| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filip Zemek, Lucie Drtinova, Eugenie Nepovimova, Vendula Sepsova, Jan Korabecny, Jiri Klimes, Kamil Kuc. Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine. Expert opinion on drug safety. vol 13. issue 6. 2015-01-02. PMID:24845946. |
outcomes of alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine. |
2015-01-02 |
2023-08-13 |
Not clear |
| Mario Esquivias-Pérez, Emna Maalej, Alejandro Romero, Fakher Chabchoub, Abdelouahid Samadi, José Marco-Contelles, María Jesús Oset-Gasqu. Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease. Chemical research in toxicology. vol 26. issue 6. 2014-12-28. PMID:23676090. |
the synthesis, toxicity, neuroprotection, and human acetylcholinesterase (hache)/ human butyrylcholinesterase (hbuche) inhibition properties of β-naphthotacrines1-14 as new drugs for alzheimer's disease (ad) potential treatment, are reported. |
2014-12-28 |
2023-08-12 |
human |
| Aamer Saeed, Parvez Ali Mahesar, Sumera Zaib, Muhammad Siraj Khan, Abdul Matin, Mohammad Shahid, Jamshed Iqba. Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases. European journal of medicinal chemistry. vol 78. 2014-12-24. PMID:24675179. |
controlled inhibition of brain acetylcholinesterase (ache) and butyrylcholinesterase (bche) may slow neurodegeneration in alzheimer's diseases (ad). |
2014-12-24 |
2023-08-12 |
Not clear |
| Marc Pudlo, Vincent Luzet, Lhassane Ismaïli, Isabelle Tomassoli, Anne Iutzeler, Bernard Refouvele. Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease. Bioorganic & medicinal chemistry. vol 22. issue 8. 2014-12-09. PMID:24657052. |
quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for alzheimer disease. |
2014-12-09 |
2023-08-12 |
Not clear |
| Shana V Stoddard, Mark T Hamann, Randy M Wadkin. Insights and ideas garnered from marine metabolites for development of dual-function acetylcholinesterase and amyloid-β aggregation inhibitors. Marine drugs. vol 12. issue 4. 2014-12-09. PMID:24714126. |
here, we focus on marine metabolites that inhibit the enzyme acetylcholinesterase, which is the cellular target for treatment of early-stage alzheimer's disease. |
2014-12-09 |
2023-08-13 |
human |
| Shana V Stoddard, Mark T Hamann, Randy M Wadkin. Insights and ideas garnered from marine metabolites for development of dual-function acetylcholinesterase and amyloid-β aggregation inhibitors. Marine drugs. vol 12. issue 4. 2014-12-09. PMID:24714126. |
currently, development of anticholinesterase drugs with improved potency, and drugs that act as dual acetylcholinesterase and amyloid-β aggregation inhibitors, are being sought to treat alzheimer's disease. |
2014-12-09 |
2023-08-13 |
human |
| Aneley Hundae, Aasim Afzal, Manish D Assar, Jeffrey M Schussle. Syncope secondary to second-degree atrioventricular block with donepezil use. Proceedings (Baylor University. Medical Center). vol 27. issue 4. 2014-12-08. PMID:25484499. |
donepezil, an acetylcholinesterase inhibitor, is approved for the treatment of mild to moderate dementia secondary to alzheimer's disease. |
2014-12-08 |
2023-08-13 |
Not clear |
| Hirbod Bahrani, Jamaludin Mohamad, Mohammad Javad Paydar, Hussin A Rotha. Isolation and characterisation of acetylcholinesterase inhibitors from Aquilaria subintegra for the treatment of Alzheimer's disease (AD). Current Alzheimer research. vol 11. issue 2. 2014-11-24. PMID:24479629. |
isolation and characterisation of acetylcholinesterase inhibitors from aquilaria subintegra for the treatment of alzheimer's disease (ad). |
2014-11-24 |
2023-08-12 |
mouse |
| Md Asaduzzaman, Md Josim Uddin, M A Kader, A H M K Alam, Aziz Abdur Rahman, Mamunur Rashid, Kiyoko Kato, Toshihisa Tanaka, Masatoshi Takeda, Golam Sadi. In vitro acetylcholinesterase inhibitory activity and the antioxidant properties of Aegle marmelos leaf extract: implications for the treatment of Alzheimer's disease. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 14. issue 1. 2014-11-24. PMID:24646308. |
in vitro acetylcholinesterase inhibitory activity and the antioxidant properties of aegle marmelos leaf extract: implications for the treatment of alzheimer's disease. |
2014-11-24 |
2023-08-12 |
Not clear |
| Wei Liu, Yadi Yang, Xuemei Cheng, Can Gong, Shuping Li, Dandan He, Li Yang, Zhengtao Wang, Changhong Wan. Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS. Journal of pharmaceutical and biomedical analysis. vol 94. 2014-11-17. PMID:24631841. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are legitimate therapeutic targets for alzheimer's disease. |
2014-11-17 |
2023-08-12 |
Not clear |
| Hiroyuki Kimura, Tomoki Kawai, Yoshio Hamashima, Hidekazu Kawashima, Kenji Miura, Yuta Nakaya, Makoto Hirasawa, Kenji Arimitsu, Tetsuya Kajimoto, Yoshiro Ohmomo, Masahiro Ono, Manabu Node, Hideo Saj. Synthesis and evaluation of (-)- and (+)-[¹¹C]galanthamine as PET tracers for cerebral acetylcholinesterase imaging. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24315193. |
improved radiopharmaceuticals for imaging cerebral acetylcholinesterase (ache) are needed for the diagnosis of alzheimer's disease (ad). |
2014-11-06 |
2023-08-12 |
mouse |
| Lucie Wade, Cynthia Forlini, Eric Racin. Generating genius: how an Alzheimer's drug became considered a 'cognitive enhancer' for healthy individuals. BMC medical ethics. vol 15. 2014-11-04. PMID:24885270. |
donepezil, an acetylcholinesterase inhibitor used in the treatment of alzheimer's disease, has been widely cited in media and bioethics literature on cognitive enhancement (ce) as having the potential to improve the cognitive ability of healthy individuals. |
2014-11-04 |
2023-08-13 |
Not clear |
| Li-Na Hou, Jian-Rong Xu, Qing-Nan Zhao, Xiao-Ling Gao, Yong-Yao Cui, Jun Xu, Hao Wang, Hong-Zhuan Che. A new motif in the N-terminal of acetylcholinesterase triggers amyloid-β aggregation and deposition. CNS neuroscience & therapeutics. vol 20. issue 1. 2014-09-29. PMID:23981668. |
as a molecular chaperone, acetylcholinesterase (ache; ec 3.1.1.7) plays a critical role in the pathogenesis of alzheimer's disease (ad). |
2014-09-29 |
2023-08-12 |
Not clear |
| Maya Mathew, Sarada Subramania. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. PloS one. vol 9. issue 1. 2014-09-29. PMID:24466247. |
inhibition of acetylcholinesterase (ache) is still considered as the main therapeutic strategy against alzheimer's disease (ad). |
2014-09-29 |
2023-08-12 |
Not clear |
| Manjinder Singh, Maninder Kaur, Hitesh Kukreja, Rajan Chugh, Om Silakari, Dhandeep Sing. Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection. European journal of medicinal chemistry. vol 70. 2014-09-19. PMID:24148993. |
acetylcholinesterase inhibitors as alzheimer therapy: from nerve toxins to neuroprotection. |
2014-09-19 |
2023-08-12 |
Not clear |
| Hui Zhi, Can Zhang, Zhixin Cheng, Zhe Jin, Erfang Huang, Shuo Li, Huangquan Lin, David Chicheong Wan, Chun H. 6-acetyl-5H-thiazolo[3,2-a]pyrimidine derivatives as the novel acetylcholinesterase inhibitors: design, synthesis, and biological activity. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 9. issue 5. 2014-09-11. PMID:23270368. |
the results provide a starting point for the development of novel drugs to treat alzheimer's disease, and a foundation in search for improved acetylcholinesterase inhibitors with the novel scaffolds. |
2014-09-11 |
2023-08-12 |
human |
| Margarita Gutiérrez, María Francisca Matus, Tomas Poblete, Jessica Amigo, Gabriel Vallejos, Luis Astudill. Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24180424. |
inhibition of acetylcholinesterase (ache) is a common treatment for early stages of alzheimer's disease. |
2014-09-05 |
2023-08-12 |
Not clear |
| Eduardo Luis Konrath, Carolina dos Santos Passos, Luiz Carlos Klein, Amélia T Henrique. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24236981. |
the inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for alzheimer's disease (ad). |
2014-09-05 |
2023-08-12 |
Not clear |
| Shunichiro Shinagawa, Masahiro Shiget. [Acetylcholinesterase inhibitors for treatment of Alzheimer's disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 66. issue 5. 2014-08-15. PMID:24807367. |
[acetylcholinesterase inhibitors for treatment of alzheimer's disease]. |
2014-08-15 |
2023-08-13 |
Not clear |
| H Eimar, A Perez Lara, I Tamimi, P Márquez Sánchez, I Gormaz Talavera, F Rojas Tomba, T García de la Oliva, F Tamim. Acetylcholinesterase inhibitors and healing of hip fracture in Alzheimer's disease patients: a retrospective cohort study. Journal of musculoskeletal & neuronal interactions. vol 13. issue 4. 2014-08-11. PMID:24292615. |
acetylcholinesterase inhibitors and healing of hip fracture in alzheimer's disease patients: a retrospective cohort study. |
2014-08-11 |
2023-08-12 |
Not clear |