| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Warwick, P D Carey, N Cassimjee, C Lochner, S Hemmings, H Moolman-Smook, E Beetge, P Dupont, D J Stei. Dopamine transporter binding in social anxiety disorder: the effect of treatment with escitalopram. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22350963. |
in this study we measured the effects of ssri pharmacotherapy on dopamine transporter (dat) binding in patients with sad, also addressing variability in dat genotype. |
2012-09-07 |
2023-08-12 |
human |
| J M Warwick, P D Carey, N Cassimjee, C Lochner, S Hemmings, H Moolman-Smook, E Beetge, P Dupont, D J Stei. Dopamine transporter binding in social anxiety disorder: the effect of treatment with escitalopram. Metabolic brain disease. vol 27. issue 2. 2012-09-07. PMID:22350963. |
the changes found in dat binding in the caudate and putamen may be due to serotonergic activation of dopamine function by ssri therapy. |
2012-09-07 |
2023-08-12 |
human |
| Haifeng Hou, Shaowe Jia, Shu Hu, Rong Fan, Wen Sun, Taotao Sun, Hong Zhan. Reduced striatal dopamine transporters in people with internet addiction disorder. Journal of biomedicine & biotechnology. vol 2012. 2012-09-07. PMID:22505818. |
the present study was designed to determine if the striatal dopamine transporter (dat) levels measured by (99m)tc-trodat-1 single photon emission computed tomography (spect) brain scans were altered in individuals with iad. |
2012-09-07 |
2023-08-12 |
human |
| Anders Borgkvist, Torun Malmlöf, Kristin Feltmann, Maria Lindskog, Björn Schilströ. Dopamine in the hippocampus is cleared by the norepinephrine transporter. The international journal of neuropsychopharmacology. vol 15. issue 4. 2012-09-05. PMID:21669025. |
in the hippocampus, there is little, if any, expression of dopamine transporters (dat), indicating that the mechanism for dopamine clearance differs from that in the striatum. |
2012-09-05 |
2023-08-12 |
rat |
| Anders Borgkvist, Torun Malmlöf, Kristin Feltmann, Maria Lindskog, Björn Schilströ. Dopamine in the hippocampus is cleared by the norepinephrine transporter. The international journal of neuropsychopharmacology. vol 15. issue 4. 2012-09-05. PMID:21669025. |
administration of the specific dat inhibitor gbr12909 at a concentration (1 mm) that robustly increased dopamine in the nucleus accumbens had a comparably smaller effect in the hippocampus. |
2012-09-05 |
2023-08-12 |
rat |
| Michael Nocker, Klaus Seppi, Eveline Donnemiller, Irene Virgolini, Gregor K Wenning, Werner Poewe, Christoph Scherfle. Progression of dopamine transporter decline in patients with the Parkinson variant of multiple system atrophy: a voxel-based analysis of [123I]β-CIT SPECT. European journal of nuclear medicine and molecular imaging. vol 39. issue 6. 2012-09-05. PMID:22460689. |
we characterized the progression of dopamine transporter (dat) decline in the striatum and extrastriatal regions including the midbrain and pons of patients with the parkinson variant of multiple system atrophy (msa-p) and compared longitudinally collected spect results with those in a cohort of patients with parkinson's disease (pd). |
2012-09-05 |
2023-08-12 |
Not clear |
| Yuhong Fu, Yuan Yuan, Glenda Halliday, Zoltán Rusznák, Charles Watson, George Paxino. A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse. Brain structure & function. vol 217. issue 2. 2012-09-04. PMID:21935672. |
the dopamine neuron groups were analysed in 15 adult c57bl/6j mice by anatomically localising tyrosine hydroxylase (th), dopamine transporter protein (dat), calbindin, and the g-protein-activated inward rectifier potassium channel 2 (girk2) proteins. |
2012-09-04 |
2023-08-12 |
mouse |
| Oleg Kovtun, Emily J Ross, Ian D Tomlinson, Sandra J Rosentha. A flow cytometry-based dopamine transporter binding assay using antagonist-conjugated quantum dots. Chemical communications (Cambridge, England). vol 48. issue 44. 2012-09-04. PMID:22543630. |
here we present the development and validation of a flow cytometry-based dopamine transporter (dat) binding assay that uses antagonist-conjugated quantum dots (qds). |
2012-09-04 |
2023-08-12 |
Not clear |
| Bradley F Boev. Mild cognitive impairment associated with underlying Alzheimer's disease versus Lewy body disease. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166451. |
patients with the amnesic subtype of mci often develop the dementia syndrome and neuroimaging findings characteristic of ad [e.g., hippocampal atrophy on magnetic resonance imaging (mri), temporoparietal and posterior cingulate hypometabolism on fluorodeoxyglucose positron emission tomography (fdg-pet), positive uptake on amyloid pet, normal striatonigral uptake on dopamine transporter scanning (dat), etc.]. |
2012-08-27 |
2023-08-12 |
Not clear |
| Akiko Muroyama, Aya Fujita, Cheng Lv, Shota Kobayashi, Yoshiyasu Fukuyama, Yasuhide Mitsumot. Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22655218. |
western blot analysis revealed that mptp injections substantially decreased protein levels of dopamine transporter (dat) and tyrosine hydroxylase (th) and increased glial fibrillary acidic protein (gfap) levels in the striatum. |
2012-08-23 |
2023-08-12 |
mouse |
| Simon Bulling, Klaus Schicker, Yuan-Wei Zhang, Thomas Steinkellner, Thomas Stockner, Christian W Gruber, Stefan Boehm, Michael Freissmuth, Gary Rudnick, Harald H Sitte, Walter Sandtne. The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. The Journal of biological chemistry. vol 287. issue 22. 2012-08-15. PMID:22451652. |
ibogaine noncompetitively inhibited transport by both sert and the homologous dopamine transporter (dat). |
2012-08-15 |
2023-08-12 |
Not clear |
| G J E Schmitt, S Dresel, T Frodl, C la Fougère, R Boerner, K Hahn, H-J Möller, E M Meisenzah. Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients. European archives of psychiatry and clinical neuroscience. vol 262. issue 3. 2012-08-08. PMID:22081145. |
the aim of this dual-isotope spect imaging study was to evaluate striatal dopamine transporter (dat) and d2 receptor availability in first-episode never-treated and haloperidol-treated schizophrenic patients and whether the availability is associated with psychopathology. |
2012-08-08 |
2023-08-12 |
Not clear |
| Heather L Kimmel, Jonathon A Nye, Ronald Voll, Jiyoung Mun, Jeffrey Stehouwer, Mark M Goodman, John R Votaw, F I Carroll, Leonard L Howel. Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys. Synapse (New York, N.Y.). vol 66. issue 6. 2012-08-07. PMID:22237864. |
several classes of drugs bind to the dopamine transporter (dat) with high affinity, but some are weaker positive reinforcers than cocaine, suggesting that affinity for and occupancy of the dat is not the only determinant of a drug's reinforcing effectiveness. |
2012-08-07 |
2023-08-12 |
monkey |
| Patrick J Riss, Jacob M Hooker, Colleen Shea, Youwen Xu, Pauline Carter, Donald Warner, Valentina Ferrari, Sung-Won Kim, Franklin I Aigbirhio, Joanna S Fowler, Frank Roesc. Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 22. issue 1. 2012-08-03. PMID:22082561. |
n-(4-fluorobut-2-yn-1-yl)-2β-carbomethoxy-3β-(4'-tolyl)nortropane (pr04.mz, 1) is a pet radioligand for the non-invasive exploration of the function of the cerebral dopamine transporter (dat). |
2012-08-03 |
2023-08-12 |
Not clear |
| David J Lapinsky, Shaili Aggarwal, Tammy L Nolan, Christopher K Surratt, John R Lever, Rejwi Acharya, Roxanne A Vaughan, Akash Pandhare, Michael P Blanto. (±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban). Bioorganic & medicinal chemistry letters. vol 22. issue 1. 2012-08-03. PMID:22119468. |
towards addressing the knowledge gap of how bupropion interacts with the dopamine transporter (dat) and nicotinic acetylcholine receptors (nachrs), a ligand was synthesized in which the chlorine of bupropion was isosterically replaced with an iodine and a photoreactive azide was added to the 4'-position of the aromatic ring. |
2012-08-03 |
2023-08-12 |
human |
| LinLin Tian, Morvarid Karimi, Susan K Loftin, Chris A Brown, HuChuan Xia, JinBin Xu, Robert H Mach, Joel S Perlmutte. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease. PloS one. vol 7. issue 2. 2012-08-03. PMID:22359591. |
no differential regulation of dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2) binding in a primate model of parkinson disease. |
2012-08-03 |
2023-08-12 |
monkey |
| LinLin Tian, Morvarid Karimi, Susan K Loftin, Chris A Brown, HuChuan Xia, JinBin Xu, Robert H Mach, Joel S Perlmutte. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease. PloS one. vol 7. issue 2. 2012-08-03. PMID:22359591. |
radioligands for dat and vmat2 are widely used presynaptic markers for assessing dopamine (da) nerve terminals in parkinson disease (pd). |
2012-08-03 |
2023-08-12 |
monkey |
| Shankar Sadasivan, Brooks B Pond, Amar K Pani, Chunxu Qu, Yun Jiao, Richard J Smeyn. Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice. PloS one. vol 7. issue 3. 2012-08-03. PMID:22470460. |
methylphenidate (mph) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (dat) and the norepinephrine transporter (net), resulting in increased monoamine levels in the synapse. |
2012-08-03 |
2023-08-12 |
mouse |
| Monica L Andersen, Eileen K Sawyer, F Ivy Carroll, Leonard L Howel. Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys. Experimental and clinical psychopharmacology. vol 20. issue 2. 2012-08-01. PMID:22023668. |
dopamine transporter (dat) inhibitors have been developed as a promising treatment approach for cocaine dependence. |
2012-08-01 |
2023-08-12 |
human |
| Monica L Andersen, Eileen K Sawyer, F Ivy Carroll, Leonard L Howel. Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys. Experimental and clinical psychopharmacology. vol 20. issue 2. 2012-08-01. PMID:22023668. |
however, the stimulant effects of dat inhibitors have the potential to disrupt sleep patterns, and the influence of long-term treatment on dopamine neurochemistry is still unknown. |
2012-08-01 |
2023-08-12 |
human |