| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Almey, Teresa A Milner, Wayne G Brak. Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum. Neuroscience letters. vol 622. 2017-07-19. PMID:27080432. |
binding at membrane-associated erα and gper1 could account for rapid estrogen-induced decreases in gaba transmission in the striatum, which, in turn, could affect dopamine transmission in this region. |
2017-07-19 |
2023-08-13 |
Not clear |
| Oscar Solís, Patricia García-Sanz, Antonio S Herranz, María-José Asensio, Rosario Moratall. L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:26966009. |
l-dopa reverses the increased free amino acids tissue levels induced by dopamine depletion and rises gaba and tyrosine in the striatum. |
2017-06-26 |
2023-08-13 |
mouse |
| Teri M Furlong, Jhodie R Duncan, Laura H Corbit, Caroline D Rae, Benjamin D Rowlands, Anthony D Maher, Fatima A Nasrallah, Carol J Milligan, Steven Petrou, Andrew J Lawrence, Bernard W Ballein. Toluene inhalation in adolescent rats reduces flexible behaviour in adulthood and alters glutamatergic and GABAergic signalling. Journal of neurochemistry. vol 139. issue 5. 2017-06-14. PMID:27696399. |
these behavioural deficits were accompanied by changes in subunit expression of both nmda and gaba receptors in adulthood, up to 10 weeks after the final exposure to toluene in the hippocampus, prefrontal cortex and ventromedial striatum; regions with recognized roles in behavioural flexibility and decision-making. |
2017-06-14 |
2023-08-13 |
rat |
| İbrahim Halil Yelkenli, Emel Ulupinar, Orhan Tansel Korkmaz, Erol Şener, Gökhan Kuş, Zeynep Filiz, Neşe Tunçe. Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats. Journal of molecular neuroscience : MN. vol 59. issue 2. 2017-03-09. PMID:27115671. |
extracellular concentration of gaba, glu, and lactate levels did not change, but gsh level significantly increased in the striatum of parkinsonian rats. |
2017-03-09 |
2023-08-13 |
rat |
| T Mori, Y Iwase, T Saeki, N Iwata, A Murata, D Masukawa, T Suzuk. Differential activation of dopaminergic systems in rat brain basal ganglia by morphine and methamphetamine. Neuroscience. vol 322. 2016-12-13. PMID:26820597. |
in contrast, the administration of morphine (10mg/kg) produced a significant increase in the release of dopamine from the nucleus accumbens, but not the striatum, which is accompanied by a decrease in the release of gaba in the ventral tegmental area. |
2016-12-13 |
2023-08-13 |
rat |
| Evgeny D Nekrasov, Vladimir A Vigont, Sergey A Klyushnikov, Olga S Lebedeva, Ekaterina M Vassina, Alexandra N Bogomazova, Ilya V Chestkov, Tatiana A Semashko, Elena Kiseleva, Lyubov A Suldina, Pavel A Bobrovsky, Olga A Zimina, Maria A Ryazantseva, Anton Yu Skopin, Sergey N Illarioshkin, Elena V Kaznacheyeva, Maria A Lagarkova, Sergey L Kisele. Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:27080129. |
huntington's disease (hd) is an incurable hereditary neurodegenerative disorder, which manifests itself as a loss of gabaergic medium spiny (gaba ms) neurons in the striatum and caused by an expansion of the cag repeat in exon 1 of the huntingtin gene. |
2016-11-08 |
2023-08-13 |
human |
| Soomaayeh Heysieattalab, Nasser Naghdi, Mohammad-Reza Zarrindast, Abbas Haghparast, Shahram Ejtemaei Mehr, Habibeh Khoshboue. The effects of GABAA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats. Pharmacology, biochemistry, and behavior. vol 142. 2016-10-31. PMID:26708956. |
the dopamine neurons in the striatum directly or indirectly regulate the gaba and glutamatergic signaling in this region and thus their outputs. |
2016-10-31 |
2023-08-13 |
rat |
| Puneet Bagga, Anup N Chugani, Anant B Pate. Neuroprotective effects of caffeine in MPTP model of Parkinson's disease: A (13)C NMR study. Neurochemistry international. vol 92. 2016-10-17. PMID:26626997. |
the levels of gaba and myo-inositol were found to be elevated in the striatum of mptp treated mice. |
2016-10-17 |
2023-08-13 |
mouse |
| V Kumar, M A Ahmad, A K Najmi, M Akhta. Effect of Sarcosine (a Glycine Transport 1 Inhibitor) and Risperidone (an Atypical antipsychotic Drug) on MK-801 Induced Learning and Memory Deficits in Rats. Drug research. vol 66. issue 1. 2016-09-30. PMID:25710578. |
the combined administration also potentiated the gaba and decreased 5-ht levels, indicating that the increased synaptic glycine concentrations may enhance nmda receptor function which is directly linked with increased gabaergic transmission in striatum region and decreased 5-ht levels showed antagonistic action hence, enhancing the cognition. |
2016-09-30 |
2023-08-13 |
rat |
| Alberto Brugnoli, Francesco Napolitano, Alessandro Usiello, Michele Morar. Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia. Neurobiology of disease. vol 85. 2016-09-21. PMID:26522958. |
finally, dyskinetic mice underwent microdialysis probe implantation in the dopamine-depleted striatum and ipsilateral substantia nigra reticulata, and gaba and glutamate levels were monitored upon acute challenge with levodopa. |
2016-09-21 |
2023-08-13 |
mouse |
| Tomasz Boczek, Malwina Lisek, Bozena Ferenc, Magdalena Wiktorska, Ivana Ivchevska, Ludmila Zylinsk. Region-specific effects of repeated ketamine administration on the presynaptic GABAergic neurochemistry in rat brain. Neurochemistry international. vol 91. 2016-09-15. PMID:26492822. |
for 5 days, and next we analyzed gaba metabolizing enzymes in cortex, cerebellum, hippocampus and striatum. |
2016-09-15 |
2023-08-13 |
rat |
| Tomasz Boczek, Malwina Lisek, Bozena Ferenc, Magdalena Wiktorska, Ivana Ivchevska, Ludmila Zylinsk. Region-specific effects of repeated ketamine administration on the presynaptic GABAergic neurochemistry in rat brain. Neurochemistry international. vol 91. 2016-09-15. PMID:26492822. |
consecutively, reduction in glutamate decarboxylase activity and gaba concentration were detected in cortex, cerebellum and striatum, but not in hippocampus. |
2016-09-15 |
2023-08-13 |
rat |
| Tomasz Boczek, Malwina Lisek, Bozena Ferenc, Magdalena Wiktorska, Ivana Ivchevska, Ludmila Zylinsk. Region-specific effects of repeated ketamine administration on the presynaptic GABAergic neurochemistry in rat brain. Neurochemistry international. vol 91. 2016-09-15. PMID:26492822. |
ketamine administration decreased gaba transaminase protein in cortex and striatum (by ∼50% and 30%, respectively), which was reflected in diminished activity of the enzyme. |
2016-09-15 |
2023-08-13 |
rat |
| Cynthia El Hage, Anne-Marie Bédard, Anne-Noël Samah. Antipsychotic treatment leading to dopamine supersensitivity persistently alters nucleus accumbens function. Neuropharmacology. vol 99. 2016-08-30. PMID:25823912. |
we either injected amph into the striatum or inhibited striatal function with microinjections of gaba receptor agonists prior to injecting amph systemically. |
2016-08-30 |
2023-08-13 |
rat |
| Carine Chassain, Christophe Melon, Pascal Salin, Flora Vitale, Sébastien Couraud, Franck Durif, Lydia Kerkerian-Le Goff, Paolo Gubellin. Metabolic, synaptic and behavioral impact of 5-week chronic deep brain stimulation in hemiparkinsonian rats. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26576509. |
in vivo metabolic neuroimaging by (1) h-magnetic resonance spectroscopy (11.7 t) showed that stn hfs normalized the tissue levels of the neurotransmission-related metabolites glutamate, glutamine and gaba in both the striatum and substantia nigra reticulata (snr), which were significantly increased in hemiparkinsonian rats, but further decreased nigral gaba levels below control values; taurine levels, which were not affected in hemiparkinsonian rats, were significantly reduced. |
2016-08-22 |
2023-08-13 |
rat |
| Carine Chassain, Christophe Melon, Pascal Salin, Flora Vitale, Sébastien Couraud, Franck Durif, Lydia Kerkerian-Le Goff, Paolo Gubellin. Metabolic, synaptic and behavioral impact of 5-week chronic deep brain stimulation in hemiparkinsonian rats. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26576509. |
the levels of glutamate and gaba in the striatum () and substantia nigra reticulata (snr) (), measured by in vivo proton magnetic resonance spectroscopy ((1) h-mrs), were increased by 6-hydroxydopamine (6-ohda) lesion, which also disrupted corticostriatal synaptic plasticity () and impaired forepaw skill () in the staircase test. |
2016-08-22 |
2023-08-13 |
rat |
| Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. |
this analysis suggests that 5-ht and ssris will have markedly different effects within the pfc, where they will induce mixed effects on gaba and glutamate neurotransmission, compared to the striatum, where they will enhance gabaergic interneuron activity and drive down the activity of medium spiny neurons. |
2016-07-19 |
2023-08-13 |
Not clear |
| Evangelia Emmanouilidou, Georgia Minakaki, Maria V Keramioti, Mary Xylaki, Evangelos Balafas, Margarita Chrysanthou-Piterou, Ismini Kloukina, Kostas Vekrelli. GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26912647. |
gaba transmission via atp-dependent k+ channels regulates α-synuclein secretion in mouse striatum. |
2016-07-18 |
2023-08-13 |
mouse |
| Evangelia Emmanouilidou, Georgia Minakaki, Maria V Keramioti, Mary Xylaki, Evangelos Balafas, Margarita Chrysanthou-Piterou, Ismini Kloukina, Kostas Vekrelli. GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26912647. |
using a combination of specific agonists and antagonists, we were able to show that, in the striatum, modulation of gaba release through the sulfonylurea receptor 1-regulated atp-dependent potassium channels located on gabaergic neurons controls α-synuclein release from the glutamatergic terminals through activation of the presynaptic gabab receptors. |
2016-07-18 |
2023-08-13 |
mouse |
| Nidhika Sharma, Sumit Jamwal, Puneet Kuma. Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 23. issue 2. 2016-05-16. PMID:26996500. |
on 28th day, animals were sacrificed and striatum were isolated for biochemical (lpo, gsh and nitrite), neuroinflammatory (tnf-α, il-1β and il-6), neurochemical (da, ne, 5-ht, gaba, glutamate, dopac, hva and 5-hiaa) and mitochondrial complex-i estimation. |
2016-05-16 |
2023-08-13 |
rat |