| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T P Giordano, S S Satpute, J Striessnig, B E Kosofsky, A M Rajadhyaksh. Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channels. Journal of neurochemistry. vol 99. issue 4. 2007-01-09. PMID:17026527. |
in this study, we used quantitative real-time pcr to specifically amplify these two splice variants to examine their mrna expression in the dorsal striatum (dstr), nucleus accumbens (nac) and the ventral tegmental area (vta) of amphetamine-sensitized c57bl/6 mice. |
2007-01-09 |
2023-08-12 |
mouse |
| Gerhard Jocham, Katharina Lezoch, Christian P Müller, Emriye Kart-Teke, Joseph P Huston, M Angélica de Souza Silv. Neurokinin receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine-enhancing action in the nucleus accumbens core. The European journal of neuroscience. vol 24. issue 6. 2007-01-05. PMID:17004936. |
increase in extracellular dopaminergic activity in the nucleus accumbens (nac). |
2007-01-05 |
2023-08-12 |
rat |
| Yan Zhou, Jacob Bendor, Lauren Hofmann, Matthew Randesi, Ann Ho, Mary Jeanne Kree. Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. The Journal of endocrinology. vol 191. issue 1. 2006-12-29. PMID:17065397. |
in this study, we investigated the effects of acute morphine administration, chronic intermittent escalating-dose morphine administration and spontaneous withdrawal from chronic morphine on mrna levels of mu opioid receptor (mop-r), and the opioid peptides pro-opiomelanocortin (pomc) and preprodynorphin (ppdyn) in several key brain regions of the rat, associated with drug reward and motivated behaviors: lateral hypothalamus (lat.hyp), nucleus accumbens (nac) core, amygdala, and caudate-putamen (cpu). |
2006-12-29 |
2023-08-12 |
rat |
| Xiuwu Zhang, Tong H Lee, Xueying Xiong, Qiang Chen, Colin Davidson, William C Wetsel, Everett H Ellinwoo. Methamphetamine induces long-term changes in GABAA receptor alpha2 subunit and GAD67 expression. Biochemical and biophysical research communications. vol 351. issue 1. 2006-12-22. PMID:17056007. |
western blot assay showed that meth sensitization decreases gaba(a) alpha2 subunit and gad(67) protein levels in the nucleus accumbens (nac) core and shell, and conversely, these proteins were increased in the caudate. |
2006-12-22 |
2023-08-12 |
rat |
| Donald C Cooper, William D Klipec, Melissa A Fowler, Emin D Ozka. A role for the subiculum in the brain motivation/reward circuitry. Behavioural brain research. vol 174. issue 2. 2006-12-20. PMID:16870273. |
the ventral subiculum (vsub) is an interface between the hippocampal formation and structures in the brain reward circuitry, such as the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2006-12-20 |
2023-08-12 |
Not clear |
| Vladimir I Chefer, Agustin Zapata, Toni S Shippenberg, Peter M Bunga. Quantitative no-net-flux microdialysis permits detection of increases and decreases in dopamine uptake in mouse nucleus accumbens. Journal of neuroscience methods. vol 155. issue 2. 2006-12-18. PMID:16466808. |
here we report that the ed for da in the nucleus accumbens (nac) of the behaving mouse is increased following pharmacological inactivation of kappa-opioid receptors, a treatment previously shown to augment da uptake. |
2006-12-18 |
2023-08-12 |
mouse |
| Taku Nagai, Mina Ito, Noritaka Nakamichi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Ayumi Fukakusa, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 47. 2006-12-15. PMID:17122062. |
in vivo microdialysis revealed that microinjection of either tpa or plasmin into the nucleus accumbens (nac) significantly potentiated whereas plasminogen activator inhibitor-1 reduced the nicotine-induced dopamine release in the nac in a dose-dependent manner. |
2006-12-15 |
2023-08-12 |
mouse |
| Pamela B Yang, Alan C Swann, Nachum Dafn. Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats. Neuropharmacology. vol 51. issue 3. 2006-12-14. PMID:16824558. |
there is some evidence that psychostimulants, such as amphetamine and cocaine, activate the ventral tegmental area (vta) and nucleus accumbens (nac). |
2006-12-14 |
2023-08-12 |
rat |
| Ryan K Bachtell, Kimberly Whisler, David Karanian, David W Sel. Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat. Psychopharmacology. vol 183. issue 1. 2006-12-12. PMID:16163523. |
dopamine signaling in the nucleus accumbens (nac) plays an important role in regulating drug-taking and drug-seeking behaviors, but the role of d(1)- and d(2)-like receptors in this regulation remains unclear. |
2006-12-12 |
2023-08-12 |
rat |
| M E Walton, S W Kennerley, D M Bannerman, P E M Phillips, M F S Rushwort. Weighing up the benefits of work: behavioral and neural analyses of effort-related decision making. Neural networks : the official journal of the International Neural Network Society. vol 19. issue 8. 2006-12-12. PMID:16949252. |
we suggest that top-down signals from acc to nucleus accumbens (nac) and/or midbrain da cells may be vital for overcoming effort-related response costs. |
2006-12-12 |
2023-08-12 |
monkey |
| Arlene C Pak, Charles R Ashby, Christian A Heidbreder, Maria Pilla, Jeremy Gilbert, Zheng-Xiong Xi, Eliot L Gardne. The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. The international journal of neuropsychopharmacology. vol 9. issue 5. 2006-12-11. PMID:16942635. |
increasing evidence suggests that enhanced dopamine (da) neurotransmission in the nucleus accumbens (nac) may play a role in mediating the reward and reinforcement produced by addictive drugs and in the attentional processing of drug-associated environmental cues. |
2006-12-11 |
2023-08-12 |
rat |
| K Ito, T Abekawa, T Koyam. Relationship between development of cross-sensitization to MK-801 and delayed increases in glutamate levels in the nucleus accumbens induced by a high dose of methamphetamine. Psychopharmacology. vol 187. issue 3. 2006-12-07. PMID:16850286. |
the present study hypothesized that delayed increases in extracellular glutamate (glu) levels in the nucleus accumbens (nac), induced by a high dose of methamphetamine (meth), can result in some functional changes of excitatory amino acid receptors, developing behavioral cross-sensitization to a non-competitive n-methyl-d-aspartate (nmda) receptor antagonist, mk-801. |
2006-12-07 |
2023-08-12 |
Not clear |
| Sachiyo Sakamoto, Shinichi Nakao, Munehiro Masuzawa, Takefumi Inada, Mervyn Maze, Nicholas P Franks, Koh Shing. The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesthesia and analgesia. vol 103. issue 6. 2006-12-07. PMID:17122223. |
dopamine release in the nucleus accumbens (nac) plays a crucial role in the action of various psychotropic and addictive drugs, such as antagonists of the n-methyl-d-aspartate subtype of the glutamate. |
2006-12-07 |
2023-08-12 |
rat |
| Mariela F Perez, Francis J White, Xiu-Ti H. Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials. Journal of neurophysiology. vol 96. issue 5. 2006-12-06. PMID:16885524. |
the nucleus accumbens (nac) is a forebrain area in the mesocorticolimbic dopamine (da) system that regulates many aspects of drug addiction. |
2006-12-06 |
2023-08-12 |
rat |
| Zhifang Dong, Huili Han, Meina Wang, Lin Xu, Wei Hao, Jun Ca. Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens. Hippocampus. vol 16. issue 10. 2006-12-04. PMID:16897719. |
learned association between drugs of abuse and context is essential for the formation of drug conditioned place preference (cpp), which is believed to engage many brain regions including hippocampus and nucleus accumbens (nac). |
2006-12-04 |
2023-08-12 |
rat |
| Mina Ito, Taku Nagai, Hiroyuki Kamei, Noritaka Nakamichi, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice. Molecular pharmacology. vol 70. issue 5. 2006-12-04. PMID:16908600. |
in the present study, we investigated the role of the tpa-plasmin system in depolarization-evoked dopamine (da) and acetylcholine (ach) release in the nucleus accumbens (nac) and hippocampus, respectively, of mice, by using in vivo microdialysis. |
2006-12-04 |
2023-08-12 |
mouse |
| Nu-Chu Liang, Andras Hajnal, Ralph Norgre. Sham feeding corn oil increases accumbens dopamine in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 291. issue 5. 2006-11-29. PMID:16763080. |
both real and sham feeding of sucrose increase dopamine (da) overflow in the nucleus accumbens (nac). |
2006-11-29 |
2023-08-12 |
rat |
| K Ito, T Abekawa, T Koyam. Valproate blocks high-dose methamphetamine-induced behavioral cross-sensitization to locomotion-inducing effect of dizocilpine (MK-801), but not methamphetamine. Psychopharmacology. vol 186. issue 4. 2006-11-28. PMID:16758239. |
our group has recently shown that methamphetamine (meth) (2.5 mg/kg) induced delayed increases in glutamate (glu) levels in the rat nucleus accumbens (nac), and that its repeated administration leads to behavioral cross-sensitization to a selective uncompetitive n-methyl-d-aspartate (nmda) receptor antagonist, dizocilpine (mk-801). |
2006-11-28 |
2023-08-12 |
rat |
| Mark S Todtenkopf, Aram Parsegian, Alipi Naydenov, Rachael L Neve, Christine Konradi, William A Carlezo. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093088. |
drugs of abuse alter expression of ampa-type glutamate receptor subunits (glurs) in the nucleus accumbens (nac), a key component of brain reward systems. |
2006-11-28 |
2023-08-12 |
rat |
| Elena Butovsky, Ana Juknat, Judith Elbaz, Maytal Shabat-Simon, Raya Eilam, Abraham Zangen, Miriam Altstein, Zvi Voge. Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas. Molecular and cellular neurosciences. vol 31. issue 4. 2006-11-22. PMID:16513365. |
; 7 days) to rats, downregulates the expression of oxytocin-neurophysin (ot-np) mrna and of ot and oxytocin-associated np (npot) immunoreactivity in nucleus accumbens (nac) and ventral tegmental area (vta), brain areas involved in reward and addiction. |
2006-11-22 |
2023-08-12 |
rat |