Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
inhibiting ache is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage ad. |
2023-10-20 |
2023-11-08 |
Not clear |
Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sánchez-Lopez, Cristian Paz, Jesús Ureña, Ester Verdaguer, Carme Auladell, Antoni Camin. Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762479. |
lico-a also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (ach) in the brain. |
2023-09-28 |
2023-10-07 |
Not clear |
Eve Braithwaite, Oliver M Todd, Abigail Atkin, Rachel Hulatt, Ragy Tadrous, David P Alldred, Munir Pirmohamed, Lauren Walker, Rebecca Lawton, Andrew Cleg. Interventions for reducing anticholinergic medication burden in older adults-a systematic review and meta-analysis. Age and ageing. vol 52. issue 9. 2023-09-23. PMID:37740900. |
anticholinergic medications block the neurotransmitter acetylcholine in the brain and peripheral nervous system. |
2023-09-23 |
2023-10-07 |
Not clear |
Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
Yash Pal Singh, Harish Kuma. Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review. Chemical biology & drug design. 2023-09-04. PMID:37665093. |
however low level of the neurotransmitter named acetylcholine (ach), aggregation of aβ peptide into toxic aβ plaque, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress are the main hallmarks of this disease. |
2023-09-04 |
2023-09-07 |
Not clear |
Junko Yaguchi, Shunsuke Yaguch. Rx and its downstream factor, Musashi1, is required for establishment of the apical organ in sea urchin larvae. Frontiers in cell and developmental biology. vol 11. 2023-09-01. PMID:37655161. |
acetylcholine, a vital neurotransmitter, plays a multifarious role in the brain and peripheral nervous system of various organisms. |
2023-09-01 |
2023-09-07 |
Not clear |
Moncef Zoual. Pharmacological and Electroceutical Targeting of the Cholinergic Anti-Inflammatory Pathway in Autoimmune Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 8. 2023-08-26. PMID:37631004. |
in the cholinergic anti-inflammatory pathway, the vagus nerve, its pivotal neurotransmitter acetylcholine, together with the corresponding receptors play a key role in modulating the immune response of mammals. |
2023-08-26 |
2023-09-07 |
Not clear |
Yann S Mineur, Marina R Picciott. How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches. Journal of neurochemistry. 2023-08-25. PMID:37621094. |
the neurotransmitter acetylcholine (ach) plays a central role in the regulation of multiple cognitive and behavioral processes, including attention, learning, memory, motivation, anxiety, mood, appetite, and reward. |
2023-08-25 |
2023-09-07 |
Not clear |
Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
Daniela Poenaru, Miruna Ioana Sandulescu, Delia Cintez. Pain Modulation in Chronic Musculoskeletal Disorders: Botulinum Toxin, a Descriptive Analysis. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509527. |
botulinum neurotoxin (bont), a product of clostridium botulinum, reversibly inhibits the presynaptic release of the neurotransmitter acetylcholine at the neuromuscular junction. |
2023-07-29 |
2023-08-14 |
Not clear |
Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
the depletion of the neurotransmitter acetylcholine has been suggested to contribute to the reduced cognitive function observed in individuals suffering from neurodegenerative diseases such as alzheimer's disease (ad). |
2023-06-26 |
2023-08-14 |
Not clear |
Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
to reduce acetylcholine degradation and help restore the pool of the neurotransmitter, specific and potent bche inhibitors are sought. |
2023-06-26 |
2023-08-14 |
Not clear |
Soyogu Yamashita, Naoki Kawada, Wei Wang, Kenta Susaki, Yumi Takeda, Mamoru Kimura, Yoshitaka Iwama, Yutaka Miura, Michihiro Sugano, Ryosuke Matsuok. Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study. Lipids in health and disease. vol 22. issue 1. 2023-06-20. PMID:37340479. |
choline, as a neurotransmitter acetylcholine precursor, is reportedly associated with cognitive function. |
2023-06-20 |
2023-08-14 |
Not clear |
Jiaxin Zheng, Sisi Peng, Lingling Cui, Xi Liu, Tian Li, Zhenyu Zhao, Yaqing Li, Yuan Hu, Miao Zhang, Linling Xu, JunJian Zhan. Enriched environment attenuates hippocampal theta and gamma rhythms dysfunction in chronic cerebral hypoperfusion via improving imbalanced neural afferent levels. Frontiers in cellular neuroscience. vol 17. 2023-06-02. PMID:37265581. |
furthermore, the expression of the three neurotransmitter vesicular transporters-vesicular acetylcholine transporters (vacht) and vesicular gaba transporters (vgat)-was significantly reduced in cch rats, whereas the expression of vesicular glutamate transporter 1 (vglut1) was abnormally elevated. |
2023-06-02 |
2023-08-14 |
rat |
Alexandra Ure, Georgina R Cox, Richard Haslam, Katrina William. Acetylcholinesterase inhibitors for autistic spectrum disorders. The Cochrane database of systematic reviews. vol 6. 2023-06-02. PMID:37267443. |
acetylcholine is a neurotransmitter for the cholinergic system and has a role in attention, novelty seeking, and memory. |
2023-06-02 |
2023-08-14 |
Not clear |
Shah Alam Khan, Mohammad Jawaid Akhtar, Urvashee Gogoi, Dhanalekshmi Unnikrishnan Meenakshi, Aparoop Da. An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities. Pharmaceuticals (Basel, Switzerland). vol 16. issue 2. 2023-06-01. PMID:37259329. |
acetylcholine (ach) neurotransmitter of the cholinergic system in the brain is involved in learning, memory, stress responses, and cognitive functioning. |
2023-06-01 |
2023-08-14 |
Not clear |
Joanna Grzelczyk, Dominik Szwajgier, Ewa Baranowska-Wójcik, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Bożena Sosnowska, Grażyna Budry. Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242249. |
butyrylcholinesterase (bche) is a major enzyme from the alpha-glycoprotein family that catalyzes the hydrolysis of neurotransmitter acetylcholine (ach), lowering the concentration of ach in the nervous system, which could cause aggravation of alzheimer's disease (ad). |
2023-05-27 |
2023-08-14 |
Not clear |
Maciej Świątkiewicz, Paweł Grie. Citicoline for Supporting Memory in Aging Humans. Aging and disease. 2023-05-17. PMID:37196134. |
choline is a precursor of acetylcholine and phospholipids; these is a neurotransmitter pivotal for learning and memory and important constituents of neuronal membranes and myelin sheaths, respectively. |
2023-05-17 |
2023-08-14 |
Not clear |
Priyanka De, Kunal Ro. Computational modeling of PET imaging agents for vesicular acetylcholine transporter (VAChT) protein binding affinity: application of 2D-QSAR modeling and molecular docking techniques. In silico pharmacology. vol 11. issue 1. 2023-04-10. PMID:37035236. |
the neurotransmitter acetylcholine (ach) plays a ubiquitous role in cognitive functions including learning and memory with widespread innervation in the cortex, subcortical structures, and the cerebellum. |
2023-04-10 |
2023-08-14 |
Not clear |