| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J F Deakin, A R Gree. The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708990. |
4 microinjections of 5,7-dihydroxytryptamine into the spinal cord resulted in a 70% fall in cord 5-ht concentrations without an effect on brain 5-ht concentrations. |
1979-01-26 |
2023-08-11 |
rat |
| J F Deakin, A R Gree. The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708990. |
the behavioural response to the putative 5-ht receptor agonist, 5-methoxy n,n-dimethyltryptamine (2 mg/kg), was potentiated in these animals suggesting that 5-ht receptors become supersensitive on denervation, and that some components of the behavioural syndrome are mediated by spinal cord 5-ht receptors. |
1979-01-26 |
2023-08-11 |
rat |
| M Ogaw. Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: a study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Japanese circulation journal. vol 42. issue 5. 1978-12-27. PMID:151755. |
an increase of serotonin (5-ht) turnover in the cortex and especially in the spinal cord was revealed in the hypertension. |
1978-12-27 |
2023-08-11 |
rat |
| M Ogaw. Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: a study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Japanese circulation journal. vol 42. issue 5. 1978-12-27. PMID:151755. |
intraperitoneally administered para-chlorophenylalanine elevated blood pressure and reduced 5-ht and 5-hydroxyindole acetic acid content in the cortex and especially in the spinal cord, indicating a decrease 5-ht turnover. |
1978-12-27 |
2023-08-11 |
rat |
| M Ogaw. Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: a study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Japanese circulation journal. vol 42. issue 5. 1978-12-27. PMID:151755. |
intraventricularlly administered 5, 6-dihydroxytryptamine (5, 6-dht) resulted in only bradycardia but not an elevation in blood pressure and did not block the development of lc hypertension, and lowered 5-ht content in the cortex and especially in the spinal cord. |
1978-12-27 |
2023-08-11 |
rat |
| M Ogaw. Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: a study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Japanese circulation journal. vol 42. issue 5. 1978-12-27. PMID:151755. |
intraspinally administrated 5, 6-dht evoked mild but significant elevation in blood pressure but not in heart rate, and lowered 5-ht content only in the spinal cord. |
1978-12-27 |
2023-08-11 |
rat |
| M Ogaw. Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: a study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Japanese circulation journal. vol 42. issue 5. 1978-12-27. PMID:151755. |
the results of these experiments demonstrate that (1) lc hypertension is probably due to a specific lesion of the lc with 6-ohda, (2) lc hypertension is accompanied by an increase of 5-ht turnover in the cortex and especially in the spinal cord, which may participate in a depressor function in lc hypertension, (3) ablation of bulbospinal serotonergic neurons produce mild elevation in blood pressure. |
1978-12-27 |
2023-08-11 |
rat |
| G Jonsson, T Pollare, H Hallman, C Sach. Developmental plasticity of central serotonin neurons after 5,7-dihydroxytryptamine treatment. Annals of the New York Academy of Sciences. vol 305. 1978-12-27. PMID:280250. |
treatment with 5,7-ht at birth produces marked and permanent 5-ht denervation in the cerebral cortex and spinal cord, whereas hyperinnervation occurs in the 5-ht cell body-near regions (mesencephalon-pons-medulla). |
1978-12-27 |
2023-08-11 |
rat |
| T Mennini, R Pataccini, R Samani. Effects of narcotic analgesics on the uptake and release of 5-hydroxytryptamine in rat synaptosomal preparations. British journal of pharmacology. vol 64. issue 1. 1978-12-20. PMID:29686. |
1 the effects of various narcotic analgesics on the uptake and release of labelled 5-hydroxytryptamine (5-ht) in brain and spinal cord synaptosomes were investigated.2 methadone was most active in inhibiting 5-ht uptake (ic(50) 2.5 x 10(-7) m). |
1978-12-20 |
2023-08-11 |
rat |
| L Segu, A Cala. The topographical distribution of serotoninergic terminals in the spinal cord of the cat: quantitative radioautographic studies. Brain research. vol 153. issue 3. 1978-12-20. PMID:308830. |
in vitro uptake of labeled serotonin (5-ht) has allowed the radioautographic detection of serotoninergic fibers in the cat spinal cord at thoracic and lumbar levels. |
1978-12-20 |
2023-08-11 |
cat |
| J P Chalmers, L M Win. Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. Clinical science and molecular medicine. Supplement. vol 2. 1978-12-02. PMID:1077778. |
depletion was most marked in the spinal cord where serotonin concentration was reduced to less than 50% of that in rabbits given control injections. |
1978-12-02 |
2023-08-11 |
rabbit |
| L M Jordan, D R Kenshalo, F R Martin, L H Haber, W D Willi. Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine. Pain. vol 5. issue 2. 1978-11-29. PMID:99715. |
the effects of iontophoretic applications of 5-hydroxytryptamine (5-ht) were tested upon primate spinothalamic tract neurons recorded extracellularly in the spinal cord of anesthetized monkeys. |
1978-11-29 |
2023-08-11 |
monkey |
| J F Deakin, J O Dostrovsk. Involvement of the periaqueductal grey matter and spinal 5-hydroxytryptaminergic pathways in morphine analgesia: effcts of lesions and 5-hydroxytryptamine depletion. British journal of pharmacology. vol 63. issue 1. 1978-07-15. PMID:206302. |
furthermore, microinjections of 5, 6-dihydroxytryptamine (5,6-dht) into the dorsal raphé nucleus produced a similar fall in 5-hiaa levels but had no effect on morphine analgesia.3 selective destruction of the periventricular catecholamine system produced by microinjection of 6-hydroxydopamine (6-ohda) caused a slight decrease in morphine analgesia, thus raising the possibility that catecholamines may be involved in the action of morphine in the pag.4 5,7-dihydroxytryptamine-induced lesions of the spinal cord 5-hydroxytryptaminergic pathways reduced cord 5-ht concentration by 70% and markedly attenuated morphine analgesia as determined by the tail flick test.5 these experiments provide additional evidence that the pag is a major site of action of opiates in producing analgesia. |
1978-07-15 |
2023-08-11 |
rat |
| P C Jobe, P F Geiger, T B Ray, T W Woods, M E Mim. The relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat. Neuropharmacology. vol 17. issue 3. 1978-06-12. PMID:148011. |
the relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat. |
1978-06-12 |
2023-08-11 |
rat |
| Rita B Messing, Loy D Lytl. Serotonin-containing neurons: their possible role in pain and analgesia. Pain. vol 4. issue 1. 1978-01-27. PMID:22060. |
this evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervous system serotonergic neurotransmission, suggests that increases in the activity of brain and spinal cord serotonin neurons are associated with analgesia and enhanced antinociceptive drug potency, whereas decreases in the activities of these neurons correlate with hyperalgesia and diminished analgesic drug potency. |
1978-01-27 |
2023-08-11 |
Not clear |
| P C Jobe, T B Ray, P F Geiger, W M Bour. Effects of Ro 4-1284 on electrically-induced spinal cord seizures and on spinal cord norepinephrine and 5-hydroxytryptamine levels. Research communications in chemical pathology and pharmacology. vol 18. issue 4. 1978-01-27. PMID:243955. |
effects of ro 4-1284 on electrically-induced spinal cord seizures and on spinal cord norepinephrine and 5-hydroxytryptamine levels. |
1978-01-27 |
2023-08-11 |
Not clear |
| P C Jobe, T B Ray, P F Geiger, W M Bour. Effects of Ro 4-1284 on electrically-induced spinal cord seizures and on spinal cord norepinephrine and 5-hydroxytryptamine levels. Research communications in chemical pathology and pharmacology. vol 18. issue 4. 1978-01-27. PMID:243955. |
the time course effects of the benzoquinolizine ro 4-1284 on spinal cord norepinephrine (ne) and 5-hydroxytryptamine (5-ht) levels were compared to the effects of this same drug on electrically-induced spinal cord seizures. |
1978-01-27 |
2023-08-11 |
Not clear |
| P C Jobe, T B Ray, P F Geiger, W M Bour. Effects of Ro 4-1284 on electrically-induced spinal cord seizures and on spinal cord norepinephrine and 5-hydroxytryptamine levels. Research communications in chemical pathology and pharmacology. vol 18. issue 4. 1978-01-27. PMID:243955. |
the possibility that spinal cord 5-ht also subserves a seizure attenuating function is not precluded. |
1978-01-27 |
2023-08-11 |
Not clear |
| T Segawa, Y Nakata, H Yajima, K Kitagaw. Further observation on the lack of active uptake system for substance P in the central nervous system. Japanese journal of pharmacology. vol 27. issue 4. 1978-01-27. PMID:926460. |
crude mitochondrial p2 fractions from bovine hypothalamus and substantia nigra, slices from rabbit spinal cord and mesencephalon and glial fractions from rabbit brain were incubated with [3h]-substance p and the uptake was measured and compared with those for 5-ht and gaba. |
1978-01-27 |
2023-08-11 |
rabbit |
| R A Brodner, G J Dohrman. Norepinephrine, dopamine and serotonin in experimental spinal cord trauma: current status. Paraplegia. vol 15. issue 2. 1977-11-30. PMID:909720. |
norepinephrine, dopamine and serotonin in experimental spinal cord trauma: current status. |
1977-11-30 |
2023-08-11 |
human |