| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Radnikow, U Misgel. Dopamine D1 receptors facilitate GABAA synaptic currents in the rat substantia nigra pars reticulata. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 6. 1998-04-13. PMID:9482788. |
we conclude that dopamine released from dendrites of dopaminergic neurons enhances gaba release in the pars reticulata of the substantia nigra through d1 receptors presumably located on striatonigral afferents. |
1998-04-13 |
2023-08-12 |
rat |
| D M Araujo, D C Hil. Glial cell line-derived neurotrophic factor attenuates the locomotor hypofunction and striatonigral neurochemical deficits induced by chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid. Neuroscience. vol 82. issue 1. 1998-04-09. PMID:9483508. |
thus, [3h]gaba uptake and [3h]tiagabine/gaba uptake sites in striatal target tissues (globus pallidus and substantia nigra), as well as [3h]choline uptake, choline acetyltransferase activity and dopamine receptor binding in the striatum were decreased by the toxin and restored to varying degrees by glial cell line-derived neurotrophic factor administration. |
1998-04-09 |
2023-08-12 |
rat |
| W Löscher, U Ebert, H Lehmann, C Rosenthal, G Nikkha. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. Journal of neuroscience research. vol 51. issue 2. 1998-03-30. PMID:9469573. |
we previously showed that amygdala kindling results in a significant decrease of gaba and its synthesizing enzyme glutamate decarboxylase in substantia nigra (sn), i.e., a region thought to be critically involved in seizure propagation in various models of epilepsy. |
1998-03-30 |
2023-08-12 |
rat |
| J Romero, R de Miguel, J A Ramos, J J Fernández-Rui. The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake. Life sciences. vol 62. issue 4. 1998-02-03. PMID:9450507. |
recently, we have demonstrated that cn-induced motor inhibition is reversed by gaba-b, but not gaba-a, receptor antagonists, presumably indicating that the activation of cnrs in striatal outflow nuclei, mainly in the substantia nigra, should be followed by an increase of gaba concentrations into the synaptic cleft of gaba-b receptor synapses. |
1998-02-03 |
2023-08-12 |
Not clear |
| J Romero, R de Miguel, J A Ramos, J J Fernández-Rui. The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake. Life sciences. vol 62. issue 4. 1998-02-03. PMID:9450507. |
we analyzed: (i) gaba synthesis, by measuring the activity of glutamic acid decarboxylase (gad) and gaba contents in brain regions that contain striatonigral gabaergic neurons, after in vivo administration of cns and/or the cnr antagonist sr141716; (ii) [3h]gaba release in vitro in the presence or the absence of a synthetic cn agonist, hu-210, by using perifusion of small fragments of substantia nigra; and (iii) [3h]gaba uptake in vitro in the presence or the absence of win-55,212-2, by using synaptosomes obtained from either globus pallidus or substantia nigra. |
1998-02-03 |
2023-08-12 |
Not clear |
| J Romero, R de Miguel, J A Ramos, J J Fernández-Rui. The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake. Life sciences. vol 62. issue 4. 1998-02-03. PMID:9450507. |
a similar lack of effect of hu-210 on in vitro [3h]gaba release, both basal and k+-evoked, was seen when this cn was added to perifused substantia nigra fragments, also suggesting no changes at the level of gaba release. |
1998-02-03 |
2023-08-12 |
Not clear |
| J Romero, R de Miguel, J A Ramos, J J Fernández-Rui. The activation of cannabinoid receptors in striatonigral GABAergic neurons inhibited GABA uptake. Life sciences. vol 62. issue 4. 1998-02-03. PMID:9450507. |
however, when synaptosome preparations obtained from the substantia nigra were incubated in the presence of win-55,212-2, a decrease in [3h]gaba uptake could be measured. |
1998-02-03 |
2023-08-12 |
Not clear |
| H Ringendahl, T Sierl. [Freezing phenomenon in Parkinson disease]. Fortschritte der Neurologie-Psychiatrie. vol 65. issue 10. 1998-01-27. PMID:9445836. |
neurotransmitter models to explain the freezing phenomena are: a noradrenalin deficiency in locus coeruleus or alternately a dopamine deficiency in substantia nigra, pars compacta, which can possibly be coupled with a gaba deficiency in substantia nigra, pars reticulata. |
1998-01-27 |
2023-08-12 |
Not clear |
| D M Araujo, D C Hil. Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease. Neuroscience. vol 81. issue 4. 1997-11-26. PMID:9330371. |
concomitant changes in neurotransmitter function as a result of the lesion were also observed: [3h]gaba uptake into striatal target tissues (globus pallidus and substantia nigra) was considerably reduced in the lesioned compared to the contralateral unlesioned tissues, as were [3h]choline and [3h]dopamine uptake into striatal synaptosomes. |
1997-11-26 |
2023-08-12 |
rat |
| S L Moshé, D S Garan. Substantia nigra GABA receptors can mediate anticonvulsant or proconvulsant effects. Epilepsy research. Supplement. vol 12. 1997-10-23. PMID:9302523. |
substantia nigra gaba receptors can mediate anticonvulsant or proconvulsant effects. |
1997-10-23 |
2023-08-12 |
Not clear |
| C D Richards, T Shiroyama, S T Kita. Electrophysiological and immunocytochemical characterization of GABA and dopamine neurons in the substantia nigra of the rat. Neuroscience. vol 80. issue 2. 1997-10-17. PMID:9284356. |
electrophysiological and immunocytochemical characterization of gaba and dopamine neurons in the substantia nigra of the rat. |
1997-10-17 |
2023-08-12 |
rat |
| K Eberle-Wang, Z Mikeladze, K Uryu, M F Chessele. Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats. The Journal of comparative neurology. vol 384. issue 2. 1997-08-29. PMID:9215720. |
double-label in situ hybridization in the substantia nigra revealed coexpression of 5-ht2c receptor mrna with glutamic acid decarboxylase but not with tyrosine hydroxylase mrna, indicating that it was restricted to gamma-aminobutyric acid (gaba)ergic neurons. |
1997-08-29 |
2023-08-12 |
rat |
| P K Telushkin, T E Shidlovskai. [Enzyme activity and level of GABA-shunt substrates in rat brain during repeated exposure to hypoglycemic doses of insulin]. Voprosy meditsinskoi khimii. vol 42. issue 4. 1997-08-08. PMID:9254515. |
this can be an evidence of decrease of gaba amount produced and secreted by nerve ends of the pathways leading from striata to substantia nigra. |
1997-08-08 |
2023-08-12 |
rat |
| E M Byrnes, A Reilly, J P Brun. Effects of AMPA and D1 receptor activation on striatal and nigral GABA efflux. Synapse (New York, N.Y.). vol 26. issue 3. 1997-08-01. PMID:9183815. |
intrastriatal perfusion of ampa (100 microm), skf 81297 (100 microm), or ampa + skf 81297 did not stimulate gaba efflux in the substantia nigra. |
1997-08-01 |
2023-08-12 |
rat |
| K M Kim, S Nakajima, Y Nakajim. Dopamine and GABA receptors in cultured substantia nigra neurons: correlation of electrophysiology and immunocytochemistry. Neuroscience. vol 78. issue 3. 1997-07-21. PMID:9153656. |
dopamine and gaba receptors in cultured substantia nigra neurons: correlation of electrophysiology and immunocytochemistry. |
1997-07-21 |
2023-08-12 |
rat |
| G D Zeevalk, L Manzino, J Hoppe, P Sonsall. In vivo vulnerability of dopamine neurons to inhibition of energy metabolism. European journal of pharmacology. vol 320. issue 2-3. 1997-07-14. PMID:9059843. |
in contrast to what was seen in substantia nigra, there was a greater loss of dopamine than gaba in striatal regions nearest the injection site. |
1997-07-14 |
2023-08-12 |
rat |
| P Bloms-Funke, W Lösche. The anticonvulsant gabapentin decreases firing rates of substantia nigra pars reticulata neurons. European journal of pharmacology. vol 316. issue 2-3. 1997-06-12. PMID:8982688. |
gabapentin is a novel anti-epileptic drug which enhances gaba (gamma-aminobutyric acid) turnover in certain brain regions, including substantia nigra. |
1997-06-12 |
2023-08-12 |
rat |
| V Compan, A Daszuta, P Salin, M Sebben, J Bockaert, A Dumui. Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996808. |
corresponding decreases of 72 and 20% in receptor density were detected in globus pallidus and substantia nigra, consistent with a presumed localization of 5-ht4 receptors on striatal gaba neurons projecting to these regions. |
1997-05-29 |
2023-08-12 |
rat |
| V Compan, A Daszuta, P Salin, M Sebben, J Bockaert, A Dumui. Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus. The European journal of neuroscience. vol 8. issue 12. 1997-05-29. PMID:8996808. |
in the substantia nigra, the decrease in [3h]gr113808 binding was localized to the pars lateralis, indicating that striatal neurons belonging to the cortico-striato-nigro-tectal pathway, and containing gaba and dynorphin, express 5-ht4 receptors. |
1997-05-29 |
2023-08-12 |
rat |
| J P Huidobro-Toro, C F Valenzuela, R A Harri. Modulation of GABAA receptor function by G protein-coupled 5-HT2C receptors. Neuropharmacology. vol 35. issue 9-10. 1997-05-12. PMID:9014152. |
two classical neurotransmitters, 5-hydroxytryptamine (5-ht) and gaba, coexist in neurons of the medulla oblongata, and activation of 5-ht receptors modulates gabaa receptor function in neurons of the ventral tegmental area, substantia nigra and cerebellum. |
1997-05-12 |
2023-08-12 |
xenopus_laevis |