| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincent Vialou, Mackenzie Thibault, Sophia Kaska, Sarah Cooper, Paula Gajewski, Andrew Eagle, Michelle Mazei-Robison, Eric J Nestler, A J Robiso. Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. Neuropharmacology. vol 99. 2016-08-24. PMID:26164345. |
we further uncover specific patterns of fosb gene product expression (i.e., differential expression of full-length fosb, Δfosb, and Δ2Δfosb) in brain regions associated with depression--the nucleus accumbens (nac), prefrontal cortex (pfc), and hippocampus--in response to chronic fluoxetine treatment, and contrast these patterns with differential induction of fosb isoforms in the chronic social defeat stress model of depression with and without fluoxetine treatment. |
2016-08-24 |
2023-08-13 |
mouse |
| J R Schank, B S Nelson, R Damadzic, J D Tapocik, M Yao, C E King, K E Rowe, K Cheng, K C Rice, M Heili. Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking. Neuropharmacology. vol 99. 2016-08-24. PMID:26188146. |
as expected, vehicle treated animals exposed to footshock showed induction of fos immunoreactivity in several regions of the brain stress circuitry, including the amygdala (amg), nucleus accumbens (nac), dorsal raphe nucleus (dr), prefrontal cortex (pfc), and bed nucleus of the stria terminalis (bnst). |
2016-08-24 |
2023-08-13 |
Not clear |
| Edita Navratilova, Christopher W Atcherley, Frank Porrec. Brain Circuits Encoding Reward from Pain Relief. Trends in neurosciences. vol 38. issue 11. 2016-08-24. PMID:26603560. |
we review findings from electrophysiological, neuroimaging, and behavioral studies supporting the concept that the rewarding effect of pain relief requires opioid signaling in the anterior cingulate cortex (acc), activation of midbrain dopamine neurons, and the release of dopamine in the nucleus accumbens (nac). |
2016-08-24 |
2023-08-13 |
Not clear |
| Nobuyuki Kai, Kayo Nishizawa, Yuji Tsutsui, Shuichi Ueda, Kazuto Kobayash. Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization. Journal of neurochemistry. vol 135. issue 6. 2016-08-22. PMID:26442961. |
the nucleus accumbens (nac) mediates the reinforcing and motor stimulating properties of psychostimulants. |
2016-08-22 |
2023-08-13 |
mouse |
| Nobuyuki Kai, Kayo Nishizawa, Yuji Tsutsui, Shuichi Ueda, Kazuto Kobayash. Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization. Journal of neurochemistry. vol 135. issue 6. 2016-08-22. PMID:26442961. |
here, we show that the nucleus accumbens (nac) shell neurons containing dopamine d1 receptor (d1r) or d2 receptor (d2r) play distinct roles in behavioral sensitization triggered by methamphetamine, and that d1r-containing neurons enhance the induction of behavioral sensitization at the early phase, whereas d2r-containing neurons act to suppress the rate of development of the behavior. |
2016-08-22 |
2023-08-13 |
mouse |
| Tara J Aitken, Venuz Y Greenfield, Kate M Wassu. Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues. Journal of neurochemistry. vol 136. issue 5. 2016-08-22. PMID:26715366. |
environmental reward-predictive stimuli provide a major source of motivation for instrumental reward-seeking activity and this has been linked to dopamine signaling in the nucleus accumbens (nac) core. |
2016-08-22 |
2023-08-13 |
rat |
| Yanhua H Huang, Oliver M Schlüter, Yan Don. Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 5. 2016-08-19. PMID:25829364. |
a transient but prominent increase in the level of "silent synapses"--a signature of immature glutamatergic synapses that contain only nmda receptors without stably expressed ampa receptors--has been identified in the nucleus accumbens (nac) following exposure to cocaine. |
2016-08-19 |
2023-08-13 |
Not clear |
| Luna Prieto-Garcia, Emil Egecioglu, Erik Studer, Lars Westberg, Elisabet Jerlha. Ghrelin and GHS-R1A signaling within the ventral and laterodorsal tegmental area regulate sexual behavior in sexually naïve male mice. Psychoneuroendocrinology. vol 62. 2016-08-18. PMID:26398679. |
the ability of ghrelin to regulate reinforcement involves the cholinergic-dopaminergic reward link, which encompasses a cholinergic projection from the laterodorsal tegmental area (ldtg) to the ventral tegmental area (vta) together with mesolimbic dopaminergic projections from the vta to the nucleus accumbens (nac). |
2016-08-18 |
2023-08-13 |
mouse |
| HaoSheng Sun, Jennifer A Martin, Craig T Werner, Zi-Jun Wang, Diane M Damez-Werno, Kimberly N Scobie, Ning-Yi Shao, Caroline Dias, Jacqui Rabkin, Ja Wook Koo, Amy M Gancarz, Ezekiell A Mouzon, Rachael L Neve, Li Shen, David M Dietz, Eric J Nestle. BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053203. |
here, we demonstrate that baz1b, an accessory subunit of the iswi family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (nac), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. |
2016-08-15 |
2023-08-13 |
mouse |
| Erin S Calipari, Rosemary C Bagot, Immanuel Purushothaman, Thomas J Davidson, Jordan T Yorgason, Catherine J Peña, Deena M Walker, Stephen T Pirpinias, Kevin G Guise, Charu Ramakrishnan, Karl Deisseroth, Eric J Nestle. In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 10. 2016-08-09. PMID:26831103. |
the reinforcing and rewarding properties of cocaine are attributed to its ability to increase dopaminergic transmission in nucleus accumbens (nac). |
2016-08-09 |
2023-08-13 |
Not clear |
| Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L Patkar, Vincent Tam, Arnauld Belmer, Selena E Bartlet. Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake. PloS one. vol 11. issue 3. 2016-08-08. PMID:27028298. |
interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (nac), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. |
2016-08-08 |
2023-08-13 |
Not clear |
| Chiung-Chun Huang, Ying-Ching Liang, Cheng-Che Lee, Kuei-Sen Hs. Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25319571. |
we previously reported that animals withdrawn from repeated cocaine exposure exhibited a selective deficit in the ability to elicit metabotropic glutamate receptor 5 (mglur5)-dependent long-term depression (ltd) in the nucleus accumbens (nac) shell. |
2016-08-08 |
2023-08-13 |
mouse |
| Christina N Nona, Marie Kristel Bermejo, Amy J Ramsey, José N Nobreg. Changes in dendritic spine density in the nucleus accumbens do not underlie ethanol sensitization. Synapse (New York, N.Y.). vol 69. issue 12. 2016-08-03. PMID:26340045. |
behavioral sensitization to various drugs of abuse has been shown to change dendritic spine density and/or morphology of nucleus accumbens (nac) medium spiny neurons, an effect seen across drug classes. |
2016-08-03 |
2023-08-13 |
mouse |
| Adam N Perry, Christel Westenbroek, Lakshmikripa Jagannathan, Jill B Becke. The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 12. 2016-08-02. PMID:25900120. |
the study objectives were to examine changes in cocaine-induced dopamine (da) overflow in the nucleus accumbens (nac) over the course of self-administration and determine the roles of α1- and β-adrenergic receptors (ar) in the loss-of-interest in food rewards following the development of an addicted phenotype in male and female rats. |
2016-08-02 |
2023-08-13 |
human |
| D Y Sakae, F Marti, S Lecca, F Vorspan, E Martín-García, L J Morel, A Henrion, J Gutiérrez-Cuesta, A Besnard, N Heck, E Herzog, S Bolte, V F Prado, M A M Prado, F Bellivier, C B Eap, S Crettol, P Vanhoutte, J Caboche, A Gratton, L Moquin, B Giros, R Maldonado, S Daumas, M Mameli, S Jamain, S El Mestikaw. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:26239290. |
tonically active cholinergic interneurons (tans) from the nucleus accumbens (nac) are centrally involved in reward behavior. |
2016-08-02 |
2023-08-13 |
mouse |
| Shane A Perrine, Farhad Ghoddoussi, Kirtan Desai, Robert J Kohler, Ajay T Eapen, Michael J Lisieski, Mariana Angoa-Perez, Donald M Kuhn, Kelly E Bosse, Alana C Conti, David Bissig, Bruce A Berkowit. Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI. NMR in biomedicine. vol 28. issue 11. 2016-08-01. PMID:26411897. |
here, we tested the hypothesis that cocaine produces locomotor (behavioral) sensitization that correlates with increased calcium channel-mediated neuroactivity in brain regions linked with drug addiction, such as the nucleus accumbens (nac), anterior striatum (ast) and hippocampus, as measured using manganese-enhanced mri (memri). |
2016-08-01 |
2023-08-13 |
rat |
| Johann du Hoffmann, Saleem M Nicol. Activation of Dopamine Receptors in the Nucleus Accumbens Promotes Sucrose-Reinforced Cued Approach Behavior. Frontiers in behavioral neuroscience. vol 10. 2016-07-29. PMID:27471453. |
dopamine receptor activation in the nucleus accumbens (nac) promotes vigorous environmentally-cued food-seeking in hungry rats. |
2016-07-29 |
2023-08-13 |
rat |
| Maggie C Evans, Vincent W Clark, Patrick J Manning, Dirk De Ridder, John N J Reynold. Optimizing Deep Brain Stimulation of the Nucleus Accumbens in a Reward Preference Rat Model. Neuromodulation : journal of the International Neuromodulation Society. vol 18. issue 7. 2016-07-27. PMID:26268572. |
as a first step, we used a rat model of nucleus accumbens (nac) dbs to rigorously compare the relative reward values of different stimulation paradigms. |
2016-07-27 |
2023-08-13 |
rat |
| Feng Zou, Xinhuai Wu, Tianye Zhai, Yu Lei, Yongcong Shao, Xiao Jin, Shuwen Tan, Bing Wu, Lubin Wang, Zheng Yan. Abnormal resting-state functional connectivity of the nucleus accumbens in multi-year abstinent heroin addicts. Journal of neuroscience research. vol 93. issue 11. 2016-07-27. PMID:26280556. |
we first examined the group differences in the resting-state functional connectivity of the nucleus accumbens (nac), a brain region implicated in relapse-related processes, including craving and reactivity to stress following acute and protracted withdrawal from heroin. |
2016-07-27 |
2023-08-13 |
human |
| Nathan J Marchant, Erin J Campbell, Leslie R Whitaker, Brandon K Harvey, Konstantin Kaganovsky, Sweta Adhikary, Bruce T Hope, Robert C Heins, Thomas E Prisinzano, Eyal Vardy, Antonello Bonci, Jennifer M Bossert, Yavin Shaha. Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 11. 2016-07-26. PMID:26985037. |
here, we studied the role of projections to nucleus accumbens (nac) shell from ventral subiculum (vsub), basolateral amygdala, paraventricular thalamus, and ventral medial prefrontal cortex in context-induced relapse after punishment-imposed abstinence. |
2016-07-26 |
2023-08-13 |
human |