| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Solveig Tiepolt, Philipp M Meyer, Marianne Patt, Winnie Deuther-Conrad, Swen Hesse, Henryk Barthel, Osama Sabr. PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue Suppl 1. 2022-06-01. PMID:35649648. |
as a neuromodulator, the neurotransmitter acetylcholine plays an important role in cognitive, mood, locomotor, sleep/wake, and olfactory functions. |
2022-06-01 |
2023-08-13 |
Not clear |
| Waisley Yang, Rohit Singla, Oshin Maheshwari, Christine J Fontaine, Joana Gil-Mohape. Alcohol Use Disorder: Neurobiology and Therapeutics. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625928. |
ethanol exerts its toxicity through changes to multiple neurotransmitter systems, including serotonin, dopamine, gamma-aminobutyric acid, glutamate, acetylcholine, and opioid systems. |
2022-05-28 |
2023-08-13 |
Not clear |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Ning-Xin Ma, Brendan Puls, Gong Che. Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion. Developmental neurobiology. 2022-05-24. PMID:35606902. |
neurod family members (neurod1/2/6) and signaling pathways (wnt, mapk, camp) as well as neurotransmitter receptors (acetylcholine, somatostatin, dopamine) were also significantly upregulated. |
2022-05-24 |
2023-08-13 |
Not clear |
| Sarah Könemann, Melissa von Wyl, Colette Vom Ber. Zebrafish Larvae Rapidly Recover from Locomotor Effects and Neuromuscular Alterations Induced by Cholinergic Insecticides. Environmental science & technology. 2022-05-16. PMID:35575681. |
owing to the importance of acetylcholine as a neurotransmitter, many insecticides target the cholinergic system. |
2022-05-16 |
2023-08-13 |
zebrafish |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Piyali Dasgupta, Stephen D Richbart, Austin T Akers, Jamie R Friedman, Sarah L Miles, Eric W Bow, John M Rimoldi, Yi Charlie Che. The choline acetyltransferase inhibitor BW813U inhibits angiogenesis and tumor growth in human lung adenocarcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555890. |
the endogenous ligand for nicotine is the neurotransmitter acetylcholine (ach). |
2022-05-13 |
2023-08-13 |
mouse |
| Pawel Dobrzy. CoA in Health and Disease. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457189. |
coenzyme a (coa) and its thioester derivatives are crucial components of numerous biosynthetic and degradative pathways of the cellular metabolism (including fatty acid synthesis and oxidation, the krebs cycle, ketogenesis, cholesterol and acetylcholine biosynthesis, amino acid degradation, and neurotransmitter biosynthesis), post-translational modifications of proteins, and the regulation of gene expression [...]. |
2022-04-23 |
2023-08-13 |
Not clear |
| Quan Feng Liu, Hoon Choi, Taekwon Son, Young- Mi Kim, Suganya Kanmani, Young- Won Chin, Seung-Nam Kim, Kwang Ki Kim, Kyu-Won Kim, Byung-Soo Ko. Co-treatment with the herbal medicine SIP3 and donepezil improves memory and depression in the mouse model of Alzheimer's disease. Current Alzheimer research. 2022-04-15. PMID:35422218. |
alzheimer's disease (ad) is a lethal, progressive neurodegenerative disorder that has been linked to a deficiency of the neurotransmitter, acetylcholine. |
2022-04-15 |
2023-08-13 |
mouse |
| Fuding Guo, Yueyi Wang, Jun Wang, Zhihao Liu, Yanqiu Lai, Zhen Zhou, Zihan Liu, Yuyang Zhou, Xiao Xu, Zeyan Li, Meng Wang, Fu Yu, Ruijie Hu, Liping Zhou, Hong Jian. Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway. Oxidative medicine and cellular longevity. vol 2022. 2022-04-15. PMID:35422894. |
choline is a precursor of the major neurotransmitter acetylcholine and has been demonstrated beneficial in diverse models of cardiovascular disease. |
2022-04-15 |
2023-08-13 |
Not clear |
| Tesfaye Hailemariam Barkae, Abdallah M Zeid, Guobao X. Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2'-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence. Sensors (Basel, Switzerland). vol 22. issue 7. 2022-04-12. PMID:35408132. |
ache is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. |
2022-04-12 |
2023-08-13 |
Not clear |
| Zhi-Ru Chen, Jia-Bao Huang, Shu-Long Yang, Fen-Fang Hon. Role of Cholinergic Signaling in Alzheimer's Disease. Molecules (Basel, Switzerland). vol 27. issue 6. 2022-03-26. PMID:35335180. |
acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. |
2022-03-26 |
2023-08-13 |
Not clear |
| Miguel A Matilla, Félix Velando, Ana Tajuelo, David Martín-Mora, Wenhao Xu, Victor Sourjik, José A Gavira, Tino Krel. Chemotaxis of the Human Pathogen Pseudomonas aeruginosa to the Neurotransmitter Acetylcholine. mBio. 2022-03-07. PMID:35254130. |
in humans, acetylcholine is the primary neurotransmitter of the peripheral nervous system; it mediates signal transmission at neuromuscular junctions. |
2022-03-07 |
2023-08-13 |
human |
| Marta Kopańska, Anna Łagowska, Barbara Kuduk, Agnieszka Banaś-Ząbczy. Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216144. |
within the cholinergic system, there are cholinergic neurons, anatomical cholinergic structures, the neurotransmitter acetylcholine (ach) and cholinergic receptors. |
2022-02-26 |
2023-08-13 |
Not clear |
| Marta Kopańska, Anna Łagowska, Barbara Kuduk, Agnieszka Banaś-Ząbczy. Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216144. |
the cellular molecular mechanism for inhibiting cytokine synthesis is attributed to acetylcholine (ach), the major vagal neurotransmitter, and the α7 nicotinic receptor (α7nachr) subunit is a key receptor for the cholinergic anti-inflammatory pathway. |
2022-02-26 |
2023-08-13 |
Not clear |
| Jia-Yu Liu, Run-Qi Zheng, Yao Wang, Yan-Hong Liu, Shuai Jiang, Xin-Zheng Wang, Kun He, Xin Pan, Tao Zhou, Tao Li, Qing Xia, Wei-Na Zhan. The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in Metabolites. vol 12. issue 2. 2022-02-25. PMID:35208251. |
the choline derivative glycerophosphocholine (gpc), an important precursor of the neurotransmitter acetylcholine, plays important roles in brain and nervous system function. |
2022-02-25 |
2023-08-13 |
mouse |
| Lukas G Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhause. Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves. Micromachines. vol 13. issue 2. 2022-02-25. PMID:35208411. |
according to the current model of nerve propagation, the function of acetylcholinesterase (ache) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ach) in the synaptic cleft to acetic acid (acetate) and choline. |
2022-02-25 |
2023-08-13 |
Not clear |
| Christian Fillafer, Yana S Koll, Matthias F Schneide. Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission. Membranes. vol 12. issue 1. 2022-01-21. PMID:35054529. |
in cholinergic synapses, the neurotransmitter acetylcholine (ach) is rapidly hydrolyzed by esterases to choline and acetic acid (ah). |
2022-01-21 |
2023-08-13 |
Not clear |
| Ana Sofía Vallés, Francisco J Barrante. Dendritic spine membrane proteome and its alterations in autistic spectrum disorder. Advances in protein chemistry and structural biology. vol 128. 2022-01-17. PMID:35034726. |
since cholinergic neurotransmission participates in the regulation of cognitive function (attention, memory, learning processes, cognitive flexibility, social interactions) brain acetylcholine receptors are likely to play an important role in the dysfunctional synapses in asd, either directly or indirectly via the modulatory functions exerted on other neurotransmitter receptor proteins and spine-resident proteins. |
2022-01-17 |
2023-08-13 |
Not clear |
| Ayland C Letsinger, Zhenglin Gu, Jerrel L Yake. α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity. Trends in neurosciences. 2021-12-17. PMID:34916082. |
cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ach) to coordinate neuronal circuit activity while simultaneously influencing the function of non-neuronal cell types. |
2021-12-17 |
2023-08-13 |
Not clear |