| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashok K Shett. Progenitor cells from the CA3 region of the embryonic day 19 rat hippocampus generate region-specific neuronal phenotypes in vitro. Hippocampus. vol 14. issue 5. 2004-10-04. PMID:15301437. |
however, a fraction of neurons (17-20%) from egf/fgf-2 neurospheres expressed gaba, and exposure to bdnf increased the number of gabaergic neurons (30%) from egf neurospheres. |
2004-10-04 |
2023-08-12 |
rat |
| Nuno Canas, Inês T Pereira, Joaquim Alexandre Ribeiro, Ana M Sebastiã. Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms. Brain research. vol 1016. issue 1. 2004-09-30. PMID:15234254. |
to compare the action of bdnf upon the release of excitatory and inhibitory neurotransmitters in the hippocampus, we studied the effect of acutely applied bdnf on the k+-evoked glutamate and on the k+-evoked gamma-aminobutyric acid (gaba) release from rat hippocampal nerve terminals (synaptosomes). |
2004-09-30 |
2023-08-12 |
rat |
| Nuno Canas, Inês T Pereira, Joaquim Alexandre Ribeiro, Ana M Sebastiã. Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms. Brain research. vol 1016. issue 1. 2004-09-30. PMID:15234254. |
in contrast, bdnf (3-100 ng/ml) inhibited k+-evoked [3h]gaba release from hippocampal synaptosomes. |
2004-09-30 |
2023-08-12 |
rat |
| Nuno Canas, Inês T Pereira, Joaquim Alexandre Ribeiro, Ana M Sebastiã. Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms. Brain research. vol 1016. issue 1. 2004-09-30. PMID:15234254. |
blockade of transport of gaba with skf 89976a (20 microm) prevented the inhibitory action of bdnf upon gaba release, indicating that bdnf influences the activity of gaba transporters. |
2004-09-30 |
2023-08-12 |
rat |
| Nuno Canas, Inês T Pereira, Joaquim Alexandre Ribeiro, Ana M Sebastiã. Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms. Brain research. vol 1016. issue 1. 2004-09-30. PMID:15234254. |
it is concluded that bdnf influences in an opposite way, through distinct mechanisms, the release of glutamate and the release of gaba from hippocampal synaptosomes. |
2004-09-30 |
2023-08-12 |
rat |
| Yoshito Mizoguchi, Hitoshi Ishibashi, Junichi Nabekur. The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. The Journal of physiology. vol 548. issue Pt 3. 2004-08-19. PMID:12640007. |
the action of bdnf on gaba(a) currents changes from potentiating to suppressing during maturation of rat hippocampal ca1 pyramidal neurons. |
2004-08-19 |
2023-08-12 |
rat |
| Yoshito Mizoguchi, Hitoshi Ishibashi, Junichi Nabekur. The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. The Journal of physiology. vol 548. issue Pt 3. 2004-08-19. PMID:12640007. |
during the development of the hippocampus, the action of gaba shifts from depolarizing to hyperpolarizing, and brain-derived neurotrophic factor (bdnf) has important roles in gabaergic transmission. |
2004-08-19 |
2023-08-12 |
rat |
| Qing Cheng, Hermes H Ye. Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA(A) receptor-mediated responses via postsynaptic mechanisms. The Journal of physiology. vol 548. issue Pt 3. 2004-08-19. PMID:12640011. |
the reduction of the gaba response recovered only partially even minutes after removal of bdnf. |
2004-08-19 |
2023-08-12 |
mouse |
| Sarina B Elmariah, Mark A Crumling, Thomas D Parsons, Rita J Balice-Gordo. Postsynaptic TrkB-mediated signaling modulates excitatory and inhibitory neurotransmitter receptor clustering at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 10. 2004-05-28. PMID:15014113. |
bdnf treatment resulted in an increase in the number of nmdar and gaba(a)r clusters and increased the proportion of clusters apposed to presynaptic terminals. |
2004-05-28 |
2023-08-12 |
rat |
| Sarina B Elmariah, Mark A Crumling, Thomas D Parsons, Rita J Balice-Gordo. Postsynaptic TrkB-mediated signaling modulates excitatory and inhibitory neurotransmitter receptor clustering at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 10. 2004-05-28. PMID:15014113. |
examination of the time course of the effects of bdnf on receptor clusters showed that the increase in gaba(a)r clusters preceded the increase in nmdar clusters by at least 12 hr. |
2004-05-28 |
2023-08-12 |
rat |
| Sarina B Elmariah, Mark A Crumling, Thomas D Parsons, Rita J Balice-Gordo. Postsynaptic TrkB-mediated signaling modulates excitatory and inhibitory neurotransmitter receptor clustering at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 10. 2004-05-28. PMID:15014113. |
in contrast, application of exogenous gaba prevented the decrease in nmdar clusters induced by bdnf scavenging. |
2004-05-28 |
2023-08-12 |
rat |
| T Nagano, Y Yanagawa, K Obata, M Narisawa-Saito, H Namba, Y Otsu, N Takei, H Naw. Brain-derived neurotrophic factor upregulates and maintains AMPA receptor currents in neocortical GABAergic neurons. Molecular and cellular neurosciences. vol 24. issue 2. 2004-01-23. PMID:14572457. |
in agreement, bdnf enhanced gaba release triggered by ampa compared to the amount triggered by high potassium. |
2004-01-23 |
2023-08-12 |
mouse |
| Isobel Lever, Joanna Cunningham, John Grist, Ping K Yip, Marzia Malcangi. Release of BDNF and GABA in the dorsal horn of neuropathic rats. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956715. |
release of bdnf and gaba in the dorsal horn of neuropathic rats. |
2003-10-23 |
2023-08-12 |
rat |
| Isobel Lever, Joanna Cunningham, John Grist, Ping K Yip, Marzia Malcangi. Release of BDNF and GABA in the dorsal horn of neuropathic rats. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956715. |
gaba release could be significantly restored following topical application of bdnf through the dorsal horn preparation. |
2003-10-23 |
2023-08-12 |
rat |
| Isobel Lever, Joanna Cunningham, John Grist, Ping K Yip, Marzia Malcangi. Release of BDNF and GABA in the dorsal horn of neuropathic rats. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956715. |
we concluded that bdnf-induced release of gaba could be a mechanism to explain the antinociceptive action of intrathecal bdnf in neuropathic animals. |
2003-10-23 |
2023-08-12 |
rat |
| Mia Ericson, Alison R Haythornthwaite, Pamela W L Yeh, Hermes H Ye. Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. Journal of neuroscience research. vol 73. issue 5. 2003-10-14. PMID:12929140. |
this study examined the effect of chronic exposure to ethanol and brain-derived neurotrophic factor (bdnf) on the responsiveness of cerebellar granule cells to gamma-aminobutyric acid (gaba). |
2003-10-14 |
2023-08-12 |
Not clear |
| Mia Ericson, Alison R Haythornthwaite, Pamela W L Yeh, Hermes H Ye. Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. Journal of neuroscience research. vol 73. issue 5. 2003-10-14. PMID:12929140. |
concomitant exposure of cultures to ethanol and bdnf mitigated the ethanol-induced attenuation of gaba response, although bdnf, by itself, did not affect responsiveness to gaba. |
2003-10-14 |
2023-08-12 |
Not clear |
| Mia Ericson, Alison R Haythornthwaite, Pamela W L Yeh, Hermes H Ye. Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. Journal of neuroscience research. vol 73. issue 5. 2003-10-14. PMID:12929140. |
bdnf increased the expression of the gaba(a) receptor alpha6 subunit, whereas ethanol had no effect, in chronically treated granule cell cultures. |
2003-10-14 |
2023-08-12 |
Not clear |
| Mia Ericson, Alison R Haythornthwaite, Pamela W L Yeh, Hermes H Ye. Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. Journal of neuroscience research. vol 73. issue 5. 2003-10-14. PMID:12929140. |
in addition, concomitant treatment with bdnf and ethanol did not increase the expression of the gaba(a) receptor alpha6 subunit, so the subunit expression alone could not account for the mitigating effect of bdnf. |
2003-10-14 |
2023-08-12 |
Not clear |
| Mia Ericson, Alison R Haythornthwaite, Pamela W L Yeh, Hermes H Ye. Brain-derived neurotrophic factor mitigates chronic ethanol-induced attenuation of gamma-aminobutyric acid responses in cultured cerebellar granule cells. Journal of neuroscience research. vol 73. issue 5. 2003-10-14. PMID:12929140. |
we propose that different mechanisms regulating responsiveness to gaba underlie the effects induced by ethanol and bdnf, with the former influencing the expression of functional gaba(a) receptors and the latter involving the activation of the trkb receptor and its downstream signaling pathways. |
2003-10-14 |
2023-08-12 |
Not clear |