| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Bo Zhao, Li-Man Liu, Ning Yu, Yan Zhu, Ling Mei, Jin Chen, Chun Lian. Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells. Journal of neurophysiology. 2021-12-15. PMID:34907797. |
moc nerve fibers are cholinergic and acetylcholine (ach) is a primary neurotransmitter. |
2021-12-15 |
2023-08-13 |
Not clear |
| b' K Szmicsekov\\xc3\\xa1, L Bies Piv\\xc3\\xa1\\xc4\\x8dkov\\xc3\\xa1, Z Kili\\xc3\\xa1nov\\xc3\\xa1, \\xc4\\xbd Slobodov\\xc3\\xa1, P K\\xc5\\x99enek, A Hrabovsk\\xc3\\xa. Aortic butyrylcholinesterase is reduced in spontaneously hypertensive rats. Physiological research. vol 70. issue 5. 2021-12-09. PMID:34505519.' |
despite the fact that vessels have sparse cholinergic innervation, acetylcholine (ach), the primary neurotransmitter of parasympathetic nervous system, has been commonly used in physiological experiments to assess vascular function. |
2021-12-09 |
2023-08-13 |
rat |
| Yangsik Kim, Esther Yang, Hyun Ki. Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin. Biochemical and biophysical research communications. vol 586. 2021-12-06. PMID:34839189. |
impaired prepulse inhibition in mice with irsp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin. |
2021-12-06 |
2023-08-13 |
mouse |
| Janet S Duerr, John R McManus, John A Crowell, James B Ran. Analysis of Caenorhabditis elegans acetylcholine synthesis mutants reveals a temperature-sensitive requirement for cholinergic neuromuscular function. Genetics. vol 218. issue 4. 2021-12-01. PMID:34028515. |
in caenorhabditis elegans, the cha-1 gene encodes choline acetyltransferase (chat), the enzyme that synthesizes the neurotransmitter acetylcholine. |
2021-12-01 |
2023-08-13 |
caenorhabditis_elegans |
| Xuan Gu, Xiaoying Wan. An overview of recent analysis and detection of acetylcholine. Analytical biochemistry. vol 632. 2021-12-01. PMID:34534543. |
acetylcholine (ach), the major neurotransmitter secreted by cholinergic neurons, is widely found in the peripheral and central nervous systems, and its main function is to complete the transmission of neural signals. |
2021-12-01 |
2023-08-13 |
Not clear |
| Xiao Xiao, Ling Yong, Bingqing Jiao, Hui Yang, Chunlai Liang, Xudong Jia, Zhaoping Liu, Yaxin Sang, Yan Son. Postweaning exposure to lanthanum alters neurological behavior during early adulthood in rats. Neurotoxicology. vol 83. 2021-11-26. PMID:33359004. |
further results showed that lanthanum treatment significantly decreased plasma neurotransmitter levels of acetylcholine and norepinephrine as well as the number of neurons in the ca1 area of the hippocampus. |
2021-11-26 |
2023-08-13 |
rat |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Kazuhiro Murata, Naotaka Yoshikawa, Kanji Yoshimoto, Akira Namera, Haruo Takeshita, Masataka Naga. BIMP affects tubulin structure and causes abnormalities in cell division. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34225093. |
these agents mainly irreversibly inhibit the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter, and are believed to cause acute symptoms of poisoning. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jiaqi Lv, Xiaoxiao Ji, Zhen Li, Huiqin Ha. The role of the cholinergic anti-inflammatory pathway in autoimmune rheumatic diseases. Scandinavian journal of immunology. vol 94. issue 4. 2021-11-25. PMID:34780075. |
the cholinergic anti-inflammatory pathway (cap) is a classic neuroimmune pathway, consisting of the vagus nerve, acetylcholine (ach)-the pivotal neurotransmitter of the vagus nerve-and its receptors. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Gloria E Uwaya, Omolola E Fayem. Enhanced Electrocatalytic Detection of Choline Based on CNTs and Metal Oxide Nanomaterials. Molecules (Basel, Switzerland). vol 26. issue 21. 2021-11-18. PMID:34770919. |
choline is an officially established essential nutrient and precursor of the neurotransmitter acetylcholine. |
2021-11-18 |
2023-08-13 |
Not clear |
| Rosana Banzato, Nathalia M Pinheiro, Clarice R Olivo, Fernanda R Santana, Fernanda D T Q S Lopes, Luciana C Caperuto, Niels O Câmara, Milton A Martins, Iolanda F L C Tibério, Marco Antônio M Prado, Vânia F Prado, Carla M Prad. Long-term endogenous acetylcholine deficiency potentiates pulmonary inflammation in a murine model of elastase-induced emphysema. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34354132. |
acetylcholine (ach), the neurotransmitter of the cholinergic system, regulates inflammation in several diseases including pulmonary diseases. |
2021-11-15 |
2023-08-13 |
mouse |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
acylcholines are comprised of an acyl chain esterified to a choline moiety; acetylcholine is the best-characterized member of this class, functioning as a neurotransmitter in the central and peripheral nervous systems as well as an inhibitor of cytokine production by macrophages and other innate immune cells. |
2021-11-11 |
2023-08-13 |
Not clear |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |
| Yoshihiko Kakinum. Significance of vagus nerve function in terms of pathogenesis of psychosocial disorders. Neurochemistry international. vol 143. 2021-11-04. PMID:33307153. |
the neurotransmitter acetylcholine, released from the cholinergic system including vn, has been known to play an anti-inflammatory role through the efferent pathways in regulating peripheral inflammatory responses profoundly involved in the pathogenesis of diseases. |
2021-11-04 |
2023-08-13 |
Not clear |
| Katarzyna M Targowska-Duda, Barbara Budzynska, Agnieszka Michalak, Artur Wnorowski, Claus J Loland, Maciej Maj, Dina Manetti, Maria Novella Romanelli, Krzysztof Jozwiak, Grazyna Biala, Hugo R Aria. Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 52. 2021-11-01. PMID:34237657. |
the aim of this study is to determine whether type i and type ii positive allosteric modulators (pams) of α7 nicotinic acetylcholine receptors (nachrs) induce antidepressant-like activity in mice after acute, subchronic, and chronic treatments, and to assess whether α7-pams inhibit neurotransmitter transporters and activate mtor (mammalian target of rapamycin) and/or erk (extracellular signal-regulated protein kinases) signaling. |
2021-11-01 |
2023-08-13 |
mouse |
| Zheng Wang, Adoulaye Issotina Zibrila, Shuhua Liu, Gongxiao Zhao, Yubei Li, Jingning Xu, Dan Liu, Chunfang Li, Weiyi Feng, Jinjun Li. Acetylcholine ameliorated TNF-α-induced primary trophoblast malfunction via muscarinic receptors†. Biology of reproduction. vol 103. issue 6. 2021-10-29. PMID:32902620. |
numerous studies have shown that acetylcholine (ach), the principal vagal neurotransmitter, plays a crucial role in attenuating oxidative stress, inflammation, and apoptosis in a variety of human diseases. |
2021-10-29 |
2023-08-13 |
human |
| Nan Wang, Yaojun Cai, Fen Wang, Xianzhong Zeng, Xuemei Jia, Fangbiao Tao, Defa Zh. Effects of thyroxin and donepezil on hippocampal acetylcholine content and syntaxin-1 and munc-18 expression in adult rats with hypothyroidism. Experimental and therapeutic medicine. vol 7. issue 3. 2021-10-21. PMID:24520241. |
the aim of the present study was to investigate the effects of adult-onset hypothyroidism on the expression levels of the synaptic proteins syntaxin-1 and munc-18, as well as the content of the neurotransmitter acetylcholine (ach) in the hippocampus. |
2021-10-21 |
2023-08-12 |
rat |
| Aijaz Ahmad Malik, Suvash Chandra Ojha, Nalini Schaduangrat, Chanin Nantasenama. ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors. Molecular diversity. 2021-10-05. PMID:34609711. |
the deficiency of the cholinergic neurotransmitter known as acetylcholine (ach) is associated with ad. |
2021-10-05 |
2023-08-13 |
Not clear |
| Wanwei Zheng, Huan Song, Zhongguang Luo, Hao Wu, Lin Chen, Yuedi Wang, Haoshu Cui, Yufei Zhang, Bangting Wang, Wenshuai Li, Yao Liu, Jun Zhang, Yiwei Chu, Feifei Luo, Jie Li. Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 11. 2021-09-23. PMID:33836585. |
as a result, acetylcholine (ach), a major neurotransmitter of the nervous system synthesized by chat, was greatly reduced in colon tissues of both ibd patients and colitis mice. |
2021-09-23 |
2023-08-13 |
mouse |