| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandra Henriques Vaz, Sofia Rapaz Lérias, Sara Parreira, Maria José Diógenes, Ana Maria Sebastiã. Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26452489. |
adenosine a2a receptor activation is determinant for bdnf actions upon gaba and glutamate release from rat hippocampal synaptosomes. |
2016-08-29 |
2023-08-13 |
rat |
| Sandra Henriques Vaz, Sofia Rapaz Lérias, Sara Parreira, Maria José Diógenes, Ana Maria Sebastiã. Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26452489. |
we thus evaluated the role of a(2a)r on the modulatory effect of bdnf upon glutamate and gaba release from isolated hippocampal nerve terminals (synaptosomes). |
2016-08-29 |
2023-08-13 |
rat |
| Sandra Henriques Vaz, Sofia Rapaz Lérias, Sara Parreira, Maria José Diógenes, Ana Maria Sebastiã. Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26452489. |
bdnf (30 ng/ml) enhanced k(+)-evoked [(3)h]glutamate release and inhibited the k(+)-evoked [(3)h]gaba release from synaptosomes. |
2016-08-29 |
2023-08-13 |
rat |
| Sandra Henriques Vaz, Sofia Rapaz Lérias, Sara Parreira, Maria José Diógenes, Ana Maria Sebastiã. Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26452489. |
the effect of bdnf on both glutamate and gaba release requires tonic activation of adenosine a(2a)r since for both neurotransmitters, the bdnf action was blocked by the a(2a)r antagonist sch 58261 (50 nm). |
2016-08-29 |
2023-08-13 |
rat |
| Sandra Henriques Vaz, Sofia Rapaz Lérias, Sara Parreira, Maria José Diógenes, Ana Maria Sebastiã. Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26452489. |
in the presence of the a(2a)r agonist, cgs21680 (30 nm), the effect of bdnf on either glutamate or gaba release was, however, not potentiated. |
2016-08-29 |
2023-08-13 |
rat |
| Sandra Henriques Vaz, Sofia Rapaz Lérias, Sara Parreira, Maria José Diógenes, Ana Maria Sebastiã. Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes. Purinergic signalling. vol 11. issue 4. 2016-08-29. PMID:26452489. |
it is concluded that both the inhibitory actions of bdnf on gaba release as well as the facilitatory action of the neurotrophin on glutamate release are dependent on the activation of adenosine a(2a)r by endogenous adenosine. |
2016-08-29 |
2023-08-13 |
rat |
| Tatjana Begenisic, Gabriele Sansevero, Laura Baroncelli, Giovanni Cioni, Alessandro Sal. Early environmental therapy rescues brain development in a mouse model of Down syndrome. Neurobiology of disease. vol 82. 2016-08-24. PMID:26244989. |
the beneficial ee effects were accompanied by increased bdnf and correction of over-expression of the gaba vesicular transporter vgat. |
2016-08-24 |
2023-08-13 |
mouse |
| André Jerónimo-Santos, Sandra Henriques Vaz, Sara Parreira, Sofia Rapaz-Lérias, António P Caetano, Valérie Buée-Scherrer, Eero Castrén, Claudia A Valente, David Blum, Ana Maria Sebastião, Maria José Diógene. Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 9. 2016-05-10. PMID:24860020. |
in the present study, we found that (1) aβ selectively increases mrna levels for the truncated trkb isoforms without affecting trkb-fl mrna levels, (2) aβ induces a calpain-mediated cleavage on trkb-fl receptors, downstream of shc-binding site, originating a new truncated trkb receptor (trkb-t') and an intracellular fragment (trkb-icd), which is also detected in postmortem human brain samples, (3) aβ impairs bdnf function in a calpain-dependent way, as assessed by the inability of bdnf to modulate neurotransmitter (gaba and glutamate) release from hippocampal nerve terminals, and long-term potentiation in hippocampal slices. |
2016-05-10 |
2023-08-13 |
human |
| Judith Becker Nissen, Christine Søholm Hansen, Anna Starnawska, Manuel Mattheisen, Anders Dupont Børglum, Henriette Nørmølle Buttenschøn, Mads Hollegaar. DNA Methylation at the Neonatal State and at the Time of Diagnosis: Preliminary Support for an Association with the Estrogen Receptor 1, Gamma-Aminobutyric Acid B Receptor 1, and Myelin Oligodendrocyte Glycoprotein in Female Adolescent Patients with OCD. Frontiers in psychiatry. vol 7. 2016-04-06. PMID:27047397. |
however, preliminary support for a difference was found for the gamma-aminobutyric acid (gaba) b receptor 1 (cg10234998, cg17099072) in blood samples at birth and for the estrogen receptor 1 (esr1) (cg10939667), the myelin oligodendrocyte glycoprotein (mog) (cg16650906), and the brain-derived neurotrophic factor (bdnf) (cg14080521) in blood samples at the time of diagnosis. |
2016-04-06 |
2023-08-13 |
Not clear |
| Henry Silver, Nina Mandiuk, Reef Einoch, Ehud Susser, Lena Danovich, Warren Bilker, Moussa Youdim, Orly Weinre. Improvement in verbal memory following SSRI augmentation of antipsychotic treatment is associated with changes in the expression of mRNA encoding for the GABA-A receptor and BDNF in PMC of schizophrenic patients. International clinical psychopharmacology. vol 30. issue 3. 2016-01-15. PMID:25756551. |
verbal memory impairment in schizophrenia is associated with abnormalities in gamma-aminobutyric acid (gaba)-ergic and brain-derived neurotrophic factor (bdnf) systems. |
2016-01-15 |
2023-08-13 |
Not clear |
| N Singewald, C Schmuckermair, N Whittle, A Holmes, K J Ressle. Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders. Pharmacology & therapeutics. vol 149. 2015-12-15. PMID:25550231. |
the purpose of this review is to outline the literature showing how pharmacological interventions targeting neurotransmitter systems including serotonin, dopamine, noradrenaline, histamine, glutamate, gaba, cannabinoids, neuropeptides (oxytocin, neuropeptides y and s, opioids) and other targets (neurotrophins bdnf and fgf2, glucocorticoids, l-type-calcium channels, epigenetic modifications) as well as their downstream signaling pathways, can augment fear extinction and strengthen extinction memory persistently in preclinical models. |
2015-12-15 |
2023-08-13 |
Not clear |
| Shuhong Dai, Zhengliang M. BDNF-trkB-KCC2-GABA pathway may be related to chronic stress-induced hyperalgesia at both the spinal and supraspinal level. Medical hypotheses. vol 83. issue 6. 2015-12-08. PMID:25454160. |
similarly, chronic stress could induce changes of bdnf, kcc2 and a depolarizing shift in the gaba reversal potential (egaba). |
2015-12-08 |
2023-08-13 |
Not clear |
| Mamoru Fukuchi, Yuya Kirikoshi, Atsumi Mori, Reika Eda, Daisuke Ihara, Ichiro Takasaki, Akiko Tabuchi, Masaaki Tsud. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. Journal of neurochemistry. vol 131. issue 2. 2015-10-16. PMID:24965890. |
excitatory gaba induces bdnf transcription via crtc1 and phosphorylated creb-related pathways in immature cortical cells. |
2015-10-16 |
2023-08-13 |
rat |
| Mamoru Fukuchi, Yuya Kirikoshi, Atsumi Mori, Reika Eda, Daisuke Ihara, Ichiro Takasaki, Akiko Tabuchi, Masaaki Tsud. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. Journal of neurochemistry. vol 131. issue 2. 2015-10-16. PMID:24965890. |
although the excitatory action of gaba has been shown to activate the expression of brain-derived neurotrophic factor (bdnf), its molecular mechanisms remain unclear. |
2015-10-16 |
2023-08-13 |
rat |
| Mamoru Fukuchi, Yuya Kirikoshi, Atsumi Mori, Reika Eda, Daisuke Ihara, Ichiro Takasaki, Akiko Tabuchi, Masaaki Tsud. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. Journal of neurochemistry. vol 131. issue 2. 2015-10-16. PMID:24965890. |
using cultured rat cortical cells, we here demonstrated that gaba induced bdnf mrna expression mainly via l-type voltage-dependent ca(2+) channels (l-vdcc) at the early stage and inhibited it at the late stage of the culture, which corresponded to the excitatory and inhibitory states of cortical cells. |
2015-10-16 |
2023-08-13 |
rat |
| Mamoru Fukuchi, Yuya Kirikoshi, Atsumi Mori, Reika Eda, Daisuke Ihara, Ichiro Takasaki, Akiko Tabuchi, Masaaki Tsud. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. Journal of neurochemistry. vol 131. issue 2. 2015-10-16. PMID:24965890. |
taken together, the excitatory action of gaba transcriptionally activated bdnf expression through the combination of nuclear-localized crtc1 and phosphorylated creb in immature cortical cells, and may be the molecular mechanisms underlying bdnf expression to control neuronal development. |
2015-10-16 |
2023-08-13 |
rat |
| Mamoru Fukuchi, Yuya Kirikoshi, Atsumi Mori, Reika Eda, Daisuke Ihara, Ichiro Takasaki, Akiko Tabuchi, Masaaki Tsud. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. Journal of neurochemistry. vol 131. issue 2. 2015-10-16. PMID:24965890. |
we demonstrated that gaba induced bdnf expression at the early stage of the culture, in which gaba exerted its excitatory action. |
2015-10-16 |
2023-08-13 |
rat |
| Saborni Roy, Hanuman Prasad Sharma, Tapas C Nag, Thirumurthy Velpandian, Ashish Datt Upadhyay, Rashmi Mathur, Suman Jai. BDNF mediated activity dependent maturation of visual Wulst following prenatal repetitive auditory stimulation at a critical developmental period in domestic chicks (Gallus domesticus). Brain research bulletin. vol 109. 2015-07-10. PMID:25305344. |
concomitant with this, there was a significant increase in the expression of bdnf and levels of neurotransmitters gaba, glutamate, norepinephrine and serotonin from e18 only in both hemispheres of the visual wulst. |
2015-07-10 |
2023-08-13 |
Not clear |
| Wenjuan Tao, Quan Chen, Lu Wang, Wenjie Zhou, Yunping Wang, Zhi Zhan. Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. Molecular pharmacology. vol 87. issue 6. 2015-07-07. PMID:25852071. |
although exogenous bdnf facilitated gaba miniature inhibitory postsynaptic currents and gad65 accumulation in nrm neuronal synapses in normal rats, it failed to do so in animals subjected to persistent inflammation. |
2015-07-07 |
2023-08-13 |
rat |
| Ja Wook Koo, Mary Kay Lobo, Dipesh Chaudhury, Benoit Labonté, Allyson Friedman, Elizabeth Heller, Catherine Jensen Peña, Ming-Hu Han, Eric J Nestle. Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 11. 2015-06-15. PMID:24853771. |
loss of bdnf signaling in d1r-expressing nac neurons enhances morphine reward by reducing gaba inhibition. |
2015-06-15 |
2023-08-13 |
mouse |