| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brad A Grueter, Patrick E Rothwell, Robert C Malenk. Integrating synaptic plasticity and striatal circuit function in addiction. Current opinion in neurobiology. vol 22. issue 3. 2012-11-19. PMID:22000687. |
these synaptic adaptations include changes in the nucleus accumbens (nac), a ventral striatal subregion important for drug reward and reinforcement, as well as the dorsal striatum, which may promote habitual drug use. |
2012-11-19 |
2023-08-12 |
Not clear |
| Kyle K Pitchers, Susanne Schmid, Andrea R Di Sebastiano, Xu Wang, Steven R Laviolette, Michael N Lehman, Lique M Coole. Natural reward experience alters AMPA and NMDA receptor distribution and function in the nucleus accumbens. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529926. |
the current study determined whether sexual experience causes long-lasting changes in mating, or ionotropic glutamate receptor trafficking or function in the nucleus accumbens (nac), following 3 different reward abstinence periods: 1 day, 1 week, or 1 month after final mating session. |
2012-11-19 |
2023-08-12 |
rat |
| Allison A Feduccia, Yuanyuan Wang, Jeffrey A Simms, Henry Y Yi, Rui Li, Leonard Bjeldanes, Chuangxing Ye, Selena E Bartlet. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacology, biochemistry, and behavior. vol 102. issue 2. 2012-11-19. PMID:22579816. |
in order to investigate the brain region where theacrine may be acting, the drug (10 or 20 μg) was infused bilaterally into nucleus accumbens (nac). |
2012-11-19 |
2023-08-12 |
rat |
| Seong Shoon Yoon, Eun Jin Yang, Bong Hyo Lee, Eun Young Jang, Hee Young Kim, Sun-Mi Choi, Scott C Steffensen, Chae Ha Yan. Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats. Psychopharmacology. vol 222. issue 2. 2012-11-16. PMID:22453546. |
we have previously demonstrated that acupuncture reduces drug self-administration and dopamine release in the nucleus accumbens (nac), a brain structure implicated in stress-induced reinstatement of drug-seeking behavior. |
2012-11-16 |
2023-08-12 |
rat |
| Y Li, G-Y Yan, J-Q Zhou, Q Bu, P-C Deng, Y-Z Yang, L Lv, Y Deng, J-X Zhao, X Shao, R-M Zhu, Y-N Huang, Y-L Zhao, X-B Ce. ¹H NMR-based metabonomics in brain nucleus accumbens and striatum following repeated cocaine treatment in rats. Neuroscience. vol 218. 2012-11-16. PMID:22609933. |
ex vivo (1)h nmr (hydrogen-1 nuclear magnetic resonance) spectroscopy-based metabonomic approach coupled with partial least squares was applied to investigate the changes of cerebral metabolites in nucleus accumbens (nac) and striatum of rats subjected to cocaine treatment. |
2012-11-16 |
2023-08-12 |
rat |
| Matthew C Hearing, Anastasia N Zink, Kevin Wickma. Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system. Reviews in the neurosciences. vol 23. issue 4. 2012-11-13. PMID:22944653. |
this system consists primarily of dopaminergic projections arising from the ventral tegmental area (vta) and projecting to the limbic and cortical brain regions, such as the nucleus accumbens (nac) and prefrontal cortex (pfc). |
2012-11-13 |
2023-08-12 |
Not clear |
| Kristina E Hoque, Anthony R Wes. Dopaminergic modulation of nitric oxide synthase activity in subregions of the rat nucleus accumbens. Synapse (New York, N.Y.). vol 66. issue 3. 2012-11-09. PMID:22034069. |
nitric oxide (no) is a gaseous neurotransmitter synthesized in the nucleus accumbens (nac) by aspiny interneurons containing neuronal no synthase (nnos). |
2012-11-09 |
2023-08-12 |
rat |
| J Luigjes, W van den Brink, M Feenstra, P van den Munckhof, P R Schuurman, R Schippers, A Mazaheri, T J De Vries, D Deny. Deep brain stimulation in addiction: a review of potential brain targets. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21931318. |
we found 7 animal studies targeting six different brain areas: nucleus accumbens (nac), subthalamic nucleus (stn), dorsal striatum, lateral habenula, medial prefrontal cortex (mpfc) and hypothalamus, and 11 human studies targeting two different target areas: nac and stn. |
2012-11-07 |
2023-08-12 |
human |
| Katarzyna Kuter, Wacław Kolasiewicz, Krystyna Gołembiowska, Anna Dziubina, Gert Schulze, Klemencja Berghauzen, Jadwiga Wardas, Krystyna Ossowsk. Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats. Pharmacological reports : PR. vol 63. issue 6. 2012-11-07. PMID:22358086. |
levels of dopamine, dopac and hva were decreased in the nucleus accumbens (nac) 2 weeks after 6-ohda but were not changed in the cp, frontal cortex (fcx) and substantia nigra (sn). |
2012-11-07 |
2023-08-12 |
rat |
| Marek Schwendt, Carmela M Reichel, Ronald E Se. Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats. PloS one. vol 7. issue 3. 2012-11-05. PMID:22479593. |
synaptosomes from the medial pfc, nucleus accumbens (nac), and the dorsal striatum (dstr) were isolated and labeled with membrane-impermeable biotin in order to measure surface mglur2/3 and mglur7 receptors. |
2012-11-05 |
2023-08-12 |
rat |
| Giovanni Hernandez, Joseph F Chee. Effect of CB1 receptor blockade on food-reinforced responding and associated nucleus accumbens neuronal activity in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 33. 2012-11-02. PMID:22895729. |
studies have shown that disruption of cannabinoid receptor signaling reduces operant responses for rewards; yet it is unknown whether changes in neural activity at dopamine terminal regions such as the nucleus accumbens (nac) underlie these behavioral effects. |
2012-11-02 |
2023-08-12 |
rat |
| Diane Damez-Werno, Quincey LaPlant, HaoSheng Sun, Kimberly N Scobie, David M Dietz, Ian M Walker, Ja Wook Koo, Vincent F Vialou, Ezekiell Mouzon, Scott J Russo, Eric J Nestle. Drug experience epigenetically primes Fosb gene inducibility in rat nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 30. 2012-10-29. PMID:22836260. |
Δfosb, a fosb gene product, is induced in nucleus accumbens (nac) and caudate-putamen (cpu) by repeated exposure to drugs of abuse such as cocaine. |
2012-10-29 |
2023-08-12 |
rat |
| Satoshi Yawata, Takashi Yamaguchi, Teruko Danjo, Takatoshi Hikida, Shigetada Nakanish. Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 31. 2012-10-26. PMID:22802650. |
in the basal ganglia, inputs from the nucleus accumbens (nac) are transmitted through both direct and indirect pathways and control reward-based learning. |
2012-10-26 |
2023-08-12 |
mouse |
| Giovanni Hernandez, Ivan Trujillo-Pisanty, Marie-Pierre Cossette, Kent Conover, Peter Shizga. Role of dopamine tone in the pursuit of brain stimulation reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875936. |
however, this effect was smaller than that produced by a regimen of cocaine administration that drove similar increases in nucleus accumbens (nac) dopamine levels in unstimulated rats. |
2012-10-26 |
2023-08-12 |
human |
| M A De Luca, M Solinas, Z Bimpisidis, S R Goldberg, G Di Chiar. Cannabinoid facilitation of behavioral and biochemical hedonic taste responses. Neuropharmacology. vol 63. issue 1. 2012-10-23. PMID:22063718. |
on the other hand, highly palatable food stimulates dopamine (da) transmission in the shell of the nucleus accumbens (nac) and this effect undergoes one trial habituation. |
2012-10-23 |
2023-08-12 |
rat |
| A Muhammad, C Carroll, B Kol. Stress during development alters dendritic morphology in the nucleus accumbens and prefrontal cortex. Neuroscience. vol 216. 2012-10-17. PMID:22542675. |
rats exposed to stress during embryonic development (prenatal stress; ps) or soon after birth (maternal separation; ms) were studied for structural alteration at the neuronal level in the nucleus accumbens (nac), orbital frontal cortex (ofc), and medial prefrontal cortex (mpfc). |
2012-10-17 |
2023-08-12 |
rat |
| R Charles Lawrence, Nicha K H Otero, Sandra J Kell. Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens. Neurotoxicology and teratology. vol 34. issue 1. 2012-10-15. PMID:21871563. |
previous behavioral findings using rat models of fasd have suggested that there are changes in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc) following ethanol exposure during development. |
2012-10-15 |
2023-08-12 |
rat |
| J Kleijn, J Wiskerke, T I F H Cremers, A N M Schoffelmeer, B H C Westerink, T Patti. Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation. Neurochemistry international. vol 60. issue 8. 2012-10-12. PMID:22426202. |
the behavioral effects of the psychostimulant drug amphetamine depend on its ability to increase monoamine neurotransmission in brain regions such as the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2012-10-12 |
2023-08-12 |
rat |
| James E McCutcheon, Stephanie R Ebner, Amy L Loriaux, Mitchell F Roitma. Encoding of aversion by dopamine and the nucleus accumbens. Frontiers in neuroscience. vol 6. 2012-10-12. PMID:23055953. |
classically, the nucleus accumbens (nac) and the dopamine projection to it are considered an integral part of the brain's reward circuit, i.e., they direct approach and consumption behaviors and underlie positive reinforcement. |
2012-10-12 |
2023-08-12 |
rat |
| Ja Wook Koo, Michelle S Mazei-Robison, Dipesh Chaudhury, Barbara Juarez, Quincey LaPlant, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N Scobie, Diane Damez-Werno, Marshall Crumiller, Yoshinori N Ohnishi, Yoko H Ohnishi, Ezekiell Mouzon, David M Dietz, Mary Kay Lobo, Rachael L Neve, Scott J Russo, Ming-Hu Han, Eric J Nestle. BDNF is a negative modulator of morphine action. Science (New York, N.Y.). vol 338. issue 6103. 2012-10-11. PMID:23042896. |
in contrast, optical stimulation of vta da terminals in nucleus accumbens (nac) completely reversed the suppressive effect of bdnf on morphine reward. |
2012-10-11 |
2023-08-12 |
Not clear |