| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Ha Kim, Hye Rim Suh, Hee Chul Ha. The effects of the cholinergic system on carrageenan-induced arthritis. Neuroscience letters. 2024-01-23. PMID:38262509. |
the cholinergic system has been found to make an anti-inflammatory effect through the cholinergic anti-inflammatory pathway (caip), which suppresses the production of pro-inflammatory cytokines by secreting acetylcholine, a major neurotransmitter. |
2024-01-23 |
2024-01-26 |
rat |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the cholinergic system, relying on the neurotransmitter acetylcholine (ach), plays a significant role in muscle contraction, cognition, and autonomic nervous system regulation. |
2024-01-11 |
2024-01-13 |
Not clear |
| Rima Obeid, Therese Karlsso. Choline - a scoping review for Nordic Nutrition Recommendations 2023. Food & nutrition research. vol 67. 2024-01-08. PMID:38187796. |
choline is an essential nutrient with metabolic roles as a methyl donor in one carbon metabolism and as a precursor for membrane phospholipids and the neurotransmitter acetylcholine. |
2024-01-08 |
2024-01-10 |
human |
| Laura Kubens, Ann-Kathrin Weishaupt, Vivien Michaelis, Isabelle Rohn, Fabian Mohr, Julia Bornhors. Exposure to the environmentally relevant fungicide Maneb: Studying toxicity in the soil nematode Caenorhabditis elegans. Environment international. vol 183. 2023-12-10. PMID:38071851. |
nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (gaba) was observed as well as morphological changes in the dopaminergic neurons upon maneb exposure, which underlines the assumption of the neurotoxic potential of maneb. |
2023-12-10 |
2023-12-17 |
caenorhabditis_elegans |
| Maciej Noga, Agata Michalska, Kamil Jurowsk. The prediction of acute toxicity (LD Archives of toxicology. 2023-12-05. PMID:38051368. |
the prediction of acute toxicity (ld nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. |
2023-12-05 |
2023-12-10 |
Not clear |
| Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A Attia, Asmaa M Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Al. Heliyon. vol 9. issue 11. 2023-11-13. PMID:37954293. |
acetylcholinesterase breaks down the neurotransmitter acetylcholine, important for neural transmission. |
2023-11-13 |
2023-11-20 |
Not clear |
| Jingxuan Guo, Jia Sun, Donghui Liu, Ji Liu, Lijuan Gui, Man Luo, Dexin Kong, Sainaiwaiergul Wusiman, Chang Yang, Ting Liu, Zhenwei Yuan, Ruixi L. Developing a Two-Photon "AND" Logic Probe and Its Application in Alzheimer's Disease Differentiation. Analytical chemistry. 2023-11-10. PMID:37947381. |
in alzheimer's disease, hypochlorous acid involved in the clearance of invading bacteria or pathogens and butyrylcholinesterase engaged in the hydrolysis of the neurotransmitter acetylcholine are relatively significantly altered. |
2023-11-10 |
2023-11-20 |
mouse |
| Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
inhibiting ache is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage ad. |
2023-10-20 |
2023-11-08 |
Not clear |
| Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sánchez-Lopez, Cristian Paz, Jesús Ureña, Ester Verdaguer, Carme Auladell, Antoni Camin. Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762479. |
lico-a also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (ach) in the brain. |
2023-09-28 |
2023-10-07 |
Not clear |
| Eve Braithwaite, Oliver M Todd, Abigail Atkin, Rachel Hulatt, Ragy Tadrous, David P Alldred, Munir Pirmohamed, Lauren Walker, Rebecca Lawton, Andrew Cleg. Interventions for reducing anticholinergic medication burden in older adults-a systematic review and meta-analysis. Age and ageing. vol 52. issue 9. 2023-09-23. PMID:37740900. |
anticholinergic medications block the neurotransmitter acetylcholine in the brain and peripheral nervous system. |
2023-09-23 |
2023-10-07 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Yash Pal Singh, Harish Kuma. Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review. Chemical biology & drug design. 2023-09-04. PMID:37665093. |
however low level of the neurotransmitter named acetylcholine (ach), aggregation of aβ peptide into toxic aβ plaque, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress are the main hallmarks of this disease. |
2023-09-04 |
2023-09-07 |
Not clear |
| Junko Yaguchi, Shunsuke Yaguch. Rx and its downstream factor, Musashi1, is required for establishment of the apical organ in sea urchin larvae. Frontiers in cell and developmental biology. vol 11. 2023-09-01. PMID:37655161. |
acetylcholine, a vital neurotransmitter, plays a multifarious role in the brain and peripheral nervous system of various organisms. |
2023-09-01 |
2023-09-07 |
Not clear |
| Moncef Zoual. Pharmacological and Electroceutical Targeting of the Cholinergic Anti-Inflammatory Pathway in Autoimmune Diseases. Pharmaceuticals (Basel, Switzerland). vol 16. issue 8. 2023-08-26. PMID:37631004. |
in the cholinergic anti-inflammatory pathway, the vagus nerve, its pivotal neurotransmitter acetylcholine, together with the corresponding receptors play a key role in modulating the immune response of mammals. |
2023-08-26 |
2023-09-07 |
Not clear |
| Yann S Mineur, Marina R Picciott. How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches. Journal of neurochemistry. 2023-08-25. PMID:37621094. |
the neurotransmitter acetylcholine (ach) plays a central role in the regulation of multiple cognitive and behavioral processes, including attention, learning, memory, motivation, anxiety, mood, appetite, and reward. |
2023-08-25 |
2023-09-07 |
Not clear |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
| Daniela Poenaru, Miruna Ioana Sandulescu, Delia Cintez. Pain Modulation in Chronic Musculoskeletal Disorders: Botulinum Toxin, a Descriptive Analysis. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509527. |
botulinum neurotoxin (bont), a product of clostridium botulinum, reversibly inhibits the presynaptic release of the neurotransmitter acetylcholine at the neuromuscular junction. |
2023-07-29 |
2023-08-14 |
Not clear |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
the depletion of the neurotransmitter acetylcholine has been suggested to contribute to the reduced cognitive function observed in individuals suffering from neurodegenerative diseases such as alzheimer's disease (ad). |
2023-06-26 |
2023-08-14 |
Not clear |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
to reduce acetylcholine degradation and help restore the pool of the neurotransmitter, specific and potent bche inhibitors are sought. |
2023-06-26 |
2023-08-14 |
Not clear |