| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jenna A McHenry, Christopher L Robison, Genevieve A Bell, Vincent V Vialou, Carlos A Bolaños-Guzmán, Eric J Nestler, Elaine M Hul. The role of ΔfosB in the medial preoptic area: Differential effects of mating and cocaine history. Behavioral neuroscience. vol 130. issue 5. 2017-11-16. PMID:27657309. |
the transcription factor deltafosb (Δfosb) is induced in the nucleus accumbens (nac) by repeated exposure to drugs of abuse and natural rewards. |
2017-11-16 |
2023-08-13 |
rat |
| J L Cadet, C Brannock, I N Krasnova, S Jayanthi, B Ladenheim, M T McCoy, D Walther, A Godino, M Pirooznia, R S Le. Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence. Molecular psychiatry. vol 22. issue 8. 2017-11-13. PMID:27046646. |
we used that model to investigate potential alterations in global dna hydroxymethylation in the nucleus accumbens (nac) because neuroplastic changes in the nac may participate in the development and maintenance of drug-taking behaviors. |
2017-11-13 |
2023-08-13 |
rat |
| Fatemeh Yazdi, Mahboubeh Jahangirvand, Somayeh Ezzatpanah, Abbas Haghparas. Role of orexin-2 receptors in the nucleus accumbens in antinociception induced by carbachol stimulation of the lateral hypothalamus in formalin test. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26871404. |
previously, it has been established that the nucleus accumbens (nac) is involved in the modulation of formalin-induced nociceptive responses, a model of tonic pain. |
2017-11-08 |
2023-08-13 |
Not clear |
| Yafang Zhang, Elizabeth J Crofton, Xiuzhen Fan, Dingge Li, Fanping Kong, Mala Sinha, Bruce A Luxon, Heidi M Spratt, Cheryl F Lichti, Thomas A Gree. Convergent transcriptomics and proteomics of environmental enrichment and cocaine identifies novel therapeutic strategies for addiction. Neuroscience. vol 339. 2017-11-06. PMID:27717806. |
the current study is a secondary analysis of the convergence of recently published separate transcriptomic and proteomic analyses of nucleus accumbens (nac) tissue from rats subjected to environmental enrichment vs. isolation and cocaine self-administration vs. saline. |
2017-11-06 |
2023-08-13 |
rat |
| Gregory N Ruegsegger, Jacob D Brown, M Cathleen Kovarik, Dennis K Miller, Frank W Boot. Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running. Neuroscience. vol 339. 2017-11-06. PMID:27743985. |
we utilized selectively bred rats for high (hvr) or low (lvr) voluntary running behavior to examine (1) inherent differences in mu-opioid receptor (oprm1) expression and function in the nucleus accumbens (nac), (2) if dopamine-related mrnas, wheel-running, and food intake are differently influenced by intraperitoneal (i.p.) |
2017-11-06 |
2023-08-13 |
rat |
| Joshua L Haight, Zachary L Fuller, Kurt M Fraser, Shelly B Flage. A food-predictive cue attributed with incentive salience engages subcortical afferents and efferents of the paraventricular nucleus of the thalamus. Neuroscience. vol 340. 2017-11-06. PMID:27793779. |
the retrograde tracer fluorogold (fg) was injected into the pvt or the nucleus accumbens (nac) of rats, and cue-induced c-fos in fg-labeled cells was quantified. |
2017-11-06 |
2023-08-13 |
rat |
| Michael P Saddori. Terminal Dopamine Release Kinetics in the Accumbens Core and Shell Are Distinctly Altered after Withdrawal from Cocaine Self-Administration. eNeuro. vol 3. issue 5. 2017-10-31. PMID:27752541. |
repeated self-administration of cocaine is associated with impairments in motivated behaviors as well as alterations in both dopamine (da) release and neural signaling within the nucleus accumbens (nac). |
2017-10-31 |
2023-08-13 |
rat |
| Laurie Hamel, Tharshika Thangarasa, Osai Samadi, Rutsuko It. Caudal Nucleus Accumbens Core Is Critical in the Regulation of Cue-Elicited Approach-Avoidance Decisions. eNeuro. vol 4. issue 1. 2017-10-31. PMID:28275709. |
the nucleus accumbens (nac) is thought to be a site of integration of positively and negatively valenced information and action selection. |
2017-10-31 |
2023-08-13 |
rat |
| Reza Arezoomandan, Marzieh Moradi, Ghassem Attarzadeh-Yazdi, Carlos Tomaz, Abbas Haghparas. Administration of activated glial condition medium in the nucleus accumbens extended extinction and intensified reinstatement of methamphetamine-induced conditioned place preference. Brain research bulletin. vol 125. 2017-10-30. PMID:27346277. |
following the establishment of cpp, the rats were given daily bilateral injections (0.5μl/side) of either vehicle, acm or ncm into the nucleus accumbens (nac) and then were tested for the maintenance and reinstatement. |
2017-10-30 |
2023-08-13 |
rat |
| Keiji Nishiyama, Hirobumi Suzuki, Toshiya Harasawa, Noriko Suzuki, Emi Kurimoto, Takayuki Kawai, Minoru Maruyama, Hidetoshi Komatsu, Kensuke Sakuma, Yuji Shimizu, Masato Shimoj. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. The Journal of pharmacology and experimental therapeutics. vol 363. issue 2. 2017-10-30. PMID:28851764. |
gpr52 is a gs-coupled g protein-coupled receptor that is predominantly expressed in the striatum and nucleus accumbens (nac) and was recently proposed as a potential therapeutic target for schizophrenia. |
2017-10-30 |
2023-08-13 |
Not clear |
| Abbas Z Kouzani, Rajas P Kale, Pablo Patricio Zarate-Garza, Michael Berk, Ken Walder, Susannah J Ty. Validation of a Portable Low-Power Deep Brain Stimulation Device Through Anxiolytic Effects in a Laboratory Rat Model. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. vol 25. issue 9. 2017-10-27. PMID:28113945. |
the in vivo tests demonstrated that chronic stimulation of the nucleus accumbens (nac) with this device significantly increased psychomotor activity, together with a dramatic reduction in anxiety-like behavior in the elevated zero-maze test. |
2017-10-27 |
2023-08-13 |
rat |
| Ernesto Solis, R Aaron Bola, Bradley J Fasulo, Eugene A Kiyatki. Brain Hyperglycemia Induced by Heroin: Association with Metabolic Neural Activation. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27736094. |
by using enzyme-based biosensors coupled with high-speed amperometry in freely moving rats, we previously showed that glucose levels in the nucleus accumbens (nac) display high variability, increasing rapidly following exposure to various arousing stimuli. |
2017-10-24 |
2023-08-13 |
rat |
| Steve C Fordahl, Sara R Jone. High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling. ACS chemical neuroscience. vol 8. issue 2. 2017-10-24. PMID:27966885. |
insulin has been shown to decrease dopamine neuron firing in the ventral tegmental area (vta), but potentiate release and reuptake at dopamine terminals in the nucleus accumbens (nac). |
2017-10-24 |
2023-08-13 |
mouse |
| Kala Venkiteswaran, Danielle N Alexander, Matthew D Puhl, Anand Rao, Amanda L Piquet, Jennifer E Nyland, Megha P Subramanian, Puja Iyer, Matthew M Boisvert, Erin Handly, Thyagarajan Subramanian, Patricia Sue Grigso. Transplantation of human retinal pigment epithelial cells in the nucleus accumbens of cocaine self-administering rats provides protection from seeking. Brain research bulletin. vol 123. 2017-10-20. PMID:26562520. |
chronic exposure to drugs and alcohol leads to damage to dopaminergic neurons and their projections in the 'reward pathway' that originate in the ventral tegmental area (vta) and terminate in the nucleus accumbens (nac). |
2017-10-20 |
2023-08-13 |
human |
| Caesar G Imperio, Ashley J McFalls, Elizabeth M Colechio, Dustin R Masser, Kent E Vrana, Patricia S Grigson, Willard M Freema. Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access. Brain research bulletin. vol 123. 2017-10-20. PMID:26733446. |
we examined the individual differences in mrna expression in the nucleus accumbens (nac) of rats that were behaviorally stratified by addiction-like behavior using next-generation sequencing. |
2017-10-20 |
2023-08-13 |
rat |
| Michael F Salvatore, Erin S Calipari, Sara R Jone. Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27124386. |
th protein decreased (∼74%), though to a significantly lesser extent than da, in striatum and nucleus accumbens (nac) in dat -/- mice, with no decrease in substantia nigra or ventral tegmental area. |
2017-10-19 |
2023-08-13 |
mouse |
| Nitish Mittal, Ani Minasyan, Nicole Romaneschi, Joshua K Hakimian, Gabriel Gonzalez-Fernandez, Ralph Albert, Nina Desai, Ian A Mendez, Timothy Schallert, Sean B Ostlund, Wendy Walwy. Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. PloS one. vol 12. issue 10. 2017-10-19. PMID:28973019. |
we then examined glutamatergic synaptic strength in wt and ko medium spiny neurons (msns) of the nucleus accumbens (nac) shell in naïve animals, and from those that underwent cocaine self-administration. |
2017-10-19 |
2023-08-13 |
mouse |
| Zhongli Yang, Tanseli Nesil, Kaitlyn P Connaghan, Ming D Li, Sulie L Chan. Modulation Effect of HIV-1 Viral Proteins and Nicotine on Expression of the Immune-Related Genes in Brain of the HIV-1 Transgenic Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 3. 2017-10-18. PMID:27147085. |
here, we compared expression of 52 immune-related genes in the prefrontal cortex (pfc), nucleus accumbens (nac), and ventral tegmental area (vta) of hiv-1tg and f344 rats treated with either nicotine (0.4 mg/kg nicotine, base, s.c.) or saline for 27 days, to identify differentially expressed genes in the presence of hiv-1 with and without nicotine treatment. |
2017-10-18 |
2023-08-13 |
human |
| Alfredo Oliveros, Phillip Starski, Daniel Lindberg, Sun Choi, Carrie J Heppelmann, Surendra Dasari, Doo-Sup Cho. Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter. Journal of proteome research. vol 16. issue 4. 2017-10-17. PMID:27998058. |
the neural circuit of the dorsal hippocampus (dhip) and nucleus accumbens (nac) contributes to cue-induced learning and addictive behaviors, as demonstrated by the escalation of ethanol-seeking behaviors observed following deletion of the adenosine equilibrative nucleoside transporter 1 (ent1 |
2017-10-17 |
2023-08-13 |
mouse |
| J G Ramaekers, J H van Wel, D Spronk, B Franke, G Kenis, S W Toennes, K P C Kuypers, E L Theunissen, P Stiers, R J Verke. Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes. Brain imaging and behavior. vol 10. issue 4. 2017-10-16. PMID:26667034. |
resting state fmri was measured in a subset of participants to determine functional connectivity between the nucleus accumbens (nac) and (sub)cortical areas. |
2017-10-16 |
2023-08-13 |
human |