| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Binney Sharma, Avishek Roy, Trina Sengupta, Lal Chandra Vishwakarma, Anuraag Singh, Ritesh Netam, Tapas Chandra Nag, Nasreen Akhtar, Hruda Nanda Mallic. Acute sleep deprivation induces synaptic remodelling at the soleus muscle neuromuscular junction in rats. Sleep. 2022-09-21. PMID:36130235. |
further acute sleep deprivation showed the depletion of the neurotransmitter acetylcholine and the overactivity of its degrading enzyme acetylcholine esterase at the neuromuscular junction. |
2022-09-21 |
2023-08-14 |
rat |
| Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. |
acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. |
2022-09-20 |
2023-08-14 |
human |
| Kyu Hwan Shim, Min Ju Kang, Niti Sharma, Seong Soo A A. Beauty of the beast: anticholinergic tropane alkaloids in therapeutics. Natural products and bioprospecting. vol 12. issue 1. 2022-09-15. PMID:36109439. |
these compounds possess the anticholinergic properties as they could block the neurotransmitter acetylcholine action in the central and peripheral nervous system by binding at either muscarinic and/or nicotinic receptors. |
2022-09-15 |
2023-08-14 |
Not clear |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Min-Sun Ki. In silico identification of the potential molecular mechanisms involved in protective effects of prolactin on motor and memory deficits induced by 1,2-Diacetylbenzene in young and old rats. Neurotoxicology. 2022-09-13. PMID:36100143. |
the most important mechanisms associated with prolactin's ability to counteract dab were identified, including "learning and memory," and "positive regulation of ion transport" in young rats, as well as "acetylcholine related pathways," "inflammatory response pathway," and "neurotransmitter release cycle" in old rats. |
2022-09-13 |
2023-08-14 |
rat |
| Luana Kamarowski Lins Alves, Valdir Cechinel Filho, Ricardo Lehtonen Rodrigues de Souza, Lupe Furtado-All. BChE inhibitors from marine organisms - A review. Chemico-biological interactions. 2022-09-12. PMID:36096160. |
acetylcholine is a key neurotransmitter for brain and muscle function, that has its levels decreased in the brain of people with alzheimer's disease (ad). |
2022-09-12 |
2023-08-14 |
Not clear |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| Meng Nie, Na Chen, Huanhuan Pang, Tao Jiang, Wei Jiang, Panwen Tian, LiAng Yao, Yangzi Chen, Ralph J DeBerardinis, Weimin Li, Qitao Yu, Caicun Zhou, Zeping H. Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse. The Journal of clinical investigation. 2022-09-01. PMID:36048538. |
here, through integration of metabolomics and transcriptomics, we found that the neurotransmitter acetylcholine (ach) was specifically accumulated in dtp cells, and illustrated that treatment with egfr-tki heightens the expression of the rate-limiting enzyme choline acetyltransferase (chat) in ach biosynthesis via yap mediation. |
2022-09-01 |
2023-08-14 |
Not clear |
| Honghua Zhang, Yan Peng, Linsheng Zhuo, Yuying Wang, Guo Zeng, Shuzhi Wang, Lin Long, Xuelin Li, Zhen Wan. Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy. European journal of medicinal chemistry. vol 242. 2022-08-31. PMID:36044812. |
due to the hugely important roles of neurotransmitter acetylcholine (ach) and amyloid-β (aβ) in the pathogenesis of alzheimer's disease (ad), the development of multi-target directed ligands (mtdls) focused on cholinesterase (che) and aβ becomes one of the most attractive strategies for combating ad. |
2022-08-31 |
2023-08-14 |
Not clear |
| Yasir Hasan Siddique, Falaq Naz, Rahul, Himanshi Varshne. Comparative study of rivastigmine and galantamine on the transgenic Current research in pharmacology and drug discovery. vol 3. 2022-08-22. PMID:35992376. |
the accumulation of amyloid plaques and neurofibrillary tangles leads to the loss of neurons including the cholinergic neurons thus decreasing the levels of acetylcholine (a neurotransmitter). |
2022-08-22 |
2023-08-14 |
Not clear |
| Letícia A Nascimento, Érica C M Nascimento, João B L Martin. In silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure. Journal of molecular modeling. vol 28. issue 9. 2022-08-10. PMID:35947248. |
in this way, we performed a set of theoretical tests of tacrine ligand and acetylcholine neurotransmitter against the human acetylcholinesterase enzyme. |
2022-08-10 |
2023-08-14 |
human |
| Patrick S R Davidson, Galit Karpov, Lauriane Giguère, Alex W Castro, François Trembla. Older adults' episodic memory is related to a neurophysiological marker of brain cholinergic activity. Experimental brain research. 2022-07-30. PMID:35907032. |
episodic memory is vulnerable to aging and may be influenced by age-related decline in the neurotransmitter acetylcholine. |
2022-07-30 |
2023-08-14 |
Not clear |
| Dominik Szwajgier, Ewa Baranowska-Wójcik, Anna Winiarska-Mieczan, Dorota Gajowniczek-Ałas. Honeys as Possible Sources of Cholinesterase Inhibitors. Nutrients. vol 14. issue 14. 2022-07-27. PMID:35889933. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. |
2022-07-27 |
2023-08-14 |
Not clear |
| Katharina Rump, Caroline Holtkamp, Lars Bergmann, Hartmuth Nowak, Matthias Unterberg, Jennifer Orlowski, Patrick Thon, Zainab Bazzi, Maha Bazzi, Michael Adamzik, Björn Koos, Tim Rahme. Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? PloS one. vol 17. issue 7. 2022-07-08. PMID:35802656. |
since delirium is associated with a malfunction of the neurotransmitter acetylcholine, midazolam appears to interfere with its proper metabolism, which can be triggered by epigenetic modifications. |
2022-07-08 |
2023-08-14 |
human |
| Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X Fernandes, Antonio J Moreno-Vargas, José M Padrón, Óscar López, José G Fernández-Bolaño. Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease. Bioorganic chemistry. vol 127. 2022-07-02. PMID:35779403. |
in particular, we have focused our attention on modulating the activity of cholinesterases (ache, buche) in order to restore the levels of the neurotransmitter acetylcholine, and of o-glcnacase (oga), which is associated with hyperphosphorylation of tau protein, in turn related to the formation of neurofibrillary tangles in the brain. |
2022-07-02 |
2023-08-14 |
Not clear |
| Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Ha. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684298. |
ache plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Solveig Tiepolt, Philipp M Meyer, Marianne Patt, Winnie Deuther-Conrad, Swen Hesse, Henryk Barthel, Osama Sabr. PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 63. issue Suppl 1. 2022-06-01. PMID:35649648. |
as a neuromodulator, the neurotransmitter acetylcholine plays an important role in cognitive, mood, locomotor, sleep/wake, and olfactory functions. |
2022-06-01 |
2023-08-13 |
Not clear |
| Waisley Yang, Rohit Singla, Oshin Maheshwari, Christine J Fontaine, Joana Gil-Mohape. Alcohol Use Disorder: Neurobiology and Therapeutics. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625928. |
ethanol exerts its toxicity through changes to multiple neurotransmitter systems, including serotonin, dopamine, gamma-aminobutyric acid, glutamate, acetylcholine, and opioid systems. |
2022-05-28 |
2023-08-13 |
Not clear |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Ning-Xin Ma, Brendan Puls, Gong Che. Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion. Developmental neurobiology. 2022-05-24. PMID:35606902. |
neurod family members (neurod1/2/6) and signaling pathways (wnt, mapk, camp) as well as neurotransmitter receptors (acetylcholine, somatostatin, dopamine) were also significantly upregulated. |
2022-05-24 |
2023-08-13 |
Not clear |