| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florence Rage, Michelle Silhol, Lucia Tapia-Arancibi. IL-1beta regulation of BDNF expression in rat cultured hypothalamic neurons depends on the presence of glial cells. Neurochemistry international. vol 49. issue 5. 2006-10-18. PMID:16621158. |
indomethacin blocked both stimulatory and inhibitory il-1beta effects on bdnf mrna expression whereas picrotoxin (a gaba(a) blocker) or mk-801 (a nmda receptor blocker) had no effect on bdnf mrna levels. |
2006-10-18 |
2023-08-12 |
rat |
| Takashi Kanematsu, Atsushi Yasunaga, Yoshito Mizoguchi, Akiko Kuratani, Josef T Kittler, Jasmina N Jovanovic, Kei Takenaka, Keiichi I Nakayama, Kiyoko Fukami, Tadaomi Takenawa, Stephen J Moss, Junichi Nabekura, Masato Hirat. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. The Journal of biological chemistry. vol 281. issue 31. 2006-10-16. PMID:16754670. |
exposure to bdnf alters properties of gaba(a) receptors and induces changes in the expression level at the cell surface. |
2006-10-16 |
2023-08-12 |
mouse |
| Takashi Kanematsu, Atsushi Yasunaga, Yoshito Mizoguchi, Akiko Kuratani, Josef T Kittler, Jasmina N Jovanovic, Kei Takenaka, Keiichi I Nakayama, Kiyoko Fukami, Tadaomi Takenawa, Stephen J Moss, Junichi Nabekura, Masato Hirat. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. The Journal of biological chemistry. vol 281. issue 31. 2006-10-16. PMID:16754670. |
instead, a gradual increase in gaba-evoked currents in these neurons correlated with a gradual increase in phosphorylation of gaba(a) receptor beta3 subunit in response to bdnf. |
2006-10-16 |
2023-08-12 |
mouse |
| Sarah A Hewitt, Jaideep S Bain. Brain-derived neurotrophic factor silences GABA synapses onto hypothalamic neuroendocrine cells through a postsynaptic dynamin-mediated mechanism. Journal of neurophysiology. vol 95. issue 4. 2006-09-25. PMID:16407427. |
in the paraventricular nucleus of the hypothalamus (pvn), experimental stress paradigms that suppress gamma-aminobutyric acid (gaba) inputs to parvocellular neuroendocrine cells (pncs) also increase the expression of brain-derived neurotrophic factor (bdnf). |
2006-09-25 |
2023-08-12 |
Not clear |
| Tomoya Matsumoto, Tadahiro Numakawa, Daisaku Yokomaku, Naoki Adachi, Satoru Yamagishi, Yumiko Numakawa, Hiroshi Kunugi, Takahisa Taguch. Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neuronal activity. Molecular and cellular neurosciences. vol 31. issue 1. 2006-05-08. PMID:16214365. |
here, we found that 24-h exposure of postnatal cortical neurons to bdnf potentiated depolarization-evoked glutamate and gaba release in a protein synthesis-dependent manner. |
2006-05-08 |
2023-08-12 |
Not clear |
| Takanori Hashimoto, David A Lewi. BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia. The American journal of psychiatry. vol 163. issue 3. 2006-04-25. PMID:16513879. |
in the prefrontal cortex of subjects with schizophrenia, decreased signaling mediated by brain-derived neurotrophic factor (bdnf) and its receptor tyrosine kinase (trkb) appears to contribute to the reduced expression of mrna encoding the 67-kilodalton isoform of glutamate decarboxylase (gad(67)), an enzyme for gaba synthesis. |
2006-04-25 |
2023-08-12 |
human |
| Sarina B Elmariah, Eun Joo Oh, Ethan G Hughes, Rita J Balice-Gordo. Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 14. 2006-03-01. PMID:15814795. |
acm from bdnf- or tyrosine receptor kinase b (trkb)-deficient astrocytes increased inhibitory presynaptic terminals and postsynaptic gaba(a)r clusters in wild-type neurons, suggesting that bdnf and trkb expression in astrocytes is not required for these effects. |
2006-03-01 |
2023-08-12 |
Not clear |
| Sarina B Elmariah, Eun Joo Oh, Ethan G Hughes, Rita J Balice-Gordo. Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 14. 2006-03-01. PMID:15814795. |
in contrast, although the increase in the number of inhibitory presynaptic terminals persisted, no increase was observed in postsynaptic gaba(a)r clusters after acm treatment of hippocampal neurons lacking bdnf or trkb. |
2006-03-01 |
2023-08-12 |
Not clear |
| Sarina B Elmariah, Eun Joo Oh, Ethan G Hughes, Rita J Balice-Gordo. Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 14. 2006-03-01. PMID:15814795. |
these results suggest that neurons, not astrocytes, are the relevant source of bdnf and are the site of trkb activation required for postsynaptic gaba(a)r modulation. |
2006-03-01 |
2023-08-12 |
Not clear |
| Gisela Gómez-Lira, Mónica Lamas, Héctor Romo-Parra, Rafael Gutiérre. Programmed and induced phenotype of the hippocampal granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 30. 2006-02-15. PMID:16049169. |
with electrophysiological, single-cell reverse transcription-pcr and immunohistological techniques, we show here that short-term (24 h) cultures of fully differentiated adult glutamatergic gcs, which express glutamate, vglut-1 (vesicular glutamate transporter) mrna, calbindin, and dynorphin mrna, can be induced to reexpress the gabaergic markers gaba, gad67 (glutamate decarboxylase 67 kda isoform), and vgat (vesicular gaba transporter) mrna, by sustained synaptic or direct activation of glutamate receptors and by activation of trkb (tyrosine receptor kinase b) receptors, with brain-derived neurotrophic factor (bdnf) (30 min). |
2006-02-15 |
2023-08-12 |
rat |
| D Ragozzino, E Palma, S Di Angelantonio, M Amici, A Mascia, A Arcella, F Giangaspero, G Cantore, G Di Gennaro, M Manfredi, V Esposito, P P Quarato, R Miledi, F Euseb. Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 42. 2005-12-05. PMID:16217016. |
use-dependent gaba(a)-receptor rundown is also found in the pyramidal neurons of tle neocortical slices and is antagonized by bdnf. |
2005-12-05 |
2023-08-12 |
human |
| Qing Cheng, Hermes H Ye. PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA. Journal of neuroscience research. vol 79. issue 5. 2005-05-09. PMID:15672445. |
plcgamma signaling underlies bdnf potentiation of purkinje cell responses to gaba. |
2005-05-09 |
2023-08-12 |
mouse |
| Qing Cheng, Hermes H Ye. PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA. Journal of neuroscience research. vol 79. issue 5. 2005-05-09. PMID:15672445. |
we reported recently that acute bdnf exposure decreased gamma-aminobutyric acid (gaba) responses in cultured mouse cerebellar granule cells through tyrosine receptor kinase b (trkb) receptor-mediated signaling. |
2005-05-09 |
2023-08-12 |
mouse |
| Qing Cheng, Hermes H Ye. PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA. Journal of neuroscience research. vol 79. issue 5. 2005-05-09. PMID:15672445. |
bdnf promptly enhanced gaba responses in purkinje cells but, consistent with our previous finding in culture, attenuated those recorded in granule cells. |
2005-05-09 |
2023-08-12 |
mouse |
| Qing Cheng, Hermes H Ye. PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA. Journal of neuroscience research. vol 79. issue 5. 2005-05-09. PMID:15672445. |
bdnf-induced potentiation of purkinje cell responses to gaba was blocked by trkb-fc (receptor body that sequesters bdnf), k252a (inhibitor of trkb receptor autophosphorylation), u73122 (inhibitor of phospholipase-cgamma [plcgamma]), kn62 (specific inhibitor of calcium/calmodulin-dependent kinase), kt5720 (specific cyclic amp-dependent kinase inhibitor), and by intracellular dialysis of rp-cyclic amp or bapta (1,2-bis(o-aminophenoxy)ethane-n,n, n',n'-tetraacetic acid). |
2005-05-09 |
2023-08-12 |
mouse |
| Qing Cheng, Hermes H Ye. PLCgamma signaling underlies BDNF potentiation of Purkinje cell responses to GABA. Journal of neuroscience research. vol 79. issue 5. 2005-05-09. PMID:15672445. |
overall, our results indicate that bdnf acutely potentiates gaba(a) receptor function in cerebellar purkinje cells via the trkb receptor-plcgamma signal transduction cascade. |
2005-05-09 |
2023-08-12 |
mouse |
| Shizu Ohba, Takamitsu Ikeda, Yuji Ikegaya, Nobuyoshi Nishiyama, Norio Matsuki, Maki K Yamad. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Cerebral cortex (New York, N.Y. : 1991). vol 15. issue 3. 2005-04-05. PMID:15238431. |
exogenous bdnf application for 48 h also increased the gad level and enhanced the gaba release probability. |
2005-04-05 |
2023-08-12 |
Not clear |
| E Palma, G Torchia, C Limatola, F Trettel, A Arcella, G Cantore, G Di Gennaro, M Manfredi, V Esposito, P P Quarato, R Miledi, F Euseb. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 5. 2005-03-28. PMID:15665077. |
it was found that exposure to the neurotrophin bdnf increased the amplitude of the "gaba currents" (currents elicited by gaba) generated by the epileptic receptors and decreased their run-down; both events being blocked by k252a, a neurotrophin tyrosine kinase receptor b inhibitor. |
2005-03-28 |
2023-08-12 |
human |
| E Palma, G Torchia, C Limatola, F Trettel, A Arcella, G Cantore, G Di Gennaro, M Manfredi, V Esposito, P P Quarato, R Miledi, F Euseb. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 5. 2005-03-28. PMID:15665077. |
in contrast, the gabaa receptors transplanted from the nonepileptic human hippocampal uncus (obtained during surgical resection as part of the nontumoral tissue from the oligodendroglioma margins) or receptors expressed by injecting rat recombinant alpha1beta2gamma2 gabaa receptor subunit cdnas generated gaba currents whose time-course and run-down were not altered by bdnf. |
2005-03-28 |
2023-08-12 |
human |
| Paul Berghuis, Marton B Dobszay, Kyle M Sousa, Gunnar Schulte, Peter P Mager, Wolfgang Härtig, Tamás J Görcs, Yuri Zilberter, Patrik Ernfors, Tibor Harkan. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons. The European journal of neuroscience. vol 20. issue 5. 2004-11-09. PMID:15341601. |
in addition, bdnf treatment led to a significant up-regulation of synaptophysin and vesicular gaba transporter expression, components of the synaptic machinery critical for gaba release, which was paralleled by an increase in synaptic strength. |
2004-11-09 |
2023-08-12 |
Not clear |