| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathogenesis of alzheimer disease. |
2015-12-09 |
2023-08-13 |
Not clear |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
the mostly used therapy of alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. |
2015-12-09 |
2023-08-13 |
Not clear |
| Eric H Hill, Yue Zhang, Deborah G Evans, David G Whitte. Enzyme-specific sensors via aggregation of charged p-phenylene ethynylenes. ACS applied materials & interfaces. vol 7. issue 9. 2015-12-01. PMID:25697234. |
phospholipase a2 is a biomarker for heart and circulatory disease, and acetylcholinesterase is a biomarker for alzheimer's, and indicative of exposure to certain pesticides and nerve agents. |
2015-12-01 |
2023-08-13 |
Not clear |
| Joshua D Vardigan, Christopher E Cannon, Vanita Puri, Mandy Dancho, AmyJo Koser, Marion Wittmann, Scott D Kuduk, John J Renger, Jason M Uslane. Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey. Psychopharmacology. vol 232. issue 11. 2015-11-30. PMID:25491927. |
the standards of care for alzheimer's disease, acetylcholinesterase inhibitors such as donepezil (aricept®), are dose-limited due to adverse side-effects. |
2015-11-30 |
2023-08-13 |
monkey |
| Yun Ju Chae, Hong Joon Lee, Ji Hyun Jeon, In-Beom Kim, Jin-Sung Choi, Ki-Wug Sung, Sang June Hah. Effects of donepezil on hERG potassium channels. Brain research. vol 1597. 2015-11-24. PMID:25498859. |
donepezil is a potent, selective inhibitor of acetylcholinesterase, which is used for the treatment of alzheimer's disease. |
2015-11-24 |
2023-08-13 |
human |
| Adam M Takos, Fred Roo. Towards a molecular understanding of the biosynthesis of amaryllidaceae alkaloids in support of their expanding medical use. International journal of molecular sciences. vol 14. issue 6. 2015-10-19. PMID:23727937. |
presently, only the amaryllidaceae alkaloid galanthamine, an acetylcholinesterase inhibitor used to treat symptoms of alzheimer's disease, is produced commercially as a drug from cultivated plants. |
2015-10-19 |
2023-08-12 |
Not clear |
| Robert Alan Mans, Brian A Warmus, Caroline C Smith, Lori L McMaho. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. Journal of neurophysiology. vol 112. issue 10. 2015-10-19. PMID:25143547. |
acetylcholinesterase (ache) inhibitors are commonly prescribed to enhance cholinergic signaling in alzheimer's disease in hopes of rescuing cognitive function, caused, in part, by degeneration of cholinergic innervation to the hippocampus and cortex. |
2015-10-19 |
2023-08-13 |
rat |
| Christina E Turi, Katarina E Axwik, Anderson Smith, A Maxwell P Jones, Praveen K Saxena, Susan J Murc. Galanthamine, an anti-cholinesterase drug, effects plant growth and development in Artemisia tridentata Nutt. via modulation of auxin and neurotransmitter signaling. Plant signaling & behavior. vol 9. issue 4. 2015-10-19. PMID:25764435. |
galanthamine is a naturally occurring acetylcholinesterase (ache) inhibitor that has been well established as a drug for treatment of mild to moderate alzheimer disease, but the role of the compound in plant metabolism is not known. |
2015-10-19 |
2023-08-13 |
Not clear |
| Nisha K Ramakrishnan, Anniek K D Visser, Marianne Schepers, Gert Luurtsema, Csaba J Nyakas, Philip H Elsinga, Kiichi Ishiwata, Rudi A J O Dierckx, Aren van Waard. Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with (11)C-SA4503 and microPET. Psychopharmacology. vol 231. issue 20. 2015-10-12. PMID:24639047. |
donepezil, an acetylcholinesterase inhibitor used for the symptomatic treatment of alzheimer's disease, is also a high-affinity sigma-1 agonist. |
2015-10-12 |
2023-08-12 |
rat |
| Natalie Cortes, Rafael Alvarez, Edison H Osorio, Fernando Alzate, Strahil Berkov, Edison Osori. Alkaloid metabolite profiles by GC/MS and acetylcholinesterase inhibitory activities with binding-mode predictions of five Amaryllidaceae plants. Journal of pharmaceutical and biomedical analysis. vol 102. 2015-09-25. PMID:25305596. |
acetylcholinesterase (ache) enzymatic inhibition is an important target for the management of alzheimer disease (ad) and ache inhibitors are the mainstay drugs for its treatment. |
2015-09-25 |
2023-08-13 |
Not clear |
| Richard L Bowen, George Perry, Chengjie Xiong, Mark A Smith, Craig S Atwoo. A clinical study of lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks. Journal of Alzheimer's disease : JAD. vol 44. issue 2. 2015-09-21. PMID:25310993. |
a clinical study of lupron depot in the treatment of women with alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks. |
2015-09-21 |
2023-08-13 |
human |
| Byoung Wook Choi, Hye Sook Lee, Hyeon-Cheol Shin, Bong Ho Le. Multifunctional activity of polyphenolic compounds associated with a potential for Alzheimer's disease therapy from Ecklonia cava. Phytotherapy research : PTR. vol 29. issue 4. 2015-09-08. PMID:25640212. |
for butyrylcholinesterase, a new target for the treatment of alzheimer's disease, phlorofucofuroeckol-a (pff-a), showed a particularly potent inhibitory activity (ic50 0.95 μm), which is over 100-fold greater than for acetylcholinesterase. |
2015-09-08 |
2023-08-13 |
Not clear |
| William James Deardorff, Ahmad Shobassy, George T Grossber. Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication. Expert review of neurotherapeutics. vol 15. issue 1. 2015-09-02. PMID:25495510. |
safety and clinical effects of evp-6124 in subjects with alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication. |
2015-09-02 |
2023-08-13 |
human |
| Shuai Qian, Lisi He, Marvin Mak, Yifan Han, Chun-Yu Ho, Zhong Zu. Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors. International journal of pharmaceutics. vol 477. issue 1-2. 2015-08-24. PMID:25445524. |
tacrine (tha), as the first approved acetylcholinesterase (ache) inhibitors for the treatment of alzheimer's disease (ad), has been extensively investigated in last seven decades. |
2015-08-24 |
2023-08-13 |
Not clear |
| Kyoung Ja Kwon, Min Kyeong Kim, Eun Joo Lee, Jung Nam Kim, Bo-Ryoung Choi, Soo Young Kim, Kyu Suk Cho, Jung-Soo Han, Hahn Young Kim, Chan Young Shin, Seol-Heui Ha. Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia. Journal of the neurological sciences. vol 347. issue 1-2. 2015-08-06. PMID:25266713. |
donepezil hydrochloride is an acetylcholinesterase inhibitor (achei) currently used for the symptomatic treatment of alzheimer's disease (ad). |
2015-08-06 |
2023-08-13 |
rat |
| Armando Méndez-Garrido, Maricarmen Hernández-Rodríguez, Rafael Zamorano-Ulloa, José Correa-Basurto, Jessica Elena Mendieta-Wejebe, Daniel Ramírez-Rosales, Martha Cecilia Rosales-Hernánde. In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25096900. |
it is well known that the principal biomolecules involved in alzheimer's disease (ad) are acetylcholinesterase (ache), acetylcholine (ach) and the amyloid beta peptide of 42 amino acid residues (aβ42). |
2015-07-29 |
2023-08-13 |
Not clear |
| N Iu Bachyns'ka, I F Rozheliuk, V O Kholyn, I M Pishel', Iu I Leono. [ApoE gene polymorphism as a predictor of therapeutic response to treatment acetylcholinesterase inhibitor for elderly patients with Alzheimer's and vascular dementia types]. Wiadomosci lekarskie (Warsaw, Poland : 1960). vol 67. issue 2 Pt 2. 2015-07-22. PMID:25796815. |
[apoe gene polymorphism as a predictor of therapeutic response to treatment acetylcholinesterase inhibitor for elderly patients with alzheimer's and vascular dementia types]. |
2015-07-22 |
2023-08-13 |
Not clear |
| Gohar Mushtaq, Nigel H Greig, Jalaluddin A Khan, Mohammad A Kama. Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus. CNS & neurological disorders drug targets. vol 13. issue 8. 2015-07-02. PMID:25345511. |
status of acetylcholinesterase and butyrylcholinesterase in alzheimer's disease and type 2 diabetes mellitus. |
2015-07-02 |
2023-08-13 |
Not clear |
| Gohar Mushtaq, Nigel H Greig, Jalaluddin A Khan, Mohammad A Kama. Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus. CNS & neurological disorders drug targets. vol 13. issue 8. 2015-07-02. PMID:25345511. |
both alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm) share the presence of systemic and neuro-inflammation, enhanced production and accumulation of β -amyloid peptide and abnormal levels of the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2015-07-02 |
2023-08-13 |
Not clear |
| Christophe Rochais, Cédric Lecoutey, Florence Gaven, Patrizia Giannoni, Katia Hamidouche, Damien Hedou, Emmanuelle Dubost, David Genest, Samir Yahiaoui, Thomas Freret, Valentine Bouet, François Dauphin, Jana Sopkova de Oliveira Santos, Céline Ballandonne, Sophie Corvaisier, Aurélie Malzert-Fréon, Remi Legay, Michel Boulouard, Sylvie Claeysen, Patrick Dallemagn. Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride. Journal of medicinal chemistry. vol 58. issue 7. 2015-06-30. PMID:25793650. |
novel multitarget-directed ligands (mtdls) with acetylcholinesterase (ache) inhibitory and serotonergic subtype 4 receptor (5-ht4r) agonist activities as potential agents against alzheimer's disease: the design of donecopride. |
2015-06-30 |
2023-08-13 |
mouse |