| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soumava Santra, Sanjib Gogoi, Bhaskar Gopishetty, Tamara Antonio, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. ChemMedChem. vol 7. issue 12. 2013-04-29. PMID:23060293. |
the new compounds were tested for their affinities for the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain by measuring their capacity to inhibit the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2013-04-29 |
2023-08-12 |
rat |
| Ramón Sotomayor-Zárate, Gabriel Quiroz, Katherine A Araya, Jorge Abarca, María R Ibáñez, Alejandro Montecinos, Carlos Guajardo, Gabriel Núñez, Angélica Fierro, Pablo R Moya, Patricio Iturriaga-Vásquez, Cristóbal Gómez-Molina, Katia Gysling, Miguel Reyes-Parad. 4-Methylthioamphetamine increases dopamine in the rat striatum and has rewarding effects in vivo. Basic & clinical pharmacology & toxicology. vol 111. issue 6. 2013-04-25. PMID:22788961. |
as little is known about dopaminergic effects of this drug, in this work the actions of mta upon the dopamine (da) transporter (dat) were studied in vitro, in vivo and in silico. |
2013-04-25 |
2023-08-12 |
human |
| Shu-Chen Li, Goran Papenberg, Irene E Nagel, Claudia Preuschhof, Julia Schröder, Wilfried Nietfeld, Lars Bertram, Hauke R Heekeren, Ulman Lindenberger, Lars Bäckma. Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22939506. |
aging compromises dopamine transporter (dat) and receptor mechanisms in the frontostriatal circuitry. |
2013-04-23 |
2023-08-12 |
Not clear |
| Shu-Chen Li, Goran Papenberg, Irene E Nagel, Claudia Preuschhof, Julia Schröder, Wilfried Nietfeld, Lars Bertram, Hauke R Heekeren, Ulman Lindenberger, Lars Bäckma. Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22939506. |
in a sample of 1288 younger and older adults, we investigated (i) whether individual differences in genotypes of the dat gene (i.e., slc6a3, the dat variable number of tandem repeat 9/9, 9/10, and 10/10) and in the d2 receptor (drd2) gene (i.e., the c957t [rs6277] cc and any t) interactively contribute to phenotype variations in episodic memory performance; and (ii) whether these genetic effects are magnified in older adults, because of considerable declines in the dopamine functions. |
2013-04-23 |
2023-08-12 |
Not clear |
| Shu-Chen Li, Goran Papenberg, Irene E Nagel, Claudia Preuschhof, Julia Schröder, Wilfried Nietfeld, Lars Bertram, Hauke R Heekeren, Ulman Lindenberger, Lars Bäckma. Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory. Neurobiology of aging. vol 34. issue 1. 2013-04-23. PMID:22939506. |
our results showed that carrying genotypes associated with higher levels of striatal synaptic dopamine (dat 9/9) and higher density of extrastriatal d2 receptors (c957t cc) were associated with better backward serial recall, an episodic memory task with high encoding and retrieval demands. |
2013-04-23 |
2023-08-12 |
Not clear |
| Walter Adriani, Susanne Koot, Sandra Columba-Cabezas, Emilia Romano, Domenica Travaglini, Ruud van den Bos, Oleg Granstrem, Syed F Ali, Giovanni Laviol. Immunization with DAT fragments is associated with long-term striatal impairment, hyperactivity and reduced cognitive flexibility in mice. Behavioral and brain functions : BBF. vol 8. 2013-04-23. PMID:23192105. |
levels of brain dopamine transporter (dat) have been implicated in several impulse-control disorders, like attention deficit / hyperactivity disorder (adhd) and obsessive-compulsive disorder (ocd). |
2013-04-23 |
2023-08-12 |
mouse |
| F Mignini, C Nasuti, M Artico, F Giovannetti, C Fabrizi, L Fumagalli, G Iannetti, E Pompil. Effects of trimethyltin on hippocampal dopaminergic markers and cognitive behaviour. International journal of immunopathology and pharmacology. vol 25. issue 4. 2013-04-23. PMID:23298501. |
in the hippocampal area of the tmt-treated group, we observed a reduction in neuronal viability accompanied by a significant decrease in the expression of the dopamine receptors (d1 and d2), and dopamine transporters (dat, vmat1 and vmat2). |
2013-04-23 |
2023-08-12 |
human |
| David Zilles, Jobst Meyer, Thomas Schneider-Axmann, Savira Ekawardhani, Eva Gruber, Peter Falkai, Oliver Grube. Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning. European archives of psychiatry and clinical neuroscience. vol 262. issue 8. 2013-04-22. PMID:22454241. |
here, we investigated the impact of well-known polymorphisms of the dopamine transporter gene (slc6a3, dat) and the catechol-o-methyl-transferase gene (comt) as well as the serotonin transporter gene (slc6a4, 5-htt) on these specific working memory subcomponents in a mixed sample of patients and healthy individuals. |
2013-04-22 |
2023-08-12 |
human |
| Claire Leroy, Laurent Karila, Jean-Luc Martinot, Michaël Lukasiewicz, Edouard Duchesnay, Claude Comtat, Frédéric Dollé, Amine Benyamina, Eric Artiges, Maria-Joao Ribeiro, Michel Reynaud, Christian Trichar. Striatal and extrastriatal dopamine transporter in cannabis and tobacco addiction: a high-resolution PET study. Addiction biology. vol 17. issue 6. 2013-04-15. PMID:21812871. |
in order to assess striatal and extrastriatal dopamine transporter (dat) availability in tobacco and cannabis addiction, three groups of male age-matched subjects were compared: 11 healthy non-smoker subjects, 14 tobacco-dependent smokers (17.6 ± 5.3 cigarettes/day for 12.1 ± 8.5 years) and 13 cannabis and tobacco smokers (cts) (4.8 ± 5.3 cannabis joints/day for 8.7 ± 3.9 years). |
2013-04-15 |
2023-08-12 |
human |
| Michael Y Aksenov, M V Aksenova, C F Mactutus, Rosemarie M Booz. D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22552781. |
this interactive meth+tat neurotoxicity does not occur in cultures of hippocampal neurons, which are predominately glutamatergic, express very low levels of dopamine receptors, and have no functional dopamine transporter (dat). |
2013-04-10 |
2023-08-12 |
Not clear |
| Narasimha M Midde, Adrian M Gomez, Jun Zh. HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22570010. |
the dopamine (da) transporter (dat) and vesicular monoamine transporter (vmat2) proteins interact as a biochemical complex to regulate dopaminergic neurotransmission. |
2013-04-10 |
2023-08-12 |
rat |
| Joshua M Bradner, Tiffany A Suragh, W Wyatt Wilson, Carlos R Lazo, Kristen A Stout, Hye Mi Kim, Min Z Wang, Douglas I Walker, Kurt D Pennell, Jason R Richardson, Gary W Miller, W Michael Caudl. Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: role of dopamine handling in neurotoxicity. Experimental neurology. vol 241. 2013-04-08. PMID:23287494. |
assessment of de-71 neurotoxicity in vivo demonstrated significant deposition of pbde congeners in the brains of mice, leading to reductions in striatal dopamine and dopamine handling, as well as reductions in the striatal dopamine transporter (dat) and vmat2. |
2013-04-08 |
2023-08-12 |
mouse |
| Maria Sierra, Pascual Sánchez-Juan, María Isabel Martínez-Rodríguez, Isabel González-Aramburu, Inés García-Gorostiaga, María Remedios Quirce, Enrique Palacio, José Manuel Carril, José Berciano, Onofre Combarros, Jon Infant. Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease. Neurology. vol 80. issue 7. 2013-04-08. PMID:23325906. |
to ascertain in a cross-sectional study whether substantia nigra (sn) echogenicity, olfaction, and dopamine transporter (dat)-spect are reliable premotor biomarkers in a cohort of asymptomatic carriers of the lrrk2 g2019s mutation (asg2019s+). |
2013-04-08 |
2023-08-12 |
Not clear |
| Clelia Dallanoce, Mara Canovi, Carlo Matera, Tiziana Mennini, Marco De Amici, Marco Gobbi, Carlo De Michel. A novel spirocyclic tropanyl-Δ²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23022052. |
their interaction with the dopamine and serotonin transporters (dat and sert, respectively) was evaluated through binding experiments. |
2013-04-05 |
2023-08-12 |
rat |
| Marcelo Q Hoexter, Gustavo Fadel, André C Felício, Mariana B Calzavara, Ilza R Batista, Marilia A Reis, Ming C Shih, Roger K Pitman, Sérgio B Andreoli, Marcelo F Mello, Jair J Mari, Rodrigo A Bressa. Higher striatal dopamine transporter density in PTSD: an in vivo SPECT study with [(99m)Tc]TRODAT-1. Psychopharmacology. vol 224. issue 2. 2013-04-04. PMID:22700036. |
the 9-repetition allele (9r) located in the 3' untranslated region of the dopamine transporter (dat) gene (slc6a3) is more frequent among ptsd patients. |
2013-04-04 |
2023-08-12 |
Not clear |
| Pedro Braga-Neto, Andre C Felicio, Marcelo Q Hoexter, José Luiz Pedroso, Lívia Almeida Dutra, Helena Alessi, Thaís Minett, Ruth F Santos-Galduroz, Antônio José da Rocha, Lucas A L Garcia, Paulo Henrique F Bertolucci, Rodrigo A Bressan, Orlando Graziani Povoas Barsottin. Cognitive and olfactory deficits in Machado-Joseph disease: a dopamine transporter study. Parkinsonism & related disorders. vol 18. issue 7. 2013-03-29. PMID:22575233. |
in this study, we investigated whether these patients had different dopamine transporter (dat) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. |
2013-03-29 |
2023-08-12 |
human |
| Philippe Huot, Tom H Johnston, Michael N Gandy, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset. PloS one. vol 7. issue 9. 2013-03-28. PMID:23029119. |
we recently described the discovery of uwa-101, a dual serotonin (sert) and dopamine (dat) transporter inhibitor, which increases the duration of "good quality" on-time provided by l-dopa in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned primate. |
2013-03-28 |
2023-08-12 |
marmoset |
| V Barth, A B Need, E T Tzavara, B Giros, C Overshiner, S D Gleason, M Wade, A M Johansson, K Perry, G G Nomikos, J M Witki. In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder. The Journal of pharmacology and experimental therapeutics. vol 344. issue 2. 2013-03-28. PMID:23197772. |
mice in which the dopamine transporter (dat) has been deleted exhibit hyperactivity that is normalized by compounds that are effective in the treatment of adhd. |
2013-03-28 |
2023-08-12 |
mouse |
| Saskia J Rietjens, Laura Hondebrink, Remco H S Westerink, Jan Meulenbel. Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. Critical reviews in toxicology. vol 42. issue 10. 2013-03-20. PMID:23030234. |
pretreatment with inhibitors of the dopamine or norepinephrine reuptake transporter (dat or net), 5-ht(2a) or α-β adrenergic receptor antagonists or antipsychotics prior to mdma exposure can also decrease one or more mdma-induced physiological and/or subjective effects. |
2013-03-20 |
2023-08-12 |
Not clear |
| Di Wang, Hei Kiu Wong, Li Zhang, Grainne M McAlonan, Xiao-Min Wang, Stephen Cho Wing Sze, Yi-Bin Feng, Zhang-Jin Zhan. Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 2. 2013-03-19. PMID:22796279. |
consistent with a d(2)-action, pgd did not affect prl in rat pituitary lactotropic tumor-derived gh3 cells that lack the d(2) receptor expression but significantly increased the expression of d(2) receptors and dopamine transporters (dat) in pc12 cells. |
2013-03-19 |
2023-08-12 |
rat |