| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesari. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors. Current medicinal chemistry. vol 20. issue 8. 2013-09-13. PMID:23210783. |
from traditional european medicine to discovery of new drug candidates for the treatment of dementia and alzheimer's disease: acetylcholinesterase inhibitors. |
2013-09-13 |
2023-08-12 |
Not clear |
| P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesari. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors. Current medicinal chemistry. vol 20. issue 8. 2013-09-13. PMID:23210783. |
the leading alzheimer's disease (ad) therapeutics to date involves inhibitors of acetylcholinesterase (ache), which should, in principle, elevate cholinergic signaling and limit inflammation. |
2013-09-13 |
2023-08-12 |
Not clear |
| Sook-Young Park, Jaeyoung Choi, Jung A Kim, Min-Hye Jeong, Soonok Kim, Yong-Hwan Lee, Jae-Seoun Hu. Draft Genome Sequence of Cladonia macilenta KoLRI003786, a Lichen-Forming Fungus Producing Biruloquinone. Genome announcements. vol 1. issue 5. 2013-09-06. PMID:24009123. |
the lichen-forming fungus cladonia macilenta strain kolri003786 is capable of producing an acetylcholinesterase inhibitor, biruloquinone, which effectively prevents neurodegeneration in alzheimer's disease. |
2013-09-06 |
2023-08-12 |
Not clear |
| Angela I Calderón, Johayra Simithy-Williams, Rocío Sanchez, Alex Espinosa, Iván Valdespino, Mahabir P Gupt. Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors. Natural product research. vol 27. issue 4-5. 2013-09-05. PMID:22746970. |
acetylcholinesterase (ache) inhibitors have been used for the symptomatic treatment of alzheimer's disease. |
2013-09-05 |
2023-08-12 |
Not clear |
| Yi-Rou Wang, Yuan-Han Yang, Chi-Yu Lu, Shun-Jin Lin, Su-Hwei Che. Trace analysis of acetylcholinesterase inhibitors with antipsychotic drugs for Alzheimer's disease by capillary electrophoresis with on column field-amplified sample injection. Analytical and bioanalytical chemistry. vol 405. issue 10. 2013-08-28. PMID:23392410. |
trace analysis of acetylcholinesterase inhibitors with antipsychotic drugs for alzheimer's disease by capillary electrophoresis with on column field-amplified sample injection. |
2013-08-28 |
2023-08-12 |
Not clear |
| Maria A Telpoukhovskaia, Brian O Patrick, Cristina Rodríguez-Rodríguez, Chris Orvi. Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease. Molecular bioSystems. vol 9. issue 4. 2013-08-16. PMID:23435553. |
exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in alzheimer's disease. |
2013-08-16 |
2023-08-12 |
Not clear |
| Chandran Remya, Kalarickal Vijayan Dileep, Ignatius Tintu, Elessery Jayadevi Variyar, Chittalakkottu Sadasiva. In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile. Journal of molecular modeling. vol 19. issue 3. 2013-08-13. PMID:23229229. |
acetylcholinesterase (ache) inhibitors are currently in focus for the pharmacotherapy of alzheimer's disease (ad). |
2013-08-13 |
2023-08-12 |
Not clear |
| Wen-Chao Yang, Qi Sun, Ning-Xi Yu, Xiao-Lei Zhu, Guang-Fu Yan. [Design of acetylcholinesterase inhibitor for Alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 47. issue 3. 2013-08-12. PMID:22645754. |
[design of acetylcholinesterase inhibitor for alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands]. |
2013-08-12 |
2023-08-12 |
Not clear |
| Wen-Chao Yang, Qi Sun, Ning-Xi Yu, Xiao-Lei Zhu, Guang-Fu Yan. [Design of acetylcholinesterase inhibitor for Alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 47. issue 3. 2013-08-12. PMID:22645754. |
drug discovery for alzheimer's disease therapy has been a hot research area and a big challenge, in which development of acetylcholinesterase (ache) inhibitors design was the most active and some ache inhibitors are commercially available for ad medication already. |
2013-08-12 |
2023-08-12 |
Not clear |
| Hailin Zheng, Moussa B H Youdim, Mati Fridki. Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities. ACS chemical neuroscience. vol 1. issue 11. 2013-08-09. PMID:22778810. |
the finding that acetylcholinesterase (ache) colocalizes with β-amyloid (aβ) and promotes and accelerates aβ aggregation has renewed an intense interest in developing new multifunctional ache inhibitors as potential disease-modifying drugs for alzheimer's therapy. |
2013-08-09 |
2023-08-12 |
human |
| Paul S Aisen, Jeffrey Cummings, Lon S Schneide. Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. Cold Spring Harbor perspectives in medicine. vol 2. issue 3. 2013-08-08. PMID:22393531. |
in this work we consider marketed drugs for alzheimer disease (ad) including acetylcholinesterase inhibitors (ache-is) and antiglutamatergic treatment involving the n-methyl-d-aspartate (nmda) receptor. |
2013-08-08 |
2023-08-12 |
Not clear |
| V Lakshmi, V Santhosh Kannan, R Boopath. Identification of potential bivalent inhibitors from natural compounds for acetylcholinesterase through in silico screening using multiple pharmacophores. Journal of molecular graphics & modelling. vol 40. 2013-08-01. PMID:23353586. |
the symptomatic cure observed in the treatment of alzheimer's disease (ad) by fda approved drugs could possibly be due to their specificity against the active site of acetylcholinesterase (ache) and not by targeting its pathogenicity. |
2013-08-01 |
2023-08-12 |
Not clear |
| Abdul Hai, Nadeem A Kizilbash, Syedahuma H Zaidi, Jamal Alruwail. Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster. Bioinformation. vol 9. issue 12. 2013-08-01. PMID:23904743. |
regional cerebral blood flow can be increased in patients with alzheimer's disease by acetylcholinesterase (ache) inhibitors. |
2013-08-01 |
2023-08-12 |
drosophila_melanogaster |
| Heng Luo, Changtian Li, Jin Cheol Kim, Yanpeng Liu, Jae Sung Jung, Young Jin Koh, Jae-Seoun Hu. Biruloquinone, an acetylcholinesterase inhibitor produced by lichen-forming fungus Cladonia macilenta. Journal of microbiology and biotechnology. vol 23. issue 2. 2013-07-26. PMID:23412057. |
at present, acetylcholinesterase (ache) inhibitors are the first group of drugs to treat mild to moderate alzheimer's disease (ad). |
2013-07-26 |
2023-08-12 |
Not clear |
| Yanhong Shen, Baoli Li, Hu Xu, Guoqiang Zhan. Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors. Die Pharmazie. vol 68. issue 5. 2013-07-25. PMID:23802426. |
as part of a project aimed at developing new agents for potential application in alzheimer's disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (ache) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. |
2013-07-25 |
2023-08-12 |
Not clear |
| Sara Garcia-Ratés, Matthew Lewis, Rosemary Worrall, Susan Greenfiel. Additive toxicity of β-amyloid by a novel bioactive peptide in vitro: possible implications for Alzheimer's disease. PloS one. vol 8. issue 2. 2013-07-19. PMID:23390503. |
one clue could be that acetylcholinesterase, also present in amyloid plaques, is aberrant in peripheral tissues such as blood and adrenal medulla that can be implicated in alzheimer's disease. |
2013-07-19 |
2023-08-12 |
Not clear |
| Toru Kubo, Takayuki Sato, Tatsuya Noguchi, Hiroaki Kitaoka, Fumiyasu Yamasaki, Naoto Kamimura, Shinji Shimodera, Tatsuo Iiyama, Naoko Kumagai, Yoshihiko Kakinuma, André Diedrich, Jens Jordan, David Robertson, Yoshinori L Do. Influences of donepezil on cardiovascular system--possible therapeutic benefits for heart failure--donepezil cardiac test registry (DOCTER) study. Journal of cardiovascular pharmacology. vol 60. issue 3. 2013-07-09. PMID:22691879. |
to study prospectively influences of donepezil, an acetylcholinesterase inhibitor against alzheimer disease, on cardiovascular system, we evaluated cardiovascular changes occurring during new initialized treatment with donepezil in 49 dementia patients over 6 months. |
2013-07-09 |
2023-08-12 |
Not clear |
| Ahmad Mohammadi-Farani, Aram Ahmadi, Hamid Nadri, Alireza Aliabad. Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 21. issue 1. 2013-07-09. PMID:23758724. |
in recent years, acetylcholinesterase (ache) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with alzheimer's disease. |
2013-07-09 |
2023-08-12 |
Not clear |
| Manuela Bartolini, Marina Naldi, Dan V Nicolau, Falco C M J M van Delft, Jeroen van Zijl, Jaap Snijder, Eric F C van den Heuvel, Emile P Naburgh, Natalia Calonghi, Vincenza Andrisan. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase. Analytical and bioanalytical chemistry. vol 405. issue 2-3. 2013-07-05. PMID:22814970. |
human acetylcholinesterase (ache) is a widely studied target enzyme in drug discovery for alzheimer's disease (ad). |
2013-07-05 |
2023-08-12 |
human |
| Da Hua Shi, Jun Hua Wu, Hui Ming Ge, Ren-Xiang Ta. Protective effect of hopeahainol A, a novel acetylcholinesterase inhibitor, on hydrogen peroxide-induced injury in PC12 cells. Environmental toxicology and pharmacology. vol 28. issue 1. 2013-07-04. PMID:21783979. |
there was potential for hopeahainol a to be used in treating alzheimer's disease (ad) that involved acetylcholinesterase, free radical, oxidative damage and cell apoptosis. |
2013-07-04 |
2023-08-12 |
Not clear |