| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Yasine Malki, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong H. Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 ( International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409005. |
syngr3 interacts with the dopamine transporter (dat) to facilitate dopamine (da) uptake and synaptic da turnover in dopaminergic transmission. |
2022-04-12 |
2023-08-13 |
human |
| Victor Blokhin, Alina V Lavrova, Sergey A Surkov, Eduard R Mingazov, Natalia M Gretskaya, Vladimir V Bezuglov, Michael V Ugrumo. A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409040. |
this method is based on the authors' hypothesis about the possibility of specifically internalizing into dopaminergic neurons substances with a high affinity for the dopamine transporter (dat). |
2022-04-12 |
2023-08-13 |
mouse |
| Ruyan Wu, Jianfeng Liu, Jun-Xu L. Trace amine-associated receptor 1 and drug abuse. Advances in pharmacology (San Diego, Calif.). vol 93. 2022-03-28. PMID:35341572. |
however, it is hypothesized that taar1 interaction with da transporter (dat) and dopamine d2 receptor (d2) and the subsequent modulation of cellular cascades may contribute to the effects of taar1 in regulating drug abuse. |
2022-03-28 |
2023-08-13 |
Not clear |
| Jordan T Lloyd, Andrew G Yee, Prasanna K Kalligappa, Anower Jabed, Pang Y Cheung, Kathryn L Todd, Rashika N Karunasinghe, Srdjan M Vlajkovic, Peter S Freestone, Janusz Lipsk. Dopamine dysregulation and altered responses to drugs affecting dopaminergic transmission in a new dopamine transporter knockout (DAT-KO) rat model. Neuroscience. 2022-03-25. PMID:35331847. |
under normal conditions, dopamine (da) clearance after release largely depends on uptake by the da transporter (dat). |
2022-03-25 |
2023-08-13 |
rat |
| Changliang Zhu, Hailiang Li, Xuerui Kong, Yezhong Wang, Tao Sun, Feng Wan. Possible Mechanisms Underlying the Effects of Glucagon-Like Peptide-1 Receptor Agonist on Cocaine Use Disorder. Frontiers in pharmacology. vol 13. 2022-03-18. PMID:35300299. |
increasing preclinical evidence suggests that glp-1ras are promising in regulating dopamine release, dopamine transporter (dat) surface expression and function, mesolimbic reward system and gabaergic neurons, and maladaptive behaviors in animal models of self-administration and conditioned place preference. |
2022-03-18 |
2023-08-13 |
Not clear |
| Hongsong Feng, Kaifu Gao, Dong Chen, Li Shen, Alfred J Robison, Edmund Ellsworth, Guo-Wei We. Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks. Journal of chemical theory and computation. 2022-03-16. PMID:35294204. |
among them, the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters are three major targets. |
2022-03-16 |
2023-08-13 |
Not clear |
| Ryota Kobayashi, Shinobu Kawakatsu, Makoto Ohba, Daichi Morioka, Masafumi Kanoto, Koichi Otan. Dopamine Transporter Imaging for Frontotemporal Lobar Degeneration With Motor Neuron Disease. Frontiers in neuroscience. vol 16. 2022-03-14. PMID:35281498. |
a previous study reported abnormal findings on dopamine transporter (dat) imaging in 30% of patients with frontotemporal dementia (ftd) in ftld. |
2022-03-14 |
2023-08-13 |
Not clear |
| Yoshikazu Nakano, Shigeki Hirano, Kazuho Kojima, Honglinag Li, Toru Sakurai, Masahide Suzuki, Hong Tai, Shogo Furukawa, Atsuhiko Sugiyama, Yoshitaka Yamanaka, Tatsuya Yamamoto, Takashi Iimori, Hajime Yokota, Hiroki Mukai, Takuro Horikoshi, Takashi Uno, Satoshi Kuwabar. Dopaminergic Correlates of Regional Cerebral Blood Flow in Parkinsonian Disorders. Movement disorders : official journal of the Movement Disorder Society. 2022-03-14. PMID:35285050. |
cerebral blood flow (cbf) and dopamine transporter (dat) images are clinically used for the differential diagnosis of parkinsonian disorders. |
2022-03-14 |
2023-08-13 |
Not clear |
| Luyin Wu, Yao Dang, Li-Xia Liang, Yan-Chen Gong, Mohammed Zeeshan, Zhengmin Qian, Sarah Dee Geiger, Michael G Vaughn, Yang Zhou, Qing-Qing Li, Chu Chu, Ya-Wen Tan, Li-Zi Lin, Ru-Qing Liu, Li-Wen Hu, Bo-Yi Yang, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Don. Perfluorooctane sulfonates induces neurobehavioral changes and increases dopamine neurotransmitter levels in zebrafish larvae. Chemosphere. 2022-03-08. PMID:35259355. |
upregulation of dopamine-related genes tyrosine hydroxylase (th) and dopamine transporter (dat) associated with increased dopamine contents in the 3.2 mg/l of pfos. |
2022-03-08 |
2023-08-13 |
zebrafish |
| Caline S Karam, Brenna L Williams, Irina Morozova, Qiaoping Yuan, Rony Panarsky, Yuchao Zhang, Colin A Hodgkinson, David Goldman, Sergey Kalachikov, Jonathan A Javitc. Functional Genomic Analysis of Amphetamine Sensitivity in Frontiers in psychiatry. vol 13. 2022-03-07. PMID:35250674. |
the actions of these drugs at the dopamine transporter (dat) play a critical role in their therapeutic efficacy as well as their liability for abuse and dependence. |
2022-03-07 |
2023-08-13 |
Not clear |
| Jonathan R Reinwald, Natalia Gass, Anne S Mallien, Alexander Sartorius, Robert Becker, Markus Sack, Claudia Falfan-Melgoza, Christian Clemm von Hohenberg, Damiana Leo, Natascha Pfeiffer, Anthonieke Middelman, Andreas Meyer-Lindenberg, Judith R Homberg, Wolfgang Weber-Fahr, Peter Gas. Dopamine transporter silencing in the rat: systems-level alterations in striato-cerebellar and prefrontal-midbrain circuits. Molecular psychiatry. 2022-03-05. PMID:35246636. |
silencing of dopamine transporter (dat), a main controlling factor of dopaminergic signaling, results in biochemical and behavioral features characteristic for neuropsychiatric diseases with presumed hyperdopaminergia including schizophrenia, attention deficit hyperactivity disorder (adhd), bipolar disorder, and obsessive-compulsive disorder (ocd). |
2022-03-05 |
2023-08-13 |
rat |
| Amgad Droby, Moran Artzi, Hedva Lerman, R Matthew Hutchison, Dafna Ben Bashat, Nurit Omer, Tanya Gurevich, Avi Orr-Urtreger, Batsheva Cohen, Jesse M Cedarbaum, Einat Even Sapir, Nir Giladi, Anat Mirelman, Avner Thale. Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-04. PMID:35241697. |
dopamine transporter (dat)-spectral positron emission computed tomography is widely used for capturing functional nigrostriatal dopaminergic activity. |
2022-03-04 |
2023-08-13 |
human |
| Anna Sara Liberati, Barbara Calcaprina, Walter Adrian. Keeping Track of the Genealogy of Heterozygotes Using Epigenetic Reference Codes and Breeding Tables. Frontiers in behavioral neuroscience. vol 15. 2022-02-28. PMID:35221940. |
studying neurobehavioral consequences of the hypofunctional dopamine transporter (dat) across several generations entails the need to monitor allelic transmission to offspring, taking into account both maternal and paternal inheritance. |
2022-02-28 |
2023-08-13 |
Not clear |
| Sharonda S Harris, Sara M Green, Mayank Kumar, Nikhil M Ur. A role for cortical dopamine in the paradoxical calming effects of psychostimulants. Scientific reports. vol 12. issue 1. 2022-02-25. PMID:35210489. |
studies using dopamine (da) transporter (dat) knockout (ko) mice have suggested that the paradoxical calming effect of psychostimulants might occur through actions on serotonin (5-ht) neurotransmission. |
2022-02-25 |
2023-08-13 |
mouse |
| Jia Guo, Ke Xu, Jiang-Wen Yin, Han Zhang, Jie-Ting Yin, Yan L. Dopamine transporter in the ventral tegmental area modulates recovery from propofol anesthesia in rats. Journal of chemical neuroanatomy. 2022-02-19. PMID:35181484. |
to investigate the role of the dopamine transporter (dat) in the ventral tegmental area (vta) in the recovery from propofol anesthesia in rats. |
2022-02-19 |
2023-08-13 |
rat |
| Yoko Shigemoto, Hiroshi Matsuda, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Moto Nakaya, Norihide Maikusa, Masayo Ogawa, Yohei Mukai, Yuji Takahashi, Kazuya Sako, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hiroshi Nagayama, Kenjiro Ono, Atsushi Kono, Kenji Sekiguchi, Shigeki Hirano, Noriko Sat. Voxel-based analysis of age and gender effects on striatal [ Annals of nuclear medicine. 2022-02-17. PMID:35174441. |
voxel-based analysis of age and gender effects on striatal [ although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (dat) binding, these studies were mostly based on a conventional regions of interest-based analysis. |
2022-02-17 |
2023-08-13 |
Not clear |
| Tzu-Feng Wang, Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yu-Min Ku. Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits. Cells. vol 11. issue 3. 2022-02-15. PMID:35159290. |
we showed that, compared to 3-month-old mice, the number of da neurons in the sn and the expression of dopamine transporter (dat) in the striatum decreased during the period of 9 to 12 months of age. |
2022-02-15 |
2023-08-13 |
mouse |
| Yasumi Ohta, Takaaki E Murakami, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta, Metin Akay, Yasemin M Aka. Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163036. |
in this study, we used this platform to photo-stimulate the vta neurons in both chrimsonr-expressing (non-specific) wild and dopamine transporter (dat)-cre (dopamine specific) mice, and measured the dopamine release in the nucleus accumbens shell (nacshell). |
2022-02-15 |
2023-08-13 |
mouse |
| Yongjie Xu, Tao Peng, Yang Xiang, Gengze Liao, Fei Zou, Xiaojing Men. Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure. The Science of the total environment. 2022-02-12. PMID:35150691. |
the terminal deoxynucleotidyl transferase dutp nick end labeling assay and acridine orange staining were performed to monitor cell apoptosis, while dopamine transporter (dat) and tyrosine hydroxylase (th) expression were detected by immunohistochemical staining. |
2022-02-12 |
2023-08-13 |
zebrafish |
| Tõnis Tokko, Grete Miškinyte, Diva Eensoo, Jaanus Harr. Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism. Nordic journal of psychiatry. 2022-02-07. PMID:35130472. |
dopaminergic dysfunction has been found to occur in adhd, with the dopamine transporter (dat) gene vntr polymorphism ( |
2022-02-07 |
2023-08-13 |
Not clear |