| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |
| A Saud, V Krishnaraju, A Taha, K Kalpana, V Malarkodi, S Durgaramani, V Vinoth Prabhu, F A Saleh, S Ezhilarasa. Potential acetylcholinesterase inhibitors to treat Alzheimer's disease. European review for medical and pharmacological sciences. vol 28. issue 6. 2024-04-03. PMID:38567612. |
a lack of the brain neurotransmitter acetylcholine has been related to the etiology of alzheimer's disease. |
2024-04-03 |
2024-04-05 |
Not clear |
| Arash Salehi, Behzad Zolfaghari, Mahmoud Aghaei, Hajar Sirous, Morteza Sadeghi, Mohammad Reza Gholami, Parham Reisi, Mustafa Ghanadia. New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2024-03-18. PMID:38498253. |
the cholinergic hypothesis posits a robust correlation between the onset of alzheimer's disease and a pronounced deficit in acetylcholine, a pivotal neurotransmitter crucial for the central cholinergic nervous system's function, pivotal for memory and learning. |
2024-03-18 |
2024-03-21 |
Not clear |
| Xiujuan Huang, Yuanyuan Cheng, Qi Zhou, Yifeng Tu, Jilin Ya. A simple fluorescence detection of acetylcholinesterase with peroxidase-like catalysis from iodide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 313. 2024-03-15. PMID:38490124. |
acetylcholinesterase (ache) is an important enzyme in the central and peripheral nervous system that regulates the balance of the neurotransmitter acetylcholine. |
2024-03-15 |
2024-03-18 |
Not clear |
| Natalia G Vallianou, Dimitris Kounatidis, Sotiria Psallida, Fotis Panagopoulos, Theodora Stratigou, Eleni Geladari, Irene Karampela, Dimitrios Tsilingiris, Maria Dalamag. The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence. Current nutrition reports. 2024-03-01. PMID:38427291. |
choline is an essential nutrient for human health and cellular homeostasis as it is necessary for the synthesis of lipid cell membranes, lipoproteins, and the synthesis of the neurotransmitter acetylcholine. |
2024-03-01 |
2024-03-03 |
human |
| Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. |
a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Min Ha Kim, Hye Rim Suh, Hee Chul Ha. The effects of the cholinergic system on carrageenan-induced arthritis. Neuroscience letters. 2024-01-23. PMID:38262509. |
the cholinergic system has been found to make an anti-inflammatory effect through the cholinergic anti-inflammatory pathway (caip), which suppresses the production of pro-inflammatory cytokines by secreting acetylcholine, a major neurotransmitter. |
2024-01-23 |
2024-01-26 |
rat |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the cholinergic system, relying on the neurotransmitter acetylcholine (ach), plays a significant role in muscle contraction, cognition, and autonomic nervous system regulation. |
2024-01-11 |
2024-01-13 |
Not clear |
| Rima Obeid, Therese Karlsso. Choline - a scoping review for Nordic Nutrition Recommendations 2023. Food & nutrition research. vol 67. 2024-01-08. PMID:38187796. |
choline is an essential nutrient with metabolic roles as a methyl donor in one carbon metabolism and as a precursor for membrane phospholipids and the neurotransmitter acetylcholine. |
2024-01-08 |
2024-01-10 |
human |
| Laura Kubens, Ann-Kathrin Weishaupt, Vivien Michaelis, Isabelle Rohn, Fabian Mohr, Julia Bornhors. Exposure to the environmentally relevant fungicide Maneb: Studying toxicity in the soil nematode Caenorhabditis elegans. Environment international. vol 183. 2023-12-10. PMID:38071851. |
nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (gaba) was observed as well as morphological changes in the dopaminergic neurons upon maneb exposure, which underlines the assumption of the neurotoxic potential of maneb. |
2023-12-10 |
2023-12-17 |
caenorhabditis_elegans |
| Maciej Noga, Agata Michalska, Kamil Jurowsk. The prediction of acute toxicity (LD Archives of toxicology. 2023-12-05. PMID:38051368. |
the prediction of acute toxicity (ld nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. |
2023-12-05 |
2023-12-10 |
Not clear |
| Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A Attia, Asmaa M Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Al. Heliyon. vol 9. issue 11. 2023-11-13. PMID:37954293. |
acetylcholinesterase breaks down the neurotransmitter acetylcholine, important for neural transmission. |
2023-11-13 |
2023-11-20 |
Not clear |
| Jingxuan Guo, Jia Sun, Donghui Liu, Ji Liu, Lijuan Gui, Man Luo, Dexin Kong, Sainaiwaiergul Wusiman, Chang Yang, Ting Liu, Zhenwei Yuan, Ruixi L. Developing a Two-Photon "AND" Logic Probe and Its Application in Alzheimer's Disease Differentiation. Analytical chemistry. 2023-11-10. PMID:37947381. |
in alzheimer's disease, hypochlorous acid involved in the clearance of invading bacteria or pathogens and butyrylcholinesterase engaged in the hydrolysis of the neurotransmitter acetylcholine are relatively significantly altered. |
2023-11-10 |
2023-11-20 |
mouse |
| Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
inhibiting ache is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage ad. |
2023-10-20 |
2023-11-08 |
Not clear |
| Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sánchez-Lopez, Cristian Paz, Jesús Ureña, Ester Verdaguer, Carme Auladell, Antoni Camin. Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762479. |
lico-a also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (ach) in the brain. |
2023-09-28 |
2023-10-07 |
Not clear |
| Eve Braithwaite, Oliver M Todd, Abigail Atkin, Rachel Hulatt, Ragy Tadrous, David P Alldred, Munir Pirmohamed, Lauren Walker, Rebecca Lawton, Andrew Cleg. Interventions for reducing anticholinergic medication burden in older adults-a systematic review and meta-analysis. Age and ageing. vol 52. issue 9. 2023-09-23. PMID:37740900. |
anticholinergic medications block the neurotransmitter acetylcholine in the brain and peripheral nervous system. |
2023-09-23 |
2023-10-07 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Yash Pal Singh, Harish Kuma. Berberine derivatives as inhibitors of acetylcholinesterase: A systematic review. Chemical biology & drug design. 2023-09-04. PMID:37665093. |
however low level of the neurotransmitter named acetylcholine (ach), aggregation of aβ peptide into toxic aβ plaque, hyperphosphorylation of tau, bio-metal imbalance, and oxidative stress are the main hallmarks of this disease. |
2023-09-04 |
2023-09-07 |
Not clear |