| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Shimada, S Hirano, H Sinotoh, T Ota, N Tanaka, K Sato, M Yamada, K Fukushi, T Irie, M R Zhang, M Higuchi, S Kuwabara, T Suhar. Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-a [11C]MP4A PET study. International journal of geriatric psychiatry. vol 30. issue 11. 2016-07-01. PMID:26280153. |
to investigate the diagnostic performance of brain acetylcholinesterase (ache) activity measurement using n-[(11) c]-methyl-4-piperidyl acetate (mp4a) and pet in patients with dementia with lewy bodies (dlb) and alzheimer's disease (ad). |
2016-07-01 |
2023-08-13 |
Not clear |
| Jeffrey F Waring, Qi Tang, Weining Z Robieson, David P King, Ujjwal Das, Jordan Dubow, Sandeep Dutta, Gerard J Marek, Laura M Gaul. APOE-ɛ4 Carrier Status and Donepezil Response in Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 47. issue 1. 2016-06-28. PMID:26402762. |
previous studies have investigated associations between apolipoprotein e (apoe)-ɛ4 allele status and acetylcholinesterase inhibitor treatment response in patients with alzheimer's disease. |
2016-06-28 |
2023-08-13 |
Not clear |
| Hammad Saleem, Irshad Ahmad, Muhammad Nabeel Shahid, Muhammad Shoaib Ali Gill, Muhammad Faisal Nadeem, Waqas Mahmood, Imran Rashi. IN VITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY POTENTIALS OF JATROPHA GOSSYPIFOLIA PLANT EXTRACTS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180434. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of alzheimer's disease (ad). |
2016-06-20 |
2023-08-13 |
Not clear |
| Ian R Macdonald, G Andrew Reid, Ian R Pottie, Earl Martin, Sultan Darves. Synthesis and Preliminary Evaluation of Phenyl 4-123I-Iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer Disease Pathology. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 2. 2016-06-14. PMID:26541777. |
acetylcholinesterase and butyrylcholinesterase accumulate with brain β-amyloid (aβ) plaques in alzheimer disease (ad). |
2016-06-14 |
2023-08-13 |
Not clear |
| Ashwani Kumar, Sandeep Jain, Milind Parle, Neelam Jain, Parvin Kuma. 3-Aryl-1-phenyl-1H-pyrazole derivatives as new multitarget directed ligands for the treatment of Alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties. EXCLI journal. vol 12. 2016-06-14. PMID:27298613. |
3-aryl-1-phenyl-1h-pyrazole derivatives as new multitarget directed ligands for the treatment of alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties. |
2016-06-14 |
2023-08-13 |
mouse |
| Giuseppe Pasqualetti, Sara Tognini, Valeria Calsolaro, Antonio Polini, Fabio Monzan. Potential drug-drug interactions in Alzheimer patients with behavioral symptoms. Clinical interventions in aging. vol 10. 2016-06-09. PMID:26392756. |
cognitive enhancers, including acetylcholinesterase inhibitors and memantine, are the most widely prescribed agents for alzheimer's disease (ad) patients. |
2016-06-09 |
2023-08-13 |
Not clear |
| Piotr Draczkowski, Anna Tomaszuk, Pawel Halczuk, Maciej Strzemski, Dariusz Matosiuk, Krzysztof Jozwia. Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry. Biochimica et biophysica acta. vol 1860. issue 5. 2016-06-09. PMID:26586471. |
acetylcholinesterase (ache), an enzyme rapidly terminating nerve signals at synapses of cholinergic neurons is an important drug target in treatment of alzheimer's disease and related memory loss conditions. |
2016-06-09 |
2023-08-13 |
Not clear |
| Fei Mao, Jianheng Li, Hui Wei, Ling Huang, Xingshu L. Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. vol 30. issue 6. 2016-06-07. PMID:25792506. |
tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of alzheimer's disease. |
2016-06-07 |
2023-08-13 |
Not clear |
| Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva, Nikola Yordanov, Irini Doytchinov. Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-05-26. PMID:26260334. |
the inhibitors of acetylcholinesterase are the main therapy against alzheimer's disease. |
2016-05-26 |
2023-08-13 |
human |
| Christopher D Ruark, Richard R Chapleau, Deirdre A Mahle, Jeffery M Gearhar. Organophosphorus Inhibition and Characterization of Recombinant Guinea Pig Acetylcholinesterase. Protein and peptide letters. vol 22. issue 10. 2016-05-23. PMID:26216268. |
organophosphorus (op) pesticides and nerve agents have been designed to inhibit the hydrolysis of the neurotransmitter acetylcholine by covalently binding to the active site serine of acetylcholinesterase while alzheimer drugs and prophylactics, such as tacrine, are characterized by reversible binding. |
2016-05-23 |
2023-08-13 |
human |
| Yao Chen, Zong-liang Liu, Ting-ming Fu, Wei Li, Xiao-li Xu, Hao-peng Su. Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening. Bioorganic & medicinal chemistry letters. vol 25. issue 17. 2016-05-18. PMID:26212777. |
targeting acetylcholinesterase (ache) using small molecule inhibitors is considered to be the most successful therapeutic strategy in the treatment of alzheimer's disease (ad). |
2016-05-18 |
2023-08-13 |
Not clear |
| Vyacheslav E Semenov, Irina V Zueva, Marat A Mukhamedyarov, Sofya V Lushchekina, Alexandra D Kharlamova, Elena O Petukhova, Anatoly S Mikhailov, Sergey N Podyachev, Lilya F Saifina, Konstantin A Petrov, Oksana A Minnekhanova, Vladimir V Zobov, Evgeny E Nikolsky, Patrick Masson, Vladimir S Rezni. 6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ChemMedChem. vol 10. issue 11. 2016-05-10. PMID:26412714. |
6-methyluracil derivatives as bifunctional acetylcholinesterase inhibitors for the treatment of alzheimer's disease. |
2016-05-10 |
2023-08-13 |
human |
| Fazal Rahim, Muhammad Tariq Javed, Hayat Ullah, Abdul Wadood, Muhammad Taha, Muhammad Ashraf, Qurat-ul-Ain, Muhammad Anas Khan, Fahad Khan, Salma Mirza, Khalid M Kha. Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease. Bioorganic chemistry. vol 62. 2016-05-09. PMID:26318401. |
synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for alzheimer disease. |
2016-05-09 |
2023-08-13 |
Not clear |
| Jerald J Nair, Johannes van Stade. Pharmacological and toxicological insights to the South African Amaryllidaceae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2016-05-06. PMID:23994658. |
the medicinal potential of the family has been realized through the commercialization of galanthamine as an alzheimer's drug due to its potent and selective inhibitory activity against the enzyme acetylcholinesterase. |
2016-05-06 |
2023-08-12 |
Not clear |
| Abdulilah Ece, Boris Peji. A computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone. Journal of enzyme inhibition and medicinal chemistry. vol 30. issue 4. 2016-04-25. PMID:25198888. |
acetylcholinesterase (ache) inhibitors are yet the best drugs currently available for the management of alzheimer's disease. |
2016-04-25 |
2023-08-13 |
Not clear |
| b' Jan Bure\\xc5\\xa1, Daniel Jun, Martina Hrabinov\\xc3\\xa1, Ilja Tachec\\xc3\\xad, Jaroslav Kv\\xc4\\x9btina, Michal Pavl\\xc3\\xadk, Stanislav Rejchrt, Tom\\xc3\\xa1\\xc5\\xa1 Douda, Martin Kune\\xc5\\xa1, Kamil Ku\\xc4\\x8da, Marcela Kop\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa. Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs. Neuro endocrinology letters. vol 36 Suppl 1. 2016-04-21. PMID:26757120.' |
tacrine was the first acetylcholinesterase inhibitor approved for therapy of alzheimer's disease. |
2016-04-21 |
2023-08-13 |
Not clear |
| Adrian Imbernón-Moya, Sebastian Podlipnik, Fernando Burgos, Elena Vargas-Laguna, Antonio Aguilar-Martínez, Eva Fernández-Cogolludo, Miguel Angel Gallego-Valde. Acquired Localized Hypertrichosis Induced by Rivastigmine. Case reports in dermatological medicine. vol 2016. 2016-04-13. PMID:27073702. |
rivastigmine is a reversible and competitive inhibitor of acetylcholinesterase and butyrylcholinesterase used for symptomatic treatment of alzheimer dementia and parkinson's disease. |
2016-04-13 |
2023-08-13 |
Not clear |
| Ping-Huang Tsai, Shih-Chieh Chang, Fang-Chun Liu, Jenho Tsao, Yung-Hung Wang, Men-Tzung L. A Novel Application of Multiscale Entropy in Electroencephalography to Predict the Efficacy of Acetylcholinesterase Inhibitor in Alzheimer's Disease. Computational and mathematical methods in medicine. vol 2015. 2016-04-06. PMID:26120358. |
a novel application of multiscale entropy in electroencephalography to predict the efficacy of acetylcholinesterase inhibitor in alzheimer's disease. |
2016-04-06 |
2023-08-13 |
Not clear |
| Andrew H Ford, Osvaldo P Almeid. Pharmacological interventions for preventing delirium in the elderly. Maturitas. vol 81. issue 2. 2016-04-04. PMID:25890587. |
acetylcholinesterase inhibitors are effective in the symptomatic treatment of alzheimer's disease but do not appear to be effective in preventing delirium. |
2016-04-04 |
2023-08-13 |
Not clear |
| Oana Cioanca, Monica Hancianu, Marius Mihasan, Lucian Hritc. Anti-acetylcholinesterase and Antioxidant Activities of Inhaled Juniper Oil on Amyloid Beta (1-42)-Induced Oxidative Stress in the Rat Hippocampus. Neurochemical research. vol 40. issue 5. 2016-04-01. PMID:25743585. |
these findings suggest that the juniper volatile oil may be a potential candidate for the development of therapeutic agents to manage oxidative stress associated with alzheimer's disease through decreasing the activity of acetylcholinesterase and anti-oxidative mechanism. |
2016-04-01 |
2023-08-13 |
rat |