| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soyogu Yamashita, Naoki Kawada, Wei Wang, Kenta Susaki, Yumi Takeda, Mamoru Kimura, Yoshitaka Iwama, Yutaka Miura, Michihiro Sugano, Ryosuke Matsuok. Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study. Lipids in health and disease. vol 22. issue 1. 2023-06-20. PMID:37340479. |
choline, as a neurotransmitter acetylcholine precursor, is reportedly associated with cognitive function. |
2023-06-20 |
2023-08-14 |
Not clear |
| Jiaxin Zheng, Sisi Peng, Lingling Cui, Xi Liu, Tian Li, Zhenyu Zhao, Yaqing Li, Yuan Hu, Miao Zhang, Linling Xu, JunJian Zhan. Enriched environment attenuates hippocampal theta and gamma rhythms dysfunction in chronic cerebral hypoperfusion via improving imbalanced neural afferent levels. Frontiers in cellular neuroscience. vol 17. 2023-06-02. PMID:37265581. |
furthermore, the expression of the three neurotransmitter vesicular transporters-vesicular acetylcholine transporters (vacht) and vesicular gaba transporters (vgat)-was significantly reduced in cch rats, whereas the expression of vesicular glutamate transporter 1 (vglut1) was abnormally elevated. |
2023-06-02 |
2023-08-14 |
rat |
| Alexandra Ure, Georgina R Cox, Richard Haslam, Katrina William. Acetylcholinesterase inhibitors for autistic spectrum disorders. The Cochrane database of systematic reviews. vol 6. 2023-06-02. PMID:37267443. |
acetylcholine is a neurotransmitter for the cholinergic system and has a role in attention, novelty seeking, and memory. |
2023-06-02 |
2023-08-14 |
Not clear |
| Shah Alam Khan, Mohammad Jawaid Akhtar, Urvashee Gogoi, Dhanalekshmi Unnikrishnan Meenakshi, Aparoop Da. An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities. Pharmaceuticals (Basel, Switzerland). vol 16. issue 2. 2023-06-01. PMID:37259329. |
acetylcholine (ach) neurotransmitter of the cholinergic system in the brain is involved in learning, memory, stress responses, and cognitive functioning. |
2023-06-01 |
2023-08-14 |
Not clear |
| Joanna Grzelczyk, Dominik Szwajgier, Ewa Baranowska-Wójcik, Horacio Pérez-Sánchez, Miguel Carmena-Bargueño, Bożena Sosnowska, Grażyna Budry. Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies. Nutrients. vol 15. issue 10. 2023-05-27. PMID:37242249. |
butyrylcholinesterase (bche) is a major enzyme from the alpha-glycoprotein family that catalyzes the hydrolysis of neurotransmitter acetylcholine (ach), lowering the concentration of ach in the nervous system, which could cause aggravation of alzheimer's disease (ad). |
2023-05-27 |
2023-08-14 |
Not clear |
| Maciej Świątkiewicz, Paweł Grie. Citicoline for Supporting Memory in Aging Humans. Aging and disease. 2023-05-17. PMID:37196134. |
choline is a precursor of acetylcholine and phospholipids; these is a neurotransmitter pivotal for learning and memory and important constituents of neuronal membranes and myelin sheaths, respectively. |
2023-05-17 |
2023-08-14 |
Not clear |
| Priyanka De, Kunal Ro. Computational modeling of PET imaging agents for vesicular acetylcholine transporter (VAChT) protein binding affinity: application of 2D-QSAR modeling and molecular docking techniques. In silico pharmacology. vol 11. issue 1. 2023-04-10. PMID:37035236. |
the neurotransmitter acetylcholine (ach) plays a ubiquitous role in cognitive functions including learning and memory with widespread innervation in the cortex, subcortical structures, and the cerebellum. |
2023-04-10 |
2023-08-14 |
Not clear |
| Yang Jiao, Guiyu Kang, Pan Pan, Huiping Fan, Qiang Li, Xiangying Li, Jingtan Li, Yan Wang, Yanfei Jia, Lulu Zhang, Haiji Sun, Xiaoli M. Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway. Cellular and molecular life sciences : CMLS. vol 80. issue 5. 2023-04-07. PMID:37029227. |
in this study, we found that chronic restraint stress increases the levels of the neurotransmitter acetylcholine (ach), and the α5-nicotinic acetylcholine receptor (α5-nachr) and decreased fragile histidine triad (fhit) expression in vivo. |
2023-04-07 |
2023-08-14 |
mouse |
| Vahulabaranan Rajagopalan, Swethaa Venkataraman, Devi Sri Rajendran, Vaidyanathan Vinoth Kumar, Vaithyanathan Vasanth Kumar, Gayathri Rangasam. Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review. Environmental research. 2023-03-22. PMID:36948285. |
acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: a literature review. |
2023-03-22 |
2023-08-14 |
human |
| Neža Žnidaršič, Malan Štrbenc, Neža Grgurevič, Tomaž Sno. Potential revival of cholinesterase inhibitors as drugs in veterinary medicine. Frontiers in veterinary science. vol 10. 2023-03-20. PMID:36937006. |
the cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ach) as almost its only neurotransmitter. |
2023-03-20 |
2023-08-14 |
Not clear |
| Francisco J Barrante. Structure and function meet at the nicotinic acetylcholine receptor-lipid interface. Pharmacological research. 2023-03-17. PMID:36931540. |
the nicotinic acetylcholine receptor (nachr) is a transmembrane protein that mediates fast intercellular communication in response to the endogenous neurotransmitter acetylcholine. |
2023-03-17 |
2023-08-14 |
Not clear |
| Abdussamat Güze. Relationship Between Phenolic Content Determined by LC-MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium Niveum L. Chemistry & biodiversity. 2023-03-09. PMID:36891984. |
the phytochemical composition of the plant, inhibition of acetylcholinesterase (ache) (which hydrolyzes the neurotransmitter acetylcholine), inhibition of paraoxonase for antiatherosclerotic activity (hpon 1) (which detoxifies organophosphates), and antioxidant capacity of this plant. |
2023-03-09 |
2023-08-14 |
Not clear |
| Brandy Somera, Marla Frick, Jim R Fade. Age-related changes in basal forebrain afferent activation in response to food paired stimuli. Neuroscience letters. 2023-02-26. PMID:36842481. |
the basal forebrain contains a phenotypically-diverse assembly of neurons, including those using acetylcholine as their neurotransmitter. |
2023-02-26 |
2023-08-14 |
rat |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
the serine hydrolase acetylcholinesterase (ache) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitter acetylcholine and other choline esters. |
2023-02-17 |
2023-08-14 |
Not clear |
| Shuai Liu, Wenhui Qiu, Rongzhen Li, Bei Chen, Xin Wu, Jason T Magnuson, Bentuo Xu, Shusheng Luo, Elvis Genbo Xu, Chunmiao Zhen. Perfluorononanoic Acid Induces Neurotoxicity via Synaptogenesis Signaling in Zebrafish. Environmental science & technology. 2023-02-16. PMID:36797597. |
neurotransmitter levels (acetylcholine, glutamate, 5-hydroxytryptamine, γ-aminobutyric acid, dopamine, and noradrenaline) were significantly decreased in zebrafish larvae, and the tg( |
2023-02-16 |
2023-08-14 |
zebrafish |
| Jianzhi Zeng, Xuelin Li, Renzimo Zhang, Mingyue Lv, Yipan Wang, Ke Tan, Xiju Xia, Jinxia Wan, Miao Jing, Xiuning Zhang, Yu Li, Yang Yang, Liang Wang, Jun Chu, Yan Li, Yulong L. Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning. Neuron. 2023-01-27. PMID:36706757. |
utilizing gpcr-activation-based (grab) neurotransmitter sensors, we found that kc-released acetylcholine (ach) activates a serotonergic dorsal paired medial (dpm) neuron, which in turn provides inhibitory feedback to kcs. |
2023-01-27 |
2023-08-14 |
drosophila_melanogaster |
| Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marde. Biological Evaluation of Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678626. |
biological evaluation of alzheimer's disease (ad) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. |
2023-01-21 |
2023-08-14 |
Not clear |
| Ben Shor. Two distinct pathways regulate chromaffin cell exocytosis. The Journal of general physiology. vol 155. issue 2. 2023-01-20. PMID:36661929. |
jgp study reveals how the neurotransmitter pacap induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine. |
2023-01-20 |
2023-08-14 |
Not clear |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Rajsekhar Roy, Juhee Khan, Krishnangsu Pradhan, Prasunpriya Nayak, Ankan Sarkar, Subhadra Nandi, Surojit Ghosh, Heera Ram, Surajit Ghos. Short Peptoid Evolved from the Key Hydrophobic Stretch of Amyloid-β42 Peptide Serves as a Potent Therapeutic Lead of Alzheimer's Disease. ACS chemical neuroscience. 2022-12-30. PMID:36583718. |
aβ42 also plays the key role in the onset of other ad-related factors including hyperphosphorylation of tau protein that forms intracellular neurofibrillary tangles, imbalances in the function of the neurotransmitter acetylcholine, and even generation of reactive oxygen species (ros), disrupting the cytoskeleton and homeostasis of the cell. |
2022-12-30 |
2023-08-14 |
Not clear |