal of the International Stroke Society. vol 10. issue 4. 2016-01-25. PMID:25727737. |
whether acetylcholinesterase inhibitors, which delay the progression of alzheimer's dementia, are relevant in small vessel disease remains unclear. |
2016-01-25 |
2023-08-13 |
Not clear |
| Vanita Puri, Xiaohai Wang, Joshua D Vardigan, Scott D Kuduk, Jason M Uslane. The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model. Behavioural brain research. vol 287. 2016-01-19. PMID:25800972. |
the effects of pqca were compared to the acetylcholinesterase inhibitor donepezil, the standard of care for alzheimer's disease. |
2016-01-19 |
2023-08-13 |
mouse |
| Elvis A F Martis, Rakesh C Chandarana, Mushtaque S Shaikh, Premlata K Ambre, Jacinta S D'Souza, Krishna R Iyer, Evans C Coutinho, Santosh R Nandan, Raghuvir R S Pissurlenka. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 33. issue 5. 2016-01-15. PMID:24905476. |
quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
| Elvis A F Martis, Rakesh C Chandarana, Mushtaque S Shaikh, Premlata K Ambre, Jacinta S D'Souza, Krishna R Iyer, Evans C Coutinho, Santosh R Nandan, Raghuvir R S Pissurlenka. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 33. issue 5. 2016-01-15. PMID:24905476. |
there is a need for continued development of acetylcholinesterase (ache) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
| H Yoon, W Myung, S-W Lim, H S Kang, S Kim, H-H Won, B J Carroll, D K Ki. Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacopsychiatry. vol 48. issue 3. 2016-01-08. PMID:25730470. |
association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in alzheimer's disease. |
2016-01-08 |
2023-08-13 |
Not clear |
| H Yoon, W Myung, S-W Lim, H S Kang, S Kim, H-H Won, B J Carroll, D K Ki. Association of the choline acetyltransferase gene with responsiveness to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacopsychiatry. vol 48. issue 3. 2016-01-08. PMID:25730470. |
the response to acetylcholinesterase inhibitors (acheis) of alzheimer's disease (ad) patients varies depending on the genetic characteristics of the patient. |
2016-01-08 |
2023-08-13 |
Not clear |
| Maleeha Waqar, Sidra Batoo. In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer's disease. Journal of theoretical biology. vol 372. 2015-12-31. PMID:25747777. |
in silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of alzheimer's disease. |
2015-12-31 |
2023-08-13 |
Not clear |
| Gayan Perera, Mizanur Khondoker, Matthew Broadbent, Gerome Breen, Robert Stewar. Factors associated with response to acetylcholinesterase inhibition in dementia: a cohort study from a secondary mental health care case register in london. PloS one. vol 9. issue 11. 2015-12-24. PMID:25411838. |
acetylcholinesterase inhibitors (acheis) are widely used to delay cognitive decline in alzheimer's disease. |
2015-12-24 |
2023-08-13 |
Not clear |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
possibility of acetylcholinesterase overexpression in alzheimer disease patients after therapy with acetylcholinesterase inhibitors. |
2015-12-09 |
2023-08-13 |
Not clear |