| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao A Zhang, Adam W Hendricson, Richard A Morriset. Dual synaptic sites of D(1)-dopaminergic regulation of ethanol sensitivity of NMDA receptors in nucleus accumbens. Synapse (New York, N.Y.). vol 58. issue 1. 2006-06-28. PMID:16037948. |
these data suggest that d(1)-like receptors modulate both the presynaptic and postsynaptic effects of ethanol on nmda receptor-mediated synaptic transmission in nucleus accumbens (nac) and that these interactions may contribute to ethanol-induced neuroadaptation of the reward pathway. |
2006-06-28 |
2023-08-12 |
Not clear |
| Joseph F Cheer, Kate M Wassum, R Mark Wightma. Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats. Journal of neurochemistry. vol 97. issue 4. 2006-06-22. PMID:16686693. |
because the nucleus accumbens (nac) shows high levels of central cannabinoid receptor 1 (cb1) expression we examined the effects of cannabinoids on the local transient alkaline shifts and increases in extracellular oxygen induced by electrical stimulation of the medial forebrain bundle (mfb) in conscious animals. |
2006-06-22 |
2023-08-12 |
rat |
| Nobuaki Egashira, Akiko Yano, Noriko Ishigami, Kenichi Mishima, Katsunori Iwasaki, Masayuki Fujioka, Michihiko Matsushita, Ryoji Nishimura, Michihiro Fujiwar. Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats. Brain research. vol 1069. issue 1. 2006-06-13. PMID:16386718. |
contrastingly, spatial memory was unaffected by microinjections of 8-oh-dpat into the other six areas examined: ventral hippocampus (vh), central amygdaloid nucleus (ace), lateral hypothalamus (lh), nucleus accumbens (nac), and dorsal (dr) and median (mr) raphe nucleus. |
2006-06-13 |
2023-08-12 |
rat |
| Elyssa B Margolis, Hagar Lock, Vladimir I Chefer, Toni S Shippenberg, Gregory O Hjelmstad, Howard L Field. Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 8. 2006-06-13. PMID:16477003. |
two major targets of these afferents are the medial prefrontal cortex (mpfc) and the nucleus accumbens (nac). |
2006-06-13 |
2023-08-12 |
Not clear |
| Yan Dong, Thomas Green, Daniel Saal, Helene Marie, Rachael Neve, Eric J Nestler, Robert C Malenk. CREB modulates excitability of nucleus accumbens neurons. Nature neuroscience. vol 9. issue 4. 2006-06-08. PMID:16520736. |
drugs of abuse cause activation of the cyclic amp response element binding protein (creb) in the nucleus accumbens (nac). |
2006-06-08 |
2023-08-12 |
rat |
| Heather G Ward, Danielle M Nicklous, Vincent J Aloyo, Kenny J Simansk. Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating. The European journal of neuroscience. vol 23. issue 6. 2006-05-30. PMID:16553624. |
acute pharmacological studies have implicated mu-opioid receptors (mors) in the shell of the nucleus accumbens (nac) in mediating responses for palatable food and other natural and drug-induced rewards. |
2006-05-30 |
2023-08-12 |
Not clear |
| Taku Nagai, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. [Role of tissue plasminogen activator in the rewarding effect of morphine]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619846. |
a single morphine treatment induced tpa mrna and protein expression in a naloxone-sensitive manner, which was associated with an increase in the enzyme activity in the nucleus accumbens (nac). |
2006-05-30 |
2023-08-12 |
mouse |
| Masahiko Funada, Mio Sato, Naoya Aoo, Kiyoshi Wad. [Role of the monoamine system in the brain on the development of psychological dependence on toluene]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619847. |
the mesolimbic dopamine pathway, which includes dopaminergic neurons in the ventral tegmental area (vta) of the midbrain and their targets in the limbic forebrain, especially the nucleus accumbens (nac), is one of the most important substrates for the development of psychological dependence on drugs such as stimulants, cocaine, and heroin. |
2006-05-30 |
2023-08-12 |
Not clear |
| Heike Franke, Benjamin Grummich, Wolfgang Härtig, Jens Grosche, Ralf Regenthal, Robert H Edwards, Peter Illes, Ute Krüge. Changes in purinergic signaling after cerebral injury -- involvement of glutamatergic mechanisms? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 24. issue 2-3. 2006-05-25. PMID:16387466. |
in microdialysis studies, endogenous atp facilitated the extracellular concentration of glutamate in the nucleus accumbens (nac) of rats. |
2006-05-25 |
2023-08-12 |
rat |
| Kenneth Blum, Brian Meshkin, B William Down. DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human. Medical hypotheses. vol 66. issue 5. 2006-05-25. PMID:16403602. |
we also propose that manipulation of neurochemical reward circuitry in the mesolimbic brain region providing dopamine release at the nucleus accumbens (nac), will have both pain and stress relief benefists, which are a cornerstone to the human inflammatory process. |
2006-05-25 |
2023-08-12 |
human |
| Lian-fang Zhou, Yong-ping Zh. Changes of CREB in rat hippocampus, prefrontal cortex and nucleus accumbens during three phases of morphine induced conditioned place preference in rats. Journal of Zhejiang University. Science. B. vol 7. issue 2. 2006-05-17. PMID:16421965. |
to investigate the changes in creb (camp response element binding protein) in hippocampus, pfc (prefrontal cortex) and nac (nucleus accumbens) during three phases of morphine induced cpp (conditioned place preference) in rats, and to elucidate the role of creb during the progress of conditioned place preference. |
2006-05-17 |
2023-08-12 |
rat |
| Malini E Singh, Iain S McGregor, Paul E Malle. Perinatal exposure to delta(9)-tetrahydrocannabinol alters heroin-induced place conditioning and fos-immunoreactivity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:15920503. |
acute administration of heroin in vehicle pretreated rats increased fos-ir in the central, medial, and dorsomedial caudate putamen (cpu), nucleus accumbens (nac, core and shell regions), lateral septum, islands of calleja-major (icjm), bed nucleus of the stria terminalis (bnst), central nucleus of the amygdala (cea), dorsolateral and dorsomedial periaqueductal gray (pag), ventral tegmental area (vta), edinger-westphal nucleus (ew). |
2006-05-12 |
2023-08-12 |
rat |
| James E Smith, Conchita Co, Michael D Coller, Scott E Hemby, Thomas J Marti. Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:15956989. |
a second experiment used microdialysis to determine the effects of this drug combination on nucleus accumbens (nac) extracellular levels of dopamine ([da](e)) in rats self-administering low doses of cocaine, heroin, or cocaine/heroin combinations. |
2006-05-12 |
2023-08-12 |
rat |
| Guillaume Casassus, Christophe Blanchet, Christophe Mull. Short-term regulation of information processing at the corticoaccumbens synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 50. 2006-05-11. PMID:16354908. |
in contrast, repeated bursts of stimulation of cortical afferents trigger a new form of short-term potentiation of synaptic transmission (rb-stp) in the nucleus accumbens (nac). |
2006-05-11 |
2023-08-12 |
Not clear |
| Susana Mato, David Robbe, Nagore Puente, Pedro Grandes, Olivier J Manzon. Presynaptic homeostatic plasticity rescues long-term depression after chronic Delta 9-tetrahydrocannabinol exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 50. 2006-05-11. PMID:16354920. |
using biochemical and electrophysiological approaches, we now report that 1 week of repeated in vivo thc treatment reduces the coupling efficiency of cannabinoid cb1 receptors (cb1rs) to g(i/o) transduction proteins, as well as cb1r-mediated inhibition of excitatory synaptic transmission at the excitatory synapses between the prefrontal cortex and the nucleus accumbens (nac). |
2006-05-11 |
2023-08-12 |
mouse |
| Ka Wan Li, Connie R Jimenez, Roel C van der Schors, Martin P Hornshaw, Anton N M Schoffelmeer, August B Smi. Intermittent administration of morphine alters protein expression in rat nucleus accumbens. Proteomics. vol 6. issue 6. 2006-05-11. PMID:16447156. |
we used a 2-d gel-based proteomics approach to examine morphine-induced temporal changes in protein expression and/or ptm in the nucleus accumbens (nac) of morphine-sensitized rats. |
2006-05-11 |
2023-08-12 |
rat |
| Gregory O Hjelmsta. Interactions between asynchronous release and short-term plasticity in the nucleus accumbens slice. Journal of neurophysiology. vol 95. issue 3. 2006-04-27. PMID:16338991. |
glutamate synapses in the nucleus accumbens (nac) display asynchronous release in response to trains of stimulation. |
2006-04-27 |
2023-08-12 |
Not clear |
| Zhu Li, Junji Ichikawa, Mei Huang, Adam J Prus, Jin Dai, Herbert Y Meltze. ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Psychopharmacology. vol 183. issue 2. 2006-04-13. PMID:16220333. |
previous studies from this laboratory using microdialysis have shown that pretreatment of the 5-ht(2a) antagonist m100907 with the typical apd and d(2) antagonist haloperidol produced an increase in the medial prefrontal cortex (mpfc), but not in the nucleus accumbens (nac), da release. |
2006-04-13 |
2023-08-12 |
rat |
| Christopher P Ford, Gregory P Mark, John T William. Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 10. 2006-04-13. PMID:16525058. |
the mesolimbic dopamine system, which mediates the rewarding properties of nearly all drugs of abuse, originates in the ventral tegmental area (vta) and sends major projections to both the nucleus accumbens (nac) and the basolateral amygdala (bla). |
2006-04-13 |
2023-08-12 |
mouse |
| Ji Hyun Kim, Jin Yong Chung, Young Kyu Kwon, Kwang Joong Kim, Chae Ha Yang, Dae-Hyun Hahm, Hye-Jung Lee, Kwang-Ho Pyun, Insop Shi. Acupuncture reduces alcohol withdrawal syndrome and c-Fos expression in rat brain. The American journal of Chinese medicine. vol 33. issue 6. 2006-04-11. PMID:16355445. |
in the present study, the effects of acupuncture on alcohol withdrawal syndrome (aws) and fos-like immunoreactivity (fli) in the striatum and the nucleus accumbens (nac) of rats were investigated. |
2006-04-11 |
2023-08-12 |
rat |