| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Varrone, Maria Teresa Pellecchi. SPECT Molecular Imaging in Familial Parkinson's Disease. International review of neurobiology. vol 142. 2019-05-08. PMID:30409254. |
dopamine transporter (dat) imaging with single-photon emission computed tomography (spect) is a diagnostic tool to study the integrity of the dopaminergic system in patients with parkinsonism and uncertain diagnosis. |
2019-05-08 |
2023-08-13 |
human |
| Mahmudur G M Rahman, Muhammad M Islam, Tetsuya Tsujikawa, Yasushi Kiyono, Hidehiko Okazaw. Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis. Annals of nuclear medicine. vol 33. issue 1. 2019-05-06. PMID:30276622. |
to calculate the specific binding ratio (sbr) appropriately in dopamine transporter (dat) imaging, a method for extracting the striatal volume of interest (voi) was developed. |
2019-05-06 |
2023-08-13 |
Not clear |
| Christopher T Smith, M Danica San Juan, Linh C Dang, Daniel T Katz, Scott F Perkins, Leah L Burgess, Ronald L Cowan, H Charles Manning, Michael L Nickels, Daniel O Claassen, Gregory R Samanez-Larkin, David H Zal. Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity in healthy adults. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30531858. |
preclinical work links reduced ventral striatal dopamine transporter (dat) availability with heightened impulsivity and novelty seeking. |
2019-05-06 |
2023-08-13 |
human |
| Laura Hautrive Milanesi, Domenika Rubert Rossato, Verônica Tironi Dias, Maikel Kronbauer, Lívia Ferraz D'avila, Sabrina Somacal, Thiago Duarte, Marta Maria Frescura Duarte, Tatiana Emanuelli, Marilise E Burge. Mediterranean X Western based diets: Opposite influences on opioid reinstatement. Toxicology letters. vol 308. 2019-04-25. PMID:30898663. |
in the nucleus accumbens, wbds increased dopamine transporter (dat) and dopamine receptor-2 (d2r) immunoreactivity and decreased dopamine receptor-1 (d1r). |
2019-04-25 |
2023-08-13 |
rat |
| Annalisa Adinolfi, Silvia Zelli, Damiana Leo, Cristiana Carbone, Liudmila Mus, Placido Illiano, Enrico Alleva, Raul R Gainetdinov, Walter Adrian. Behavioral characterization of DAT-KO rats and evidence of asocial-like phenotypes in DAT-HET rats: The potential involvement of norepinephrine system. Behavioural brain research. vol 359. 2019-04-23. PMID:30472113. |
dopamine (da) is a key neurotransmitter of the central nervous system, whose availability is regulated by the dopamine transporter (dat). |
2019-04-23 |
2023-08-13 |
mouse |
| Irene Dall'Antonia, Karel Šonka, Petr Duše. Olfaction and Colour Vision: What Can They Tell Us about Parkinson's Disease? Prague medical report. vol 119. issue 2-3. 2019-04-22. PMID:30414359. |
clinical markers that indicate early progression from rbd to manifest synucleinopathies include abnormal dopamine transporter (dat) imaging, motor and non-motor symptoms. |
2019-04-22 |
2023-08-13 |
Not clear |
| Veerappan Venkatesh Gobi, Srinivasagam Rajasankar, William Moses Swaminathan Johnson, Kaliyaperumal Prabu, Muthu Ramkuma. Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson's disease. Frontiers in bioscience (Elite edition). vol 11. 2019-04-16. PMID:30468634. |
a. blazei extract blocked the rotenone-mediated diminution of dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat 2) expression and the downregulation of bcl-2 and the upregulation of bax, caspases-3, -6, -8 and caspase-9. |
2019-04-16 |
2023-08-13 |
mouse |
| Minh-Thanh T Nguyen, Shruti Vemaraju, Gowri Nayak, Yoshinobu Odaka, Ethan D Buhr, Nuria Alonzo, Uyen Tran, Matthew Batie, Brian A Upton, Martin Darvas, Zbynek Kozmik, Sujata Rao, Rashmi S Hegde, P Michael Iuvone, Russell N Van Gelder, Richard A Lan. An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye. Nature cell biology. vol 21. issue 4. 2019-04-16. PMID:30936473. |
we demonstrate that 380-nm light stimulation via opn5 and vgat (the vesicular gaba/glycine transporter) in retinal ganglion cells enhances the activity of inner retinal dat (also known as slc6a3; a dopamine reuptake transporter) and thus suppresses vitreal dopamine. |
2019-04-16 |
2023-08-13 |
mouse |
| b' Nata\\xc5\\xa1a Popovi\\xc4\\x87, Vesna Stojiljkovi\\xc4\\x87, Sne\\xc5\\xbeana Peji\\xc4\\x87, Ana Todorovi\\xc4\\x87, Ivan Pavlovi\\xc4\\x87, Ljubica Gavrilovi\\xc4\\x87, Sne\\xc5\\xbeana B Pajovi\\xc4\\x8. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. Oxidative medicine and cellular longevity. vol 2019. 2019-04-15. PMID:30911352.' |
in addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (da) and malondialdehyde (mda), protein levels of brain-derived neurotrophic factor (bdnf), tyrosine hydroxylase (th), dopamine transporter (dat), and catechol-o-methyltransferase (comt), as well as activity of monoamine oxidase (mao) in chronically stressed rats. |
2019-04-15 |
2023-08-13 |
rat |
| Shigetoshi Takaya, Nobukatsu Sawamoto, Tomohisa Okada, Gosuke Okubo, Sei Nishida, Kaori Togashi, Hidenao Fukuyama, Ryosuke Takahash. Differential diagnosis of parkinsonian syndromes using dopamine transporter and perfusion SPECT. Parkinsonism & related disorders. vol 47. 2019-04-12. PMID:29157745. |
we aimed to assess whether a combined analysis of dopamine transporter (dat)- and perfusion-spect images (or either) could: (1) distinguish atypical parkinsonian syndromes (aps) from lewy body diseases (lbd; majority parkinson disease [pd]), and (2) differentiate among aps subgroups (progressive supranuclear palsy [psp], corticobasal syndrome [cbs], and multiple system atrophy [msa]). |
2019-04-12 |
2023-08-13 |
Not clear |
| Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochemistry international. vol 113. 2019-04-10. PMID:29197543. |
moreover, 3-fma significantly produced dopaminergic impairments [i.e., increase in dopamine (da) turnover rate and decreases in da level, and in the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat-2)] with behavioral impairments. |
2019-04-10 |
2023-08-13 |
mouse |
| Zhong-Bao Gao, Wei Wang, Xing-Li Zhao, Tong Chen, Li-Ping Fu, Bai-Xuan Xu, Zhen-Fu Wan. Multi-modality molecular imaging characteristics of dementia with Lewy bodies. The Journal of international medical research. vol 46. issue 6. 2019-04-03. PMID:29619853. |
molecular neuroimaging using dopamine transporter (dat), pittsburgh compound b (pib), and fluorodeoxyglucose (fdg) positron emission tomography (pet) has advantages in detecting dopaminergic neuron loss, abnormal amyloid β-protein deposition, and glucose metabolism changes in patients with neurodegenerative disorders. |
2019-04-03 |
2023-08-13 |
Not clear |
| Amine Bahi, Jean-Luc Dreye. Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice. Behavioural brain research. vol 359. 2019-04-03. PMID:30367968. |
dopamine transporter (dat) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice. |
2019-04-03 |
2023-08-13 |
mouse |
| Amine Bahi, Jean-Luc Dreye. Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice. Behavioural brain research. vol 359. 2019-04-03. PMID:30367968. |
many epidemiological and clinical studies have demonstrated a strong comorbidity between anxiety and depression, and a number of experimental studies indicates that the dopamine transporter (dat) is involved in the pathophysiology of anxiety and depression. |
2019-04-03 |
2023-08-13 |
mouse |
| Mu-Fa Zou, Jianjing Cao, Ara M Abramyan, Theresa Kopajtic, Claudio Zanettini, Daryl A Guthrie, Rana Rais, Barbara S Slusher, Lei Shi, Claus J Loland, Amy Hauck Newma. Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. Journal of medicinal chemistry. vol 60. issue 24. 2019-04-01. PMID:29227643. |
structure-activity relationship studies on a series of 3α-[bis(4-fluorophenyl)methoxy]tropanes and 3α-[bis(4-fluorophenyl)methylamino]tropanes as novel atypical dopamine transporter (dat) inhibitors for the treatment of cocaine use disorders. |
2019-04-01 |
2023-08-13 |
mouse |
| Mu-Fa Zou, Jianjing Cao, Ara M Abramyan, Theresa Kopajtic, Claudio Zanettini, Daryl A Guthrie, Rana Rais, Barbara S Slusher, Lei Shi, Claus J Loland, Amy Hauck Newma. Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders. Journal of medicinal chemistry. vol 60. issue 24. 2019-04-01. PMID:29227643. |
as the dopamine transporter (dat) plays a prominent role in the reinforcing effects of cocaine that can lead to addiction, atypical dat inhibitors have been developed that prevent cocaine from binding to dat, but they themselves are not cocaine-like. |
2019-04-01 |
2023-08-13 |
mouse |
| Jordan T Lloyd, Alessandro Martini, Alice McDouall, Rahul Sood, Peter S Freestone, Nicola B Mercuri, Janusz Lipsk. Electrophysiological Characterization of Novel Effects of the Uptake-2 Blocker Decynium-22 (D-22) on Dopaminergic Neurons in the Substantia Nigra Pars Compacta. Neuroscience. vol 396. 2019-04-01. PMID:30447392. |
extracellular levels of dopamine (da) and other monoamines in the brain depend not only on the classic transporters encoded by slc6a gene family such as dat, net and sert, but also a more recently identified group of low-affinity/high-capacity 'uptake-2' transporters, mainly oct3 and pmat. |
2019-04-01 |
2023-08-13 |
mouse |
| Hui-Jun Yang, Seol Hoon Park, Minjung Seo, Young Cheol Weon, Yangho Ki. Neurotoxicology. vol 64. 2019-03-21. PMID:28259768. |
we report the clinical features and imaging findings of presynaptic dopamine transporter (dat) positron emission tomography (pet) in four of patients with liver cirrhosis and concurrent parkinsonism. |
2019-03-21 |
2023-08-13 |
Not clear |
| Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Le. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. vol 379. 2019-03-18. PMID:29559387. |
our biochemical data showed that ee-induced neuroprotection occurs in combination with multiple synergic neuroprotective pathways: (1) increased neurogenesis shown by an increase in brdu-positive neurons; (2) diminished loss of dopaminergic neurons evidenced by upregulated tyrosine hydroxylase (th) and dopamine transporter (dat) levels; (3) increased antioxidant capacity (e.g., cuznsod, catalase, gpx1/2, ho-1, dj1 and prxiii); and (4) enhanced autophagy (lc3 ii, p62, beclin1, bnip3, lamp2, cathepsin l and tfeb). |
2019-03-18 |
2023-08-13 |
mouse |
| Sathiya Sekar, Sugumar Mani, Barathidasan Rajamani, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Abid Bhat, Bipul Ray, Musthafa Mohamed Essa, Gilles J Guillemin, Saravana Babu Chidambara. Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism. Neurotoxicity research. vol 34. issue 3. 2019-03-14. PMID:30006683. |
on the other hand, tel upregulated tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) expressions. |
2019-03-14 |
2023-08-13 |
mouse |