| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filipa Marcelo, Catarina Dias, Alice Martins, Paulo J Madeira, Tiago Jorge, M Helena Florêncio, F Javier Cañada, Eurico J Cabrita, Jesús Jiménez-Barbero, Amélia P Raute. Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: a new binding site detected by NMR spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany). vol 19. issue 21. 2013-12-24. PMID:23536497. |
acetylcholinesterase (ache) inhibition is one of the most currently available therapies for the management of alzheimer's disease (ad) symptoms. |
2013-12-24 |
2023-08-12 |
Not clear |
| Kaitlyn E Shaw, Corina O Bondi, Samuel H Light, Lire A Massimino, Rose L McAloon, Christina M Monaco, Anthony E Klin. Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. Journal of neurotrauma. vol 30. issue 7. 2013-11-26. PMID:23227953. |
the acetylcholinesterase (ache) inhibitor donepezil is used as a therapy for alzheimer's disease and has been recommended as a treatment for enhancing attention and memory after traumatic brain injury (tbi). |
2013-11-26 |
2023-08-12 |
rat |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
there is currently great interest in developing radiolabeled substrates for acetylcholinesterase that would be useful in the in vivo imaging of patients with alzheimer's disease. |
2013-11-26 |
2023-08-12 |
rat |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c and (18)f-labeled acetylcholine analogues. |
2013-11-26 |
2023-08-12 |
rat |
| Sarawalee Arunkhamkaew, Anan Athipornchai, Nuttapon Apiratikul, Apichart Suksamrarn, Vachiraporn Ajavako. Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters. vol 23. issue 10. 2013-11-26. PMID:23583510. |
the evaluation of acetylcholinesterase inhibitors for alzheimer's disease of these compounds showed that they exhibited higher inhibitory activity than their parent analogues. |
2013-11-26 |
2023-08-12 |
Not clear |
| Steven H Ferris, Martin Farlo. Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors. Clinical interventions in aging. vol 8. 2013-11-26. PMID:23946647. |
language impairment in alzheimer's disease and benefits of acetylcholinesterase inhibitors. |
2013-11-26 |
2023-08-12 |
Not clear |
| Steven H Ferris, Martin Farlo. Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors. Clinical interventions in aging. vol 8. 2013-11-26. PMID:23946647. |
trials of acetylcholinesterase inhibitors, used for the treatment of clinical symptoms of alzheimer's disease, have generally focused on overall cognitive effects. |
2013-11-26 |
2023-08-12 |
Not clear |
| Steven H Ferris, Martin Farlo. Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors. Clinical interventions in aging. vol 8. 2013-11-26. PMID:23946647. |
however, in the current report, we review data indicating specific beneficial effects of acetylcholinesterase inhibitors on language abilities in patients with alzheimer's disease, with a particular focus on outcomes among patients in the moderate and severe disease stages, during which communication is at risk and preservation is particularly important. |
2013-11-26 |
2023-08-12 |
Not clear |
| Ren-Shi Li, Xiao-Bing Wang, Xiao-Jun Hu, Ling-Yi Kon. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 23. issue 9. 2013-11-08. PMID:23511019. |
design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against alzheimer's disease. |
2013-11-08 |
2023-08-12 |
Not clear |
| Seyyede Faeze Razavi, Mehdi Khoobi, Hamid Nadri, Amirhossein Sakhteman, Alireza Moradi, Saeed Emami, Alireza Foroumadi, Abbas Shafie. Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors. European journal of medicinal chemistry. vol 64. 2013-11-05. PMID:23644208. |
a series of 4-hydroxycoumarin derivatives were designed and synthesized as new acetylcholinesterase (ache) inhibitors which could be considered for alzheimer's disease therapeutics. |
2013-11-05 |
2023-08-12 |
Not clear |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
an impaired central cholinergic system is at least partly involved in alzheimer's disease (ad) pathogenesis, with cholinergic markers such as acetylcholinesterase (ache) activity and protein levels decreasing as cognitive decline progresses. |
2013-11-04 |
2023-08-12 |
mouse |
| Yueqing Hu, Jun Zhang, Oormila Chandrashankra, Fanny C F Ip, Nancy Y I. Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 21. issue 3. 2013-11-04. PMID:23273608. |
four series of novel heterodimers comprised of donepezil and huperzine a (hupa) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (ache) inhibitors as potential therapeutic treatment for alzheimer's disease. |
2013-11-04 |
2023-08-12 |
Not clear |
| Yao-Dong Zhang, Ya-Nan Cai, Qi Zhang, Zong-Li Qi, Qun-Qun Ga. [Inhibitory effect of icariin on acetylcholinesterase]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 47. issue 9. 2013-10-21. PMID:23227542. |
acetylcholinesterase (ache) inhibitors are mainly used in the treatment of alzheimer's disease (ad). |
2013-10-21 |
2023-08-12 |
Not clear |
| Simona Gabriella Di Santo, Federica Prinelli, Fulvio Adorni, Carlo Caltagirone, Massimo Musicc. A meta-analysis of the efficacy of donepezil, rivastigmine, galantamine, and memantine in relation to severity of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 2. 2013-10-17. PMID:23411693. |
randomized clinical trials have evaluated the efficacy of acetylcholinesterase inhibitors (ache-is) and memantine across a wide range of alzheimer's disease (ad) severity. |
2013-10-17 |
2023-08-12 |
Not clear |
| Noll L Campbell, Paul Dexter, Anthony J Perkins, Sujuan Gao, Lang Li, Todd C Skaar, Amie Frame, Hugh C Hendrie, Chris M Callahan, Malaz A Boustan. Medication adherence and tolerability of Alzheimer's disease medications: study protocol for a randomized controlled trial. Trials. vol 14. 2013-10-17. PMID:23782591. |
the class of acetylcholinesterase inhibitors (chei), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate alzheimer's disease (ad). |
2013-10-17 |
2023-08-12 |
Not clear |
| Anna-Katharine Brem, Natasha J Atkinson, Erica E Seligson, Alvaro Pascual-Leon. Differential pharmacological effects on brain reactivity and plasticity in Alzheimer's disease. Frontiers in psychiatry. vol 4. 2013-10-10. PMID:24109459. |
acetylcholinesterase inhibitors (acheis) are the most commonly prescribed monotherapeutic medications for alzheimer's disease (ad). |
2013-10-10 |
2023-08-12 |
Not clear |
| Osamu Kano, Yoshihisa Urita, Hirono Ito, Takanori Takazawa, Yuji Kawase, Kiyoko Murata, Takehisa Hirayama, Ken Miura, Yuichi Ishikawa, Tetsuhito Kiyozuka, Jo Aoyagi, Yasuo Iwasak. Domperidone effective in preventing rivastigmine-related gastrointestinal disturbances in patients with Alzheimer's disease. Neuropsychiatric disease and treatment. vol 9. 2013-10-04. PMID:24092978. |
while acetylcholinesterase inhibitors, such as donepezil, galantamine, and rivastig-mine, are beneficial in treating behavioral symptoms of patients with alzheimer's disease (ad), their dose-limiting effects include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. |
2013-10-04 |
2023-08-12 |
Not clear |
| M Kannan, P Manivel, K Geetha, J Muthukumaran, H Surya Prakash Rao, R Krishn. Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase. Journal of chemical biology. vol 5. issue 4. 2013-09-20. PMID:24052808. |
synthesis and in silico evaluation of 1n-methyl-1s-methyl-2-nitroethylene (nmsm) derivatives against alzheimer disease: to understand their interacting mechanism with acetylcholinesterase. |
2013-09-20 |
2023-08-12 |
human |
| M Kannan, P Manivel, K Geetha, J Muthukumaran, H Surya Prakash Rao, R Krishn. Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase. Journal of chemical biology. vol 5. issue 4. 2013-09-20. PMID:24052808. |
anomalous action of human acetylcholinesterase (hache) in alzheimer's disease (ad) was restrained by various ache inhibitors, of which the specific and potent lead candidate donepezil is used for treating the disease ad. |
2013-09-20 |
2023-08-12 |
human |
| Anthony J Veloso, Paul M Nagy, Biao Zhang, Devjani Dhar, Anqi Liang, Tarek Ibrahim, Svetlana Mikhaylichenko, Isabelle Aubert, Kagan Kerma. Miniaturized electrochemical system for cholinesterase inhibitor detection. Analytica chimica acta. vol 774. 2013-09-18. PMID:23567119. |
the utility of a simple, low-cost detection platform for label-free electrochemical characterization of acetylcholinesterase (ache) inhibition is demonstrated as a potential tool for screening of small-molecule therapeutic agents for alzheimer's disease (ad). |
2013-09-18 |
2023-08-12 |
mouse |