| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z A Siddiqi, A Peter. The effect of aging on pars compacta of the substantia nigra in rhesus monkey. Journal of neuropathology and experimental neurology. vol 58. issue 9. 1999-10-07. PMID:10499434. |
the substantia nigra was therefore examined in golgi impregnated material, in sections labeled with antibodies to tyrosine hydroxylase and to gaba, and in tissue embedded in plastic for light and electron microscopy. |
1999-10-07 |
2023-08-12 |
monkey |
| L Garcia-Gil, R de Miguel, J Romero, A Perez, J A Ramos, J J Fernández-Rui. Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats. Neurotoxicology and teratology. vol 21. issue 3. 1999-08-24. PMID:10386831. |
delta9-thc exposure did not modify either gad activity or gaba content in the ventral-tegmental area, nucleus accumbens, substantia nigra, caudate-putamen, and globus pallidus, thus suggesting no changes in the basal presynaptic activity of gaba-containing neurons. |
1999-08-24 |
2023-08-12 |
rat |
| L Garcia-Gil, R de Miguel, J Romero, A Perez, J A Ramos, J J Fernández-Rui. Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats. Neurotoxicology and teratology. vol 21. issue 3. 1999-08-24. PMID:10386831. |
however, our results were negative, because perinatal delta9-thc exposure did not increase baclofen-stimulated [35s]-gtpgammas binding in the areas studied; in particular, in the substantia nigra, an area of interest for the interactions gaba(b) receptor/cannabinoid receptor. |
1999-08-24 |
2023-08-12 |
rat |
| L Garcia-Gil, R de Miguel, J Romero, A Perez, J A Ramos, J J Fernández-Rui. Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats. Neurotoxicology and teratology. vol 21. issue 3. 1999-08-24. PMID:10386831. |
however, this increase was not due to changes in gaba(b) receptor activation of signal transduction mechanisms, as revealed the analysis of the percentage of stimulation by baclofen of [35s]-gtpgammas binding in the substantia nigra and other structures of males and females perinatally exposed to delta9-thc. |
1999-08-24 |
2023-08-12 |
rat |
| C A Paladini, J M Teppe. GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse (New York, N.Y.). vol 32. issue 3. 1999-07-15. PMID:10340627. |
these data demonstrate that dopaminergic neurons in vivo are under tonic gabaergic inhibition mediated by gaba(a) receptors and suggest that gabaergic afferents to substantia nigra comprise a major pathway by which the firing pattern of dopaminergic neurons is controlled in vivo. |
1999-07-15 |
2023-08-12 |
rat |
| C Deransart, V Riban, B T Lê, V Hechler, C Marescaux, A Depauli. Evidence for the involvement of the pallidum in the modulation of seizures in a genetic model of absence epilepsy in the rat. Neuroscience letters. vol 265. issue 2. 1999-06-29. PMID:10327186. |
furthermore, the antiepileptic effects of intrapallidal injections of a gaba(a) antagonist were correlated with a decrease of extracellular levels of glutamate in the substantia nigra. |
1999-06-29 |
2023-08-12 |
rat |
| W Lösche. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Progress in neurobiology. vol 58. issue 1. 1999-06-16. PMID:10321796. |
as shown in this review, there is substantial evidence that valproate increases gaba synthesis and release and thereby potentiates gabaergic functions in some specific brain regions, such as substantia nigra, thought to be involved in the control of seizure generation and propagation. |
1999-06-16 |
2023-08-12 |
Not clear |
| L Ferraro, T Antonelli, W T O'Connor, S Tanganelli, F A Rambert, K Fux. The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neuroscience letters. vol 253. issue 2. 1999-06-04. PMID:9774168. |
on the contrary, in the substantia nigra modafinil reduced gaba release only at the 300 mg/kg dose (59+/-5%) without affecting glutamate release. |
1999-06-04 |
2023-08-12 |
rat |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
modulation of gaba release by dopamine in the substantia nigra. |
1999-06-01 |
2023-08-12 |
rat |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
the role of specific dopamine receptor subtypes in the regulation of gaba release in the substantia nigra was investigated using microdialysis in the awake rat. |
1999-06-01 |
2023-08-12 |
rat |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
both basal and potassium-stimulated changes in the extracellular concentrations of gaba were examined in response to the local perfusion of tetrodotoxin (ttx), the d1 agonist skf 38393, or the d2 agonist ly 171555 through the microdialysis probe in the substantia nigra. |
1999-06-01 |
2023-08-12 |
rat |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
although ttx (1 microm) did not alter the basal extracellular concentrations of gaba in the substantia nigra, it attenuated the potassium-stimulated (80 mm k+) release of gaba. |
1999-06-01 |
2023-08-12 |
rat |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
these data indicate that although basal extracellular concentrations of gaba in the substantia nigra may not be derived from neuronal pools, k+ -stimulated release of gaba is impulse-mediated and is modulated by the d1 and the d2 receptors. |
1999-06-01 |
2023-08-12 |
rat |
| L Matuszewich, B K Yamamot. Modulation of GABA release by dopamine in the substantia nigra. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188635. |
local interactions between dopamine and gaba in the substantia nigra may have important implications for the direct regulation of basal ganglia efferent activity and motor behavior. |
1999-06-01 |
2023-08-12 |
rat |
| H Liu, M C Sañuda-Peña, J D Harvey-White, S Kalra, S A Cohe. Determination of submicromolar concentrations of neurotransmitter amino acids by fluorescence detection using a modification of the 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate method for amino acid analysis. Journal of chromatography. A. vol 828. issue 1-2. 1999-02-18. PMID:9916319. |
the low detection limits permitted the analysis of a number of different microdialysate samples including those from cerebrospinal fluid, as well as substantia nigra and hypothalamus from brain samples, even at basal levels where gamma-aminobutyric acid concentration may be < 50 nm. |
1999-02-18 |
2023-08-12 |
Not clear |
| K K Yung, Y C Tse, Z G Gao, S Y Choi, F S Kwo. Localization of GABA transaminase immunoreactivity in the rat substantia nigra pars reticulata. Neuroscience letters. vol 253. issue 1. 1998-12-02. PMID:9754804. |
precise cellular localization of gamma-aminobutyric acid transaminase (gaba(t)), a degrading enzyme for the neurotransmitter gaba, was determined in the rat substantia nigra (sn) by immunocytochemical experiments using a recently developed monoclonal antibody. |
1998-12-02 |
2023-08-12 |
rat |
| L Bianchi, M A Colivicchi, J P Bolam, L Della Cort. The release of amino acids from rat neostriatum and substantia nigra in vivo: a dual microdialysis probe analysis. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722150. |
it has previously been demonstrated, in dual probe microdialysis studies, that stimulation of the neostriatum with kainic acid causes the release of gaba both locally within the neostriatum and distally in the substantia nigra, observations that are consistent with the known anatomy of the basal ganglia. |
1998-10-26 |
2023-08-12 |
rat |
| L Bianchi, M A Colivicchi, J P Bolam, L Della Cort. The release of amino acids from rat neostriatum and substantia nigra in vivo: a dual microdialysis probe analysis. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722150. |
the application of kainic acid to neostriatum enhanced the release of gaba, taurine, aspartate and glutamate locally in the neostriatum and distally in the substantia nigra. |
1998-10-26 |
2023-08-12 |
rat |
| L Bianchi, M A Colivicchi, J P Bolam, L Della Cort. The release of amino acids from rat neostriatum and substantia nigra in vivo: a dual microdialysis probe analysis. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722150. |
it is concluded that the release of taurine from the substantia nigra has similar characteristics to that of gaba and may be released from the terminals of striatonigral neurons following the stimulation of their cell bodies in the neostriatum. |
1998-10-26 |
2023-08-12 |
rat |
| S Erhardt, B Andersson, H Nissbrandt, G Engber. Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by gamma-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA(B) receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 6. 1998-10-16. PMID:9686936. |
previous studies have shown that administration of gamma-hydroxybutyric acid (ghba) or the gaba(b) receptor agonist baclofen are associated with a decrease in firing rate, a regularisation of firing pattern and a decrease in burst activity of midbrain dopamine (da) neurons in the substantia nigra (sn). |
1998-10-16 |
2023-08-12 |
rat |