| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kymry T Jones, Juan Zhen, Maarten E A Reit. Importance of cholesterol in dopamine transporter function. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957537. |
the conformation and function of the dopamine transporter (dat) can be affected by manipulating membrane cholesterol, yet there is no agreement as to the impact of cholesterol on the activity of lipid-raft localized dats compared with non-raft dats. |
2013-01-10 |
2023-08-12 |
Not clear |
| Dominik Pöltl, Stefan Schildknecht, Christiaan Karreman, Marcel Leis. Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. Neurotoxicology. vol 33. issue 4. 2013-01-04. PMID:22206971. |
biochemical assays indicated that in the homogeneously differentiated cell cultures, mpp(+) was taken up by the dopamine transporter (dat). |
2013-01-04 |
2023-08-12 |
human |
| Taro Ueno, Jun Tomita, Hiromu Tanimoto, Keita Endo, Kei Ito, Shoen Kume, Kazuhiko Kum. Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nature neuroscience. vol 15. issue 11. 2013-01-03. PMID:23064381. |
enhancement of dopamine signals by a mutation in the dopamine transporter (dat) decreases sleep, but the underlying dopamine circuit responsible for this remains unknown. |
2013-01-03 |
2023-08-12 |
drosophila_melanogaster |
| Maarten E A Reith, Solav Ali, Audrey Hashim, Imran S Sheikh, Naresh Theddu, Narendra V Gaddiraju, Suneet Mehrotra, Kyle C Schmitt, Thomas F Murray, Henry Sershen, Ellen M Unterwald, Franklin A Davi. Novel C-1 substituted cocaine analogs unlike cocaine or benztropine. The Journal of pharmacology and experimental therapeutics. vol 343. issue 2. 2012-12-31. PMID:22895898. |
analog 2 was equipotent to cocaine as an inhibitor of the dopamine transporter (dat), whereas 3 and 6 were 3- and 10-fold more potent, respectively. |
2012-12-31 |
2023-08-12 |
mouse |
| Mélanie Bourque, Dean E Dluzen, Thérèse Di Paol. Sex and temporally-dependent effects of methamphetamine toxicity on dopamine markers and signaling pathways. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22369785. |
methamphetamine-induced decreases in dopamine concentrations and dopamine transporter (dat) specific binding in the medial striatum were similar in female and male mice when evaluated 1 day post-methamphetamine (40 mg/kg). |
2012-12-20 |
2023-08-12 |
mouse |
| Mélanie Bourque, Dean E Dluzen, Thérèse Di Paol. Sex and temporally-dependent effects of methamphetamine toxicity on dopamine markers and signaling pathways. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22369785. |
at 3 days post-methamphetamine, striatal dopamine concentration and dat specific binding continued to decline in males, whereas females showed a recovery with increases in dopamine content and dat specific binding in medial striatum at day 3 versus day 1 post-methamphetamine. |
2012-12-20 |
2023-08-12 |
mouse |
| Oliver H Winz, Sabine Hellwig, Michael Mix, Wolfgang A Weber, Felix M Mottaghy, Wolfgang M Schäfer, Philipp T Meye. Image quality and data quantification in dopamine transporter SPECT: advantage of 3-dimensional OSEM reconstruction? Clinical nuclear medicine. vol 37. issue 9. 2012-12-13. PMID:22889776. |
reconstruction of striatal dopamine transporter (dat) spect is commonly done by filtered back projection (fbp). |
2012-12-13 |
2023-08-12 |
Not clear |
| Christopher L German, Glen R Hanson, Annette E Fleckenstei. Amphetamine and methamphetamine reduce striatal dopamine transporter function without concurrent dopamine transporter relocalization. Journal of neurochemistry. vol 123. issue 2. 2012-12-11. PMID:22804716. |
amphetamine (amph) and methamphetamine (meth) alter dopamine transporter (dat) function. |
2012-12-11 |
2023-08-12 |
Not clear |
| Ruth Tellez, Leticia Gómez-Viquez, Gustavo Liy-Salmeron, Alfredo Menese. GABA, glutamate, dopamine and serotonin transporters expression on forgetting. Neurobiology of learning and memory. vol 98. issue 1. 2012-12-03. PMID:22633984. |
notwithstanding several neurotransmission systems are frequently related to memory formation; forgetting process and neurotransmission systems or their transporters; the role of γ-aminobutyric acid (gat1), glutamate (eacc1), dopamine (dat) and serotonin (sert) is poorly understood. |
2012-12-03 |
2023-08-12 |
rat |
| Feng Yue, Sien Zeng, Di Wu, Deqiao Yi, Y Alex Zhang, Piu Cha. Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22327353. |
the function of the dopaminergic system was semi-quantitatively measured by (99m)tc-trodat-1 uptake rates, a dopamine transporter (dat) specific radiopharmaceutical with spect imaging. |
2012-11-29 |
2023-08-12 |
human |
| Jonghan Kim, Yuan Li, Peter D Buckett, Mark Böhlke, Khristy J Thompson, Masaya Takahashi, Timothy J Maher, Marianne Wessling-Resnic. Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency. PloS one. vol 7. issue 3. 2012-11-19. PMID:22479410. |
although tissue dopamine concentrations were similar in the striatum, dopamine transporter (dat) and dopamine receptor d(1) (d1r) levels were reduced and dopamine receptor d(2) (d2r) levels were increased in manganese-instilled rats, suggesting that manganese-induced changes in post-synaptic dopaminergic signaling contribute to the compensatory effect. |
2012-11-19 |
2023-08-12 |
rat |
| Stephen J Kohut, Kathleen L Decicco-Skinner, Shirin Johari, Zachary E Hurwitz, Michael H Baumann, Anthony L Rile. Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels. Neuropharmacology. vol 63. issue 2. 2012-11-19. PMID:22516586. |
dopamine (dat), serotonin (sert) and norepinephrine (net) transporter levels in mesocorticolimbic areas were also measured using western blotting after stress exposure to determine if the relative ratio of these proteins may explain differences in behavior. |
2012-11-19 |
2023-08-12 |
rat |
| James D Foster, Jae-Won Yang, Amy E Moritz, Sathyavathi Challasivakanaka, Margaret A Smith, Marion Holy, Kyle Wilebski, Harald H Sitte, Roxanne A Vaugha. Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux. The Journal of biological chemistry. vol 287. issue 35. 2012-11-19. PMID:22722938. |
in the central nervous system, levels of extraneuronal dopamine are controlled primarily by the action of the dopamine transporter (dat). |
2012-11-19 |
2023-08-12 |
rat |
| Thomas Steinkellner, Jae-Won Yang, Therese R Montgomery, Wei-Qiang Chen, Marie-Therese Winkler, Sonja Sucic, Gert Lubec, Michael Freissmuth, Ype Elgersma, Harald H Sitte, Oliver Kudlace. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of biological chemistry. vol 287. issue 35. 2012-11-19. PMID:22778257. |
the dopamine transporter (dat) is a crucial regulator of dopaminergic neurotransmission, controlling the length and brevity of dopaminergic signaling. |
2012-11-19 |
2023-08-12 |
mouse |
| Thomas Steinkellner, Jae-Won Yang, Therese R Montgomery, Wei-Qiang Chen, Marie-Therese Winkler, Sonja Sucic, Gert Lubec, Michael Freissmuth, Ype Elgersma, Harald H Sitte, Oliver Kudlace. Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome. The Journal of biological chemistry. vol 287. issue 35. 2012-11-19. PMID:22778257. |
recent findings suggest that dat interacting proteins may also play a significant role in the modulation of reverse dopamine transport. |
2012-11-19 |
2023-08-12 |
mouse |
| A Anandhan, U Janakiraman, T Manivasaga. Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. Neuroscience. vol 218. 2012-11-16. PMID:22634505. |
administration of mptp (30 mg/kg bw for four consecutive days) led to increased oxidative stress and reduced behavior patterns (open field, rotarod and hang test), nigrostriatal dopamine transporter (dat) (immunohistochemistry and western blot) and vesicular monoamine transporter 2 (vmat2) (western blot) expressions. |
2012-11-16 |
2023-08-12 |
mouse |
| Kuo-Chang Cheng, Jhen-Ni Liao, Ping-Chiang Ly. Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism. The Biochemical journal. vol 446. issue 3. 2012-11-13. PMID:22716280. |
drosophila melanogaster dat (dopamine n-acetyltransferase) is an aanat. |
2012-11-13 |
2023-08-12 |
drosophila_melanogaster |
| Lisa M McFadden, Kristen A Stout, Paula L Vieira-Brock, Scott C Allen, Shannon M Nielsen, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration acutely decreases monoaminergic transporter function. Synapse (New York, N.Y.). vol 66. issue 3. 2012-11-09. PMID:22120988. |
numerous preclinical studies have demonstrated that noncontingent methamphetamine (meth) administration rapidly decreases both dopamine (da) transporter (dat) and vesicular monoamine-2 transporter (vmat-2) function. |
2012-11-09 |
2023-08-12 |
rat |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
investigation of the proteins that regulate dopamine, such as tyrosine hydroxylase (th) protein, th phosphorylation, dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) protein often do not include analysis of dopamine tissue content in the same sample. |
2012-11-02 |
2023-08-12 |
Not clear |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
the ability to analyze both dopamine tissue content and its regulating proteins (including post-translational modifications) not only gives inherent power to interpreting the relationship of dopamine with the protein level and function of th, dat, or vmat2, but also extends sample economy. |
2012-11-02 |
2023-08-12 |
Not clear |