| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monica Rosa Loizzo, Mariem Ben Jemia, Felice Senatore, Maurizio Bruno, Francesco Menichini, Rosa Tundi. Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23831310. |
essential oils were screened also for their potential antioxidant effects (by dpph, abts, frap and β-carotene bleaching test) and their acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activity, useful for prevention and treatment of alzheimer's disease. |
2014-03-28 |
2023-08-12 |
Not clear |
| Ansel T Hillmer, Dustin W Wooten, Mohammed Farhoud, Andrew T Higgins, Patrick J Lao, Todd E Barnhart, Jogeshwar Mukherjee, Bradley T Christia. PET imaging of acetylcholinesterase inhibitor-induced effects on α4β2 nicotinic acetylcholine receptor binding. Synapse (New York, N.Y.). vol 67. issue 12. 2014-03-25. PMID:23913347. |
acetylcholinesterase inhibitors (acheis) are drugs that increase synaptic acetylcholine (ach) concentrations and are under investigation as treatments for symptoms accompanying alzheimer's disease. |
2014-03-25 |
2023-08-12 |
human |
| Koteswara Rao Valasani, Michael O Chaney, Victor W Day, Shirley Shidu Ya. Acetylcholinesterase inhibitors: structure based design, synthesis, pharmacophore modeling, and virtual screening. Journal of chemical information and modeling. vol 53. issue 8. 2014-03-21. PMID:23777291. |
acetylcholinesterase (ache) is a main drug target, and its inhibitors have demonstrated functionality in the symptomatic treatment of alzheimer's disease (ad). |
2014-03-21 |
2023-08-12 |
human |
| Cho Rong Kim, Soo Jung Choi, Seung Sang Oh, Yoon Kyung Kwon, Na Young Lee, Gwi Gun Park, Youn-Jung Kim, Ho Jin Heo, Woo Jin Jun, Cheung-Seog Park, Dong-Hoon Shi. Rubus coreanus Miquel inhibits acetylcholinesterase activity and prevents cognitive impairment in a mouse model of dementia. Journal of medicinal food. vol 16. issue 9. 2014-03-21. PMID:24044488. |
to find acetylcholinesterase (ache) inhibitors for the prevention of neurological disorders, such as alzheimer's disease, ethanol extracts of promising traditional edible korean plants were tested. |
2014-03-21 |
2023-08-12 |
mouse |
| Katja S Kroker, Jens Moreth, Lothar Kussmaul, Georg Rast, Holger Rosenbroc. Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists. Brain research bulletin. vol 96. 2014-03-19. PMID:23639920. |
as nicotinic acetylcholine receptor (nachr) agonists directly address cholinergic neurotransmission with potential impact on glutamatergic function, they are considered as potential new symptomatic treatment options for alzheimer's disease compared to the indirectly operating acetylcholinesterase inhibitors such as the current gold standard donepezil. |
2014-03-19 |
2023-08-12 |
rat |
| Shuqing Gu, Youlan Lu, Yaping Ding, Li Li, Fenfen Zhang, Qingsheng W. Droplet-based microfluidics for dose-response assay of enzyme inhibitors by electrochemical method. Analytica chimica acta. vol 796. 2014-03-19. PMID:24016585. |
this system was validated by measuring dose-response curves of three types of acetylcholinesterase (ache) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating alzheimer's disease. |
2014-03-19 |
2023-08-12 |
Not clear |
| Anish Kundu, Adinpunya Mitr. Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities. Plant foods for human nutrition (Dordrecht, Netherlands). vol 68. issue 3. 2014-03-10. PMID:23715789. |
acetylcholinesterase inhibitors (acheis) are important for treatment of alzheimer's disease and other neurological disorders. |
2014-03-10 |
2023-08-12 |
Not clear |
| Anna Minarini, Andrea Milelli, Elena Simoni, Michela Rosini, Maria Laura Bolognesi, Chiara Marchetti, Vincenzo Tumiatt. Multifunctional tacrine derivatives in Alzheimer's disease. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931443. |
tacrine (1) was the first acetylcholinesterase inhibitor (achei) introduced in therapy for the treatment of alzheimer's disease (ad), but similarly to the most recent approved acheis and memantine, an n-methyl-d-aspartate receptor (nmdar) antagonist, it does not represent an effective drug in halting the progression of ad. |
2014-03-10 |
2023-08-12 |
Not clear |
| Veronica Tello-Franco, Maria Concepcion Lozada-García, Manuel Soriano-Garcí. Experimental and computational studies on the inhibition of acetylcholinesterase by curcumin and some of its derivatives. Current computer-aided drug design. vol 9. issue 2. 2014-02-26. PMID:23106780. |
recent studies have demonstrated several biological activities of curcumin with therapeutic potential against alzheimer's disease, among them the inhibition of the enzyme acetylcholinesterase (ache). |
2014-02-26 |
2023-08-12 |
Not clear |
| Loganathan Chitra, Chinnadurai Raj Kumar, Haleema M Basha, Saravanaraman Ponne, Rathanam Boopath. Interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in Alzheimer's disease treatment. Proteins. vol 81. issue 7. 2014-02-21. PMID:23408593. |
interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in alzheimer's disease treatment. |
2014-02-21 |
2023-08-12 |
Not clear |
| Loganathan Chitra, Chinnadurai Raj Kumar, Haleema M Basha, Saravanaraman Ponne, Rathanam Boopath. Interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in Alzheimer's disease treatment. Proteins. vol 81. issue 7. 2014-02-21. PMID:23408593. |
the peripheral anionic site (pas) of acetylcholinesterase (ache) is involved in amyloid beta (aβ) peptides aggregation of alzheimer's disease (ad). |
2014-02-21 |
2023-08-12 |
Not clear |
| Marwan Sabbagh, Jeffrey Cummings, Daniel Christensen, Rachelle Doody, Martin Farlow, Liang Liu, Joan Mackell, Randi Fai. Evaluating the cognitive effects of donepezil 23 mg/d in moderate and severe Alzheimer's disease: analysis of effects of baseline features on treatment response. BMC geriatrics. vol 13. 2014-02-10. PMID:23742728. |
treatment of alzheimer's disease with acetylcholinesterase inhibitors can result in symptomatic benefits, but patients often show variable responses. |
2014-02-10 |
2023-08-12 |
Not clear |
| Sinikka Rahte, Richard Evans, Philippe J Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemi. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles. Planta medica. vol 79. issue 9. 2014-01-27. PMID:23670626. |
because of an increased risk of menopausal women to suffer from alzheimer's disease, an in vitro acetylcholinesterase inhibition assay was also employed. |
2014-01-27 |
2023-08-12 |
Not clear |
| Jerald J Nair, Jaume Bastida, Caries Codina, Francesc Viladomat, Johannes van Stade. Alkaloids of the South African Amaryllidaceae: a review. Natural product communications. vol 8. issue 9. 2014-01-23. PMID:24273880. |
of greater significance are the medicinal attributes of the family, which has already spawned the alzheimer's prescription drug galanthamine, a potent and selective inhibitor of the enzyme acetylcholinesterase, of significance in the progression of neurodegeneration associated with motor neuron diseases, with annual global sales of around $150 million. |
2014-01-23 |
2023-08-12 |
Not clear |
| Seyed Behzad Jazayeri, Arash Amanlou, Naghmeh Ghanadian, Parvin Pasalar, Massoud Amanlo. A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 22. issue 1. 2014-01-20. PMID:24401532. |
the aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in iran to introduce a new source for management of alzheimer's disease. |
2014-01-20 |
2023-08-12 |
Not clear |
| Debora Cutuli, Paola De Bartolo, Paola Caporali, Anna Maria Tartaglione, Diego Oddi, Francesca Romana D'Amato, Annalisa Nobili, Marcello D'Amelio, Laura Petrosin. Neuroprotective effects of donepezil against cholinergic depletion. Alzheimer's research & therapy. vol 5. issue 5. 2014-01-09. PMID:24401551. |
here we administered donepezil, a potent acetylcholinesterase inhibitor developed for treating alzheimer's disease, 15 days before 192-igg-saporin injection, and thus we examined donepezil effects on neurodegeneration and cognitive deficits. |
2014-01-09 |
2023-08-12 |
Not clear |
| Lushan Yu, Yan Jiang, Lu Wang, Rong Sheng, Yongzhou Hu, Su Zen. Metabolism of BYZX in human liver microsomes and cytosol: identification of the metabolites and metabolic pathways of BYZX. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555822. |
byzx, [(e)-2-(4-((diethylamino)methyl)benzylidene)-5,6-dimethoxy-2,3-dihydroinden-one], belongs to a series of novel acetylcholinesterase inhibitors and has been synthesized as a new chemical entity for the treatment of alzheimer's disease symptoms. |
2014-01-07 |
2023-08-12 |
human |
| Min-Young Noh, Seong H Koh, Sung-Min Kim, Tangui Maurice, Sae-Kwang Ku, Seung H Ki. Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity. Journal of neurochemistry. vol 127. issue 4. 2014-01-06. PMID:23711227. |
the main purpose of this study was to evaluate whether donepezil, acetylcholinesterase inhibitor, shown to play a protective role through inhibiting glycogen synthesis kinase-3β (gsk-3β) activity, could also exert neuroprotective effects by stimulating protein phosphatase 2a (pp2a) activity in the amyloid-beta (aβ)42-induced neuronal toxicity model of alzheimer's disease. |
2014-01-06 |
2023-08-12 |
Not clear |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
as acetylcholinesterase (ache) inhibitors are an important therapeutic strategy in alzheimer's disease, efforts are being made in search of new molecules with anti-ache activity. |
2014-01-01 |
2023-08-12 |
Not clear |
| Christophe Petiau, Hakki Onen, Antonio Delgado, Jacques Toucho. Exploring sleep-related outcomes in patients with mild to moderate Alzheimer's disease initiating acetylcholinesterase inhibitor therapy: the Morpheus survey. International journal of geriatric psychiatry. vol 28. issue 6. 2013-12-30. PMID:23649861. |
exploring sleep-related outcomes in patients with mild to moderate alzheimer's disease initiating acetylcholinesterase inhibitor therapy: the morpheus survey. |
2013-12-30 |
2023-08-12 |
Not clear |