| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunice Y Yuen, Jing Wei, Zhen Ya. Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats. The Journal of steroid biochemistry and molecular biology. vol 160. 2017-06-12. PMID:26321384. |
repeated stress has been found to impair cognitive behaviors via suppressing glutamatergic transmission and glutamate receptor surface expression in pyramidal neurons of prefrontal cortex (pfc) in male rats. |
2017-06-12 |
2023-08-13 |
human |
| Marianna E Jung, Daniel B Metzger, Hriday K Da. The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27278235. |
the prefrontal cortex of ethanol-withdrawn rats or ht22 cells showed an increase in ps1 and p38α, which was attenuated by mk-801 and sb203580, but mimicked by glutamate treatment to ethanol-free ht22 cells. |
2017-05-26 |
2023-08-13 |
mouse |
| Sudie E Back, Jenna L McCauley, Kristina J Korte, Daniel F Gros, Virginia Leavitt, Kevin M Gray, Mark B Hamner, Stacia M DeSantis, Robert Malcolm, Kathleen T Brady, Peter W Kaliva. A Double-Blind, Randomized, Controlled Pilot Trial of N-Acetylcysteine in Veterans With Posttraumatic Stress Disorder and Substance Use Disorders. The Journal of clinical psychiatry. vol 77. issue 11. 2017-05-25. PMID:27736051. |
this study explored the efficacy of n-acetylcysteine in the treatment of posttraumatic stress disorder (ptsd), which frequently co-occurs with sud and shares impaired prefrontal cortex regulation of basal ganglia circuitry, in particular at glutamate synapses in the nucleus accumbens. |
2017-05-25 |
2023-08-13 |
Not clear |
| Yong-Ku Kim, Joonho Choi, Seon-Cheol Par. A Novel Bio-Psychosocial-Behavioral Treatment Model in Schizophrenia. International journal of molecular sciences. vol 18. issue 4. 2017-04-28. PMID:28358303. |
since cognitive and negative symptoms rather than positive symptoms are more closely associated with psychosocial impairments in patients with schizophrenia, the non-dopaminergic systems including glutamate and γ-aminobutyric acid (gaba) of the prefrontal cortex should be of concern as well. |
2017-04-28 |
2023-08-13 |
Not clear |
| Martin J Brodie, Frank Besag, Alan B Ettinger, Marco Mula, Gabriella Gobbi, Stefano Comai, Albert P Aldenkamp, Bernhard J Steinhof. Epilepsy, Antiepileptic Drugs, and Aggression: An Evidence-Based Review. Pharmacological reviews. vol 68. issue 3. 2017-04-20. PMID:27255267. |
we review the common neurotransmitter systems and brain regions implicated in both epilepsy and aggression, including the gaba, glutamate, serotonin, dopamine, and noradrenaline systems and the hippocampus, amygdala, prefrontal cortex, anterior cingulate cortex, and temporal lobes. |
2017-04-20 |
2023-08-13 |
Not clear |
| Maryam Farahmandfar, Atefeh Bakhtazad, Ardeshir Akbarabadi, Mohammad-Reza Zarrindas. The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice. European journal of pharmacology. vol 781. 2017-03-08. PMID:27041647. |
dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (pfc) behavioral and cognitive functions. |
2017-03-08 |
2023-08-13 |
mouse |
| Laura Jiménez-Sánchez, Anna Castañé, Laura Pérez-Caballero, Marc Grifoll-Escoda, Xavier López-Gil, Leticia Campa, Mireia Galofré, Esther Berrocoso, Albert Adel. Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 6. 2017-03-06. PMID:26088969. |
we also used in vivo microdialysis to evaluate the release of glutamate, γ-aminobutyric acid, serotonin, dopamine, and noradrenaline in the prefrontal cortex and c-fos immunohistochemistry to determine the brain regions activated by dbs. |
2017-03-06 |
2023-08-13 |
Not clear |
| Laura Jiménez-Sánchez, Anna Castañé, Laura Pérez-Caballero, Marc Grifoll-Escoda, Xavier López-Gil, Leticia Campa, Mireia Galofré, Esther Berrocoso, Albert Adel. Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 6. 2017-03-06. PMID:26088969. |
one hour of dbs of the infralimbic prefrontal cortex has antidepressant-like effects in fst and nsft, and increases prefrontal efflux of glutamate, which would activate ampa receptors (ampars). |
2017-03-06 |
2023-08-13 |
Not clear |
| Ana Paula Pesarico, Eluza Curte Stangherlin, Suzan Gonçalves Rosa, Anderson C Mantovani, Gilson Zeni, Cristina Wayne Nogueir. Contribution of NMDA, GABAA and GABAB receptors and l-arginine-NO-cGMP, MEK1/2 and CaMK-II pathways in the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. European journal of pharmacology. vol 782. 2017-03-03. PMID:27112660. |
the administration of fdpi (50mg/kg) to mice increased the glutamate uptake and reduced no levels in the prefrontal cortex of mice. |
2017-03-03 |
2023-08-13 |
mouse |
| Ali Siahposht-Khachaki, Zahra Fatahi, Asal Yans, Fariba Khodagholi, Abbas Haghparas. Involvement of AMPA/Kainate Glutamate Receptor in the Extinction and Reinstatement of Morphine-Induced Conditioned Place Preference: A Behavioral and Molecular Study. Cellular and molecular neurobiology. vol 37. issue 2. 2017-02-23. PMID:27053349. |
glutamate receptors in mesolimbic areas such as the nucleus accumbens, ventral tegmental area, prefrontal cortex (pfc), and hippocampus (hip) are a component of the mechanisms of drug-induced reward and can modulate the firing pattern of dopaminergic neurons in the reward system. |
2017-02-23 |
2023-08-13 |
rat |
| Eric S Wohleb, Danielle Gerhard, Alex Thomas, Ronald S Duma. Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine. Current neuropharmacology. vol 15. issue 1. 2017-02-07. PMID:26955968. |
moreover, preclinical work has shown that the antidepressant actions of ketamine and scopolamine in rodent models are caused by an increase of extracellular glutamate, elevated bdnf, activation of the mammalian target of rapamycin complex 1 (mtorc1) cascade, and increased number and function of spine synapses in the prefrontal cortex (pfc). |
2017-02-07 |
2023-08-13 |
Not clear |
| Eric S Wohleb, Danielle Gerhard, Alex Thomas, Ronald S Duma. Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine. Current neuropharmacology. vol 15. issue 1. 2017-02-07. PMID:26955968. |
furthermore, we discuss evidence that ketamine and scopolamine antagonize inhibitory interneurons in the pfc leading to disinhibition of pyramidal neurons and increased extracellular glutamate that promotes the rapid antidepressant responses to these agents. |
2017-02-07 |
2023-08-13 |
Not clear |
| Felipe Schmitz, Paula Pierozan, André F Rodrigues, Helena Biasibetti, Daniella M Coelho, Ben Hur Mussulini, Mery S L Pereira, Mariana M Parisi, Florencia Barbé-Tuana, Diogo L de Oliveira, Carmen R Vargas, Angela T S Wys. Chronic Treatment with a Clinically Relevant Dose of Methylphenidate Increases Glutamate Levels in Cerebrospinal Fluid and Impairs Glutamatergic Homeostasis in Prefrontal Cortex of Juvenile Rats. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26001762. |
chronic treatment with a clinically relevant dose of methylphenidate increases glutamate levels in cerebrospinal fluid and impairs glutamatergic homeostasis in prefrontal cortex of juvenile rats. |
2016-12-26 |
2023-08-13 |
rat |
| Felipe Schmitz, Paula Pierozan, André F Rodrigues, Helena Biasibetti, Daniella M Coelho, Ben Hur Mussulini, Mery S L Pereira, Mariana M Parisi, Florencia Barbé-Tuana, Diogo L de Oliveira, Carmen R Vargas, Angela T S Wys. Chronic Treatment with a Clinically Relevant Dose of Methylphenidate Increases Glutamate Levels in Cerebrospinal Fluid and Impairs Glutamatergic Homeostasis in Prefrontal Cortex of Juvenile Rats. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26001762. |
taken together, our results suggest that chronic treatment with methylphenidate at early age induces excitotoxicity, at least in part, due to inhibition of glutamate uptake probably caused by disturbances in the na(+),k(+)-atpase function and/or in protein damage observed in the prefrontal cortex. |
2016-12-26 |
2023-08-13 |
rat |
| Edith Liemburg, Anita Sibeijn-Kuiper, Leonie Bais, Gerdina Pijnenborg, Henderikus Knegtering, Jorien van der Velde, Esther Opmeer, Annerieke de Vos, Jozarni Dlabac-De Lange, Lex Wunderink, André Alema. Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study. Scientific reports. vol 6. 2016-12-21. PMID:26903078. |
in the current study we investigated the levels of glutamate + glutamine (glx, neurotransmitter and precursor) and n-acetyl aspartate + glutamic acid (naa + naag; neuronal viability) in the prefrontal cortex of patients with a psychotic disorder and people at ultra high risk (uhr) for psychosis. |
2016-12-21 |
2023-08-13 |
Not clear |
| Kevin D Lominac, Sema G Quadir, Hannah M Barrett, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Rianne R Campbell, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh Rajasekar, Dan Maliniak, Andrew B Thompson, Lawrence E Urman, Tod E Kippin, Tamara J Phillips, Karen K Szumlinsk. Prefrontal glutamate correlates of methamphetamine sensitization and preference. The European journal of neuroscience. vol 43. issue 5. 2016-12-13. PMID:26742098. |
our understanding of how repeated ma impacts excitatory glutamatergic transmission within the pfc is limited, as is information about the relationship between pfc glutamate and addiction vulnerability/resiliency. |
2016-12-13 |
2023-08-13 |
mouse |
| Kevin D Lominac, Sema G Quadir, Hannah M Barrett, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Rianne R Campbell, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh Rajasekar, Dan Maliniak, Andrew B Thompson, Lawrence E Urman, Tod E Kippin, Tamara J Phillips, Karen K Szumlinsk. Prefrontal glutamate correlates of methamphetamine sensitization and preference. The European journal of neuroscience. vol 43. issue 5. 2016-12-13. PMID:26742098. |
upon extracellular glutamate in c57bl/6j mice and upon glutamate receptor and transporter expression, within the medial pfc. |
2016-12-13 |
2023-08-13 |
mouse |
| Kevin D Lominac, Sema G Quadir, Hannah M Barrett, Courtney L McKenna, Lisa M Schwartz, Paige N Ruiz, Melissa G Wroten, Rianne R Campbell, Bailey W Miller, John J Holloway, Katherine O Travis, Ganesh Rajasekar, Dan Maliniak, Andrew B Thompson, Lawrence E Urman, Tod E Kippin, Tamara J Phillips, Karen K Szumlinsk. Prefrontal glutamate correlates of methamphetamine sensitization and preference. The European journal of neuroscience. vol 43. issue 5. 2016-12-13. PMID:26742098. |
these data provide novel evidence that repeated, low-dose ma is sufficient to perturb pre- and post-synaptic aspects of glutamate transmission within the medial pfc and that glutamate anomalies within this region may contribute to both genetic and idiopathic variance in ma addiction vulnerability/resiliency. |
2016-12-13 |
2023-08-13 |
mouse |
| Shane A Perrine, Andrew L Eagle, Sophie A George, Kostika Mulo, Robert J Kohler, Justin Gerard, Arman Harutyunyan, Steven M Hool, Laura L Susick, Brandy L Schneider, Farhad Ghoddoussi, Matthew P Galloway, Israel Liberzon, Alana C Cont. Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress. Behavioural brain research. vol 303. 2016-12-13. PMID:26821287. |
following a 7-day undisturbed period, mice were tested for cue-induced fear behavior, effects of paroxetine on cue-induced fear behavior, extinction retention of a previously extinguished fear memory, dexamethasone suppression of corticosterone (cort) response, dorsal hippocampal glucocorticoid receptor protein and mrna expression, and prefrontal cortex glutamate levels. |
2016-12-13 |
2023-08-13 |
mouse |
| Shane A Perrine, Andrew L Eagle, Sophie A George, Kostika Mulo, Robert J Kohler, Justin Gerard, Arman Harutyunyan, Steven M Hool, Laura L Susick, Brandy L Schneider, Farhad Ghoddoussi, Matthew P Galloway, Israel Liberzon, Alana C Cont. Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress. Behavioural brain research. vol 303. 2016-12-13. PMID:26821287. |
msps also disrupted extinction retention, enhanced suppression of stress-induced cort response, increased mrna expression of dorsal hippocampal glucocorticoid receptors and decreased prefrontal cortex glutamate levels. |
2016-12-13 |
2023-08-13 |
mouse |