| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siobhan S Pattwell, Kevin G Bath, Rosalia Perez-Castro, Francis S Lee, Moses V Chao, Ipe Nina. The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396415. |
while bdnf enhanced non-nmda receptor transmission and depressed gaba receptor transmission in the wild-type mice, both effects were absent in bdnf(met/met) mice after bdnf treatment. |
2012-04-23 |
2023-08-12 |
mouse |
| Siobhan S Pattwell, Kevin G Bath, Rosalia Perez-Castro, Francis S Lee, Moses V Chao, Ipe Nina. The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 7. 2012-04-23. PMID:22396415. |
bdnf-mediated selective reversal of the deficit in plasticity and nmda receptor transmission, but its lack of effect on gaba and non-nmda receptor transmission in bdnf(met/met) mice, suggests separate mechanisms of val66met polymorphism upon synaptic transmission. |
2012-04-23 |
2023-08-12 |
mouse |
| Young-Hwan J. Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus. Journal of neurophysiology. vol 107. issue 1. 2012-04-19. PMID:21994261. |
hence, this increased gaba drive onto sf-1 neurons may, in part, explain the cellular mechanisms that mediate the anorexigenic effects of bdnf. |
2012-04-19 |
2023-08-12 |
mouse |
| Dong Hyun Kim, Jong Min Kim, Se Jin Park, Mudan Cai, Xiaotong Liu, Seungheon Lee, Chan Young Shin, Jong Hoon Ry. GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21900885. |
gaba(a) receptor blockade enhances memory consolidation by increasing hippocampal bdnf levels. |
2012-04-17 |
2023-08-12 |
mouse |
| Dong Hyun Kim, Jong Min Kim, Se Jin Park, Mudan Cai, Xiaotong Liu, Seungheon Lee, Chan Young Shin, Jong Hoon Ry. GABA(A) receptor blockade enhances memory consolidation by increasing hippocampal BDNF levels. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21900885. |
here we examined a potential role for brain-derived neurotrophic factor (bdnf) in mediating the enhanced memory consolidation induced by the gaba(a) receptor antagonist, bicuculline methiodide. |
2012-04-17 |
2023-08-12 |
mouse |
| Ying Huang, Ho Ko, Zelda H Cheung, Ken K L Yung, Tai Yao, Jian-Jun Wang, Alexei Morozov, Ya Ke, Nancy Y Ip, Wing-Ho Yun. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178325. |
the ability to regulate inhibitory synapses is a critical feature of the nervous system and a growing body of evidence indicates that brain-derived neurotrophic factor (bdnf) acutely modulates the efficacy of gaba synaptic transmission. |
2012-03-26 |
2023-08-12 |
rat |
| Ying Huang, Ho Ko, Zelda H Cheung, Ken K L Yung, Tai Yao, Jian-Jun Wang, Alexei Morozov, Ya Ke, Nancy Y Ip, Wing-Ho Yun. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178325. |
although the neuronal potassium-chloride cotransporter 2 (kcc2) has been implied in this bdnf-induced ionic plasticity, the reports about actions of bdnf on gaba signaling remain conflicting. |
2012-03-26 |
2023-08-12 |
rat |
| Ying Huang, Ho Ko, Zelda H Cheung, Ken K L Yung, Tai Yao, Jian-Jun Wang, Alexei Morozov, Ya Ke, Nancy Y Ip, Wing-Ho Yun. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178325. |
however, in the absence of kcc2 activity, bdnf directly potentiated rather than inhibited gaba(a) receptor, which was reflected by an increase in the amplitude of outward ipscs. |
2012-03-26 |
2023-08-12 |
rat |
| Ying Huang, Ho Ko, Zelda H Cheung, Ken K L Yung, Tai Yao, Jian-Jun Wang, Alexei Morozov, Ya Ke, Nancy Y Ip, Wing-Ho Yun. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178325. |
the effects of bdnf on both gaba(a) receptor and kcc2 were dependent on trkb and also activation of cyclin-dependent kinase 5 (cdk5). |
2012-03-26 |
2023-08-12 |
rat |
| Ying Huang, Ho Ko, Zelda H Cheung, Ken K L Yung, Tai Yao, Jian-Jun Wang, Alexei Morozov, Ya Ke, Nancy Y Ip, Wing-Ho Yun. Dual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178325. |
taken together, these data highlight distinct actions of bdnf on kcc2 and gaba(a) receptor in the regulation of gabaergic synaptic transmission. |
2012-03-26 |
2023-08-12 |
rat |
| Ahmad A Khundakar, Tyra S C Zetterströ. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. European journal of pharmacology. vol 671. issue 1-3. 2012-03-01. PMID:21930121. |
the present study aimed to understand the mechanism behind the acute inhibitory action on bdnf gene expression by investigating the possible involvement of γ-aminobutyric acid (gaba) receptors in mediating this effect. |
2012-03-01 |
2023-08-12 |
rat |
| Ahmad A Khundakar, Tyra S C Zetterströ. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. European journal of pharmacology. vol 671. issue 1-3. 2012-03-01. PMID:21930121. |
the inhibitory effect of baclofen on hippocampal bdnf mrna expression was significantly attenuated by pre-treatment the selective gaba(b) antagonists, cgp 46381 and cgp 55845 (10mg/kg, i.p.). |
2012-03-01 |
2023-08-12 |
rat |
| Ahmad A Khundakar, Tyra S C Zetterströ. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. European journal of pharmacology. vol 671. issue 1-3. 2012-03-01. PMID:21930121. |
our findings suggest a role for gaba(b), but not gaba(a), receptor-mediated mechanisms in the inhibitory regulation of basal hippocampal bdnf gene expression. |
2012-03-01 |
2023-08-12 |
rat |
| Ahmad A Khundakar, Tyra S C Zetterströ. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. European journal of pharmacology. vol 671. issue 1-3. 2012-03-01. PMID:21930121. |
our results indicate that gaba(b) receptor activation may play a role in the antidepressant drug-induced inhibition of bdnf gene expression in the hippocampus. |
2012-03-01 |
2023-08-12 |
rat |
| Sandra H Vaz, Trine N Jørgensen, Sofia Cristóvão-Ferreira, Sylvie Duflot, Joaquim A Ribeiro, Ulrik Gether, Ana M Sebastiã. Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21969376. |
brain-derived neurotrophic factor (bdnf) enhances gaba transport by modulating the trafficking of gaba transporter-1 (gat-1) from the plasma membrane of rat cortical astrocytes. |
2012-01-16 |
2023-08-12 |
rat |
| Sandra H Vaz, Trine N Jørgensen, Sofia Cristóvão-Ferreira, Sylvie Duflot, Joaquim A Ribeiro, Ulrik Gether, Ana M Sebastiã. Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21969376. |
it has previously been shown that brain derived neurotrophic factor (bdnf) modulates gat-1-mediated gaba transport in nerve terminals and neuronal cultures. |
2012-01-16 |
2023-08-12 |
rat |
| Sandra H Vaz, Trine N Jørgensen, Sofia Cristóvão-Ferreira, Sylvie Duflot, Joaquim A Ribeiro, Ulrik Gether, Ana M Sebastiã. Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21969376. |
we now report that bdnf enhances gat-1-mediated gaba transport in cultured astrocytes, an effect mostly due to an increase in the v(max) kinetic constant. |
2012-01-16 |
2023-08-12 |
rat |
| Sandra H Vaz, Trine N Jørgensen, Sofia Cristóvão-Ferreira, Sylvie Duflot, Joaquim A Ribeiro, Ulrik Gether, Ana M Sebastiã. Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21969376. |
bdnf may thus play an active role in the clearance of gaba from synaptic and extrasynaptic sites and in this way influence neuronal excitability. |
2012-01-16 |
2023-08-12 |
rat |
| Henry Silver, Ehud Susser, Lena Danovich, Warren Bilker, Moussa Youdim, Vladimir Goldin, Orly Weinre. SSRI augmentation of antipsychotic alters expression of GABA(A) receptor and related genes in PMC of schizophrenia patients. The international journal of neuropsychopharmacology. vol 14. issue 5. 2012-01-06. PMID:21208484. |
rna encoding for gaba(a)β3, 5-ht2a, and 5-ht7 receptors, pkcβ2, and brain-derived neurotrophic factor (bdnf) was assayed with real-time rt-pcr. |
2012-01-06 |
2023-08-12 |
Not clear |
| Henry Silver, Ehud Susser, Lena Danovich, Warren Bilker, Moussa Youdim, Vladimir Goldin, Orly Weinre. SSRI augmentation of antipsychotic alters expression of GABA(A) receptor and related genes in PMC of schizophrenia patients. The international journal of neuropsychopharmacology. vol 14. issue 5. 2012-01-06. PMID:21208484. |
we found significant increase in mrna encoding for gaba(a)β3 and 5-ht2a, 5-ht7 receptors and bdnf and a reduction in pkcβ2 mrna. |
2012-01-06 |
2023-08-12 |
Not clear |