| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Zhao, Ping Wu, Jianjun Wu, Matthias Brendel, Jiaying Lu, Jingjie Ge, Chunmeng Tang, Jimin Hong, Qian Xu, Fengtao Liu, Yimin Sun, Zizhao Ju, Huamei Lin, Yihui Guan, Claudio Bassetti, Markus Schwaiger, Sung-Cheng Huang, Axel Rominger, Jian Wang, Chuantao Zuo, Kuangyu Sh. Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning. European journal of nuclear medicine and molecular imaging. 2022-05-19. PMID:35588012. |
this work attempts to decode the discriminative information in dopamine transporter (dat) imaging using deep learning for the differential diagnosis of parkinsonism. |
2022-05-19 |
2023-08-13 |
Not clear |
| Dino Luethi, Gerhard J Schütz, Harald H Sitt. Single Molecule Analysis Reveals Dimer Formation of the Norepinephrine Transporter at the Plasma Membrane of Live Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552962. |
using single molecule microscopy, we previously reported that the serotonin transporter (sert) co-exists as monomers, dimers, and higher-order oligomers, while the dopamine transporter (dat) forms monomers and dimers only. |
2022-05-13 |
2023-08-13 |
Not clear |
| Christina Besada, Stacia I Lewandowski, Ole V Mortense. MKP3 Overexpression and ERK1/2 Phosphorylation in Dopaminergic Neurons Regulate DAT Trafficking and Function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552965. |
dopamine neurotransmission is regulated by the dopamine transporter (dat), which translocates dopamine from the extracellular space to the presynaptic neuron. |
2022-05-13 |
2023-08-13 |
rat |
| Jonté Roberts, Sherry Wang, Mar Medrano, Haigou Sun, Rong Che. Atorvastatin Modulates the Function and Trafficking of Dopamine Transporters. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554025. |
the dopamine transporter (dat) is the primary mechanism for terminating this signaling via da uptake. |
2022-05-13 |
2023-08-13 |
Not clear |
| Nikhil M Urs, Sharonda Harris, Sara M Green, Mayank M Kuma. A Role for Cortical Dopamine in the Paradoxical Calming Effects of Psychostimulants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554609. |
studies using the dopamine (da) transporter (dat) knockout mice, which have elevated striatal da levels and are considered an animal model of adhd, have suggested that the paradoxical calming effect of psychostimulants might be through the actions on serotonin neurotransmission. |
2022-05-13 |
2023-08-13 |
mouse |
| Nikki J Clauss, W A Owens, Melissa Vitela, Melodi A Bowman, Felix P Mayer, Diethart Schmid, Marion Holy, Harrold H Sitte, Geogianna G Gould, Wouter Koek, Lynette C Daw. Ethanol Inhibits Dopamine Uptake and Augments Rewarding Effects of Cocaine via Organic Cation Transporter 3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554677. |
both cocaine (blocker of dopamine (da), norepinephrine and serotonin transporters, dat, net and sert, respectively) and ethanol (etoh) increase extracellular levels of these monoamines. |
2022-05-13 |
2023-08-13 |
Not clear |
| Yibin Xu, Stacia Lewandowski, Christina Besad. Allosteric Dopamine transporter modulator inhibits cocaine-induced behavior. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555950. |
the dopamine transporter (dat) is a transmembrane protein responsible for reuptake the neurotransmitter dopamine back into the presynaptic neurons. |
2022-05-13 |
2023-08-13 |
rat |
| Suzanne Underhill, Susan Amar. 3,4-methylenedioxymethamphetamine (MDMA) stimulates activation of TAAR1 and subsequent neurotransmitter transporter internalization in serotonin neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556756. |
in previous studies, we have shown that a closely-related compound, amphetamine (amph), enters neurons through the dopamine and norepinephrine transporters (dat and net) and activates taar1. |
2022-05-13 |
2023-08-13 |
mouse |
| Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukl. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022-05-09. PMID:35533351. |
further, the dize-mediated activation of ace2 led to increased tyrosine hydroxylase (th) and dopamine transporters (dat) expression in the rat brain, indicating the protection of dopaminergic (daergic) neurons from 6-ohda induced neurotoxicity. |
2022-05-09 |
2023-08-13 |
rat |
| Vesna Sossi, Joseph R Patterson, Siobhan McCormick, Christopher J Kemp, Kathryn M Miller, Anna C Stoll, Nathan Kuhn, Michael Kubik, Joseph Kochmanski, Kelvin C Luk, Caryl E Sortwel. Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2022-05-07. PMID:35524682. |
positron emission tomography (pet) imaging in early parkinson's disease (pd) subjects reveals that increased dopamine (da) turnover and reduced dopamine transporter (dat) density precede decreases in da synthesis and storage. |
2022-05-07 |
2023-08-13 |
human |
| Tyra S C Zetterström, Emmanuel Quansah, Martin Grootvel. Effects of Methylphenidate on the Dopamine Transporter and Beyond. Current topics in behavioral neurosciences. 2022-05-04. PMID:35507284. |
the dopamine transporter (dat) is the main target of methylphenidate (mph), which remains the number one drug prescribed worldwide for the treatment of attention-deficit hyperactivity disorder (adhd). |
2022-05-04 |
2023-08-13 |
Not clear |
| Hans-Christoph Aster, Marcel Romanos, Susanne Walitza, Manfred Gerlach, Andreas Mühlberger, Albert Rizzo, Marta Andreatta, Natalie Hasenauer, Philipp E Hartrampf, Kai Nerlich, Christoph Reiners, Reinhard Lorenz, Andreas K Buck, Lorenz Desern. Responsivity of the Striatal Dopamine System to Methylphenidate-A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder. Frontiers in psychiatry. vol 13. 2022-05-02. PMID:35492708. |
mph binds to the dopamine (da) transporter (dat), which has high density in the striatum. |
2022-05-02 |
2023-08-13 |
Not clear |
| Hans-Christoph Aster, Marcel Romanos, Susanne Walitza, Manfred Gerlach, Andreas Mühlberger, Albert Rizzo, Marta Andreatta, Natalie Hasenauer, Philipp E Hartrampf, Kai Nerlich, Christoph Reiners, Reinhard Lorenz, Andreas K Buck, Lorenz Desern. Responsivity of the Striatal Dopamine System to Methylphenidate-A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder. Frontiers in psychiatry. vol 13. 2022-05-02. PMID:35492708. |
assessments of the striatal dopamine transporter by single positron emission computed tomography (spect) in childhood and adolescent patients are rare but can provide insight on how the effects of mph affect dat availability. |
2022-05-02 |
2023-08-13 |
Not clear |
| Ge Ou, Qian Li, Lin Zhu, Yuanyuan Zhang, Yijing Liu, Xin Li, Lina Du, Yiguang Ji. Intranasal hydrogel of armodafinil hydroxypropyl-β-cyclodextrin inclusion complex for the treatment of post-traumatic stress disorder. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 3. 2022-05-02. PMID:35498223. |
besides, the western blot (wb) of hippocampal brain-derived neurotrophic factor (bdnf) and amygdala dopamine transporter (dat) immunohistochemistry sections indicated that aic hydrogel had a protective effect on the brain tissue of ptsd mice. |
2022-05-02 |
2023-08-13 |
mouse |
| Anna C Everett, Ben E Graul, Joakim W Ronström, J Kayden Robinson, Daniel B Watts, Rodrigo A España, Cody A Siciliano, Jordan T Yorgaso. Effectiveness and Relationship between Biased and Unbiased Measures of Dopamine Release and Clearance. ACS chemical neuroscience. 2022-04-28. PMID:35482592. |
fast-scan cyclic voltammetry (fscv) is an effective tool for measuring dopamine release and clearance throughout the brain, especially the striatum where dopamine terminals are abundant and signals are heavily regulated by release machinery and the dopamine transporter (dat). |
2022-04-28 |
2023-08-13 |
human |
| Kai-Chun Yang, Mu-N Liu, Bang-Hung Yang, Yuan-Hwa Cho. Role of dopamine transporter in the relationship between plasma cortisol and cognition. Psychosomatic medicine. 2022-04-26. PMID:35472074. |
regarding the effects of cortisol on the dopamine system and the association between dopamine transporter (dat) and cognition, dat might be a central target linking cortisol and cognition. |
2022-04-26 |
2023-08-13 |
Not clear |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Chiara Domenicale, Daniela Mercatelli, Federica Albanese, Salvatore Novello, Fabrizio Vincenzi, Katia Varani, Michele Morar. Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453631. |
western analysis showed elevation of membrane dopamine transporter (dat) levels at 9 and 12 months of age, along with a reduction of vesicular monoamine transporter 2 (vmat2) levels at 12 months. |
2022-04-23 |
2023-08-13 |
mouse |
| Greta Manoni, Concetto Puzzo, Antonella Gigantesco, Walter Adrian. Behavioral Phenotype in Heterozygous DAT Rats: Transgenerational Transmission of Maternal Impact and the Role of Genetic Asset. Brain sciences. vol 12. issue 4. 2022-04-21. PMID:35448000. |
dopamine transporter (dat) is involved in dopamine (da) reuptake in presynaptic terminals. |
2022-04-21 |
2023-08-13 |
rat |
| Clarissa Catale, Luisa Lo Iacono, Alessandro Martini, Constantin Heil, Ezia Guatteo, Nicola Biagio Mercuri, Maria Teresa Viscomi, Daniela Palacios, Valeria Carol. Early Life Social Stress Causes Sex- and Region-Dependent Dopaminergic Changes that Are Prevented by Minocycline. Molecular neurobiology. 2022-04-18. PMID:35435618. |
we found that social stress in early life altered da neurons morphology, reduced dopamine transporter (dat) and tyrosine hydroxylase expression, and lowered dat-mediated currents in the ventral tegmental area but not substantia nigra of male mice only. |
2022-04-18 |
2023-08-13 |
mouse |