| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandy Somera, Marla Frick, Jim R Fade. Age-related changes in basal forebrain afferent activation in response to food paired stimuli. Neuroscience letters. 2023-02-26. PMID:36842481. |
the basal forebrain contains a phenotypically-diverse assembly of neurons, including those using acetylcholine as their neurotransmitter. |
2023-02-26 |
2023-08-14 |
rat |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
the serine hydrolase acetylcholinesterase (ache) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitter acetylcholine and other choline esters. |
2023-02-17 |
2023-08-14 |
Not clear |
| Shuai Liu, Wenhui Qiu, Rongzhen Li, Bei Chen, Xin Wu, Jason T Magnuson, Bentuo Xu, Shusheng Luo, Elvis Genbo Xu, Chunmiao Zhen. Perfluorononanoic Acid Induces Neurotoxicity via Synaptogenesis Signaling in Zebrafish. Environmental science & technology. 2023-02-16. PMID:36797597. |
neurotransmitter levels (acetylcholine, glutamate, 5-hydroxytryptamine, γ-aminobutyric acid, dopamine, and noradrenaline) were significantly decreased in zebrafish larvae, and the tg( |
2023-02-16 |
2023-08-14 |
zebrafish |
| Jianzhi Zeng, Xuelin Li, Renzimo Zhang, Mingyue Lv, Yipan Wang, Ke Tan, Xiju Xia, Jinxia Wan, Miao Jing, Xiuning Zhang, Yu Li, Yang Yang, Liang Wang, Jun Chu, Yan Li, Yulong L. Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning. Neuron. 2023-01-27. PMID:36706757. |
utilizing gpcr-activation-based (grab) neurotransmitter sensors, we found that kc-released acetylcholine (ach) activates a serotonergic dorsal paired medial (dpm) neuron, which in turn provides inhibitory feedback to kcs. |
2023-01-27 |
2023-08-14 |
drosophila_melanogaster |
| Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernán Gerónimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marde. Biological Evaluation of Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678626. |
biological evaluation of alzheimer's disease (ad) is a neurodegenerative disorder whose pathophysiology includes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. |
2023-01-21 |
2023-08-14 |
Not clear |
| Ben Shor. Two distinct pathways regulate chromaffin cell exocytosis. The Journal of general physiology. vol 155. issue 2. 2023-01-20. PMID:36661929. |
jgp study reveals how the neurotransmitter pacap induces a secretory response in chromaffin cells that differs from the one induced by acetylcholine. |
2023-01-20 |
2023-08-14 |
Not clear |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Rajsekhar Roy, Juhee Khan, Krishnangsu Pradhan, Prasunpriya Nayak, Ankan Sarkar, Subhadra Nandi, Surojit Ghosh, Heera Ram, Surajit Ghos. Short Peptoid Evolved from the Key Hydrophobic Stretch of Amyloid-β42 Peptide Serves as a Potent Therapeutic Lead of Alzheimer's Disease. ACS chemical neuroscience. 2022-12-30. PMID:36583718. |
aβ42 also plays the key role in the onset of other ad-related factors including hyperphosphorylation of tau protein that forms intracellular neurofibrillary tangles, imbalances in the function of the neurotransmitter acetylcholine, and even generation of reactive oxygen species (ros), disrupting the cytoskeleton and homeostasis of the cell. |
2022-12-30 |
2023-08-14 |
Not clear |
| Júlia L B Simões, Leilane D Sobierai, Inayá F Leal, Miriam V R Dos Santos, João Victor Coiado, Margarete D Bagatin. Action of the purinergic and cholinergic anti-inflammatory pathways on oxidative stress in patients with Alzheimer's disease in the context of the COVID-19 pandemic. Neuroscience. 2022-12-16. PMID:36526078. |
the cholinergic system, through neurons and the neurotransmitter acetylcholine (ach), modulates various physiological pathways, such as the response to stress, sleep and wakefulness, sensory information, and the cognitive system. |
2022-12-16 |
2023-08-14 |
Not clear |
| Mahmut O Karaytug, Neslihan Balcı, Fikret Türkan, Mahmut Gurbuz, Mehmet E Demirkol, Zeynep Namlı, Lut Tamam, İlhami Gulci. Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S-transferase inhibitors. Journal of biochemical and molecular toxicology. 2022-11-24. PMID:36419212. |
cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ach), a naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous system to function properly. |
2022-11-24 |
2023-08-14 |
human |
| Sana Latif, Young-Sook Kan. Protective Effects of Choline against Inflammatory Cytokines and Characterization of Transport in Motor Neuron-like Cell Lines (NSC-34). Pharmaceutics. vol 14. issue 11. 2022-11-11. PMID:36365192. |
choline, a component of the neurotransmitter acetylcholine, is essential for nervous system functions, brain development, and gene expression. |
2022-11-11 |
2023-08-14 |
Not clear |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Binney Sharma, Avishek Roy, Trina Sengupta, Lal Chandra Vishwakarma, Anuraag Singh, Ritesh Netam, Tapas Chandra Nag, Nasreen Akhtar, Hruda Nanda Mallic. Acute sleep deprivation induces synaptic remodelling at the soleus muscle neuromuscular junction in rats. Sleep. 2022-09-21. PMID:36130235. |
further acute sleep deprivation showed the depletion of the neurotransmitter acetylcholine and the overactivity of its degrading enzyme acetylcholine esterase at the neuromuscular junction. |
2022-09-21 |
2023-08-14 |
rat |
| Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. |
acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. |
2022-09-20 |
2023-08-14 |
human |
| Kyu Hwan Shim, Min Ju Kang, Niti Sharma, Seong Soo A A. Beauty of the beast: anticholinergic tropane alkaloids in therapeutics. Natural products and bioprospecting. vol 12. issue 1. 2022-09-15. PMID:36109439. |
these compounds possess the anticholinergic properties as they could block the neurotransmitter acetylcholine action in the central and peripheral nervous system by binding at either muscarinic and/or nicotinic receptors. |
2022-09-15 |
2023-08-14 |
Not clear |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Min-Sun Ki. In silico identification of the potential molecular mechanisms involved in protective effects of prolactin on motor and memory deficits induced by 1,2-Diacetylbenzene in young and old rats. Neurotoxicology. 2022-09-13. PMID:36100143. |
the most important mechanisms associated with prolactin's ability to counteract dab were identified, including "learning and memory," and "positive regulation of ion transport" in young rats, as well as "acetylcholine related pathways," "inflammatory response pathway," and "neurotransmitter release cycle" in old rats. |
2022-09-13 |
2023-08-14 |
rat |
| Luana Kamarowski Lins Alves, Valdir Cechinel Filho, Ricardo Lehtonen Rodrigues de Souza, Lupe Furtado-All. BChE inhibitors from marine organisms - A review. Chemico-biological interactions. 2022-09-12. PMID:36096160. |
acetylcholine is a key neurotransmitter for brain and muscle function, that has its levels decreased in the brain of people with alzheimer's disease (ad). |
2022-09-12 |
2023-08-14 |
Not clear |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| Meng Nie, Na Chen, Huanhuan Pang, Tao Jiang, Wei Jiang, Panwen Tian, LiAng Yao, Yangzi Chen, Ralph J DeBerardinis, Weimin Li, Qitao Yu, Caicun Zhou, Zeping H. Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse. The Journal of clinical investigation. 2022-09-01. PMID:36048538. |
here, through integration of metabolomics and transcriptomics, we found that the neurotransmitter acetylcholine (ach) was specifically accumulated in dtp cells, and illustrated that treatment with egfr-tki heightens the expression of the rate-limiting enzyme choline acetyltransferase (chat) in ach biosynthesis via yap mediation. |
2022-09-01 |
2023-08-14 |
Not clear |
| Honghua Zhang, Yan Peng, Linsheng Zhuo, Yuying Wang, Guo Zeng, Shuzhi Wang, Lin Long, Xuelin Li, Zhen Wan. Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy. European journal of medicinal chemistry. vol 242. 2022-08-31. PMID:36044812. |
due to the hugely important roles of neurotransmitter acetylcholine (ach) and amyloid-β (aβ) in the pathogenesis of alzheimer's disease (ad), the development of multi-target directed ligands (mtdls) focused on cholinesterase (che) and aβ becomes one of the most attractive strategies for combating ad. |
2022-08-31 |
2023-08-14 |
Not clear |