| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Soiza-Reilly, F J Meye, J Olusakin, L Telley, E Petit, X Chen, M Mameli, D Jabaudon, J-Y Sze, P Gaspa. SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior. Molecular psychiatry. vol 24. issue 5. 2020-03-03. PMID:30279456. |
complete or cortex-specific ablation of sert increases the number of functional pfc glutamate synapses on both 5-ht and gaba neurons in the drn. |
2020-03-03 |
2023-08-13 |
mouse |
| H Trantham-Davidson, A Lavi. Loss of dysbindin-1 affects GABAergic transmission in the PFC. Psychopharmacology. vol 236. issue 11. 2020-01-28. PMID:31201475. |
it has been shown that dystrobrevin-binding protein 1 gene that encodes the protein dysbindin-1 is associated with risk for cognitive deficits, and studies have shown decreases in glutamate and correlated decreases in dysbindin-1 protein in the prefrontal cortex (pfc) and hippocampus of post-mortem tissue from schizophrenia patients. |
2020-01-28 |
2023-08-13 |
mouse |
| Yan Zheng, Aiyi Liu, Zi-Jun Wang, Qing Cao, Wei Wang, Lin Lin, Kaijie Ma, Freddy Zhang, Jing Wei, Emmanuel Matas, Jia Cheng, Guo-Jun Chen, Xiaomin Wang, Zhen Ya. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 3. 2020-01-06. PMID:30668640. |
concomitantly, h3k9me2 at glutamate receptors was increased in prefrontal cortex of aged fad mice, which was linked to the diminished transcription, expression and function of ampa and nmda receptors. |
2020-01-06 |
2023-08-13 |
mouse |
| Yan Zheng, Aiyi Liu, Zi-Jun Wang, Qing Cao, Wei Wang, Lin Lin, Kaijie Ma, Freddy Zhang, Jing Wei, Emmanuel Matas, Jia Cheng, Guo-Jun Chen, Xiaomin Wang, Zhen Ya. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 3. 2020-01-06. PMID:30668640. |
treatment of fad mice with specific ehmt1/2 inhibitors reversed histone hyper-methylation and led to the recovery of glutamate receptor expression and excitatory synaptic function in prefrontal cortex and hippocampus. |
2020-01-06 |
2023-08-13 |
mouse |
| Mohammed Abul Kashem, Nilufa Sultana, David V Pow, Vladimir J Balca. GLAST (GLutamate and ASpartate Transporter) in human prefrontal cortex; interactome in healthy brains and the expression of GLAST in brains of chronic alcoholics. Neurochemistry international. vol 125. 2020-01-03. PMID:30817938. |
glast (glutamate and aspartate transporter) in human prefrontal cortex; interactome in healthy brains and the expression of glast in brains of chronic alcoholics. |
2020-01-03 |
2023-08-13 |
human |
| Mohammed Abul Kashem, Nilufa Sultana, David V Pow, Vladimir J Balca. GLAST (GLutamate and ASpartate Transporter) in human prefrontal cortex; interactome in healthy brains and the expression of GLAST in brains of chronic alcoholics. Neurochemistry international. vol 125. 2020-01-03. PMID:30817938. |
we have analysed post-mortem samples of prefrontal cortex from control and alcoholic human brains by the technique of western blotting to estimate and compare the expressions of glutamate transporter glast (excitatory amino acid transporter one; eaat1). |
2020-01-03 |
2023-08-13 |
human |
| Fatin Atrooz, Hesong Liu, Camila Kochi, Samina Sali. Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes. Neuroscience. vol 406. 2019-12-24. PMID:30826520. |
pfc expression of glutamate receptor subunits, post synaptic density protein (psd-95), calcium/calmodulin-dependent protein kinase (camkii), and extracellular signal-regulated kinase (erk |
2019-12-24 |
2023-08-13 |
rat |
| Gyorgy Lur, Mona Fariborzi, Michael J Higle. Ketamine disrupts neuromodulatory control of glutamatergic synaptic transmission. PloS one. vol 14. issue 3. 2019-12-23. PMID:30865708. |
here, we combine electrophysiology with 2-photon imaging and glutamate uncaging in acute slices of mouse pfc to further examine how ketamine alters glutamatergic synaptic transmission. |
2019-12-23 |
2023-08-13 |
mouse |
| Gavin A Scott, Andrew J Roebuck, Quentin Greba, John G Howlan. Performance of the trial-unique, delayed non-matching-to-location (TUNL) task depends on AMPA/Kainate, but not NMDA, ionotropic glutamate receptors in the rat posterior parietal cortex. Neurobiology of learning and memory. vol 159. 2019-12-09. PMID:30731234. |
additionally, we investigated the effects of blocking nmda or non-nmda parietal ionotropic glutamate receptors on tunl and found that, in contrast to the prefrontal cortex, nmda receptors in the ppc are not necessary for tunl performance, whereas blockade of ampa/kainate receptors significantly impaired accuracy. |
2019-12-09 |
2023-08-13 |
rat |
| Erin K Kirschmann, Michael W Pollock, Vidhya Nagarajan, Mary M Torregross. Development of working memory in the male adolescent rat. Developmental cognitive neuroscience. vol 37. 2019-11-22. PMID:30497917. |
moreover, expression of glutamate and gaba receptor subunits was examined in the prelimbic and infralimbic prefrontal cortex across development. |
2019-11-22 |
2023-08-13 |
rat |
| Thérèse M. Jay, Anne-Marie Thierry, Leif Wiklund, Jacques Glowinsk. Excitatory Amino Acid Pathway from the Hippocampus to the Prefrontal Cortex. Contribution of AMPA Receptors in Hippocampo-prefrontal Cortex Transmission. The European journal of neuroscience. vol 4. issue 12. 2019-11-20. PMID:12106392. |
in a second series of experiments, the excitatory transmission from the hippocampus to the prefrontal cortex was pharmacologically analysed to provide further evidence for the involvement of glutamate and/or aspartate in the pathway. |
2019-11-20 |
2023-08-12 |
rat |
| Thérèse M. Jay, Anne-Marie Thierry, Leif Wiklund, Jacques Glowinsk. Excitatory Amino Acid Pathway from the Hippocampus to the Prefrontal Cortex. Contribution of AMPA Receptors in Hippocampo-prefrontal Cortex Transmission. The European journal of neuroscience. vol 4. issue 12. 2019-11-20. PMID:12106392. |
all prefrontal cortex neurons responding to the stimulation of the hippocampus were activated by selective agonists of the glutamate receptor subtypes alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (ampa) and n-methyl-d-aspartate (nmda), and these effects were selectively antagonized by 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx) and 2-amino-5-phosphonopentanoic acid (apv) respectively. |
2019-11-20 |
2023-08-12 |
rat |
| Thérèse M. Jay, Anne-Marie Thierry, Leif Wiklund, Jacques Glowinsk. Excitatory Amino Acid Pathway from the Hippocampus to the Prefrontal Cortex. Contribution of AMPA Receptors in Hippocampo-prefrontal Cortex Transmission. The European journal of neuroscience. vol 4. issue 12. 2019-11-20. PMID:12106392. |
these results suggest that the hippocampal input to the prefrontal cortex utilizes glutamate and/or aspartate as a transmitter. |
2019-11-20 |
2023-08-12 |
rat |
| Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Oht. Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus. Clinical and experimental pharmacology & physiology. 2019-11-20. PMID:29757463. |
furthermore, there were significant changes in 5-ht concentrations in the prefrontal cortex, and in gaba and glutamate concentrations in the hippocampus in sdt fatty compared with controls. |
2019-11-20 |
2023-08-13 |
rat |
| Sayuri Ishiwata, Asami Umino, Toru Nishikaw. Involvement of neuronal and glial activities in control of the extracellular d-serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex. Neurochemistry international. vol 119. 2019-09-30. PMID:28966065. |
we have recently found by using an in vivo dialysis method that an intra-medial prefrontal cortex infusion of s-α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (s-ampa), a selective ampa-type glutamate receptor agonist, causes a reduction in the extracellular levels of d-serine in a calcium-permeable ampa receptor antagonist-sensitive manner. |
2019-09-30 |
2023-08-13 |
mouse |
| Wallace C Duncan, Elizabeth D Ballard, Carlos A Zarat. Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood. Handbook of experimental pharmacology. vol 253. 2019-09-13. PMID:28939975. |
ketamine treatment elevates extracellular glutamate in the prefrontal cortex. |
2019-09-13 |
2023-08-13 |
Not clear |
| Sawsan Aboul-Fotouh, Mohamed Habib, Tarek Asaad, Samar K Kassim, Mohamed H Ghane. Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. Behavioural pharmacology. vol 29. issue 5. 2019-07-31. PMID:29561292. |
long-term administration of eri ameliorated crs-induced depressive-like symptoms and hypothalamic-pituitary-adrenal axis hyperactivity alongside reducing levels of hippocampal and pfc inflammatory cytokines, restoring gaba and glutamate balance, and enhancing pfc and hippocampal neurogenesis, by increasing bdnf gene and protein expression in a dose-dependent manner. |
2019-07-31 |
2023-08-13 |
rat |
| Eric A Woodcock, Mark K Greenwald, Dalal Khatib, Vaibhav A Diwadkar, Jeffrey A Stanle. Pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation. NeuroImage. vol 186. 2019-07-15. PMID:30458306. |
pharmacological stress impairs working memory performance and attenuates dorsolateral prefrontal cortex glutamate modulation. |
2019-07-15 |
2023-08-13 |
Not clear |
| Y M Geng, J T Xue, J P Su, H Y L. Molecular mechanism of action of valproate acid alone or in combination with chlorpromazine in the epigenetic regulation of schizophrenia. Journal of biological regulators and homeostatic agents. vol 32. issue 6. 2019-06-14. PMID:30574748. |
the real time pcr assay was used to detect the mrna expression changes of gaba system gene [gabbr1 (gaba b receptor 1)], gad1 (glutamic acid decarboxylase1), gad2 (glutamic acid decarboxylase2), lipase metabolic key enzyme lpl (lipoprotein lipase) gene, glutamate neurotransmitter gene gria2 (ampa subtype glutamate receptors 2), inward rectifier potassium channel members kcnj4 (potassium voltage-gated channel subfamily j member 4) and neuropeptide signal gene tac1 (tachykinin precursor 1,tac1) in four brain regions: the prefrontal cortex (pc), the amygdala (am), the caudate-putamen (cpu) and the hippocampus (hip). |
2019-06-14 |
2023-08-13 |
rat |
| Coleman B Calva, Habiba Fayyaz, Jim R Fade. Increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-A (hypocretin-1). Journal of neurochemistry. vol 145. issue 3. 2019-05-08. PMID:29250792. |
increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-a (hypocretin-1). |
2019-05-08 |
2023-08-13 |
rat |