| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominik Szwajgier, Ewa Baranowska-Wójcik, Anna Winiarska-Mieczan, Dorota Gajowniczek-Ałas. Honeys as Possible Sources of Cholinesterase Inhibitors. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889933. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. |
2022-07-27 |
2023-08-14 |
Not clear |
| Katharina Rump, Caroline Holtkamp, Lars Bergmann, Hartmuth Nowak, Matthias Unterberg, Jennifer Orlowski, Patrick Thon, Zainab Bazzi, Maha Bazzi, Michael Adamzik, Björn Koos, Tim Rahme. Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? PloS one. vol 17. issue 7. 2022-07-08. PMID:35802656. |
since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to interfere with its proper metabolism, which can be triggered by epigenetic modifications. |
2022-07-08 |
2023-08-14 |
human |
| Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X Fernandes, Antonio J Moreno-Vargas, José M Padrón, Óscar López, José G Fernández-Bolaño. Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease. Bioorganic chemistry. vol 127. 2022-07-02. PMID:35779403. |
in particular, we have focused our attention on modulating the activity of cholinesterases (ache, buche) in order to restore the levels of the neurotransmitter acetylcholine, and of o-glcnacase (oga), which is associated with hyperphosphorylation of tau protein, in turn related to the formation of neurofibrillary tangles in the brain. |
2022-07-02 |
2023-08-14 |
Not clear |
| Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Ha. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684298. |
ache plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Solveig Tiepolt, Philipp M Meyer, Marianne Patt, Winnie Deuther-Conrad, Swen Hesse, Henryk Barthel, Osama Sabr. PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue Suppl 1. 2022-06-01. PMID:35649648. |
as a neuromodulator, the neurotransmitter acetylcholine plays an important role in cognitive, mood, locomotor, sleep/wake, and olfactory functions. |
2022-06-01 |
2023-08-13 |
Not clear |
| Waisley Yang, Rohit Singla, Oshin Maheshwari, Christine J Fontaine, Joana Gil-Mohape. Alcohol Use Disorder: Neurobiology and Therapeutics. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625928. |
ethanol exerts its toxicity through changes to multiple neurotransmitter systems, including serotonin, dopamine, gamma-aminobutyric acid, glutamate, acetylcholine, and opioid systems. |
2022-05-28 |
2023-08-13 |
Not clear |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Ning-Xin Ma, Brendan Puls, Gong Che. Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion. Developmental neurobiology. 2022-05-24. PMID:35606902. |
neurod family members (neurod1/2/6) and signaling pathways (wnt, mapk, camp) as well as neurotransmitter receptors (acetylcholine, somatostatin, dopamine) were also significantly upregulated. |
2022-05-24 |
2023-08-13 |
Not clear |
| Sarah Könemann, Melissa von Wyl, Colette Vom Ber. Zebrafish Larvae Rapidly Recover from Locomotor Effects and Neuromuscular Alterations Induced by Cholinergic Insecticides. Environmental science & technology. 2022-05-16. PMID:35575681. |
owing to the importance of acetylcholine as a neurotransmitter, many insecticides target the cholinergic system. |
2022-05-16 |
2023-08-13 |
zebrafish |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Piyali Dasgupta, Stephen D Richbart, Austin T Akers, Jamie R Friedman, Sarah L Miles, Eric W Bow, John M Rimoldi, Yi Charlie Che. The choline acetyltransferase inhibitor BW813U inhibits angiogenesis and tumor growth in human lung adenocarcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555890. |
the endogenous ligand for nicotine is the neurotransmitter acetylcholine (ach). |
2022-05-13 |
2023-08-13 |
mouse |
| Pawel Dobrzy. CoA in Health and Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457189. |
coenzyme a (coa) and its thioester derivatives are crucial components of numerous biosynthetic and degradative pathways of the cellular metabolism (including fatty acid synthesis and oxidation, the krebs cycle, ketogenesis, cholesterol and acetylcholine biosynthesis, amino acid degradation, and neurotransmitter biosynthesis), post-translational modifications of proteins, and the regulation of gene expression [...]. |
2022-04-23 |
2023-08-13 |
Not clear |
| Quan Feng Liu, Hoon Choi, Taekwon Son, Young- Mi Kim, Suganya Kanmani, Young- Won Chin, Seung-Nam Kim, Kwang Ki Kim, Kyu-Won Kim, Byung-Soo Ko. Co-treatment with the herbal medicine SIP3 and donepezil improves memory and depression in the mouse model of Alzheimer's disease. Current Alzheimer research. 2022-04-15. PMID:35422218. |
alzheimer's disease (ad) is a lethal, progressive neurodegenerative disorder that has been linked to a deficiency of the neurotransmitter, acetylcholine. |
2022-04-15 |
2023-08-13 |
mouse |
| Fuding Guo, Yueyi Wang, Jun Wang, Zhihao Liu, Yanqiu Lai, Zhen Zhou, Zihan Liu, Yuyang Zhou, Xiao Xu, Zeyan Li, Meng Wang, Fu Yu, Ruijie Hu, Liping Zhou, Hong Jian. Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-04-15. PMID:35422894. |
choline is a precursor of the major neurotransmitter acetylcholine and has been demonstrated beneficial in diverse models of cardiovascular disease. |
2022-04-15 |
2023-08-13 |
Not clear |
| Tesfaye Hailemariam Barkae, Abdallah M Zeid, Guobao X. Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2'-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence. Sensors (Basel, Switzerland). vol 22. issue 7. 2022-04-12. PMID:35408132. |
ache is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. |
2022-04-12 |
2023-08-13 |
Not clear |
| Zhi-Ru Chen, Jia-Bao Huang, Shu-Long Yang, Fen-Fang Hon. Role of Cholinergic Signaling in Alzheimer's Disease. Molecules (Basel, Switzerland). vol 27. issue 6. 2022-03-26. PMID:35335180. |
acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. |
2022-03-26 |
2023-08-13 |
Not clear |
| Miguel A Matilla, Félix Velando, Ana Tajuelo, David Martín-Mora, Wenhao Xu, Victor Sourjik, José A Gavira, Tino Krel. Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine. mBio. 2022-03-07. PMID:35254130. |
in humans, acetylcholine is the primary neurotransmitter of the peripheral nervous system; it mediates signal transmission at neuromuscular junctions. |
2022-03-07 |
2023-08-13 |
human |
| Marta Kopańska, Anna Łagowska, Barbara Kuduk, Agnieszka Banaś-Ząbczy. Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216144. |
within the cholinergic system, there are cholinergic neurons, anatomical cholinergic structures, the neurotransmitter acetylcholine (ach) and cholinergic receptors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Marta Kopańska, Anna Łagowska, Barbara Kuduk, Agnieszka Banaś-Ząbczy. Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216144. |
the cellular molecular mechanism for inhibiting cytokine synthesis is attributed to acetylcholine (ach), the major vagal neurotransmitter, and the α7 nicotinic receptor (α7nachr) subunit is a key receptor for the cholinergic anti-inflammatory pathway. |
2022-02-26 |
2023-08-13 |
Not clear |