| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kellie S Gross, Dieter D Brandner, Luis A Martinez, M Foster Olive, Robert L Meisel, Paul G Mermelstei. Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density. PloS one. vol 11. issue 9. 2017-08-02. PMID:27618534. |
we investigated the individual effects of mglur1a or mglur5 activation on dendritic spine density in medium spiny neurons in the nucleus accumbens (nac), which has become relevant with the potential use of group i mglur based therapeutics in the treatment of drug addiction. |
2017-08-02 |
2023-08-13 |
Not clear |
| Paula A Gajewski, Gustavo Turecki, Alfred J Robiso. Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. PloS one. vol 11. issue 8. 2017-07-31. PMID:27494187. |
the transcription factor Δfosb is induced in the prefrontal cortex (pfc) and hippocampus (hpc) of rodents in response to stress or cocaine, and its expression in these regions is thought to regulate their "top down" control of reward circuitry, including the nucleus accumbens (nac). |
2017-07-31 |
2023-08-13 |
human |
| Colby R Keistler, Emma Hammarlund, Jacqueline M Barker, Colin W Bond, Ralph J DiLeone, Christopher Pittenger, Jane R Taylo. Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 17. 2017-07-31. PMID:28336571. |
previous studies have demonstrated that the regulation of cue-guided alcohol seeking is mediated by the basolateral amygdala (bla), nucleus accumbens (nac), and medial prefrontal cortex (mpfc). |
2017-07-31 |
2023-08-13 |
rat |
| Jianbo Zhang, Na Wang, Bo Chen, Yi'nan Wang, Jing He, Xintong Cai, Hongbo Zhang, Shuguang Wei, Shengbin L. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Neuroscience letters. vol 630. 2017-07-26. PMID:27461790. |
in the present study, we investigated the relationship between cb1r and the extracellular signal-regulated kinase (erk), camp response element-binding protein (creb), brain-derived neurotrophic factor (bdnf) signaling in the nucleus accumbens (nac) and hippocampus in morphine-induced conditioned place preference (cpp), which is used to assess the morphine-induced reward memory. |
2017-07-26 |
2023-08-13 |
mouse |
| R Adron Harris, Michal Bajo, Richard L Bell, Yuri A Blednov, Florence P Varodayan, Jay M Truitt, Giordano de Guglielmo, Amy W Lasek, Marian L Logrip, Leandro F Vendruscolo, Amanda J Roberts, Edward Roberts, Olivier George, Jody Mayfield, Timothy R Billiar, David J Hackam, R Dayne Mayfield, George F Koob, Marisa Roberto, Gregg E Homanic. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 5. 2017-07-24. PMID:27986929. |
members of the integrative neuroscience initiative on alcoholism (inia-neuroimmune) consortium tested the hypothesis that tlr4 mediates excessive ethanol drinking using the following models: (1) tlr4 knock-out (ko) rats, (2) selective knockdown of tlr4 mrna in mouse nucleus accumbens (nac), and (3) injection of the tlr4 antagonist (+)-naloxone in mice. |
2017-07-24 |
2023-08-13 |
mouse |
| Tianyuan Wang, Janine H Santos, Jian Feng, David C Fargo, Li Shen, Gonzalo Riadi, Elizabeth Keeley, Zachary S Rosh, Eric J Nestler, Richard P Woychi. A Novel Analytical Strategy to Identify Fusion Transcripts between Repetitive Elements and Protein Coding-Exons Using RNA-Seq. PloS one. vol 11. issue 7. 2017-07-20. PMID:27415830. |
we applied it to an rna-seq dataset from the nucleus accumbens (nac) of mice repeatedly exposed to cocaine. |
2017-07-20 |
2023-08-13 |
mouse |
| Daniel Vallöf, Jesper Vestlund, Jörgen A Engel, Elisabet Jerlha. The Anorexigenic Peptide Neuromedin U (NMU) Attenuates Amphetamine-Induced Locomotor Stimulation, Accumbal Dopamine Release and Expression of Conditioned Place Preference in Mice. PloS one. vol 11. issue 5. 2017-07-19. PMID:27139195. |
this reward link consists of a dopamine projection from the ventral tegmental area to the nucleus accumbens (nac) suggesting that these brain areas are important for reward. |
2017-07-19 |
2023-08-13 |
mouse |
| Qiang Fu, Xiaoyan Zhou, Yun Dong, Yonghong Huang, Jianhua Yang, Ki-Wan Oh, Zhenzhen H. Decreased Caffeine-Induced Locomotor Activity via Microinjection of CART Peptide into the Nucleus Accumbens Is Linked to Inhibition of the pCaMKIIa-D3R Interaction. PloS one. vol 11. issue 7. 2017-07-19. PMID:27404570. |
the purpose of this study was to characterize the inhibitory modulation of cocaine- and amphetamine-regulated transcript (cart) peptides, particularly with respect to the function of the d3 dopamine receptor (d3r), which is activated by its interaction with phosphorylated camkiiα (pcamkiiα) in the nucleus accumbens (nac). |
2017-07-19 |
2023-08-13 |
rat |
| Binbin Wu, Yuyuan Liang, Zhanglei Dong, Zhichuan Chen, Gaolong Zhang, Wenxuan Lin, Sicong Wang, Benfu Wang, Ren-Shan Ge, Qingquan Lia. Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens. Neuroscience. vol 328. 2017-07-18. PMID:27126557. |
the expression of dopamine d1 receptor in the nucleus accumbens (nac) was examined by western blot and the concentrations of plasma corticosterone were measured by enzyme-linked immunosorbent assay (elisa). |
2017-07-18 |
2023-08-13 |
human |
| Hee-Dae Kim, Jennifer Hesterman, Tanessa Call, Samantha Magazu, Elizabeth Keeley, Kristyna Armenta, Hope Kronman, Rachael L Neve, Eric J Nestler, Deveroux Ferguso. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511015. |
in the present study, we show that chronic social defeat stress, an ethologically validated model of depression in mice, increases sirt1 levels in the nucleus accumbens (nac), a key brain reward region. |
2017-07-14 |
2023-08-13 |
mouse |
| Ellen M McGlinchey, Morgan H James, Stephen V Mahler, Caroline Pantazis, Gary Aston-Jone. Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 33. 2017-07-14. PMID:27535915. |
glutamate inputs to nucleus accumbens (nac) facilitate conditioned drug-seeking behavior and primarily originate from medial prefrontal cortex (mpfc), basolateral amygdala (bla), and ventral subiculum of the hippocampus (vsub). |
2017-07-14 |
2023-08-13 |
rat |
| Eric J Nestle. Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function". Brain research. vol 1645. 2017-07-13. PMID:26740398. |
moreover, in the same study we showed similar induction of adenylyl cyclase and pka activity in nucleus accumbens (nac) in response to chronic administration of cocaine, but not of several non-abused psychoactive drugs. |
2017-07-13 |
2023-08-13 |
rat |
| Francesco Leri, Franco J Vaccarin. Tribute to: Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area [William Corrigall, Kathleen Coen and Laurel Adamson, Brain Res. 653 (1994) 278-284]. Brain research. vol 1645. 2017-07-13. PMID:26867702. |
the nicotinic receptor antagonist dihydro-β-erythroidine (dhβe) was infused in the ventral tegmental area (vta) or nucleus accumbens (nac) of rats trained to self-administer nicotine intravenously. |
2017-07-13 |
2023-08-13 |
rat |
| Rafael Renteria, Esther Y Maier, Tavanna R Buske, Richard A Morriset. Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure. Neuropharmacology. vol 112. issue Pt A. 2017-07-11. PMID:26946430. |
in this study, we determined whether such short term intermittent ethanol exposure modulates nmdar function as well as other prominent electrophysiological properties and the expression of plasticity in both d1 (d1+) and d2 (d1-) dopamine receptor expressing medium spiny neurons (msns) in the nucleus accumbens (nac) shell. |
2017-07-11 |
2023-08-13 |
mouse |
| Courtney M Cameron, R Mark Wightman, Regina M Carell. One month of cocaine abstinence potentiates rapid dopamine signaling in the nucleus accumbens core. Neuropharmacology. vol 111. 2017-07-11. PMID:27616012. |
given the importance of the mesolimbic dopamine (da) system in drug addiction, we sought to characterize cocaine abstinence induced changes in rapid da signaling in the nucleus accumbens (nac). |
2017-07-11 |
2023-08-13 |
rat |
| Jorge R Bergado Acosta, Evelyn Kahl, Georgios Kogias, Taygun C Uzuneser, Markus Fend. Relief learning requires a coincident activation of dopamine D1 and NMDA receptors within the nucleus accumbens. Neuropharmacology. vol 114. 2017-07-11. PMID:27894877. |
we previously demonstrated that the nmda receptors within the nucleus accumbens (nac) are involved in relief learning. |
2017-07-11 |
2023-08-13 |
rat |
| Anushree N Karkhanis, Kimberly N Huggins, Jamie H Rose, Sara R Jone. Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27450094. |
kors are located on presynaptic dopamine terminals in the nucleus accumbens (nac) and inhibit release, an effect which has been linked to negative affective behaviors. |
2017-07-10 |
2023-08-13 |
mouse |
| Natalia Duque-Wilckens, Michael Q Steinman, Sarah A Laredo, Rebecca Hao, Allison M Perkeybile, Karen L Bales, Brian C Traino. Inhibition of vasopressin V1a receptors in the medioventral bed nucleus of the stria terminalis has sex- and context-specific anxiogenic effects. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27452721. |
in females stress also increased v1ar binding in the nucleus accumbens (nac). |
2017-07-10 |
2023-08-13 |
mouse |
| Zheng Liu, Yao Wang, Li Cai, Yizhi Li, Bo Chen, Yan Dong, Yanhua H Huan. Prefrontal Cortex to Accumbens Projections in Sleep Regulation of Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466335. |
in the nucleus accumbens (nac), a key brain region regulating emotional and motivational responses, we observed a decrease in the ratio of the overall excitatory over inhibitory synaptic inputs onto nac principle neurons after sde. |
2017-07-10 |
2023-08-13 |
mouse |
| Avani Shukla, Anna Beroun, Myrto Panopoulou, Peter A Neumann, Seth Gn Grant, M Foster Olive, Yan Dong, Oliver M Schlüte. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference. The EMBO journal. vol 36. issue 4. 2017-07-10. PMID:28077487. |
exposure to cocaine generates silent synapses in the nucleus accumbens (nac), whose eventual unsilencing/maturation by recruitment of calcium-permeable ampa-type glutamate receptors (cp-ampars) after drug withdrawal results in profound remodeling of nac neuro-circuits. |
2017-07-10 |
2023-08-13 |
mouse |