| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Junaid, Nazrul Islam, Md Kamal Hossain, M Obayed Ullah, Mohammad A Hali. Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease. PloS one. vol 14. issue 2. 2019-11-04. PMID:30785927. |
metal based donepezil analogues designed to inhibit human acetylcholinesterase for alzheimer's disease. |
2019-11-04 |
2023-08-13 |
human |
| Lili Wan, Jin Lu, Jianliang Fu, Jinlu Huang, Quanjun Yang, Bo Xin, Li Chen, Yan Huo, Yuan Zhong, Cheng Gu. Acetylcholinesterase Inhibitor Donepezil Effects on Plasma β-Hydroxybutyrate Levels in the Treatment of Alzheimer's Disease. Current Alzheimer research. vol 15. issue 10. 2019-10-16. PMID:29852870. |
acetylcholinesterase inhibitor donepezil effects on plasma β-hydroxybutyrate levels in the treatment of alzheimer's disease. |
2019-10-16 |
2023-08-13 |
Not clear |
| Kelvin Kf Tsoi, Joyce Yc Chan, Felix Ch Chan, Hoyee W Hirai, Timothy Cy Kwok, Samuel Ys Won. Monotherapy Is Good Enough for Patients with Mild-to-Moderate Alzheimer's Disease: A Network Meta-analysis of 76 Randomized Controlled Trials. Clinical pharmacology and therapeutics. vol 105. issue 1. 2019-10-15. PMID:29717478. |
memantine and the acetylcholinesterase inhibitors (acheis) are two classes of drugs that are used to treat patients with alzheimer's disease. |
2019-10-15 |
2023-08-13 |
Not clear |
| Jason M Uslaner, Scott D Kuduk, Marion Wittmann, Henry S Lange, Steve V Fox, Chris Min, Natasa Pajkovic, Dawn Harris, Caroline Cilissen, Chantal Mahon, Kate Mostoller, Steve Warrington, Douglas C Beshor. Preclinical to Human Translational Pharmacology of the Novel M The Journal of pharmacology and experimental therapeutics. vol 365. issue 3. 2019-10-14. PMID:29563325. |
preclinical to human translational pharmacology of the novel m the current standard of care for treating alzheimer's disease is acetylcholinesterase inhibitors, which nonselectively increase cholinergic signaling by indirectly enhancing activity of nicotinic and muscarinic receptors. |
2019-10-14 |
2023-08-13 |
human |
| M Figueiredo-González, P Reboredo-Rodríguez, C González-Barreiro, J Simal-Gándara, P Valentão, A Carrasco-Pancorbo, P B Andrade, B Cancho-Grand. Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays. Food research international (Ottawa, Ont.). vol 106. 2019-09-30. PMID:29579961. |
in this work, phenol-rich extracts from 'cornicabra' and 'picual' virgin-olive oils (evoos) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in alzheimer's disease (ad) (acetylcholinesterase (ache), butyrylcholinesterase (buche) and 5-lipoxygenase (lox)), major depressive disorder (mdd) and parkinson's disease (pd) (monoamine oxidases: hmao-a and hmao-b respectively), and diabetes mellitus (dm) (α-glucosidase and α-amylase). |
2019-09-30 |
2023-08-13 |
Not clear |
| Wei Ni, Huan Wang, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao, Haiyan Zhang, Jian L. Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5). ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29616790. |
on the basis of the drug-repositioning and redeveloping strategy, first-generation dual-target inhibitors of acetylcholinesterase (ache) and phosphodiesterase 5 (pde5) have been recently reported as a potentially novel therapeutic method for the treatment of alzheimer's disease (ad), and the lead compound 2 has proven this method was feasible in ad mouse models. |
2019-09-30 |
2023-08-13 |
mouse |
| Fatma M Abdel Bar, Diaaeldin M Elimam, Amira S Mira, Fardous F El-Senduny, Farid A Badri. Derivatization, molecular docking and Natural product research. vol 33. issue 18. 2019-09-20. PMID:29656653. |
derivatization, molecular docking and acetylcholinesterase inhibitors (ache-is) increase both level and duration of action of acetylcholine (ach); thus, alleviate symptoms of alzheimer's disease (ad). |
2019-09-20 |
2023-08-13 |
Not clear |
| M Pohank. Copper and copper nanoparticles toxicity and their impact on basic functions in the body. Bratislavske lekarske listy. vol 120. issue 6. 2019-08-29. PMID:31223019. |
keywords: reactive oxygen species; alzheimer disease; acetylcholinesterase; copper; fenton reaction; disorder; heavy metal; pollution; nanoparticle. |
2019-08-29 |
2023-08-13 |
human |
| Jasmina Ćilerdžić, Milica Galić, Jelena Vukojević, Mirjana Staji. Pleurotus ostreatus and Laetiporus sulphureus (Agaricomycetes): Possible Agents against Alzheimer and Parkinson Diseases. International journal of medicinal mushrooms. vol 21. issue 3. 2019-08-07. PMID:31002611. |
previous studies showed that some mushrooms are highly efficient in inhibiting acetylcholinesterase and tyrosinase, the increased activity of which can trigger the development of alzheimer and parkinson diseases. |
2019-08-07 |
2023-08-13 |
Not clear |
| Zhengping Pu, Wenjie Xu, Yong Lin, Juanhui Shen, Yunying Su. Donepezil decreases heart rate in elderly patients with Alzheimer's disease. International journal of clinical pharmacology and therapeutics. vol 57. issue 2. 2019-08-05. PMID:30378536. |
donepezil is an acetylcholinesterase inhibitor (achi) that improves cognitive function in alzheimer's disease (ad) patients. |
2019-08-05 |
2023-08-13 |
Not clear |
| Elham Manouchehrizadeh, Azar Mostoufi, Elham Tahanpesar, Masood Fereidoonnezha. Alignment-independent 3D-QSAR and molecular docking studies of tacrine-4-oxo-4H-Chromene hybrids as anti-Alzheimer's agents. Computational biology and chemistry. vol 80. 2019-08-05. PMID:31170562. |
a series of novel tacrine derivatives as multifunctional agents with potential inhibitory effects on both acetylcholinesterase(ache) and butyrylcholinesterase (buche) enzymes for the treatment of alzheimer's disease(ad), were applied to alignment independent 3d-qsar methods using pentacle software. |
2019-08-05 |
2023-08-13 |
Not clear |
| Kevin Mullane, Michael William. Preclinical Models of Alzheimer's Disease: Relevance and Translational Validity. Current protocols in pharmacology. vol 84. issue 1. 2019-07-31. PMID:30802363. |
the only drugs currently approved for the treatment of alzheimer's disease (ad) are four acetylcholinesterase inhibitors and the nmda antagonist memantine. |
2019-07-31 |
2023-08-13 |
mouse |
| Teobaldo Cuya, Leonardo Baptista, Tanos Celmar Costa Franç. A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease. Journal of biomolecular structure & dynamics. vol 36. issue 14. 2019-07-29. PMID:29096599. |
a molecular dynamics study of components of the ginger (zingiber officinale) extract inside human acetylcholinesterase: implications for alzheimer disease. |
2019-07-29 |
2023-08-13 |
human |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Vinod Kaushik, Sarah Toombs Smith, Emmanuel Mikobi, Mukaila A Raj. Acetylcholinesterase Inhibitors: Beneficial Effects on Comorbidities in Patients With Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 33. issue 2. 2019-07-24. PMID:28974110. |
acetylcholinesterase inhibitors: beneficial effects on comorbidities in patients with alzheimer's disease. |
2019-07-24 |
2023-08-13 |
Not clear |
| Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Le. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 4. 2019-07-17. PMID:30823604. |
discovery of novel acetylcholinesterase inhibitors as potential candidates for the treatment of alzheimer's disease. |
2019-07-17 |
2023-08-13 |
human |
| Enrica Cavedo, Michel J Grothe, Olivier Colliot, Simone Lista, Marie Chupin, Didier Dormont, Marion Houot, Stephane Lehéricy, Stefan Teipel, Bruno Dubois, Harald Hampe. Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-15. PMID:28916821. |
acetylcholinesterase inhibitors are approved drugs currently used for the treatment of alzheimer's disease (ad) dementia. |
2019-07-15 |
2023-08-13 |
Not clear |
| Shibaji Ghosh, Kalyanashis Jana, Bishwajit Gangul. Revealing the mechanistic pathway of cholinergic inhibition of Alzheimer's disease by donepezil: a metadynamics simulation study. Physical chemistry chemical physics : PCCP. vol 21. issue 25. 2019-07-10. PMID:31173012. |
donepezil, an acetylcholinesterase inhibitor, is an approved drug for the symptomatic treatment of alzheimer's disease (ad). |
2019-07-10 |
2023-08-13 |
human |
| Shaik Jeelan Basha, Penumala Mohan, Daniel Pushparaju Yeggoni, Zinka Raveendra Babu, Palaka Bhagath Kumar, Ampasala Dinakara Rao, Rajagopal Subramanyam, Amooru Gangaiah Dam. New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of β-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer's Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase. Molecular pharmaceutics. vol 15. issue 6. 2019-07-03. PMID:29745222. |
new flavone-cyanoacetamide hybrids with a combination of cholinergic, antioxidant, modulation of β-amyloid aggregation, and neuroprotection properties as innovative multifunctional therapeutic candidates for alzheimer's disease and unraveling their mechanism of action with acetylcholinesterase. |
2019-07-03 |
2023-08-13 |
Not clear |
| Claudiane S Marinho, Marcos V F Matias, Iago G F Brandão, Elton L Santos, Sonia S Machado, Carmem L P S Zant. Characterization and kinetic study of the brain and muscle acetylcholinesterase from Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 222. 2019-07-01. PMID:30981910. |
acetylcholinesterase (ache) plays an important role in the therapy of alzheimer's disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. |
2019-07-01 |
2023-08-13 |
zebrafish |